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All Journal Jurnal Ilmu Kimia Universitas Brawijaya KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST CHEESA: Chemical Engineering Research Articles JOPS (Journal Of Pharmacy and Science) Jurnal Surya Masyarakat Klinikal Sains (Jurnal Analis Kesehatan) Surya Abdimas Jurnal Biomedika INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Ilmiah Farmako Bahari Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Surya Masyarakat Indonesian Journal of Cultural and Community Development Borneo Journal Of Pharmascientech Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis SWARNA Journal of Pharmacy Science and Technology
Ersalina Nidianti
Universitas Nahdlatul Ulama Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

 1 
Toxicity of Cisplatin and Herbal Medicine Complexed with Bovine Serum Albumin (BSA) and Folic Acid Nanoparticles as Anticancer Candidates: Perbandingan Uji Toksisitas Obat Cisplatin dan Obat Herbal Kombinasi Nanopartikel Bovine Serum Albumin (BSA) dan Asam Folat Sebagai Kandidat Antikanker Ersalina Nidianti; Rizka Amalia; Nisrina Salsabila Firdaus
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 2 (2022): (October 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i2.15838

Abstract

The prevalence of cancer in Indonesia has increased by 8.8 percent in the last two years (2018 and 2020) in terms of adding new cases and mortality. Because of therefor cancer treatment becomes important in reducing the high number of additional new cases and mortality due to cancer patients. Intensive cancer treatment is by surgery, chemotherapy, radiotherapy and immunotherapy. Chemotherapy drugs used for cancer treatment include herbal plant-based cancer drugs (Cancer Fit) and cisplatin its buy from online shop. This study aims to compare the toxicity of herbal drugs (Cancer fit) with cisplatin, a combination of BSA nanoparticles and folic acid as anticancer candidates. The research method is through the synthesis of nanoparticles with the desolvation method, then characterization is carried out using XRD and FT-IR tests. After that proceed to the toxicity test with the BSLT method. The results obtained from XRD analysis on BSA and folic acid nanoparticles from cisplatin (As-NP-BSA-CP) showed a peak of 34.45 while BSA and folic acid nanoparticles from herbal medicine (As-NP-BSA-Oh) obtained a peak of 22.77. The purpose of XRD analysis was to determine the crystalline characteristics of the synthesized nanoparticles and to analyze the crystalline index. FT-IR analysis on (As-NP-BSA-CP) showed that there are functional groups O-H alcohol, C-H, C-C, NO2 that play a role in the synthesis of nanoparticles. Meanwhile, (As-NP-BSA-Oh) showed that the functional groups were C-H alkene, C-O alcohol, and C-N amine/amide. The toxicity level of As-NP-BSA-CP LC50 is 69.14 ppm while the toxicity level of As-NP-BSA-Oh LC50 is 44.14 ppm. Nanoparticles consisting of a combination of bovine serum albumin (BSA), folic acid and cisplatin drugs or herbal drugs can be used as candidates for anticancer drugs.
Co-Authors Adinda Priyanti Dewi Aini, Fadlilah Nur Aisah Humairoh Andreas Putro Ragil Santoso Ary Andini Ary Andini Aulia, Ilmiah Alvi Nisa Chika Nur Azizah Dea Ayu Rahmawati Desi Susanti Devyana Dyah Wulandari Devyana Dyah Wulandari Endah Prayekti Endah Prayekti Fadlilah Nur Aini Farah Nuriannisa Gilang Nugraha Halimah Prisilia Herliani Rahmania Sari Himawan, Toto Ilmiah Alvi Nisa Aulia Kartika Yuliani Mubarokator Rizkiyah Muhammad Fifin Kombih Muhammad Taufiq Hidayat Ngiluhtara Aditiya Putri Nia Kurniaty Rukman Nila Dwi Utami Nisrina Salsabila Firdaus Nurul Hidayatih Rahmawati Fitri Awalia Rizka Amalia Rizka Amalia Rizma Defva Santoso Salfa Salsabilah Zain Salfa Salsabilah Zain Sari, Herliani Rahmania Saumia Khoirunnisa Syadzila Siti Basiroh Sri Surya Suciati Suciati, Sri Surya Sunaryo, Merry Syadzila, Saumia Khoirunnisa Utami, Nila Dwi Utomo, Edi Priyo Wardah Rohmah Wieke Sri Wulan Wieke Sri Wulan Yauwan Tobing Lukiyono Yuni Nur Malita Sari