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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Respirasi (JR) Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology

Resti Yudhawati

Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya, Indonesia.

Author-ID : 359632

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Other

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IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Frederika, Edith; Mareta, Aldise; Poetranto, Djoko; Wulandari, Laksmi; Setyoningrum, Retno Asih; Setyowati, Lucia Landia; Yudhawati, Resti; Soegiarto, Gatot; Yamaoka, Masaoki
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2006.144 KB)

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as âfluâ. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.

Profile of Pneumocystis JiroveciiPneumoia in HIV/AIDS Patients in Dr. Soetomo General Hospital of East Java Province Pius Sebastian Ginting; Bramantono; RestiYudhawati Meliana; Musofa Rusli
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17933

Background: Human immunodeficiency virus (HIV)-infected patients if not treated will experienceacquired immunodeficiency syndrome (AIDS). People with AIDS will suffer opportunistic infection.One of the common opportunistic infections is Pneumocystis jirovecii pneumonia (PCP). PCP is aninfection caused by the fungus Pneumocystis jirovecii which infects patient’s lungs. The purpose of thisstudy is to analyze the profile of HIV/AIDS patients with PCP in Dr. Soetomo Hospital.Methods: This is a retrospective descriptive study based on medical records obtained from the inpatientward of Dr. Soetomo General Hospital Surabaya. A total 21 patients enrolled in this study who met theinclusion criteria. The data are retrospectively described by demographic characteristics, CD4 count,clinical symptoms, blood gas, and lungs radiographic features.Conclusion:Major findings of PCP in HIV/AIDS patients was in the group of age 25-49 years (85,7%),male (85,7%), high school graduate (71,4%), employed and unmarried (66,7%). The most commonclinical symptoms were dyspnea (100%), PaO2 ≥70 mmHg (61,97%), CD4 count <50 cells/μL (76,2%)and the most common radiographic features was bilateral interstitial infiltrates (95,2%).

Viral Profile and Clinical Characteristic in Acute Asthma Exacerbation Patients Resti Yudhawati; Erwin Winaya; Laksmi Wulandari; Aldise M Nastri; Retno A Setyoningrum; Kazufumi Shimizu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14872

Background: Asthma is a heterogeneous disease characterized by chronic airway inflammation. Thevirus infection in respiratory tract will activate greater pro-inflammatory cytokines in asthma patients.The enhancement of pro-inflammatory cytokines induces various clinical symptoms. This study aims toinvestigate the respiratory virus and clinical characteristics among patients with acute asthma exacerbation.Methods: In this study, subjects were divided into 3 groups based on acute asthma exacerbation triggers.The first group triggered by virus infection; the second group triggered by non-virus infection with ILI; andthe third group without any infection. Nasopharynx or throat swabs were collected to detect any respiratoryvirus. Virus was detected by Multiplex PCR (xTAG Respiratory Viral Panel Fast V2/ LUMINEX)Results: According to PCR examination, the prevalence of virus infection was 46.2%. Only two types ofviruses identified, which were Influenza A virus and Rhinovirus. All patients in the second groups showeda symptom of cough with purulent sputum, while no patients from the other two groups showed similarsymptoms. PEFR and % PEFR prediction of patients with Influenza A virus infection were higher than inRhinovirus infected-patients (210 L/min and 48.6% vs 195 L/min and 45%).Conclusion: Acute asthma exacerbation is one of the most reasons patients came to emergency ward. Themajority of acute asthma exacerbation was caused by infection, and most of it was viral infection. Clinicalsign differs according to the trigger, therefore the use of antibiotics should be avoided, unless there are signsand symptoms of bacterial infections

Capillary Lactate Level in Non-Severe and Severe CommunityAcquired Pneumonia Patients Resti Yudhawati; Kowiy Akbar
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14873

Background: Community-acquired pneumonia is an inflammatory disease of the lung caused bymicroorganisms acquired from a non-hospital environment. The pneumonia severity index and ATS/IDSAseverity criteria are widely used to predict the severity of CAP. Lactate is a biomarker that can be measuredby point-of-care devices that provide results in a short of time. This study aimed to determine the differencein capillary lactate level between non-severe and severe pneumonia to provide an additional method toquickly stratify pneumonia severity and treat it accordingly.Methods: This cross-sectional study was performed in the emergency room of a regional research hospital.The pneumonia diagnosis was determined by the symptoms, physical examination and radiological findings.Capillary lactate level was measured with Accutrend Plus lactate point-of care device. Severity stratificationwas done according to ATS/IDSA criteria. The mean of lactate level in all subjects was 3.40±1.52, in nonsevere pneumonia subgroup was 2.25±0.94, and 4.56±1.01 in severe pneumonia subgroup. Lactate issignificantly higher in severe pneumonia subgroup. The cut-off point of lactate level for severity group was3.2 mmol/L (95.5% sensitivity, 86.4% specificity).Conclusion: The early prediction of CAP severity is essential to determine the need for admission in theintensive care unit and close follow up. The lactate level can be used for immediate severity stratification inemergency departments.

