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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Kedokteran Gigi Universitas Padjadjaran Health Notions Journal of Dentomaxillofacial Science Indonesian Journal for Health Sciences (IJHS) Denta: Jurnal Kedokteran Gigi Odonto dental journal
Pudji Astuti
Bagian Biomedik Fakultas Kedokteran Gigi Universitas Jember Jember, Indonesia
Dentistry Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health

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The Influence of Oral Hygiene Behavior on Periodontal Disease Status of Fishpond Community in District Sidoarjo Narita Ajeng Loviana; Melok Aris Wahyukundari; Ristya Widi Endah Yani; Peni Pudjiastuti; Hestieyonini Hadnyanawati; Sri Lestari; I Dewa Ayu Ratna Dewanti
Health Notions Vol 2, No 7 (2018): July
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.548 KB) | DOI: 10.33846/hn.v2i7.254

Abstract

Background: Periodontal disease is one of the most common oral diseases in Indonesia. Poor oral hygiene behavior has been seen as a risk factor for periodontal disease. Oral hyigiene behavior is different in each individual or group, as well as the fishpond community. Purpose: To analyze the influence of oral hygiene behavior on periodontal disease status of fishpond community. Methods: This study was a observational analytic study with cross sectional approach. The samples were fishpond community in Banjar Kemuning village, district Sidoarjo which amounts 100 people in age range between 26 to 65 years old. Oral hygiene behavior in the form of knowledges and attitudes were measured using a closed questionnaire and oral hygiene behavior in the form of practices were measured using a checklist questionnaire, while Periodontal Disease Index (PDI) was used to measured periodontal disease status. Results: Ordinal regression analysis of the oral hygiene behavior on periodontal disease status showed significant value that was 0,043. Conclusion: Oral hygiene behavior has influence on periodontal disease status of fishpond community in District Sidoarjo. Keywords: Oral hygiene behavior, Knowledge, Attitude, Practice, Periodontal disease status, Fishpond
Uji Daya Hambat Ekstrak Metanol Daun Ungu (Graptophillum pictum (L.) Griff) terhadap Pertumbuhan Bakteri Saluran Akar Gigi (Inhibition Test of Purple Leaf (Graptophillum pictum (L.) Griff) Methanol Extract toward Root Canal Bacteria's Growth) Resti Ayu Indriana; Pudji Astuti; Atik Kurniawati
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background: Root canal bacteria in necrotizing pulp are dominated by polymicrobial bacterial colonization. Bacteria control were performed by using antribacterial irrigation. Purple leaf methanol extract contains triterpenoids, alkaloids, flavonoids, glycosides, saponins, and tanins which are to own antibacterial capability. Objective: To determine a wide range of consentrations, the minimal concentration of purple leaf methanol extract which able to inhibit the growth of root canal bacteria, and how much is the concentration of the purple leaf methanol extract which is equivalent to 2.6% sodium hypochlorite. Methods: The method was used well diffusion. Antibacterial test was indicated by the existance of the inhibition zone around the well hole. Total samples used were 56 samples for  each 7 group treatment, which are concentration 100%, 50%, 25%, 12,5%, 6,25% of purple leaf methanol extract, 2.6% of sodium hypochlorite, and sterile water. The results of the study was then tested by the statistical parametric one way ANOVA and LSD. Results and Conclusion: The concentration of purple leaf methanol extract which ables to inhibit the growth of root canal bacteria is 12,5%, 25%, 50%, and 100% also the minimum concentration is 12,5%, and the concentration of purple leaf methanol extract which is equivalent to 2.6% of sodium hypochlorite is concentration of 25%.Keywords: Antibacterial, Root Canal Bacteria, Purple Leaf Methanol Extract, Graptophillum pictum (L.) Griff
Uji Klinis Penggunaan Pasta Gigi Herbal Terhadap Penurunan Indeks Plak Rongga Mulut (Clinical Trial of Herbal Toothpaste to Reduce Plaque Index in Oral Cavity ) Danang Dewantara Ananda Putra; Pudji Astuti; Abdul Rochim
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Toothpaste with a toothbrush are control hygiene and health of the oral cavity by means of cleaning plaque and food residues. Maintenance of teeth and cleaning the mouth is one of the efforts to improve health, but there are many people did not know is there a difference in cleaning the plaque herbals toothpastes. Objective: To compare plaque index pre and post given herbal toothpaste, and compare plaque index among herbal toothpaste. Methods: Research clinical trials that followed by 15 subject of study was more than 12 years old or arrangement of teeth complete permanent eruptive. Fifteen the subject divided into three groups using pre post test control group design and cross over design, the subject of brushing teeth with three different toothpaste. Result: Paired t-test result showed (p<0,05) there was significant reduction of plaque index between pre and post intervension herbal toothpaste and control toothpaste. One Way Annova test showed (p>0,05) there was no significant differences between those toothpaste to reduce plaque index. Conclusion: All of herbal toothpaste significant reduction of plaque index between pre and post intervension. There was no significant differences between those herbal toothpaste to reduce plaque index. Keywords: plaque index, herbal toothpaste
Aktivitas Antibakteri Kombinasi Vitamin C dan Amoksisilin sebagai Bahan Alternatif Intrakanal Medikamen terhadap Enterococcus faecalis secara In Vitro Julia Eka Putri Ayuningtyas; Pudji Astuti; Dwi Warna Aju Fatmawati
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.19794

