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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM JURNAL ILMU KEFARMASIAN INDONESIA JURNAL FARMASI GALENIKA Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Jurnal Ilmiah Farmasi Farmasyifa Jurnal Ilmiah Farmako Bahari Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Kesehatan Tambusai Medical Sains : Jurnal Ilmiah Kefarmasian
Sinata, Novia
Sekolah Tinggi Ilmu Farmasi Riau
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Uji Aktivitas Antidiabetes Fraksi dari Ekstrak Etanol Daun Karamunting (Rhodomyrtus tomentosa (Ait.) Hassk.) Terhadap Mencit Diabetes Sinata, Novia
JURNAL FARMASI GALENIKA Vol 3 No 2 (2016): Jurnal Farmasi Galenika Volume 3 No. 2, 2016
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.894 KB)

Abstract

Diabetes mellitus merupakan penyakit yang ditandai dengan  kadar gula darah yang melebihi normal (hiperglikemia) sebagai akibat dari tubuh yang kekurangan insulin relatif maupun absolut. Karamunting (Rhodomyrtus tomentosa (Ait.) Hassk.) salah  satu tumbuhan yang secara tradisional digunakan  untuk mengobati diabetes  mellitus. Adanya aktivitas antidiabetes dari tumbuhan karamunting dikarenakan pada tumbuhan ini terkandung senyawa-senyawa kimia salah satunya golongan flavonoid.Penelitian telah dilakukan terhadap uji antidiabetes  fraksi dari ekstrak etanol daun karamunting Rhodomyrtus tomentosa (Ait.) Hassk pada mencit putih jantan diabetes yang diinduksi dengan aloksan dosis 200 mg/kgbb secara intraperitonial. Fraksi dari ekstrak etanol yang diberi fraksi etil asetat, fraksi n-heksana dan fraksi air dengan dosis masing-masing 25 mg/kgbb diberikan secara oral sekali sehari selama tujuh hari. Parameter yang diukur adalah kadar glukosa darah mencit. Hasil penelitian menunjukkan bahwa fraksi air secara oral menunjukkan penurunan kadar glukosa darah yang lebih tinggi dibandingkan mencit diabetes yang diberi fraksi etil asetat dan fraksi n-heksan secara oral. Persentase efek penurunan glukosa darah  fraksi air sebesar 58,87 %, fraksi etil asetat  52,09 %, dan fraksi heksan 24,30 %.
Formulasi Dan Uji Aktivitas Emulgel Minyak Ikan Gabus (Channa striata) Sebagai Penyembuh Luka Bakar : Formulation and Activity Test of Snakehead (Channa striata) Oil as A Burns Healing Nofriyanti; Novia Sinata; Aida Mistawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15013

Abstract

Burns often occur in various daily activities, second-degree burns are the most common. Snakehead oil (Channa striata) contains fatty acids such as omega-3 and omega-6 which can accelerate the wound healing process. This study aims to determine the physical stability and effectiveness of emulgel preparations containing snakehead oil for 8 weeks of storage of the wound healing process, which was given topically to 5 groups of treated mice.Second degree burns were made on the skin of mice, then the wound was smeared with emulgel preparations and the healing process was observed for 21 days. Cork fish oil was formulated in several concentrations; F1 (5%), F2 (10%) and F3 (15%). Organoleptic datas showed that all formulas formed as semisolid dosage form with a pale yellow color and distinctive smell of snakehead oil. The emulgel has homogenous state, not irritating effect and pH range of 5,7 to 5,3. The dosage which has a concentration of 15% gives the smallest spread but has the longest adhesion. In the Freeze and Thaw stability test conducted at 40C and 400C the dosage remains stable with an increase in globule size. Data analysis of the effectiveness of burn healing was done by two-way ANOVA statistical tests and continued with the Tukey test. The independent variable is the treatment group and the recovery time of mice while the dependent variable is the diameter of the burn. Statistical results showed that all formulas differed significantly (p <0.05) against negative controls indicating that they had effectiveness in wound healing. F3 has a better effectiveness of healing burns on the 15th day with 100% healing percent compared with F1 and F2 on the 21th day.
AKTIVITAS FRAKSI ETIL ASETAT Artocarpus altilis (Parkinson Ex F.A.Zorn) Fosberg TERHADAP KADAR ASAM URAT DARAH MENCIT PUTIH JANTAN HIPERURISEMIA Novia Sinata
Jurnal Ilmiah Farmasi Farmasyifa Vol 2, No 2 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v2i2.4795

