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All Journal Majalah Kedokteran Bandung Global Medical and Health Communication JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Jurnal Sistem Kesehatan Journal of Medicine and Health Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Andalas obstetrics and gynecology journal Jurnal Kesehatan Rajawali
Ruswana Anwar
Departement Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts Anwar, Ruswana; Alif, Muhammad; Pribadi, Adhi
Journal of Medicine and Health Vol 1, No 1 (2015)
Publisher : Maranatha Christian University

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Abstract

Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis. Keywords: Ki-67, endometriosis stage, endometriosis cyst
ADIPONECTIN SERUM LEVEL DIFFERENCE IN WOMEN WITH ENDOMETRIOTIC AND NON-ENDOMETRIOTIC CYSTS Anwar, Ruswana; Fahdiansyah, Fahdiansyah
Journal of Medicine and Health Vol 1, No 2 (2015)
Publisher : Maranatha Christian University

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Abstract

Endometriosis is an estrogen-dependent disease. Low levels of adiponectin resulted in an increased free estrogen levels and the inability to inhibit angiogenesis and the inflammatory process resulting in the development of increasingly severe endometriosis.This study is aimed to determine the differences in serum adiponectin levels in patient with nonendometriotic cyst with endometriosis cyst and its relationship with endometriosis stages. This is an analytical comparative study with cross-sectional method in group of women with endometriotic cyst (n=25) and women with non-endometriotic cysts (n=25), performed either laparoscopic or laparotomy surgery. The serum levels of adiponectin in both groups then compared with statistical analysis.The results showed there were no significant differences (p>0,05) on the characteristics of the study subjects in terms of age (p=0.994) and BMI (p=0.27). Significant differences of adiponectin levels were found between endometriotic patient group (mean=3.91) and nonendometriotic patients group (mean=8.59). There were no significant differences of adiponectin level in stages III endometriosis (mean = 4.24) and stage IV endometriosis (mean = 3.54).It is concluded that serum adiponectin levels in patients with endometriosis is lower than patient with non-endometriotic cyst. There is no relationship between adiponectin levels with endometriosis stage. Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage
Serum Adiponectin Level is Lower in Patients with Endometriotic Cyst Anwar, Ruswana
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.433 KB)

Abstract

Objectives: To analyse the difference of serum adiponectin level between patients with endometriotic cyst and those with non-endometriotic cyst, and its difference between endometriosis stages. Methods: This is a cross-sectional comparative analytical study involving 25 women with endometriotic cyst and 25 women with nonendometriotic cyst, which had undergone laparoscopy or laparotomy surgery. Blood samples were withdrawn and checked for serum adiponectin level in PRODIA laboratory in Jakarta. Serum adiponectin level of both groups were then measured and compared. The study was conducted in Dr. Hasan Sadikin Hospital in September- December 2012. Results: Shows no significant difference in subjects’ characteristic which are age (p = 0.994) and BMI (p = 0.267). There is a significant difference (p < 0.0001) between serum adiponectin level in endometriosis group (mean = 3.91 ± 1.976) with level of which in nonendometriosis group (mean = 8.59 ± 1.977). There is no significant difference (p = 0.384) of serum adiponectin level between stage III endometriosis (mean = 4.24 ± 1.8168) and stage IV endometriosis (mean = 3.54 ± 2.1531). Conclusion: Serum adiponectin level in patients with endometriotic cyst is significantly lower compared to level of which in patients with non-endometriotic cyst. There is no significant difference of serum adiponectin level between endometriosis stages. [Indones J Obstet Gynecol 2013; 1-3: 119-23] Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage
Serum Adiponectin Level is Lower in Patients with Endometriotic Cyst Fahdiansyah, Fahdiansyah; Anwar, Ruswana; Irianti, setyorini
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.433 KB) | DOI: 10.32771/inajog.v1i3.349