Abstract

Bacteria that are often found in cases of pulp necrosis and root canal treatment are Enterococcus faecalis. Elimination of microorganisms in the root canal can use intracanal medicament. The intracanal medicament can be used from antibiotics such as amoxicillin. The antibacterial power of amoxicillin can be increased by combination with vitamin C to prevent resistance. This research aimed to determine the zone of inhibition of vitamin C and amoxicillin against Enterococcus faecalis. The method used in this study is well diffusion method. Inhibition is shown through the clear zone around the wellbore at 24 hours, 48 ​​hours, 72 hours after incubation. The number of research samples is 16 consisted of 4 groups consisting of amoxicillin, vitamin C, a combination of vitamin C and amoxicillin, and 3 MIX MP. The data were tested by non-parametric statistical analysis Kruskal Wallis and Mann Whitney. The result showed that vitamin C and amoxicillin's antibacterial activity as alternative material intracanal medicament is equivalent to antibacterial 3 MIX MP.
Aktivitas antibakteri ekstrak daun sirih merah (Piper crocatum) terhadap pertumbuhan Aggregatibacter actinomycetemcomitansAntibacterial activity of red betel (Piper crocatum) leaf extract on the growth of Aggregatibacter actinomycetemcomitans Rosanita Firdausi Oktaviani; Pudji Astuti; Melok Aris Wahyukundari
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 34, No 1 (2022): April 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v34i1.34833

