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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter The Indonesian Biomedical Journal Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Djoni Susanto
Department Of Anatomy And Histology, Faculty Of Medicine, Universitas Airlangga, Surabaya
Biochemistry, Genetics & Molecular Biology Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Use of bee honey as alternative medicine in protein energy deficiency R. Heru Prasetyo; Willy Sandhika; Djoni Susanto
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 3, No 1 (2013): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (519.323 KB)

Abstract

The protein energy deficiency cause intestinal villus atrophy and epithel mucous damage. The effect of bee honey on histostructure of intestine was studied in the experimental mice as model of proteinenergy deficiency. The use bee honey in protein-energy deficiency shown to improve intestinal villus atrophy and epithel damage. In conclusion that bee honey can use as alternative medicine in protein energydeficiency
The Effects of Propolis Extract Administration on HIV Patients Receiving ARV Erwin Astha Triyono; Sarah Firdausa; Heru Prasetyo; Joni Susanto; James Hutagalung; Lilis Masyfufah; Budiono Budiono; Ivan Hoesada
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1381

Abstract

BACKGROUND: Human Immunodeficiency Virus (HIV) is an infectious disease that targets the human immune system by attacking cluster of differentiation (CD)4 cells. The use of propolis in HIV patients is expected to be safe and beneficial in terms of increasing endurance and immunity by its role in increasing CD4 level. This study aimed to analyze the influence of propolis supplementation in increasing the CD4 level in anti-retroviral (ARV)-treated HIV patients.METHODS: Double-blind randomized controlled clinical trial was conducted in 50 HIV patients who took regular ARV therapy. The subjects were divided into two groups, one group was treated with ARV and propolis, while another one was given ARV and placebo. The CD4 cell count was measured during pre-treatment, in the 3rd month, in the 6th month after treatment. The level of hemoglobin, leukocyte, and platelets were also measured. The SF-12 questionnaire was used to evaluate quality of life of the subject.RESULTS: Out of 50 subjects, 43 subjects completed the study, which were 19 subjects from the propolis group and 24 subjects from the placebo group. After 3-month of treatment, there was a statistically significant difference in the increase of CD 44 level in propolis group, while the increment was not significant in the placebo group. After 6-month treatment, the increase of CD4 level was occurred in both groups, propolis and placebo, however the increment was not statistically significant. The levels of hemoglobin, leukocyte, and platelets were not altered by the treatment and remained normal throughout the study. The quality of life was improved during the study; however, it was also not statistically significant. Mild adverse events occurred in 3 subjects which were relieved after the treatment stopped.CONCLUSION: Based on the result of this study, the administration of propolis on HIV patients receiving ARV bring significant difference in the increase of CD4 in propolis group from baseline to 3 month after the treatment. While in placebo group, this increment was not significant. At the end of study, CD4 count continued to rise up, however the increase was not statistically significant. There are no hemoglobin, leukocyte, platelets, and quality of life abnormalities. Therefore, it is necesary to do further research with a spesific CD4 count. However, it may be beneficial in relieving the clinical symptoms and quality of life of patient living with HIV.KEYWORDS: CD4, ARV, HIV, propolis
The Comparison of Visual Acuity After Congenital Cataract Surgery between Children ≤2 Years and >2-17 Years Adam Surya Romadhon; Joni Susanto; Rozalina Loebis
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22140

Abstract

Introduction: Congenital cataract is turbidity occurs in eye lens that present at birth or immediately after. We aim to find out visual acuity after congenital surgery between children under 2 years old and 2-17 years old after following up 3, 6, 12 months.Methods: This was a cross-sectional study. Data were gathered from medical record of congenital cataract aged ≤2 years and >2-17 years including age of surgery, frequency of eyes, sex, laterality, and visual acuity of patients with best corrected visual acuity (BCVA). All data analyzed using Mann-Whitney test.Results: 41 children (67 affected eyes) in which 45 eyes that were operated at aged ≤2 years and 22 eyes were operated at aged >2-17 years. There was average difference of visual acuity between age group of ≤2 years and >2-17 years while following-up 3 months (1.60 ± 0.34 logMAR, 1.23 ± 0.67 logMAR, p = 0,003). Whereas in follow up 6 months (1.23 ± 0.47 logMAR, 1.15 ± 0.68 logMAR, p = 0,242) and 12 months (0.94 ± 0.47 logMAR, 0.96 ± 0.44 logMAR, p = 0,840), there were no difference significant average of visual acuity.Conclusion: Visual acuity after following-up 3 and 6 months in age group of >2-17 years were better than age group of ≤2 years, whereas after following-up 12 months in age group ≤2 years, it was obtained that visual acuity was better than age group of >2-17 years.
GLUT 4 DI JARINGAN ADIPOSA (GLUT 4 in Adipose Tissue) Dewi Ratna Sari; Rimbun Rimbun; Tri Hartini Yuliawati; Joni Susanto; Ari Gunawan; Harjanto JM
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1263

Abstract

The decreasing of glucose transporter 4 (GLUT 4) in adipose tissue of diabetic and obesity patients are associated withhyperinsulinaemia and insulin resistance. The adipose tissue can be used as therapeutic targets in the treatment of Diabetes Mellitus(DM). Visceral adipose tissue has different morphology and functional with subcutaneous adipose tissue and Vitamin D has been knownto have contributed in DM. The aim of this study is to know the role of cholecalciferol on the expression of GLUT 4 in subcutaneous andvisceral adiposity of diabetic rats by elucidated in those tissues. The subjects of the study consisted of nineteen male diabetic rats of Wistarstrain, which were divided into control group (K) and three (3) treatment groups (X1, X2 and X3). In order to induce the condition ofDM, the animals were fed with high fat diet for three (3) weeks and administered a single intraperitoneal injection of streptozotocin (35mg/kgBW) at the end of the second week. Cholecalciferol were administered with doses of 6.25 μg/kgBW in X1, 12.5 μg/kgBW in X2and 25 μg/kgBW in X3 per oral everyday within 14 days. The subcutaneous and visceral adipose tissues of the subjects were processedinto histological slides with immunohistochemistry staining. The data were analyzed by one way ANOVA test and paired t-test (α= 0.05,significance p<0.05). In this study was found the significance of GLUT 4 expression in subcutaneous adiposity (p=0.035) is differentbetween the groups, the differences were found between group K and groups X1, X2 and X3. Also there were found the significance differentof GLUT 4 expression in subcutaneous adiposities compared with visceral adiposities in all treatment groups (p>0.05). Based on thisstudy it can be concluded that cholecalciferol could increase the expression of GLUT 4 in the subcutaneous adiposity, but not in visceraladiposity of the diabetic rats.
Co-Authors Adam Surya Romadhon Ari Gunawan Budiono Budiono Dewi Ratna Sari Dewi Ratna Sari Erwin Astha Triyono Firdausa, Sarah Harjanto JM Heru Prasetyo Ivan Hoesada James Hutagalung Masyfufah, Lilis R Heru Prasetyo R. Heru Prasetyo Rimbun Rimbun Rimbun Rimbun Rozalina Loebis Tri Hartini Yuliawati Willy Sandhika Willy Sandika