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All Journal Althea Medical Journal Global Medical and Health Communication Majalah Kedokteran Journal of Medicine and Health Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Mekanik Terapan
Adhi Pribadi
Department Of Obstetric And Gynecology, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Automotive Engineering Dentistry Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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 1 
Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts Anwar, Ruswana; Alif, Muhammad; Pribadi, Adhi
Journal of Medicine and Health Vol 1, No 1 (2015)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis. Keywords: Ki-67, endometriosis stage, endometriosis cyst
The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus Sutomo, Adisti Erlina; Sitorus, Trully D.; Pribadi, Adhi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.353 KB)

Abstract

Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]
Ki-67 Expression is Correlated with Cyst Size and Stage of Endometriosis Alif, Muhammad; Anwar, Ruswana; Pribadi, Adhi
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.209 KB) | DOI: 10.32771/inajog.v1i3.350

Abstract

Objectives: To analyze the association between Ki-67 expression with the cyst size and stage of endometriosis, and the correlation strength between them. Methods: A cross-sectional analytic observational study involving 56 paraffin blocks from subjects diagnosed with endometriosis, who had undergone laparotomy or laparoscopic surgery. The study is conducted in Dr. Hasan Sadikin Hospital in September-November 2012. Results: Shows a significant association between Ki-67 expression and the size of endometriotic cyst (p &lt; 0.0001), also with a strong correlation (r = 0.55) according to Guilford criteria. There is also a significant association between Ki-67 expression and the endometriosis stage (p &lt; 0.0001), with a strong correlation (r = 0.564) according to Guilford criteria. Conclusion: Ki-67 expression is correlated with the cyst size and stage of endometriosis. [Indones J Obstet Gynecol 2013; 1-3: 124-8] Keywords: endometriosis stage, endometriotic cyst size, Ki-67
Cover JMT vol 1 no 2 Nov 2020 Adhi, Pribadi
Jurnal Mekanik Terapan Vol 1, No 2 (2020): November
Publisher : Jurnal Mekanik Terapan

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Abstract

The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus Adisti Erlina Sutomo; Trully D. Sitorus; Adhi Pribadi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.353 KB)

Abstract

Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]
Sindrom Metabolik: Komplikasi Pertumbuhan Janin Intrauterin yang Terhambat Adhi Pribadi; Johanes C. Mose
Majalah Kedokteran UKI Vol. 30 No. 2 (2014): APRIL - JUNI
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Perkembangan manusia intrauterin berkorelasi dengan penyakit yang timbul pada periode dewasa. Hipotesis perkembangan menyatakan bahwa risiko suatu penyakit dalam jangka panjang secara inisial diinduksi respons adaptasi janin. Respons termasuk perubahan metabolisme dan hormon, yang mungkin berpengaruh terhadap pertumbuhan organ. Penelitian epidemiologi menunjukkan BBLR dan PJT berhubungan dengan penyakit jantung, Stroke, DM tipe 2, obesitas, Sindrom Metabolik, dan osteoporosis. Periode perikonsepsi merupakan masa yang sensitif terhadap perubahan dan defisiensi nutrisi. Memori isyarat lingkungan terekam sejak konsepsi sampai persalinan oleh janin dan diturunkan pada generasi berikutnya. Hal ini meningkatkan dugaan bahwa penyakit metabolik diturunkan berbasis epigenetik dan tidak murni berbasis multigenik.Kata Kunci: intrauterin, perkembangan, PJT, sindrom metabolik Abstract Adult period diseases correlate with intrauterine development. Hypothesis development notes that the risk in latter life is induced by intrauterine fetal adaptive responses. The responses include: mal-development of metabolism and hormone that can influence alter fetal organs development. Result of epidemiology study stated that IUGR has significant correlation with cardiac disease, stroke attack, Diabetes Mellitus type 2, obesity, metabolic syndrome, and osteoporosis. Periconception period is a sensitive period of change and nutrition deficiency. Environment memory has been recorded by the fetus since conception until fetal delivery and has consequences to be transfered to the offspring. This increases the assumption that metabolic diseases signal have epigenetic memory base and not merely multigenic base.Kay Words: intrauterine, development, IUGR, metabolic syndrome
Effect of Integrated Antenatal Care Training on Midwife Service Quality Improvement Melsa Sagita Imaniar; Hadi Susiarno; Adhi Pribadi; Herry Herman; Dida Akhmad Gurnida; Hadyana Sukandar
Global Medical & Health Communication (GMHC) Vol 8, No 2 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.705 KB) | DOI: 10.29313/gmhc.v8i2.3457