Abstract

ABSTRAK Hiperurisemia suatu kondisi terjadi peningkatan kadar asam urat dalam darah. Penimbunan kristal asam urat pada persendiaan menimbulkan rasa sakit dan nyeri yang dikenal sebagai penyakit gout. Salah satu tanaman yang dapat digunakan sebagai obat tradisional untuk pengobatan asam urat adalah daun sukun (Artocarpus altilis (Parkinson Ex F.A.Zorn) Fosberg). Penelitian ini bertujuan untuk menguji aktivitas antihiperurisemia fraksi etil asetat dari daun sukun terhadap kadar asam urat darah mencit putih jantan hiperurisemia. Metode penelitian ini dilakukan dengan penginduksian hiperurisemia menggunakan Makanan Diet Purin Tinggi (MDPT ) jus hati sapi segar 0,6 mL/20gBB selama 28 hari menggunakan mencit galur swiss webster yang dikelompokkan menjadi 6 kelompok yaitu kelompok kontrol normal, kontrol negatif,  kontrol positif (allopurinol 13 mg/kgBB), dosis 100 mg/kgBB, kelompok dosis 200 mg/kgBB dan  dosis 400 mg/kgBB. Pemberian bahan uji dilakukan selama 14 hari dimulai pada hari ke 15 sampai ke 28. Pengukuran kadar asam urat dilakukan pada hari ke-0, 15, 22 dan 29 menggunakan alat digital Easy Touch® GCU. Hasil penelitian menunjukkan bahwa fraksi etil asetat daun sukun (Artocarpus altilis (Parkinson Ex F.A.Zorn) Fosberg) dosis 100 mg/kgBB, 200 mg/kgBB dan 400 mg/kgBB dapat menurunkan kadar asam urat dan memberikan efek menurunkan kadar asam urat  yang hampir sama dengan allopurinol dosis 13 mg/kgBB. Kesimpulan nya fraksi etil asetat dari daun sukun memiliki aktivitas dalam menurunkan kadar asam urat dan dosis yang paling efektif yaitu dosis 100 mg/kgBB.Keywords: Antihiperurisemia, sukun, fraksi etil asetat, MDPT ABSTRACT Hyperuricemia is a condition when there is an increase in uric acid levels in blood. Hyperuricemia can cause accumulation of urate crystal in joints, causing pain dan pain known as gout. One of the plants that can be used as a traditional medicine gout is breadfruit leaves (Artocarpus altilis (Parkinson Ex F.A.Zorn) Fosberg. This study aimed to evaluate the antihyperuricemia activity of ethyl acetate fraction of breadfruit leaves. The research was conducted by inducing hyperuricemia using a High Purine Diet Food (MDPT) of  0.6 ml / 20gBW juice of  fresh beef liver for 28 days by using swiss webster mice devided into 6 groups normal control, negative control, positive control (allopurinol 13 mg/KgBW), dose 100 mg/ KgBW, dose 200 mg/KgBW, dose 400mg / KgBW. Treatment was performed for 14 days starting on days 15 to 28. Uric acid levels was measured on the 0, 15,22, and 29 th days  using a digital tool Easy Touch® GCU. The results showed that ethyl acetate fraction of breadfruit leaves (Artocarpus altilis (Parkinson Ex F.A.Zorn) Fosberg) dose 100 mg/kgBB, 200 mg/kgBB and 400 mg/kgBB might decrease uric acid levels almost the same as allopurinol 13 mg/kgBB and the effective dose in 100 mg/kgBBKeywords: Antihyperuricemia, sukun, ethyl acetate fraction, MDPT
GAMBARAN PENGGUNAAN ANTIHIPERTENSI PADA PASIEN RAWAT JALAN DI PUSKESMAS SIDOMULYO PEKANBARU TAHUN 2020 Novia Sinata; Siti Aisyah Rahmadani
Jurnal Kesehatan Tambusai Vol. 2 No. 4 (2021): Desember 2021
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v2i4.3198

Abstract

Hipertensi adalah peningkatan tekanan darah sistolik ≥ 140 mmHg atau tekanan darah diastolik ≥ 90 mmHg. Penyakit ini salah satu penyebab kematian. Manajemen yang tepat dalam mengontrol penyakit hipertensi dengan memberikan terapi antihipertensi. Tujuan penelitian ini adalah untuk mengetahui gambaran penggunaan obat antihipertensi pada pasien rawat jalan di Puskesmas Sidomulyo Pekanbaru tahun 2020. Penelitian dirancang dengan metode observasional secara deskriptif menggunakan teknik purposive sampling. Populasi penelitian adalah seluruh resep antihipertensi pasien rawat jalan dari bulan Januari sampai bulan Desember 2020 yang memenuhi kriteria inklusi. Hasil penelitian 131 pasien (55,98 % ) dari 234 pasien hipertensi pada perempuan, rentang usia pasien hipertensi yang paling banyak dewasa madya (41-60 tahun) yaitu 115 pasien (49,15%). Golongan obat antihipertensi yang banyak digunakan di Puskesmas Sidomulyo yaitu amlodipin golongan Calcium Chanel Blocker (CCB) 53,33%, obat generik 99,3% dan terapi tunggal 193 pasien ( 81,97%)
Uji Toksisitas Subkronis Ekstrak Etanol Daun Pucuk Merah (Syzygium Myrtifolium Walp.) Terhadap Fungsi Hati Dan Ginjal Syilfia Hasti; Rahmayati Rusnedy; Musdalifah Musdalifah; Asnila Asnila; Lisa Renita; Ferelina Santi; Shella Anggraini; Novia Sinata
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1103