Diabetes Mellitus and History of Tuberculosis Treatment as Risk Factors of Developing Multidrug-Resistant Tuberculosis at TB Polyclinic Dr. Soetomo General Hospital 2019 - 2020 Muhammad Raihan Habibi; Arief Bakhtiar; Danti Nur Indiastuti; Resti Yudhawati Meliana
Jurnal Ilmiah Universitas Batanghari Jambi Vol 22, No 1 (2022): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v22i1.1908

Multidrug-Resistant Tuberculosis (MDR TB) is a condition when Mycobacterium tuberculosis were resistant to Isoniazid and Rifampicin simultaneously, with or without being followed by other first-line Anti-Tuberculosis Drugs. Diabetic patients who also have TB are more susceptible to drug resistance. There is ample evidence noting that a history of previous TB treatment is one of the main factors contributing to the development of MDR TB. This study was a case-control study. The sample of this study was all patients from TB Polyclinic Dr. Soetomo Hospital who were diagnosed with pulmonary TB by pulmonologists on January 1, 2019 – December 31, 2020, who met the inclusion criteria. The data obtained were analyzed using the IBM SPSS Statistics 23 application with a binary logistic regression test.There were 178 samples of this study. MDR TB (65.8%) was the dominant resistance type in Drug-Resistant Tuberculosis (DR TB) patients. Patients with DM were 2.2 times more likely to develop MDR TB than patients without DM. Patients with histories of previous tuberculosis (TB) treatment tended to be three times more likely to develop MDR TB than new patients. Other factors such as age, sex, BMI, history of alcohol consumption, and history of smoking did not show a significant relationship with the incidence of MDR TB. Diabetes Mellitus comorbidity and history of previous Tuberculosis treatment were significant risk factors for developing MDR TB.

Case Report: Survival of A Coronavirus Disease-2019 (Covid-19) Patient with Acute Respiratory Distress Syndrome (ARDS) in Dr. Soetomo Hospital, Surabaya, Indonesia Soedarsono Soedarsono; Bambang Pudjo Semedi; Rosy Setiawati; Resti Yudhawati Meliana; Tutik Kusmiati; Ariani Permatasari; Arief Bakhtiar; Irmi Syafa’ah; Dwi Wahyu Indrawanto
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China has spread rapidly in multiple countries of the world and has become a pandemic. Currently, there is no vaccine or specific antiviral for COVID-19. A study reported 7.3% of critical patients admitted to ICU, 71% of them required mechanical ventilation, and 38.5% of them were survived. Herein, we reported a 54 year old man with Acute Respiratory Distress Syndrome (ARDS) of COVID-19 who survived the disease. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasopharyngeal and oropharingeal swabs were positive for SARS-CoV-2. Diagnosis of ARDS was also according to clinical symptoms, laboratory, chest radiograph, and chest CT scan. Alcaligenes faecalis and Candida albicans were also identified from sputum culture. Treatment for this patient was causal and supportive therapy, including antibiotic, antiviral, and antifungal therapy according to the culture results, fluid resuscitation, and oxygen supply from the mechanical ventilator. This patient was survived and discharged on hospital day-29. A fibrosis in parenchyma pulmonary and sensory peripheral neuropathy occurred after survived from ARDS. Monitoring of clinical, laboratory, and chest radiograph were continued after the patient discharged from the hospital. This case highlights the importance of early diagnosis and effective treatment to the care of COVID-19 patient.

IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Edith Frederika; Aldise Mareta; Djoko Poetranto; Laksmi Wulandari; Retno Asih Setyoningrum; Lucia Landia Setyowati; Resti Yudhawati; Gatot Soegiarto; Masaoki Yamaoka
Indonesian Journal of Tropical and Infectious Disease Vol. 4 No. 4 (2013)
Publisher : Institute of Topical Disease Universitas Airlangga

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as “flu”. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.

