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All Journal Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Dental Medicine
Wisnu Setyari Juliastuti
Faculty Of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Dentistry

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Effect of electrolyzed reduced water on Wistar rats with chronic periodontitis on malondialdehyde levels Rini Devijanti Ridwan; Wisnu Setyari Juliastuti; R. Darmawan Setijanto
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 1 (2017): March 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.867 KB) | DOI: 10.20473/j.djmkg.v50.i1.p10-13

Abstract

Background: Periodontal disease is a progressive destructive change that causes loss of bone and periodontal ligaments around the teeth that can eventually lead to its loss. The main bacteria in chronic periodontitis is Porphyromonas gingivalis. Aggregatibacter actinomycetemcomitans, a pathogen associated with aggressive periodontitis, initiates a proinflammatory response that causes tissue destruction of periodontal, alveolar bone resorption and subsequent tooth loss. Electrolyzed reduced water (ERW) is an alkaline water, ERW not only has a high pH and low oxidation reduction potential (ORP), but also contains several magnesium ions. Magnesium ions proven effective for the prevention of various diseases. Purpose: To analyze the level of malondialdehyde (MDA) in Wistar rats with cases of chronic and aggressive periodontitis that consumed ERW. Method: Wistar rats were divided into four groups, each group with 10 rats. The first and second group were Wistar rat with chronic periodontitis and consume drinking water and ERW. The third and fourth group were Wistar rat with aggressive periodontitis and consume drinking water and ERW. This experiment is done by calculating the levels of MDA. The calculation of the levels of MDA is done with spectrophotometric assay for MDA. Result: The results of this experiment show that the level of MDA in serum in group that consume ERW had decreased significantly different with thegroup that consume drinking water with the statistical test. Conclusion: It can be concluded that ERW can decrease the MDA level in Wistar rat with chronic and aggressive periodontitis case.
The effect of Avocado leaf extract (Persea americana Mill.) on the fibroblast cells of post-extraction dental sockets in Wistar rats Christian Khoswanto; Wisnu Setyari Juliastuti; Karina Awanis Adla
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 3 (2018): September 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (825.205 KB) | DOI: 10.20473/j.djmkg.v51.i3.p129-132

Abstract

Background: Tooth extraction, a common practice among the dental profession, causes trauma to the blood vessels during the wound healing process. The acceleration of wound healing, within which fibroblasts play an important role, is influenced by nutrition. Avocado leaves contain a variety of chemicals, including flavonoid compounds, tannins, katekat, kuinon, saponin and steroids/triterpenoid. Avocado leaves also contain glycosides, cyanogenic, alkaloids and phenols which function as anti-inflammatory, antibacterial and antioxidant agents. This avocado leaf content could be used as an alternative medicine to accelerate the wound healing process in post-tooth extraction sockets. Purpose: To determine the role of avocado leaves (Persea americana Mill) in accelerating fibroblast cells proliferation in tooth socket post-extraction. Methods: The sample was divided into four groups, a control group and three treatment groups. The treatment groups used avocado leaf extract and 3% CMC Na solution which was inserted into the tooth sockets of Wistar rats. Both the control and treatment groups had their mandibula decapitated with all the required specimens being prepared on the 3rd and 7th days of the experiment. Mandibular decapitation and tooth extraction socket were prepared by HPA (Histology Pathology Anatomy) with Hematoxylin Eosin (HE) staining. The  fibroblast proliferation was analyzed by means of a light microscope at 400x magnification. The obtained data was analyzed using a t-Test. Result: The t-Test obtained a significance value 0.001 (p <0.05) between the control and treatment groups. The number of fibroblast cells increased in the group treated on the third day and decreased in the group treated on the seventh day. Conclusion: Avocado leaf extract (Persea americana Mill.) accelerates proliferation of fibroblast cells in Wistar rats post-tooth extraction.
A mucoadhesive gingival patch with Epigallocatechin-3-gallate green tea (Camellia sinensis) as an alternative adjunct therapy for periodontal disease: A narrative review Yeka Ramadhani; Riski Rahayu Putri Rahmasari; Kinanti Nasywa Prajnasari; Moh. Malik Alhakim; Mohammed Aljunaid; Hesham Mohammed Al-Sharani; T. Tantiana; Wisnu Setyari Juliastuti; Rini Devijanti Ridwan; Indeswati Diyatri
Dental Journal (Majalah Kedokteran Gigi) Vol. 55 No. 2 (2022): June 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i2.p114-119