Abstract

For the development of natural medicines from the ethanolic extract of Syzygium myrtifolium Walp leaves it is necessary to know the pre-clinical safety test so that its safety if used in the long term. The subchronic toxicity test of the ethanolic extract of Syzygium myrtifolium Walp leaves l was carried out by assessing the kidney and liver function of the test animals given after 60 days of test preparation, in the form of blood biochemical examination using the Mindray®BA-88A device and histological examination of the kidneys and liver. The results showed that the administration of ethanol extract of Syzygium myrtifolium Walp leaves at doses of 300, 600 and 900 mg/kgBW did not significantly affect the activity of SGOT, SGPT, serum creatinine levels (p>0.05). Microscopically on the percentage of damage to the glomerulus of the right and left kidneys. at doses of 600 and 900 mg/kgBW there was a significant difference to the control group (p<0.05). For qualitative microscopic examination, namely observation of sinusoids and hepatocyte cells at each level, there were abnormal changes. Meanwhile, quantitative microscopic examination at doses of 600 and 900 mg/kgBW caused an increase in the percentage of central vein damage (p<0.05). From the research, it was found that the ethanolic extract of Syzygium myrtifolium Walp leaves of white mice was safe for liver and kidney function at a dose of 300 mg/kgBW, but the doses group of 600 and 900 mg/kgBW gave a toxic effect on the kidneys and liver when compared to the control group.
Antidiabetes dari Fraksi Air Daun Karamunting (Rhodomyrtus tomentosa (Ait.) Hassk.) Terhadap Kadar Glukosa Darah Mencit Diabetes Novia Sinata; Helmi Arifin
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (358.842 KB) | DOI: 10.29208/jsfk.2016.3.1.102

Abstract

Karamunting is one of the plants used in traditional medicine of diabetes mellitus. The antidiabetic effect of aqueous fraction of Rhodomyrtus tomentosa (Ait.) Hassk leaves has been investigated on male white mice that were induced with alloxan dose 200 mg/kgBW intraperitoneally. The fraction was given orally at dose 10, 20, 40 mg/KgBW for 15 days. Parameters that were measured are decrease concentration of blood glucose, body weight, urin output and water intake. Result showed that the aqueous fraction of Rhodomyrtus tomentosa (Ait.) Hassk leaves at dose 10, 20, 40 mg/KgBW has effect on decreasing blood glucose level on diabetic mice induced alloxan (P<0.05). This fraction also improved body weight, urine output dan reduced water intake (P<0.05).
Uji efek analgetik infusa daun sukun (artocarpus altilis forst) terhadap mencit putih ( mus musculus l) jantan diinduksi asam asetata 1% nisa aulia; novia sinata
Jurnal Penelitian Farmasi Indonesia Vol. 8 No. 1 (2019)
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.149 KB) | DOI: 10.51887/jpfi.v8i1.504

Abstract

ABSTRACTA study of the analgesic effect of breadfruit leaf infusion (ArtocarpusaltilisForst) on male white mice (Musmusculus L) was induced by 1% acetic acid. This study aims to look at the effect of the analgesic effect of breadfruit leaf infusion (ArtocarpusaltilisForst) on male white mice (Musmusculus L) by using the Writhing Test method. Experimental animals were divided into 5 groups. The negative control group was only given aquadest, the positive group was given acetylsalicylic acid at a dose of 1.3 mg / 20 gBB suspended with 1% Na CMC, the treatment group was given breadfruit leaf infusion preparation (ArtocarpusaltilisForst) with a concentration of 5%, 10% and 20 %. The experimental animals were given an oral preparation of 1% BB, 30 minutes after which each group was induced with 1% acetic acid as much as 0.1 ml. The data obtained is processed using two-way Analysis of Variance (ANOVA). The results showed that breadfruit leaf infusion (ArtocarpusaltilisForst) had an analgesic effect similar to acetylsalicylic acid (positive control) at 10% and 20% concentrations, significantly different from negative controland 5% infusion concentration (p <0.05).
Uji Efek Analgetik Infusa Daun Jeruk Nipis (Citrus aurantifolia (Christm.) Swing) terhadap Mencit Putih (Mus musculus L) Jantan yang Diinduksi Asam Asetat 1% Novia Sinata
Jurnal Penelitian Farmasi Indonesia Vol. 9 No. 1 (2020): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v9i1.795