Abstract

Objectives: To analyse the difference of serum adiponectin level between patients with endometriotic cyst and those with non-endometriotic cyst, and its difference between endometriosis stages. Methods: This is a cross-sectional comparative analytical study involving 25 women with endometriotic cyst and 25 women with nonendometriotic cyst, which had undergone laparoscopy or laparotomy surgery. Blood samples were withdrawn and checked for serum adiponectin level in PRODIA laboratory in Jakarta. Serum adiponectin level of both groups were then measured and compared. The study was conducted in Dr. Hasan Sadikin Hospital in September- December 2012. Results: Shows no significant difference in subjects’ characteristic which are age (p = 0.994) and BMI (p = 0.267). There is a significant difference (p &lt; 0.0001) between serum adiponectin level in endometriosis group (mean = 3.91 ± 1.976) with level of which in nonendometriosis group (mean = 8.59 ± 1.977). There is no significant difference (p = 0.384) of serum adiponectin level between stage III endometriosis (mean = 4.24 ± 1.8168) and stage IV endometriosis (mean = 3.54 ± 2.1531). Conclusion: Serum adiponectin level in patients with endometriotic cyst is significantly lower compared to level of which in patients with non-endometriotic cyst. There is no significant difference of serum adiponectin level between endometriosis stages. [Indones J Obstet Gynecol 2013; 1-3: 119-23] Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage
Ki-67 Expression is Correlated with Cyst Size and Stage of Endometriosis Alif, Muhammad; Anwar, Ruswana; Pribadi, Adhi
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.209 KB) | DOI: 10.32771/inajog.v1i3.350

Abstract

Objectives: To analyze the association between Ki-67 expression with the cyst size and stage of endometriosis, and the correlation strength between them. Methods: A cross-sectional analytic observational study involving 56 paraffin blocks from subjects diagnosed with endometriosis, who had undergone laparotomy or laparoscopic surgery. The study is conducted in Dr. Hasan Sadikin Hospital in September-November 2012. Results: Shows a significant association between Ki-67 expression and the size of endometriotic cyst (p &lt; 0.0001), also with a strong correlation (r = 0.55) according to Guilford criteria. There is also a significant association between Ki-67 expression and the endometriosis stage (p &lt; 0.0001), with a strong correlation (r = 0.564) according to Guilford criteria. Conclusion: Ki-67 expression is correlated with the cyst size and stage of endometriosis. [Indones J Obstet Gynecol 2013; 1-3: 124-8] Keywords: endometriosis stage, endometriotic cyst size, Ki-67
KORELASI EKSPRESI IMMUNOSITOKIMIA VASCULAR ENDOTHELIAL GROWTH FACTOR A (VEGF A) DENGAN PROTEIN GENE PRODUCT 9,5 (PGP 9,5) DARAH HAID PADA PATOFISIOLOGI ENDOMETRIOSIS Dedy Hendry; Tita Husnitawati Madjid; Ruswana Anwar; Anita Rachmawati
Andalas Obstetrics And Gynecology Journal Vol 1, No 1 (2017)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.1.1.38-46.2017

Abstract

There are changes of eutopic endometrium molecular fenotipe in endometriosis such as changes in gene expression, steroid hormone response, increase of inflammation marker and cellular adhesion molecule, decrease of apoptotic index and decidualization capacity, increase of oxidative stress marker, increase activity of angiogenesis and neurogenesis. This study was conducted to analyze the differences in the expression of angiogenic factors (VEGF A) and neurogenesis factors (PGP 9.5) eutopic endometrium of menstrual bleeding among patients with endometriosis and non endometriosis and then the correlation of the two factors. This study is a cross sectional that examines the relationship between the incidence of endometriosis with risk factors such as VEGF expression and PGP 9.5 in menstrual blood. There were significant differences in the expression of VEGF A eutopic endometrium menstrual blood between endometriosis and non endometriosis group (p=0.002). There are significant differences expression of VEGF A and PGP 9.5 eutopic endometrial of menstrual blood between endometriosis and non endometriosis groups. There is a positive correlation between the expression of VEGF A with PGP 9.5 eutopic endometrial of menstrual blood on endometriosis patients.Keywords: eutopic endometrium, menstrual blood, VEGF A expression, PGP 9.5 expression, immunocytochemistry
Pengaruh Penggunaan Media Video pada Pembelajaran Praktikum terhadap Pengetahuan dan Keterampilan Mahasiswa dalam Penanganan Distosia Bahu di Universitas Ubudiyah Indonesia Ulfa Farrah Lisa; Bethy S. Hernowo; Ruswana Anwar
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 2, No 1 (2016): April 2016
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v2i1.348