Abstract

Background: Periodontitis is a progressive destructive periodontal disease. The prevalence of periodontal disease in Indonesia reaches 74.1% and mostly occurs in the productive age group. Most of the periodontopathogenic bacteria are gram-negative bacteria and have endotoxin in the form of lipopolysaccharide (LPS), which can penetrate the periodontal tissue and induce an inflammatory response. In inflammatory conditions, osteoclastic activity is higher than osteoblastic activity, which causes bone destruction. This results in an imbalance between osteoclast-induced bone resorption and osteoblast-induced bone formation. The current preferred treatment for periodontitis is scaling root planning (SRP), but this therapy cannot repair the damaged periodontal tissue caused by periodontitis. Purpose: To describe the possibility of using a mucoadhesive gingival patch with Epigallocatechin-3-gallate (EGCG) green tea (Camellia sinensis) as alternative adjunct therapy for periodontal disease. Review: EGCG is the main component of green tea catechins, which have antitumor, antioxidant, anti-inflammatory, anti-fibrotic, and pro-osteogenic effects. However, the weaknesses so far regarding the use of EGCG as an alternative treatment is its low oral bioavailability and the concentration of EGCG absorbed by the body decreasing when accompanied by food. EGCG can be used with a mucoadhesive gingival patch to optimise bioavailability and absorption and increase local concentration and sustained release of EGCG. EGCG encourages bone development and braces mesenchymal stem cells (MSCs) differentiation for osteoblast by enhancing the expression of bone morphogenic protein 2 (BMP2). EGCG also has been proven to increase the expression of RUNX2 and ALP activity that induces osteoblast differentiation and bone mineralisation. Conclusion: A mucoadhesive gingival patch containing EGCG Green Tea (C. sinensis) may potentially induce osteoblastic activity as an adjunct therapy to repair the periodontal tissue damage due to periodontal disease.
The Effect Of Giving Okra (Abelmoschus Esculentus) Extract On The Increase Of Vascular Endhothelial Growth Factor (Vegf) Muhammad Luthfi; Wisnu Setyari Juliastuti; Nidya Pramesti Olifia Asyhari
Indonesian Journal of Dental Medicine Vol. 2 No. 2 (2019): July - December
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v2i2.2019.35-40

Abstract

Background: People with diabetes mellitus who perform tooth extraction related to the complications that disrupt the process wound healing. Diabetics have persistent inflammatory phase and abnormal angiogenesis in proliferation phase. Treatment for people with diabetes mellitus is done through increase VEGF. Herbal medicine that use extracts from plants have benefits in wound healing processes such as okra fruit extract because it contains flavonoids. Flavonoids in accelerating wound healing in patients diabetes mellitus can through its role as anti-diabetic, anti-inflammatory and antioxidant. This plays a role in the persistent inflammatory resolution process leading to proliferation by macrophages and immunomodulatory effects of macrophage function in issuing growth factors. Objective: To prove okra fruit extract (Abelmoschus esculentus) influences the increase in VEGF expression in the process of healing wounds from tooth extraction of diabetes mellitus Wistar rats. Method: Laboratory experimental research with randomized post test only The control group used 24 Wistar mice which were divided into two groups namely the control group (STZ induction) and the treatment group (STZ induction by giving okra fruit extract). Tooth extraction is done on the incisors left lower jaw. 4 mice from each group were sacrificed on day 3, 5 and 7 after revocation. A Socket is cut for inspection immunohistochemistry. Results: VEGF expression of the control group compared to the group the treatment showed significant results (p <0.05). Conclusion: Administration of extracts okra (Abelmoschus esculentus) has the effect of increasing expression VEGF in the healing process of wistar tooth extraction wounds with diabetes mellitus.
Co-Authors Christian Khoswanto, Christian Hesham Mohammed Al-Sharani Indeswati Diyatri Karina Awanis Adla Kinanti Nasywa Prajnasari Moh. Malik Alhakim Mohammed Aljunaid Muhammad Luthfi Nidya Pramesti Olifia Asyhari R. Darmawan Setijanto Rini Devijanti Ridwan Riski Rahayu Putri Rahmasari Tantiana Tantiana Yeka Ramadhani