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All Journal Dentika Dental Journal Journal of Mathematical and Fundamental Sciences STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Kesehatan Gigi UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Health Notions Journal of Dentomaxillofacial Science AloHA International Journal of Health Advancement (AIJHA)
I Dewa Ayu Ratna Dewanti
Department Of Biomedical Science, Faculty Of Dentistry, Jember University, Jl. Kalimantan 37, Jember 68121
Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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KEJADIAN HIV/AIDS DENGAN MANIFESTASI ORAL PADA ANAK-ANAK Hikmah, Nuzulul; Dewanti, I Dewa Ayu Ratna
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 7, No 1 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Nowadays HIV/AIDS infection was increase to children in the world. In development countries include Indonesia, it was caused fourth killer to children. Oral manifestation to the children who has infected HIV have a different been compared with adult. Discussion.Candidiasis and necrotizing ulcerative gingivitis is oral lesion who was found in the children. Linear gingival erythema leukoplakia, caries and kaposis sarcoma can be an indicator of moderate and hard immunosupression. Parotis swollen, herpes simplex virus infection and recurrent aphtous stomatitis not special connected with immunosupression grade. The best of management patients was consider immunology status andexamined oral continuity. Conclusion. Oral manifestation in the childen very important to known because it was often first indication clinical so that someone had been infected of HIV.
INFEKSI Cytomegalo virus (CMV) PADA IBU HAMIL DAN MANIFESTASINYA DI RONGGA MULUT Dewanti, I Dewa Ayu Ratna
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 7, No 1 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Immune status in pregnancy was very impotant, because the effect for life to fetus andmother. If immune in pregnancy has’nt been attended, it will attack infection. Infection diseases was found in pregnancy was Cytomegalo virus (CMV) infection. Aims. This literature reviews purposes to information of CMV infection in pregnancy and manifestation in oral mucosa. Discussion. Infection in fetus could happen when mother could be reactivation, reinfection, it was assimptomatic and it ungiven sequele if it has been compared primer infection. That was caused maternal Ig G anti-CMVcould throug placenta and protective. Clinical symptom had been known from inflammation reaction. Oral manifestation could be vesicle and ulcer. Conclusion. CMV infection in pregnancy wasdanger infection for fetus and mother. It caused status immunity in pregnancy have been kept for prevent so that haven’t infection.
MANIFESTASI ORAL HUMAN IMMUNE DEFICIENCY VIRUS (HIV)/ AQUIRED IMMUNO DEFICIENCY SYNDROME PADA ANAK Dewanti, I Dewa Ayu Ratna
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 7, No 2 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Introduction. These days HIV/AIDS infection is fast to children in the world. In developing countries such as Indonesia, this was caused first death and fourth in the world. Like at adult, HIV/AIDS to child can be manifestation in oral. Purposed of writing. This writing purposed for given information to medical and public for oral manifestation from AIDS to children. Writing benefit. This information expected to dentis can do protection and dental managemant with right. Discused. Oral manifestation HIV to children have different to adult. It may be relates to immune system in rough. Candidosis and necrotizing ulcerative gingivitis were oral lesion to child were HIV with hard immunosupresion. Linear erythema leukoplakia and sarcoma kaposi could indicator midle immunosupresion and hard. Magnification of paratis, herpes simplex virus infection and recurrent aphtous stomatitis not special relates to level ofimmunosupresion. Development of dental caries could be correlates with level of immunosupresion. Conclusion. BestManagement was by considering immunology status via precaution and inspection tooth and oral routinely formaintains health and reachs quality of good life.
SEPUTAR REAKSI HIPERSENSITIVITAS (ALERGI) Hikmah, Nuzulul; Dewanti, I Dewa Ayu Ratna
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 7, No 2 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Introduction. Till now allergy was a piquancy to be submitted, because most all people have everexperienced it. Symptom and also allergen all kinds and varies can come from neither outside body nor in bodyxself. Purpose of Writing. Co-signature deeper in around allergic reaction. Discussion. Allergic reaction is immunesystem trouble marked by abundant reaction from immune response. Allergic reaction entangles allergen, is causingcells discharges matters or mediator chemistry which can destroy or hurts network in vinicity. Allergen can in the formof mote, crop powder, drug or food, is acting as antigen stimulating the happening of immune responds. Allergicreaction divided to become allergic reaction type I entangling Ig E, type II Antibody-Mediated Cytotoxi ity ( Ig G),type III ( Immune Complex Disorders) and type IV (delayed hypersensitivities). Conclusion. Allergic reaction is caused[by] allergen having manifestation to vary and divided to become reaction quickly ( type I), type II, type III and typeIV.
TLR4 macrophage expression of the wistar rats were inoculated by Candida albicans Dewanti, I Dewa Ayu Ratna
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 7, No 3 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Multidimentional crisis in Indonesia caused to multi effects. In heatlh aspect caused increase infection diseases, otherwhise mouth become some gate for entrance pathogen flora into human body. One of the most infection diseases was found in the mouth is candidiasis caused by C albicans. TLR4 were play a pivotal role in recognition of Candida albicans.The purposed experimental : This experimental purposed to know comparation of TLR4 expression macrophage of the wistar rats were inoculated C albicans. Method : The subjects of this research are 20 male-wistar rats divided into five groups : Control Group (KO) were 10 rats that were not given treatment. Experimental Groups (KP), 10 rats that were inoculated by C albicans. After 21 days, will been kill and cut on tongue for analized by imunohistochemic. The data obtained will be analyzed using t test. The result : The result this research showed that there was not a significant different (p<0,05) to comparation of TLR4 macrophage expression of Experimental Groups 1 (KP). A significant different was found at decreasing of TLR4 between KO with KP Discused : These decreasing are assumed that C albicans infection could inhibit TLR4 activities, so the decreasing of macrophage activity caused TLR4 decreased. All of those activity causes the decreasing immune response and killed activity to C albicans. The conclusion : The fact of this research is dereasing TLR4 macrophage of wistar rat was inoculated by C albicans.
PERAN TOLL LIKE RECEPTORS (TLRs) PADA INNATE IMMUNITY (The Role of Toll Like Receptors to Innate immunity) Hikmah, Nuzulul; Dewanti, I Dewa Ayu Ratna
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 8, No 1 (2011)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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TRLS is a homologous protein located at APC membrane cell worl as a functional receptor to activate leucocyte lead to onduce mentriger responsimun innate or inflamatory respons against palogenic againt. Functional receptor is associated wuth kinase respons to produce sitokyn and microbidal subtance. The aim of the study is to examine the respons to produce sitokyn and microbidal subtance. The aim of the study is to examine the role TLRs on innate immunity it is concluded that the role of TLRS is important functional receptor which activate leucocyte to induce mentriger respons imun innate or an inflamators respons against patogenic agent.
ACTIVITY TEST OF IMMUNOMODULATORY COMPONENT FROM NEEM LEAVES TO CANDIDA ALBICANS: UJI AKTIVITAS KOMPONEN IMUNOMODULATOR DARI NEEM TERHADAP CANDIDA ALBICANS I Dewa Ayu Ratna Dewanti; I Dewa Ayu Susilawat; Purwanto; Depi Praharani
Dentika: Dental Journal Vol. 16 No. 2 (2011): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.333 KB) | DOI: 10.32734/dentika.v16i2.1845