THE CLINICAL PROFILES OF AVIAN INFLUENzA IN ENDEMIC AND NON-ENDEMIC REGIONS IN INDONESIA. HOSPITAL-BASED STUDIES AND ITS IMPLICATION ON CLINICAL MANAGEMENT IN THE FUTURE Muhammad Jusuf Wibisono; Resti Yudhawati Meliana
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 3 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Indonesia is a greatest burden country of H5N1 avian influenza (AI) virus infection in the world, since first outbreak in Central Java 2005 until August 2010 there was 168 confirmed cases and 138 dead cases. The incidence increasing rapidly in widespread area endemic in Java, Sumatera, Bali and Sulawesi, and sporadic outbreaks in other areas. The World Health Organization stated that AI still became a treat in the next pandemic. H5N1 AI virus infection spreads in almost all provinces, but its endemic in Jakarta, Tangerang and Banten and in other area such Surabaya, Bali were sporadic outbreaks. There are 27 confirmed H5N1 AI infection cases in Jakarta from 296 suspected cases, while in Surabaya only 5 confirmed H5N1 AI infection cases from 12 suspected cases. The age of patient mean with H5N1 AI infection was 16.9 ± 11.6 yo in Jakarta and 24 ± 8.51 yo in Surabaya. There was no difference between male and female. Mortality rate was 77.7% in Jakarta and 60% in Surabaya. A large number of case has indirect contact history, predominantly by visiting market or areas where outbreaks of poultry disease. The clinical feature H5N1 AI virus infection could manifest as mild until severe pneumonia that often progress rapidly to ARDS. In Jakarta, 74% case showed abnormality chest radiography as bilateral pneumonia, while in Surabaya showed lobar pneumonia and bilateral pneumonia. Management patient of H5N1 AI infection is supportive therapy and antiviral, whereas a large number of cases needed mechanical ventilator support.

Primary Pulmonary Lymphoma with Superior Vena Cava Syndrome Alfian Nur Rosyid; Resti Yudhawati Meliana
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Primary Pulmonary Lymphoma (PPL) is a clonal proliferation of lymphoid cells that involve one or two lungs (parenchyma and or bronchi. PPL is found in approximately 0.4% of all lymphoma cases and 3.6% of NHL cases. Five years survival rate at stage I and II is 90%, and 80% in stage III and IV. A 63-year-old male farmer presented with chief complaint of shortness of breath for one week before admission and preceded by coughing for a month, loss of appetite and night sweating. There was an abnormal physical examination on the right side of the chest with non-tender lymph node enlargements in the right supraclavicular and neck region and superior vena cava syndrome. CT guided FNAB suggesting NHL. Patient was treated with CHOP chemotherapy regiment. However, with high grade lymphoma, patient did not respond well.

The Role of N-Acetyl Sistein in Pulmonary Tuberculosis Resti Yudhawati; Nitya Prasanta
Jurnal Respirasi Vol. 6 No. 1 (2020): January 2020
Publisher : Faculty of Medicine Universitas Airlangga

Pulmonary Tuberculosis is a chronic infection that caused by Mycobacterium tuberculosis (M.tb) infection and it is still the major health problem worldwide. Mycobacterium tuberculosis infection can induce oxidative stress. Some studies has proved that active TB patients have an association with excessive oxidative stress which causes glutathione (GSH) level decrease and free radicals increase. Glutathione (GSH) facilitates the control of M.TB intracellular bacterial growth in macrophages and has direct antimicrobial activity. N-acetylcysteine (NAC) is thiol, a precursor of L-cysteine and glutathione synthesis (GSH) that has been used for decades as a mucolytic agent in the treatment of respiratory diseases. Some studies report beneficial role of NAC as immunomodulator, besides NAC also has anti-inflammatory and antimicrobial effect in TB management.

Co-Authors Aldise M Nastri Aldise Mareta Aldise Mareta Nastri Aldise Mareta, Aldise Ariani Permatasari Ayurveda Zaynabila Heriqbaldi Bakhtiar, Arief Bambang Pudjo Semedi Bramantono - Danti Nur Indiastuti Desak Putu Agung Krisdanti Djoko Poetranto Djoko Poetranto, Djoko Dwi Wahyu Indrawanto Edith Frederika Edith Frederika, Edith Emmanuel Djoko Poetranto Erwin Winaya Gatot Soegiarto Irmi Syafa'ah Kazufumi Shimizu Kowiy Akbar Laksmi Wulandari Landia Setiawati Lucia Landia Setyowati Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Masaoki Yamaoka Masaoki Yamaoka Masaoki Yamaoka, Masaoki Megawati Rif’atyyah Nozomi Guntur Muhammad Jusuf Wibisono Muhammad Raihan Habibi Musofa Rusli Nitya Prasanta Nurjanah Lihawa Pius Sebastian Ginting Rebekah Setiabudi, Rebekah Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Rosy Setiawati Rosyid, Alfian Nur Soedarsono Soedarsono Tutik Kusmiati Whendy Wijaksono Yuyus Dwi Prasetiyo

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