Abstract

Pendahuluan: Penyakit periodontal merupakan salah satu penyakit inflamasi kronis yang menyerang periodonsium yang disebabkan oleh salah satu mikroorganisme yaitu Aggregatibacter actinomycetemcomitans. Perawatan penyakit periodontal dapat dilakukan dengan bahan alam salah satunya daun sirih merah (Piper crocatum). Daun sirih merah memiliki aktivitas senyawa antibakteri yang dapat menghambat pertumbuhan A. actinomycetemcomitans. Tujuan dari penelitian ini adalah untuk mengetahui daya antibakteri ekstrak daun sirih merah (Piper crocatum) terhadap pertumbuhan A. actinomycetemcomitans. Metode: Penelitian dilakukan dengan metode difusi cakram pada media MHA (Mueller Hinton Agar) dengan mengukur zona bening yang terbentuk menggunakan jangka sorong. Jenis penelitian yang digunakan eksperimental laboratoris dengan sampel sebanyak 30 sampel. Hasil: Daya hambat ekstrak daun sirih merah (Piper crocatum) terhadap A. actinomycetemcomitans terdapat pada kelompok perlakuan dengan konsentrasi 25%, 50%, dan 100%. Aktivitas antibakteri konsentrasi 25% dikategorikan sedang, konsentrasi 50% dan 100% dikategorikan kuat. Kelompok kontrol positif terdapat aktivitas daya hambat bakteri dengan nilai rerata diameter 23,42 mm, sedangkan kelompok kontrol negatif tidak menunjukkan adanya zona hambat. Hasil uji Kruskal Wallis menunjukkan bahwa signifikansi (0,00) dengan p<0,05 dilanjutkan dengan uji Mann Whitney menunjukkan nilai signifikansi lebih kecil dari 0,05 (p < 0,05) pada semua kelompok konsentrasi. Simpulan: Ekstrak daun sirih merah (Piper crocatum) terdapat aktivitas antibakteri terhadap pertumbuhan A. actinomycetemcomitans dengan daya hambat yang terkecil pada konsentrasi 25% dan daya hambat ekstrak daun sirih merah yang terbesar pada konsentrasi 100%.Kata kunci: penyakit periodontal; daun sirih merah; Aggregatibacter actinomycetemcomitans ABSTRACTIntroduction: Periodontal disease is a chronic inflammatory disease of the periodontium caused by microorganisms such as Aggregatibacter actinomycetemcomitans. Periodontal disease treatment can be carried out with natural ingredients such as red betel (Piper crocatum) leaf. Red betel leaf has an antibacterial activity which can inhibit the growth of A. actinomycetemcomitans. This study aimed to determine the antibacterial activity of red betel (Piper crocatum) leaf extract on the growth of A. actinomycetemcomitans. Methods: The study used the disc diffusion method on MHA (Mueller Hinton Agar) media by measuring the clear zone formed using a calliper. The type of study was an experimental laboratory conducted on 30 samples. Results: The inhibitory activity of red betel (Piper crocatum) leaf extract against A. actinomycetemcomitans was found in the treatment group of 25%, 50%, and 100%. The antibacterial activity in the concentration of 25% was categorised as moderate, while categorised as strong in the concentrations of 50% and 100%. The positive control group had a bacterial inhibitory activity with a mean diameter of 23.42 mm, while the negative control group showed no inhibition zone. The results of the Kruskal-Wallis test showed significant results (0.00; p<0.05), followed by the Mann-Whitney test, which also showed a significant value of less than 0.05 (p<0.05) in all concentration groups. Conclusion: Red betel leaf (Piper crocatum) extract has antibacterial activity against the growth of A. actinomycetemcomitans with the lowest inhibition at a concentration of 25% and the highest inhibitory activity at a concentration of 100%.Keywords: periodontal disease; red betel leaf; Aggregatibacter actinomycetemcomitans
Potensi ekstrak daun singkong (Manihot esculenta Crantz.) terhadap profil leukosit darah tepi model tikus disfungsi ovarium dan periodontitisPotential of cassava leaves (Manihot esculenta Crantz.) extract on peripheral blood leukocyte profile in ovary dysfunction and periodontitis rat model Lutfi Meiga Sari; Zahara Meilawaty; Pudji Astuti; Amandia Dewi Permana Shita; Agustin Wulan Suci Dharmayanti; Zahreni Hamzah
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 33, No 1 (2021): April 2021
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v33i1.30751

