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All Journal Medali Jurnal : Media Dental Intelektual ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Odonto dental journal Jurnal Pengabdian Masyarakat Dentmas Journal of Fisheries & Marine
Arlina Nurhapsari
Fakultas Kedokteran Gigi, Universitas Islam Sulan Agung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Medali Jurnal : Media Dental Intelektual

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COMPARISON OF THE NUMBER OF MACROPHAGES IN THE RAT REVERSIBLE PULPITIS AFTER APPLICATION OF BIODENTIN AND SIWAK EXTRACT Andina Rizkia Putri Kusuma; Rahmawati Sri Praptiningsih; Arlina Nurhapsari
Jurnal Medali Vol 4: Special Issue 1. Desember 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.4.3.6-11

Abstract

Background: Oral disease still need special attention, especially in dentistry. Inflammation of the pulp is caused by the presence of irritants. One of the mechanical irritants is iatrogenic factors caused by operator error during preparation so that roof of pulp chamber is exposed. This condition is called reversible pulpitis/inflammation of the pulp. Cells that play a role during inflammation are macrophages which are the second defense cell after neutrophil apoptosis. A direct pulp capping procedure is indicated for this condition. The material commonly used is biodentin, but because the price tends to be expensive, alternative materials are needed. Siwak contains flavonoids which are known to play an important anti-inflammatory role in the healing of exposed pulp. The purpose of this study was to compare the number of macrophages in the dental pulp of rats with reversible pulpitis after administration of biodentin and siwak extract.Method: This research is a true experimental with a post test only group design, consisting of 2 treatment groups, namely the 75% siwak extract group and the biodentin group. The material is applied after the tooth has been prepared. The research sample used male wistar rats and sacrificed on the 3rd day. Samples were stained with Hematoxylin Eosin to see macrophage cells.Result: The data obtained were analyzed using the independent T-test. The test results showed a significant difference, with a value of p = 0.008 (p <0.05).Conclusion: The conclusion of this study that the siwak extract group showed a lower mean number of macrophage cells than the biodentin group.
EFFECT OF ASIATIC ACID ISOLATE ON DECREASING REACTIVE OXYGEN SPECIES (ROS) LEVELS IN MICE REVERSIBLE PULPITIS shella indri novianty; Arlina Nurhapsari; Anitalia Sukma Permata Sari
Jurnal Medali Vol 4: Special Issue 1. Desember 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.4.3.56-62

Abstract

Background: Pulpitis is a form of pulp inflammation that occurs due to the response of vascular connective tissue to a trauma or continuation of caries. During inflammation the release of Tumor Necrosis Factor Alpha (TNF-) will regulate excess ROS. Reactive Oxygen Species (ROS) can damage cellular lipids that cause oxidative stress, cell or tissue damage in mice caused by ROS to be seen with malondhydehyde biomarker (MDA) donors. Asiatic acid is a natural antioxidant that is able to neutralize free radicals by suppressing oxidative stress. This study aims to determine the effect of asiatic acid isolates on the reduction of ROS levels in reversible pulpitis mouse models.Method: This type of research is an experimental laboratory in vivo, conducted by making pulpitis on the right and left teeth of the right and left jaws of 24 male Wistar rats who were treated in the form of a control group, Asiatic Acid 0.5%, 1% and 2%, then examined using elisa sandwich method Result: The One way anova test showed that the highest mean rank was the control group and the lowest was the Asiatic Acid group of 1%. The p value < 0.05, there was a significant difference in the concentration of Asiatic Acid isolates against the significant reduction in ROS levels in reversible pulpitis between the four groups. Post Hoc LSD (Least Significant Difference test in between control groups and 1%, 0.5% and 1% group, and 1% and 2% groups obtained p < 0.05 which means there is a significant difference in reactive oxygen species (ROS) levels in reversible pulpitis between the two groups.Conclusion: Asiatic Acid was able to reduce the amount of Reactive Oxygen Species (ROS) as seen from the parameters of Malondialdehyde antibodies (MDA) in male wistar mice that developed reversible pulpitis
Co-Authors Ade Ismail Ade Ismail A.K Alphania Esty Luthfaida Andhika Ambo Andina Rizkia Putri Kusuma Andina Rizkia Putri Kusuma Ani Labibah Aning Susilowati Anitalia Sukma Permata Sari Atiek Amalia Ahsanti Balqis Nureska Khomsiana Benni Benyamin Berti Silviana Intani Beti Ratnasari Chariza Hanum Mayvita Iskandar Denis Yusfa Diyah Fatmasari Erwid Fatchur Rahman Ferry Gustiningrum Grahita Aditya Hafid Nur Arzanudin Helmi Fathurrahman, Helmi Hesty Pradini Irma Dewi Ratnawati Islamy Rahma Hutami, Islamy Rahma Kris Adityawarman Kusuma, Andina Rizkia P M. Dian Firdausy Mayya Nailullathifah Moh. Baehaqi Muh. Dian Firdausy Muhammad Dimas P. P. Novia Indasari Rahma, Destari Amelia Rahmawati Sri Praptiningsih Rama Putranto Recita Indraswary Recita Indraswary Regilia Shinta Mayangsari Rifqi Wahyu Febrian Rizki Amalina Rochman Mujayanto Rosa Pratiwi Rosalita Amelia Rr. Sarah Ladytama Rusna Fiki Kafalia Sandy Christiono Savira Nurazky Yuniar Savira Nurazky Yuniar Seno Pradopo shella indri novianty Silvia Vera Indrawati Suparmi Sutji Asri Tjitra A Syarifah Nur Laili Siyam Uswatun N.A Darjono Widyasari, Ferina Yayun Siti Rochmah Yayun Siti Rochmah Rochmah Yunita Setyaningrum Yunita Styaningrum Zurairah Ibrahim