Abstract

Distosia bahu merupakan salah satu penyebab paling bermasalah dalam kebidanan yang berkaitan erat dengan morbiditas bahkan mortalitas janin. Tenaga kesehatan harus siap dalam  menangani kedaruratan obstetrik ini. Tenaga bidan yang berkualitas dihasilkan oleh institusi pendidikan kebidanan yang dikelola dengan memperhatikan perkembangan ilmu  pengetahuan, teknologi informasi dan regulasi, salah satunya adalah pembelajaran praktikum selama pendidikan menggunakan media video. Kegiatan praktikum  menggunakan metode dan media pembelajaran yang tepat dan bervariasi akan membawa mahasiswa kepada pembentukan keterampilan dan kreativitas dalam menerima pengetahuan. Metode penelitian adalah quasi eksperimental dengan rancangan control group design. Subjek penelitian adalah mahasiswa semester IV Prodi DIII kebidanan Universitas Ubudiyah Indonesia yang berjumlah 32 orang.Teknik pengambilan sampel menggunakan populasi seluruhnya. Analisis digunakan analisis univariat, bivariat dengan uji Mann Whitneydan t test dan multivariatmenggunakan uji manova dengan taraf signifikan 0,05. Hasil penelitian menunjukkan peningkatan pengetahuan pada kelompok perlakuan dari 76,7 menjadi 86,7, sedangkan pada kelompok kontrol 66,7 menjadi 80 yang berbeda signifikan (p=0,001).  Peningkatan keterampilan pada kelompok perlakuan 50,8 menjadi 90, pada kelompok kontrol 48,6 menjadi 75,5,  perbedaan ini secara statistik bermakna (p<0,001). Penggunaan media video berpengaruh secara bersamaan terhadap pengetahuan dan keterampilan pada kelompok perlakuan (p<0,001). Simpulan hasil penelitian, pengetahuan dan keterampilan mahasiswa tentang distosia bahu lebih tinggi pada kelompok yang menggunakan media video dibandingkan dengan kelompok tanpa media video.
Correlation between Estrogen Receptorβ (ERβ), Neurofilament Protein (NF), and Protein Gene Product 9.5 (PGP9.5) Expressions as a Marker of Pain on Adenomyosis Etiopathogenesis Arief Setiawan; Ruswana Anwar; Tita Husnitawati; Tono Djuwantono; Wiryawan Permadi
Majalah Kedokteran Bandung Vol 53, No 4 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n4.2363

Abstract

Adenomyosis is a pathological condition characterized by the presence of endometrial glands and stroma within the myometrium. Endometrial like cells development was influenced by local inflammatory reactions, increases local estradiol due to asynchromatized estrogen synthesis (ERβ) and then stimulated to proliferation and fibrosis, are also irritation on small nerve fibers in women with painful characterized symptoms on adenomyosis. There are expressions of neurofilament protein (NF) and protein gene product 9.5 (PGP 9.5) is a highly specific pan-neuronal marker for microfilament nerve fibers and is related to presenting pain with adenomyosis symptoms. A retrospective immunohistochemical study of thirty samples histopathological of adenomyosis as study groups and 30 with control groups between 25–49 ages which were established at Dr. Hasan Sadikin General Hospital and the satellites in April 2014–May 2015. This case-control analyzed ERβ, NF, and PGP 9.5 expressions compared and correlation between study groups and controls. The results showed there were significant differences in expression of ERβ, NF, and PGP 9.5 on adenomyosis higher than the control study (p<0.05). The intensity was higher and very strong into the study groups (p<0,001). Cut off point of ERβ was more than>6(sensitivity 66.7%; specificity 70%), NF>3 (sensitivity 93%; specificity 46%), PGP 9.5>4 (sensitivity 90%; specificity 67%). Odds Ratio (CI 95%) ERβ>6= 4.67; NF >3=12.25; PGP 9.5 >4=24.75 (p<0.001). The value of histoscore of ERβ and PGP9.5 have correlates to adenomyosis, the differences were statistically significant (p<0.05). The conclusion were that the adenomyosis had higher ERβ, NF, and PGP 9.5 expressions. There are simultant correlates and positive values between ERβ, NF, and PGP9.5 based on etiophatogenesis of pain on adenomyosis.
Pengaruh Media Booklet Dan Metode Ceramah Tanya Jawab Terhadap Pengetahuan Keluarga Tentang Dukungan Pada Lansia Dona Tri Subdari; Ruswana Anwar; Adjat Sedjati Rasyad; Hidayat Wijayanegara; Roni Rowawi; Sri Komalaningsih
Jurnal Sistem Kesehatan Vol 5, No 4 (2020): Volume 5 Nomor 4 Juni 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jsk.v5i4.31285