Abstract

Pendahuluan: Disfungsi ovarium merupakan keadaan ovarium yang mengalami kegagalan dalam sekresi hormon seks steroid. Penurunan sekresi hormon terutama estrogen dapat memicu peningkatan sitokin proinflamasi seperti IL-1, IL-6 dan TNF-α yang berperan dalam resorpsi tulang dan reaksi inflamasi periodontal. Salah satu drug of choice dari periodontitis adalah metronidazole. Penggunaan metronidazole secara sistemik dapat mengakibatkan efek samping, sehingga diperlukan bahan alternatif yang memiliki efek terapi antiinflamasi. Salah satu tanaman yang memiliki efek antiinflamasi adalah daun Singkong. Tujuan penelitian adalah menganalisis potensi ekstrak daun Singkong sebagai antiinflamasi terhadap profil leukosit darah tepi model tikus disfungsi ovarium dan periodontitis. Metode: Jenis penelitian eksperimental laboratoris dengan post-test only control group design. Sampel penelitian sebanyak 18 ekor tikus betina yang dibagi menjadi dua kelompok besar yakni kelompok disfungsi ovarium dan kelompok kecil periodontitis. Pembuatan model tikus disfungsi ovarium dan tikus periodontitis dilakukan selama 28 hari. Setelah masing-masing kelompok dibagi menjadi 3 kelompok yang diberikan perlakuan aquades, metronidazole dan ekstrak daun Singkong selama 7 hari. Setiap tikus diambil darahnya melalui plexus infraorbitalis pada hari ke-1, hari ke-3 dan hari ke-7. Darah yang diambil selanjutnya dilakukan perhitungan jumlah sel leukosit darah tepi menggunakan kamar hitung dan perhitungan jenis dengan cara visual. Hasil: Hasil uji LSD menunjukkan bahwa terdapat perbedaan bermakna jumlah leukosit darah tepi antar hari pada kelompok tikus yang mengalami disfungsi ovarium (p≤0,05). Simpulan: Ekstrak daun Singkong (Manihot esculenta Crantz) dapat menurunkan profil leukosit perifer model tikus disfungsi ovarium dan periodontitis.Kata kunci: Disfungsi ovarium, periodontitis, profil leukosit perifer, ekstrak daun singkong. ABSTRACTIntroduction: Ovarian dysfunction is when the ovaries fail in the secretion of steroid sex hormones. Decreased secretion of hormones, especially estrogen, can trigger an increase in pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, which play a role in bone resorption and periodontal inflammatory reactions. One drug of choice for periodontitis is metronidazole. Systemic use of metronidazole can cause side effects, so an alternative material with a therapeutic anti-inflammatory effect is needed. One of the plants that have an anti-inflammatory effect is cassava leaves. The research objective was to analyse the potential of cassava leaf extract as an anti-inflammatory against the peripheral blood leukocyte profile in a mouse model of ovarian dysfunction and periodontitis. Methods: This was an experimental laboratory study with a post-test only control group design. The research sample consisted of 18 female rats divided into two large groups: the ovarian dysfunction group and the small periodontitis group. The making of mouse models of ovarian dysfunction and periodontitis rats was carried out for 28 days. After each group was divided into three groups treated with distilled water, metronidazole and cassava leaf extract for seven days. Blood was drawn from each mouse through the infraorbital plexus on day 1, day three, and 7. The blood that was taken was then performed to calculate the number of peripheral blood leukocytes using the counting room and the calculation of the type by visual means. Results: The results of the LSD test showed that there was a significant difference in the number of peripheral blood leukocytes between days in the group of rats with ovarian dysfunction (p≤0.05). Conclusion: Cassava leaf extract (Manihot esculenta Crantz) can reduce the profile of peripheral leukocytes in a mouse model of ovarian dysfunction and periodontitis.Keywords: Ovarian dysfunction, periodontitis, peripheral leukocytes profile, cassava leaf extract.
Uji efektivitas waktu aplikasi gel bromelain konsentrasi 10% terhadap degradasi jaringan karies pada dentin menggunakan scanning electron microscope (SEM)The effectiveness test of application time of 10% bromelain gel on the degradation of carious tissue in dentin using a scanning electron microscope (SEM) Berlian Prihatiningrum; Indah Widyanti; Pudji Astuti
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 34, No 1 (2022): April 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v34i1.34537