Abstract

Empirically, societies have utilized neem plant to treat worm infection, scabies, malaria, candidal infection, and allergy. Several researches have indicated that consuming neem leaves could improve antibody production. Our previous research had demonstrated the existence of immunomodulatory component in neem leaves weighted 70 and 100 kDA. The aimed of study was to test the activity immunomodulatory components to Candida albicans. This research was an in vitro study with rats as experimental subject. The rats were divided into three treatment groups and one control group, which were labeled as KO (no treatment), KP1 (inoculated by C. albicans only), KP2 (inoculated by C. albicans and were given the 70 kDA immunomodulatory component), KP3 (inoculated by C. albicans and were given the 100 kDA immunomodulatory component). In day 21, preparations from rats’ tongue were done with immunohistochemistry staining and were analyzed for the activity of TNF-α macrophage phagocytosis and also for calculation of C. albicans colony from tongue swab. The result showed that there was no significant difference between the 70 and 100 kDA immunomodulatory components in increasing activity of TNF-α and macrophage phagocytosis and in decreasing the number of C. albicans colony. It was assumed that those components might actívate NF-κB and AP-1 that play role in protein transcription, which stimulated gene expression like TNF-α, which played role in phagocytosis. In conclusión, 70 dan 100 kDA immunomodulatory components increased the activity of TNF-α and macrophage phagocytosis and also decrease the number of C. albicans colony.
COMPARISON OF TOLL LIKE RECEPTOR 2 AND 4 MACROPHAGE EXPRESSION CAUSED BY NEEM LEAVES AQUEOES EXTRACT IN ORAL CAVITY: PERBANDINGAN TOLL-LIKE RECEPTOR 2 DAN 4 ESKPRESI MAKROFAG CAIRAN EKSTRAK DAUN NEEM DALAM RONGGA MULUT I Dewa Ayu Ratna Dewanti
Dentika: Dental Journal Vol. 15 No. 1 (2010): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2556.807 KB) | DOI: 10.32734/dentika.v15i1.1992

