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All Journal Zuriat Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan BERKALA SAINSTEK Indonesian Journal of Agricultural Science Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) The Journal of Pure and Applied Chemistry Research UNEJ e-Proceeding ALCHEMY Jurnal Penelitian Kimia Jurnal Abdi: Media Pengabdian Kepada Masyarakat
Ika Oktavianawati
Jurusan Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Education Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Journal : e-Journal Pustaka Kesehatan

 1 
Sintesis Asam 2-(2-(n-(2,6-diklorofenil)-4 fluorobenzamida)fenil)asetat sebagai Kandidat Obat Penghambat COX (siklooksigenase) Triodora Hutahuruk; Ayik Rosita; Ika Oktavianawati
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Sodium diclofenac is a non selectif NSAID that used as an inflammatory, analgesic, and antipyretic. Several experiment about compound as a derivate sodium diclofenac has been synthesized for reduce side effect. 2-(2-(N-(2,6-dichlorophenyl)-4-fluorobenzamido)phenil)acetat acid (N4FND) is derivate of sodium diclofenac that synthesized for development of drugs. The target compound has been synthesized by benzoylation reaction between sodium diclofenac with 4-fluorobenzoylchloride. And then, the target compound has been purified using Coloumn Chromatography. The isolate was identified using 1HNMR 400 MHz and KBr FTIR. Spectra of of 1HNM 00 MHz and KBr FTIR showed that 2-(2-(N-(2,6-dichlorophenyl)-4-fluorobenzamido)phenil)acetat acid was successfully synthesized. Pure product compound form yellowish white crystals with melting point 165-1670C.
Sintesis asam 2-(2-(4-kloro-N-(2,6-Diklorofenil)benzamida) fenil)asetat sebagai salah satu turunan diklofenak yang merupakan kandidat obat penghambat COX (siklooksigenase) (Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenil)benzamido)phenil)acetic acid as dic Wahyu Novandari Herdiyanti; Ayik Rosita Puspaningtyas; Ika Oktavianawati
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Sodium diclofenac is an analgetic agent as an antimetabolite that used for treating pain. Several compound as a derivative diclofenac has been synthesis for increase its activity and reduce side effect. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid is a derivate of Sodium diclofenac that synthesized for development new drugs. Synthesis 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic has benzoylation reaction between Sodium diclofenac and 4-Chlorobenzoil Chloride to give the target compound (2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid).This compound has been purified by Column Chromatography and give yellow color with melting point 143-145oC and then fix identification by H-NMR 400 MHz and KBr FTIR. 2-(2-(4-Chloro-N-(2,6-dichlorophenyl) benzamido)phenyl)acetic acid can synthesized and resulted 8.39 % of yield.   Keywords: Sodium diclofenac, 2-(2-(4-Chloro-N-(2,6-dichlorophenyl)benzamido)phenyl)acetic acid, pain.
Sintesis 1-(4-metoksibenzoiloksimetil)-5-fluorourasil sebagai Agen Antikanker . Ifada; Ayik Rosita Puspaningtyas1; Ika Oktavianawati; Yuni Retnaningtyas; Nia Kristiningrum
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5-fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4-methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid. Keywords: 5-fluorouracil derivates, anticancer, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil, benzoylation.
Co-Authors . Ifada Achmad Sjaifullah Agung Budi Santoso Alidion, Moch. Yoris Anak Agung Istri Ratnadewi Anita Karolina Ari Satya Nugraha Arifulloh Arifulloh Ayik Rosita Puspaningtyas Ayik Rosita Puspaningtyas1 Bambang Sugiharto Bambang Sugiharto Bambang Sugiharto Bella J Zhentya Djenal . Djenal Djenal Dwi Indarti Dwi Purwita Utari Elis Nur Farida Elis Nur Farida, Elis Nur I Nyoman Adi Winata Meirinda Hermiastuti Meirinda Hermiastuti, Meirinda Nanda Letisya Nanda Letitia Ivana Nia Kristiningrum Niken Widya Palupi Novita Rahmawati Novita Rahmawati, Novita Priscillia Citra RD Ratih Sattya Arimurti Sovia MW Sholihah Suharjono Suharjono Tanti Haryati Tri Agus Siswoyo Tri Mulyono Triodora Hutahuruk Untung Murdiyanto Untung Murdiyanto Untung Murdiyanto Wahyu Novandari Herdiyanti Wawan Badrianto Wawan Badrianto, Wawan Wuriyanti Handayani Wuriyanti Handayani Wuriyanti Handayani, Wuriyanti Wuryanti Handayani Yuni Retnaningtyas