Abstract

Pendahuluan: Enzim bromelin dari bagian daging dan bonggol buah nanas (Ananas comosus (L.) Merr,) berpotensi sebagai bahan chemo-mechanical caries removal (CMCR) berbasisenzim yang aman dan ekonomis. Namun, belum ada penelitian yang membahas lebih lanjut mengenai waktu aplikasi yang efektif bagi enzim bromelin dalam melakukan degradasi jaringan karies pada dentin. Tujuan penelitian adalah menganalisis waktu aplikasi yang efektif bagi enzim bromelin konsentrasi 10% dalam mendegradasi jaringan karies pada dentin dengan waktu aplikasi selama 1, 2, dan 3 menit. Metode: Penelitian ini merupakan penelitian eksperimental laboratories menggunakan 36 sampel gigi premolar permanen rahang atas dengan kondisi karies klas I yang dibagi menjadi 9 kelompok penelitian. Bahan uji yang digunakan dalam penelitian merupakan gel enzim bromelin konsentrasi 10% yang diperoleh melalui proses presipitasi menggunakan ammonium sulfat 60% dan dilanjutkan dengan proses sentrifugasi. Seluruh sampel diukur kedalaman degradasi jaringan karies yang terbentuk menggunakan SEM. Data yang diperoleh dilakukan uji statistic Kruskall Wallis kemudian dilanjutkan uji Mann Whitney. Hasil: Uji Kruskall Wallis menyatakan terdapat perbedaan yang bermakna dengan nilai p=0,002 (p<0,05) rerata kedalaman degradesi jaringan karies pada dentin berdasarkan kelompok perlakuan (kontrol, plasebo dan perlakuan aplikasi gel bromelin 10%). Uji Mann Whitney menunjukkan bahwa tidak terdapat perbedaan yang bermakna secara statistik antarkelompok dengan lama waktu aplikasi bahan 1 menit dengan nilai p=0,644 (p>0,05), sedangkan pada kelompok dengan waktu aplikasi 2 menit dan 3 menit terdapat perbedaan yang bermakna secara statistik dengan nilai p=0,000 (p<0,05). Simpulan: Waktu aplikasi bahan gel bromelin konsentrasi 10% untuk memperoleh degradasi jaringan karies pada dentin yang efektif adalah 3 menit.Kata kunci: gel bromelain; chemo-mechanical caries removal; degradasi jaringan karies ABSTRACTIntroduction: Bromelain enzyme from the flesh and tubers of pineapple (Ananas comosus (L.) Merr.) has the potential as a safe and economical enzyme-based chemo-mechanical caries removal (CMCR) material. However, no further study discusses the effective application time of the bromelain enzyme in the degradation of carious tissue in dentin. Therefore, the study aimed to analyse the effective application time of 10% bromelain enzyme in degrading carious tissue in dentin with application times of 1, 2, and 3 minutes. Methods: This study was an experimental laboratory study using 36 samples of permanent maxillary premolars with class I caries conditions which were divided into 9 study groups. The test material used in this study was a bromelain enzyme gel with a concentration of 10% obtained through a precipitation process using 60% ammonium sulfate and followed by a centrifugation process. All samples have measured the depth of caries tissue degradation using SEM. The Kruskall-Wallis statistical test carried out the data obtained and then continued by the Mann-Whitney test. Results: Kruskall-Wallis test stated that there was a significant difference with a p-value=0.002 (p<0.05) in the mean depth of caries tissue degradation in dentin based on treatment groups (control, placebo and 10% bromelain gel application treatment). The Mann-Whitney test showed no statistically significant difference between groups with 1 minute of application time with p-value=0.644 (p>0.05), whereas, in the group with 2 minutes and 3 minutes of application time, there was a statistically significant difference with a value of p = 0.000 (p <0.05). Conclusion: The application time of 10% bromelain gel material to effectively degrade carious tissue in dentin is 3 minutes.Keywords: bromelain gel; chemo-mechanical caries removal; carious tissue degradation
Daya Hambat Ekstrak Biji Kopi Robusta (Coffea Canephora) terhadap Bakteri Porphyromonas gingivalis (in vitro) Rr. Nektara Titan Dianastri; Pudji Astuti; Rendra Chriestedy Prasetya
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 18 No 2 (2021)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v18i2.28060

Abstract

Periodontitis is mostly caused by plaque and Pophyromonas gingivalis bacteria as the main cause. The outer membrane layer of the Porphyromonas gingivalis wall produces pathogenic virulence factors, such as lipopolysaccharides which will activate inflammatory cells and cause phagocytosis of antigens thereby triggering free radicals. Robusta coffee beans naturally contain caffeine, phenolic compounds, trigonellin, and chlorogenic acids as antibacterial and anti-inflammatory. The purpose of this study was to determine the inhibition of Robusta (Coffea canephora) coffee bean extract 0.5%; 0.75%; 1%; 1.25%; 1.5% and 3% on the growth of Porphyromonas gingivalis in vitro and to find out the lowest concentration of Robusta (Coffea canephora) coffee bean extract which has inhibitory effect on the growth of Porphyromonas gingivalis. In this study were divided into 8 treatment groups namely positive control, negative control, 0.5% robusta coffee bean extract, 0.75%, 1%, 1.25%, 1.5% and 3%. Petridish dishes containing TSA media that have been sterilized, added P. gingivalis suspension with density according to Mc standard. Farland Then a sterile white test blank with a diameter of 6 mm that is still sterile is placed on top of the bacterial growth media in accordance with the placement of the treatment group and dropped with all 8 treatment materials. After 24 hours incubated in a desiccator, the inhibition of robusta coffee bean extracts against the growth of Porphyromonas gingivalis bacteria was observed and data collection was done by measuring the inhibition zone using calipers. The results obtained robusta coffee bean extract at concentrations of 3%, 1.5%, 1.25% and 1%, have an antibacterial power which is suspected because Robusta coffee beans naturally contain ingredients such as caffeine, polyphenols and chlorogenic acids which have antibacterial activity while the robusta coffee bean extract with a concentration of 0.5% and 0.75% does not have antibacterial power against Pophyromonas gingivalis. Robusta coffee bean extract with a concentration of 1% is the smallest concentration of Robusta (Coffea canephora) coffee bean extract which can inhibit the growth of Porphyromonas gingivalis.
Khasiat Ekstrak Buah Markisa Kuning (P. Edulis Sims) sebagai Antiinflamasi Dilihat dari Jumlah Monosit pada Tikus Wistar Jantan (Rattus norvegicus) Hardhika Oktarianda Fachri; Winny Adriatmoko; Pudji Astuti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 15 No 2 (2018)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v15i2.17930