Abstract

Neem is one of the traditional medicine trees known by society and has function as immunomodulatory. TLR2 and TLR4played an important role in recognition of infection. This experimental study aimed to know the comparison of TLR2with TLR4 macrophage expression of Aqueous extract from neem (Azadirachta indica) leaves in oral cavity. The subjectsof this research were 24 male-wistar rats divided into five groups: Control Group (ko) had no treatment. Group II was fedwith 50 mg/day/kg body weigth aqueous extracts from neem leaves (KP1), group III was fed with 100 me¢/day/kg bodyweigth aqueous extract from neem leaves (KP2), group IV was fed with 200 mg/day/kg body weigth aqueous extractfrom neem leaves (KP3). After 21 days, rats would be killed and cut there tongues and analized by imunohistochemy.Data obtained will be analyzed using Anova and followed by HSD and linier regression. The result showed that there wasno significant different (p<0,05) between comparison of TLR2 with TLR4 macrophage expression of experimentalgroups V. There was significant difference in the increasing of TLR2 and TLR4 between KO with KP. As conclusion.there was increasing of TLR2 and TLR4 macrophage expression of aqueous extract {rom neem leaves in oral cavity, butthere was no significant difference.
The Influence of Oral Hygiene Behavior on Periodontal Disease Status of Fishpond Community in District Sidoarjo Narita Ajeng Loviana; Melok Aris Wahyukundari; Ristya Widi Endah Yani; Peni Pudjiastuti; Hestieyonini Hadnyanawati; Sri Lestari; I Dewa Ayu Ratna Dewanti
Health Notions Vol 2, No 7 (2018): July
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.548 KB) | DOI: 10.33846/hn.v2i7.254

Abstract

Background: Periodontal disease is one of the most common oral diseases in Indonesia. Poor oral hygiene behavior has been seen as a risk factor for periodontal disease. Oral hyigiene behavior is different in each individual or group, as well as the fishpond community. Purpose: To analyze the influence of oral hygiene behavior on periodontal disease status of fishpond community. Methods: This study was a observational analytic study with cross sectional approach. The samples were fishpond community in Banjar Kemuning village, district Sidoarjo which amounts 100 people in age range between 26 to 65 years old. Oral hygiene behavior in the form of knowledges and attitudes were measured using a closed questionnaire and oral hygiene behavior in the form of practices were measured using a checklist questionnaire, while Periodontal Disease Index (PDI) was used to measured periodontal disease status. Results: Ordinal regression analysis of the oral hygiene behavior on periodontal disease status showed significant value that was 0,043. Conclusion: Oral hygiene behavior has influence on periodontal disease status of fishpond community in District Sidoarjo. Keywords: Oral hygiene behavior, Knowledge, Attitude, Practice, Periodontal disease status, Fishpond
Analisis Jumlah Sel Monosit yang Mengekspresikan Tnf-Α setelah dipapar Porphyromonas Gingivalis dan Tulang Ikan Kuniran (Upeneus Sulphureus) dengan Teknik Imunositokimia Fiona Budi Amarta Domini; I Dewa Ayu Ratna Dewanti; Erawati Wulandari
Jurnal Kesehatan Gigi Vol 6, No 2 (2019): Desember 2019
Publisher : Jurusan Keperawatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v6i2.5480

Abstract

Monocytes play a role in the first defense against microorganisms that harm the body by activating nuclear factor kβ (Nf-kβ) which is the main regulator of inflammatory genes, one of which is TNF-α. TNF-α at excessive levels will cause tissue damage. Therefore an immunomodulator is needed which can regulate the body's immune system. One natural ingredient that acts as an immunomodulator is fish bones. Purpose of research: To analyze the effect of goatfish’s bone extract on TNF-α expression in human monocytes exposed to P. gingivalis. Method: experimental laboratories in vitro. TNF-α expression was tested by imunocytochemical techniques. Results: The results showed that the average number of monocytes expressing TNF-α in group P1 (group of diclofenac sodium) was 42.33 cells per cell. In the P2 group (P. gingivalis group) was 95 cell percent cells and for P3 (fish bone group) was 74.33 cells per cell and the control group was 11.66 cells per hundred cells. Conclusion: goatfish’s bone extract can act as an anti-inflammatory which is effective in reducing TNF-α expression in monocyte exposed to P. gingivalis but less effective than diclofenac sodium.
Co-Authors Depi Praharani Dheamira Rosida Dyah Setyorini Erawati Wulandari Farah Rachmah Aulia Wardani Fiona Budi Amarta Domini Hestieyonini Hadnyanawati I Dewa Ayu Susilawat I Dewa Ayu Susilawati Melok Aris Wahyukundari Nadie Fatimatuzzahro Narita Ajeng Loviana Nuzulul Hikmah P. Purwanto Pudji Astuti Pujiana Endah Pujiana Endah Lestari Purwanto Purwanto , Ristya Widi Endah Lestari Ristya Widi Endah Yani Roedy Budirahardjo Sri Lestari Sunana Ageng Hikmawati Sunlip Wibisono