Abstract

Antenatal care (ANC) is the most effective strategy for preventing complications in pregnancy. However, the current quality of midwife antenatal care services is still considered low. One of the indicators used for assessing midwifery service quality is the technical competency indicator that includes history taking, physical examination, case management and follow up, examination recording, and effective information, communication, and education (IEC). This study aimed to measure the effect on integrated antenatal care training on the quality of midwife services. The design was a pre-test and post-test quasi-experimental study conducted in Manonjaya Public Health Center, Tasikmalaya district, from November to December 2017. Simple random sampling was applied to get 20 respondents for each intervention and control groups. The bivariate analyses used in this study were the paired t test and the Mann-Whitney test. Results showed an overall increase in service quality scores in the intervention and control groups by 5.5% and 0.86%, respectively, with a significant difference in the increase between the two groups (p<0.05). Therefore, there is a significant increase in the quality of midwife after implementing the integrated ANC module and training to midwives. PENGARUH PELATIHAN ANTENATAL CARE TERPADU TERHADAP PENINGKATAN KUALITAS PELAYANAN BIDANAntenatal care (ANC) merupakan strategi pencegahan komplikasi dalam kehamilan paling efektif. Namun, kualitas pelayanan antenatal care bidan saat ini dinilai masih rendah. Salah satu indikator yang digunakan untuk menilai kualitas pelayanan kebidanan adalah indikator kompetensi teknis yang meliputi anamnesis, pemeriksaan fisik, penatalaksanaan dan tindak lanjut kasus, pencatatan pemeriksaan, serta komunikasi, informasi, dan edukasi (KIE) yang efektif. Penelitian ini bertujuan mengukur pengaruh pelatihan antenatal care terpadu terhadap kualitas pelayanan bidan. Desain penelitian ini menggunakan pre-test and post-test quasi-experimental yang dilaksanakan di Puskesmas Manonjaya Kabupaten Tasikmalaya dari November hingga Desember 2017. Pengambilan sampel dilakukan secara simple random sampling untuk mendapatkan 20 responden untuk tiap-tiap kelompok intervensi dan kontrol. Analisis bivariat yang digunakan dalam penelitian ini adalah uji t berpasangan dan Uji Mann-Whitney. Hasil penelitian menunjukkan peningkatan skor kualitas pelayanan secara keseluruhan pada kelompok intervensi dan kontrol sebesar 5,5% dan 0,86% masing-masing dengan perbedaan peningkatan yang signifikan antara kedua kelompok (p<0,05). Simpulan, terdapat peningkatan kualitas bidan yang signifikan setelah penerapan modul ANC terintegrasi dan pelatihan kepada bidan.
Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts Ruswana Anwar; Muhammad Alif; Adhi Pribadi
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (187.129 KB) | DOI: 10.28932/jmh.v1i1.496

Abstract

Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis. Keywords: Ki-67, endometriosis stage, endometriosis cyst
Co-Authors Adisti Erlina Sutomo Adisti Erlina Sutomo, Adisti Erlina Dida Akhmad Gurnida Hadyana Sukandar Herry Herman Johanes C. Mose Melsa Sagita Imaniar Muhammad Alif Muhammad Alif Ruswana Anwar Susiarno, Hadi Trully D. Sitorus Trully D. Sitorus