Abstract

Dukungan keluarga merupakan bagian dari dukungan sosial. Kehidupan lansia kurang berkualitas dipengaruhi oleh pengetahuan keluarga yang kurang baik. Salah satu upaya meningkatkan pengetahuan keluarga adalah dengan penyuluhan menggunakan media booklet dan metode ceramah tanya jawab. Tujuan Penelitian ini untuk menganalisis pengaruh media booklet dan metode ceramah tanya jawab terhadap pengetahuan keluarga tentang dukungan pada lansia.Metode penelitian yang digunakan adalah Quasi Eksperrimen dengan pendekatan pretest-posttest control group design dengan jumlah sampel 38 orang setiap kelompok di wilayah kerja Puskesmas Ibrahim Adjie Kota Bandung. Penelitian dilaksanakan dari bulan Juni sampai Juli 2019. Pengambilan sampel dengan menggunakan consecutive sampling. Pengumpulan data diperoleh melalui kuesioner secara pretest dan posttest, kemudian data diolah dan dianalisis secara deskriptif analitik menggunakan Mann Whitney, Wilcoxone dan Chi Square.Hasil penelitian pada kelompok intervensi menunjukkan bahwa media booklet disertai metode ceramah tanya jawab lebih meningkatkan pengetahuan keluarga dibandingkan hanya diberikan metode ceramah tanya jawab sebesar 28,62±9,923 berbanding 10,53±5,260 dengan nilai p<0,001.Simpulan, terdapat pengaruh yang signifikan pemberian informasi kesehatan menggunakan media booklet dan metode ceramah tanya jawab dibandingkan hanya dengan metode ceramah tanya jawab.Kata kunci : Dukungan Keluarga Lansia, Metode Ceramah Tanya Jawab, Media Booklet
EFEKTIVITAS KANTUNG PENAMPUNG DARAH DIBANDINGKAN DENGAN ALAT PENAMPUNG DARAH KONVENSIONAL DALAM UPAYA PENAMPUNGAN DARAH PADA PERSALINAN Anita Fitriaturohmah; Ruswana Anwar; Ma&#039;mun Sutisna; Hidayat Wijayanegara; Adjat Sedjati Rasyad; Herri Sastramihardja
Jurnal Sistem Kesehatan Vol 5, No 2 (2019): Volume 5 Nomor 2 Desember 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jsk.v5i2.25659

Abstract

World Health Organization mendefinisikan perdarahan pascasalin yaitu ≥ 500 mL pada persalinan normal, pengukuran jumlah darah pada proses persalinan sangat sulit dilakukan, karena belum terdapat alat yang tepat untuk menampung jumlah darah pada proses persalinan. Kantung penampung darah merupakan alternatif alat untuk menampung jumlah darah lebih akurat. Penelitian ini bertujuan untuk mengukur efektivitas kantong penampung darah dibandingkan dengan alat konvensional. Metode penelitian menggunakan Quasi Experiment dengan rancangan penelitian posttest only with two group design untuk melihat hasil observasi keefektifan dan kepraktisan alat. Subjek I penelitian adalah ibu bersalin yang melahirkan di ruang ponek RSUD Kelas B Kabupaten Subang sebanyak 60 responden dan subjek II penelitian ini adalah bidan yang bertugas di ruang ponek RSUD Kelas B Kabupaten Subang. Hasil penelitian menunjukan rata-rata jumlah darah yang ditampung oleh kantung penampung darah pada persalinan normal yaitu, sebanyak 360.6 mL sedangkan dengan cara konvensional rata-rata 214.5 mL. Simpulan, Penggunaan kantong penampung darah lebih efektif secara signifikan dibandingkan dengan alat konvensional dengan Nilai p-value 0,000 < 0,05.Kata kunci: Efektivitas, Kantung penampung darah, Kepraktisan, Penggunaan alat konvensional
Co-Authors Achmad Suardi Adhi Pribadi Adhi Pribadi Adjat Sedjati Rasyad Adjat Sedjati Rasyad Anita Deborah Anwar Anita Fitriaturohmah Anita Rachmawati Arief Setiawan Benny Hasan Purwara Bethy S. Hernowo Dadang Syarif Effendi Damayanti, Melly Dedy Hendry Dewi Nawang Sari Dodi Suardi Dona Tri Subdari Fahdiansyah Fahdiansyah Fahdiansyah Fahdiansyah Fahdiansyah Fahdiansyah Farid Husin Farid Husin Firman Fuad Wirakusumah Hadi Supriadi Hadyana Sukandar Herri S. Sastramihardja Herry Herman Hidayat Wijayanegara I Ketut Suada Jaeni Pringgowibowo Jaeni Pringgowibowo Lisnawati Lisnawati Ma&#039;mun Sutisna Meita Dhamayanti Melia Juwita Adha Muhammad Alif Muhammad Alif Muhammad Alif Nanan Sekarwana Ratna Ratna Rena Nurita Roni Rowawi Setyorini Irianti Sri Komalaningsih Tita Husnitawati Tita Husnitawati Madjid Tono Djuwantono Ulfa Farrah Lisa, Ulfa Farrah Wiryawan Permadi