Abstract

Yellow passion fruit contains carotenoids and polyphenols which are believed to be used as alternative treatments. Yellow passion fruit is thought to provide anti- inflammatory effects. The objective was to determine the efficacy of giving yellow passion fruit extract to inflammation seen from monocyte counts. This study used 12 male Wistar rats were divided into normal groups, treatment groups, and control groups. In the treatment group, yellow passion fruit extract was given 100% concentration. On the 1st, 3rd, and 7th day the blood edge of the rat was taken and the number of monocyte cell counts was performed. Based on the results of One Way Anova analysis there were differences in the number of monocyte cells between all groups. Yellow passion fruit extract (Passiflora edulis Sims) is efficacious as anti-inflammatory due to a decrease in the number of monocytes.
EFEK MEPIVAKAIN TERHADAP VITAL SIGN PADA ANASTESI LOKAL BLOK NERVUS ALVEOLARIS INFERIOR Pudji Astuti; Abdul Rochim
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 9 No 3 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Local anesthetics are believed to be the most frequently used drugs in clinical dentistry. Lidocaine and mepivacaine are commonly used in RSGM (Oral and Dental Hospital Jember University), although they are generally regarded as safe, some adverse reactions can be expected and do occur. This study was undertaken to know the effect of vital sign on mepivacaine in local anaesthetic on dental clinical use. Material and Methods: A total of 42 (14 males, and 28 females) healthy students of Faculty of Dentistry Jember University were included in this clinical trial. They were locally injected as block anaesthesia of inferior alveolaris nerve. Blood pressure, pulse, and respiration were examined pre and post injection. Result: Mean of respiration pre/post (18.7/1.8) p>0.05, pulse pre/post (79.8/79.9) p>0.05, and diastole pre/post (74.9/73.9) p>0.05, and systole pre/post (112.0/110.2) p>0.05. There were no clinical and statistical differences on vital sign between pre and post injection. Conclusions: Mepivacaine as local anaesthetic is clinically safe on vital sign.
Co-Authors Abdul Rochim Abdul Rochim Agustin Wulan Suci Dharmayanti Akhmad Yusuf Sulaiman Amandia Dewi Permana Shita Amandia Dewi Permana Shita Atik Kurniawati Berlian Prihatiningrum Danang Dewantara Ananda Putra Dwi Warna Aju Fatmawati Erna Sulistyani Hardhika Oktarianda Fachri Hestieyonini Hadnyanawati I Dewa Ayu Ratna Dewanti Iin Eliana Triwahyuni Ika Wahyu Purnamasari Indah Widyanti Julia Eka Putri Ayuningtyas Lutfi Meiga Sari Melok Aris Wahyukundari Narita Ajeng Loviana Rendra Chriestedy Prasetya Resti Ayu Indriana Rindang Swandari Ristya Widi Endah Yani Rosanita Firdausi Oktaviani Rr. Nektara Titan Dianastri Sari Setyaningsih Savira Aulia Rachim Sri Lestari Tantin Ermawati Winny Adriatmoko Zahara Meilawaty Zahara Meylawaty Zahreni Hamzah