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Analisis Penggunaan Antibiotik pada Pasien Sepsis Neonatus di RSUD Arifin Ahmad Provinsi Riau Nazardi Oyong; Inayah Inayah; Yuni Novita; Rizki Giofani
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Sepsis that is commonly caused by bacterial infection may cause death in neonates. The appropiate antibioticadministered will increase the life expectancy of neonates with sepsis. Objective of this study was to know the patternof antibiotic use and appropriateness of antibiotic use based on sensitivity test. The study used observational methodwith cross sectional design. The collected data were retrospective. The study population were neonates with sepsis inperinatal ward from Januari – December 2014. The criteria of inclusion were positive blood culture with sensitivity testsand use of antibiotics. The percentage of particular antibiotics used in neonates with sepsis before sensitivity testwere amikacin 64,3%; meropenem 62,9% and piperazine/tazobactam 50% with suitability of 27,1%. However, aftersensitivity test there were meropenem 38,6%, amikacin 30%, vancomycin 14,3% and piperaciline/tazobactam 14,3%with appropriateness of 64,3%. The most number of antibiotic used before and after sensitivity test were amikacin andmeropenem, respectively. There was a suitability enhancement between the use of antibiotics and sensitivity testresults.

POLA RESISTENSI Staphylococcus KOAGULASE NEGATIF TERHADAP ANTIBIOTIK YANG DIISOLASI DARI KULTUR DARAH NEONATUS TERSANGKA SEPSIS DI INSTALASI PERAWATAN NEONATUS RSUD ARIFIN ACHMAD PROVINSI RIAU PERIODE 01 JANUARI-31 DESEMBER 2014 Karina "; Dewi Anggraini; Nazardi Oyong
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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ABSTRACTNeonatal sepsis is one of several most common causes of neonates mortality in developing countries. Neonatal sepsis is defined as a disseminated disease with positive blood culture during the first month of life. The aim of this study was to find how many cultures presented positive and negative results and also to detect the most common bacterial causes of neonatal sepsis and determination of their sensitivity to antibiotics. This research design using a descriptive study with retrospective approach. The sampling technique is performed by total sapling method adn the amount of sample is 568 blood cultures which 196 reported as positive (34,51%) and 372 reported as negative (65,49%). The most common isolated bacteria were coagulase negative Staphylococcus (29,08%), Burkholderia cepacia (12,76%), Acinetobacter baumanii (9,18%), Klebsiella pneumoniae (8,16%), Escherichia coli (4,08%) and, Enterobacter aerogenes (4,98%). Neonatal sepsis caused by infection of coagulase negative Staphylococcus can be treated by vancomycin, linezolid and tigecycline.Keywords : neonatal sepsis, bacterial pattern, antimicrobial susceptibility, sensitivity, antibiotics.

UJI DIAGNOSTIK PEMERIKSAAN C-REAKTIF PROTEIN (CRP) PADA NEONATUS TERSANGKA SEPSIS YANG DIRAWAT DI INSTALASI NEONATUS RSUD ARIFIN ACHMAD PROVINSI RIAU Rum Affida Rasfa; Nazardi Oyong; Fatmawati "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Neonatal sepsis is a collection of clinical symptoms and laboratory associated with infection due to the invasion of microorganisms during the first 28 days of a child's life time. The certain diagnosis of neonatal sepsis is the isolation of bacteria from blood or body fluids. However, this method takes at least 72 hours. Therefore, It is necessary an investigation with a relatively short time. One of methods is C-Reactive Protein (CRP) examination. Even though CRP examination has been done in many of diagnosis of sepsis,however this examination also has some limitations. This research designusing a diagnostic test with retrospective approach. The sampling technique is performed by consecutive sampling method and amount of sample is 313 people. The results showed that the characteristics of the neonatal sepsis suspect in accordance with age is early neonatal (0-6 h), which amount to 235 (75%), and majority is male by 182 (58%). The most risk factor for gestational age <37 weeks is 133 samples with a median value is 11.4 mg / dl. Late Onset Neonatal Sepsis (LONS) is the highest classification of sepsis group at 93 (82%) with a median value is 192 mg/dl. The diagnostic value of CRP examination are sensitivity 65.7%, specificity 79.3%, positive predictive value 64.6%, negative predictive value 80.2%, positive contingency ratio 3.25, negative contingency ratio 0.43 and accuracy of 74.4%. As the result, we obtain cut off the recommended point is ≥10,2 mg / dl.Keywords : sepsis, C-Reactive Protein (CRP), LONS

