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All Journal International Journal of Applied Biology Jurnal Penelitian Pendidikan IPA (JPPIPA) JCDD Society: Jurnal Pengabdian Masyarakat JEC Journal of Community Empowerment
muhamad iksan
Universitas Muhammadiyah Buton
Religion Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics Social Sciences Other

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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

 1 
Environment-based Learning Media with Green Biochemistry Approach Muhamad Iksan; Frida Maryati Yusuf; Dyah Pramesti Istana Ardiyati
Jurnal Penelitian Pendidikan IPA Vol 9 No 2 (2023): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i2.2966

Abstract

Southeast Sulawesi is one of the provinces that has the largest mining area in Indonesia. One of the main mining commodities is nickel, which has the largest natural resource potential of around 97.3 billion tons of nickel minerals. Mining has an important role in the development of a region because it produces industrial raw materials, a source of foreign exchange, employment and increases local revenue. On the other hand, mining can cause various threats or adverse impacts in the form of environmental damage and pollution. One of the areas experiencing adverse impacts from mining is Baliara Village, Bombana Regency. This study aims to determine the formulation of efforts to overcome and prevent seawater pollution by nickel waste using the green biochemistry approach. This research was conducted in April 2022 in Baliara Village, Bombana Regency using observation, interview and literature study approaches. The results showed that there are approaches that can be used to control or reduce nickel waste, namely using the flotation-filtration method, silica-modified tofu solid waste, utilization of mangrove vegetation as nickel heavy metal phytoremediation and the establishment of corporate social responsibility (CRS) by mining companies in controlling or monitoring environmental pollution. This approach is considered very effective in controlling pollution in the aquatic environment in Baliara Village, Bombana Regency, so that it can serve as scientific input and information for relevant parties in taking actions and policies in controlling pollution in the area
Antipyretic Drug Candidates Through Reverse Docking Techniques Used In Science Learning Muhamad Iksan; Frida M Yusuf; Fitriani Fitriani B; Wa Ode Al Zarliani
Jurnal Penelitian Pendidikan IPA Vol 9 No 8 (2023): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i8.4863

Abstract

Red ginger (Zingiber officinale var. Rubrum) is a commonly used rhizome known for its fragrant and spicy taste. It contains gingerol and shogaol compounds that have antipyretic effects by inhibiting prostaglandin formation and stimulating the production of interleukin-10, an endogenous antipyretic. This study aimed to evaluate the potential of gingerol and shogaol compounds as antipyretic drug candidates through reverse docking techniques targeting interleukin-10 (IL-10). Ten natural compounds from red ginger were predicted for their potential as antipyretic drugs and docked with the IL-10 receptor protein using various computer programs. The molecular docking results showed that (6)-shogaol had four amino acid bond residues that were the same as the ibuprofen control compound, indicating its potential as an antipyretic drug candidate. Furthermore, (6)-shogaol had the same binding affinity as the control compound and was safe for oral consumption based on pharmacokinetic and toxicity tests using Lipinski's Rule, Toxtree, and admet-T. These findings suggest that (6)-shogaol is a promising antipyretic drug candidate compared to other compounds. In conclusion, this study identified the potential of (6)-shogaol as an antipyretic drug candidate through reverse docking techniques targeting interleukin-10. Red ginger could provide a natural alternative for antipyretic drugs, and further research is recommended to explore the role of gingerol and shogaol compounds in targeting other proteins
Co-Authors Azaluddin Azaluddin Bugis, Riki Dyah Pramesti Istana Ardiyati Fitriani Fitriani B Frida M Yusuf Frida Maryati Yusuf Herman Lawelai Ibnu Hajar Irwan Irwan M Rusdi M. Rusdi Mariyati Mariyati Muhammad Awaluddin Rahma Satya Masna Hatuwe Riska Sumini Galela Samritin Samritin Susiati s Susiati Susiati Wa Ode Al Zarliani Wa Ode Alzarliani Wilda Fesanrey