EVALUATION USAGE OF ANTIBIOTIC TO SEPSIS NEONATUS PATIENT IN RSUD ARIFIN ACHMAD PROVINCE RIAU Rizki Giofani; Nazardi Oyong; Inayah "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 2 (2016): Wisuda Oktober 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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ABSTRACTSepsis neonatus is systemic clinical syndrome usually accompanied withbacteremia that needed prompt and proper antibiotic therapy. This study purposewas evaluating usage of antibiotic to sepsis neonatus patient in RSUD Arifin AchmadProvince Riau. This study method was descriptive retrospective. Data sources weretaken from medical record of sepsis neonatus patient in RSUD Arifin AchmadProvince Riau period 1 January - 31 December 2015. Based on characteristic ofpatient, neonatal sepsis mostly found on female 57,4%, low birth weight 57,8%, lowgestational age 66,2%, and pervaginum labor 52,9%. Blood culture time, found thatmost culture more than 3 days 63,2%. Microorganism of cause mostly foundCoagulase Negative Staphylococci 35,3%. Usage of empirical antibiotics mostlygiven 2 antibiotics 60,3%, type of antibiotic was aminoglycoside 42,1%, withduration more than 72 hours 55,5%. Usage of definitive antibiotics mostly were notgiven to sepsis neonatus patient 44,1%, while mostly they were given single antibiotic30,9%, most used type of antibiotic were aminoglycoside 40% (20 of 60 antibiotics),and duration less than 7 days 50% (30 of 60 antibiotics). Conclusion of this studywere duration of empiric antibiotics mostly given combination of two antibiotics withduration more than 72 hours and empiric antibiotics were suitable withmicroorganism that caused sepsis in RSUD Arifin Achmad 2015.Key word : sepsis neonatus, empiric antibiotic, definitive antibiotic

EVALUATION USAGE OF ANTIBIOTIC TO SEPSIS NEONATUS PATIENT IN RSUD ARIFIN ACHMAD PROVINCE RIAU Rizki Giofani; Nazardi Oyong; Inayah "
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 3, No 2 (2016): Wisuda Oktober 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRACTSepsis neonatus is systemic clinical syndrome usually accompanied withbacteremia that needed prompt and proper antibiotic therapy. This study purposewas evaluating usage of antibiotic to sepsis neonatus patient in RSUD Arifin AchmadProvince Riau. This study method was descriptive retrospective. Data sources weretaken from medical record of sepsis neonatus patient in RSUD Arifin AchmadProvince Riau period 1 January - 31 December 2015. Based on characteristic ofpatient, neonatal sepsis mostly found on female 57,4%, low birth weight 57,8%, lowgestational age 66,2%, and pervaginum labor 52,9%. Blood culture time, found thatmost culture more than 3 days 63,2%. Microorganism of cause mostly foundCoagulase Negative Staphylococci 35,3%. Usage of empirical antibiotics mostlygiven 2 antibiotics 60,3%, type of antibiotic was aminoglycoside 42,1%, withduration more than 72 hours 55,5%. Usage of definitive antibiotics mostly were notgiven to sepsis neonatus patient 44,1%, while mostly they were given single antibiotic30,9%, most used type of antibiotic were aminoglycoside 40% (20 of 60 antibiotics),and duration less than 7 days 50% (30 of 60 antibiotics). Conclusion of this studywere duration of empiric antibiotics mostly given combination of two antibiotics withduration more than 72 hours and empiric antibiotics were suitable withmicroorganism that caused sepsis in RSUD Arifin Achmad 2015.Key word : sepsis neonatus, empiric antibiotic, definitive antibiotic

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