Abstract

Research has been carried out on the analgesic effect of infusion of lime leaves (Citrus aurantifolia (Christm.) Swing) on male white mice (Mus musculus L) induced 1% acetic acid.The purpose of this study was to see the effect of analgesic effect of infusion of lime leaves (Citrus aurantifolia (Christm.) Swing) on male white mice (Mus musculus L) using the Writhing Test method. Experimental animals were divided into 5 groups. The negative control group was only given aquades, a positive control group of acetyl salicylate acid with a dose of 1.3 mg / 20g BB which was suspended with 1% Na CMC, the treatment group was given a lime leaf infusion (Citrus aurantifolia (Christm.) Swing) with a concentration of 5 %, 10% and 20%.The experimental animals were given oral preparations as much as 1% BB, 30 minutes after which each group was induced with 1% acetic acid as much as 0.1 ml ip. The data obtained is processed using two-way Analysis of Variance (ANOVA). The results showed that the infusion of lime leaves at concentrations of 10% and 20% (Citrus aurantifolia (Christm.) Swing) has analgesic effects on mice induced 1% acetic acid, .significantly different from negative controls (p<0.05) but not as strong as acetyl salicylate (positive control) Keywords : Analgetic, infusion, lime leaves, acetic acid
Gambaran Pengetahuan Masyarakat Melati Tentang Nutrisi Selama Pandemi Covid-19 Ferdy Firmansyah; Emma Susanti; Erniza Pratiwi; Novia Sinata
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 5, No 4 (2022): Volume 5 No 4 April 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v5i4.4760

Abstract

ABSTRAK Prevalensi Covid-19 yang muncul pada akhir 2019 terus meningkat hingga saat ini dan masih dikategorikan sebagai pandemi. Berbagai upaya telah dilakukan mulai dari penerapan protokol kesehatan, mengonsumsi vitamin, hingga melakukan aktivitas dari rumah. Upaya tersebut harus dilakukan oleh setiap individu untuk menekan dan memutus rantai penyebaran virus ini. Oleh karena itu perlu diberikan penyuluhan dengan tujuan meningkatkan kesadaran dan pengetahuan masyarakat tentang Covid-19 serta nutrisi yang diperlukan selama pandemi. Kegiatan ini diikuti sebanyak 30 responden di Kecamatan Tampan, Pekanbaru dengan menggunakan media leaflet. Pada saat pemberian informasi juga diberikan masker serta vitamin C. Vitamin dapat berfungsi sebagai antioksidan dan digunakan untuk meningkatkan daya tahan tubuh selama pandemi. Berdasarkan kegiatan, terjadi peningkatan pengetahuan masyarakat yang dibuktikan dengan nilai rerata pre-test 44,04 menjadi 92,87 pada saat post-test. Disarankan kedepannya untuk melakukan pengabdian dengan ruang lingkup yang lebih besar. Kata Kunci: Covid-19, Nutrisi, Pengetahuan ABSTRACT The prevalence of Covid-19 which emerged at the end of 2019 continues to increase until now and is still categorized as a pandemic. Various efforts have been made, starting from implementing health protocols, vitamins consumptions, and activities or work from home (WFH). These efforts must be made by each individual to suppress and break the chain of infection stopping covid-19. Therefore, it is necessary to provide counseling with the aim of increasing public awareness and knowledge about Covid-19 and the nutrition needed during the pandemic. This activity was attended by 30 respondents in Tampan District, Pekanbaru using leaflet media. At the time of providing information, masks and vitamin C were also given. Vitamins can function as antioxidants and are used to increase body resistance during a pandemic. Based on the activity, there was an increase in public knowledge as evidenced by the mean value of the pre-test from 44.04 to 92.87 at the time of the post-test. It is recommended in the future to do service with a larger scope. Keywords: covid-19, nutrition, knowledge
AKTIVITAS ANTIHIPERURISEMIA EKTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) PADA MENCIT JANTAN HIPERURISEMIA Novia Sinata; Rahma Dona; Muthui’ah Muthui’ah
Jurnal Ilmiah Farmako Bahari Vol 13, No 2 (2022): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v13i2.1223

Abstract

Hiperurisemia adalah  peningkatan  kadar  asam  urat darah di atas normal. Hiperurisemia  terjadi  akibat  meningkatnya  produksi  atau menurunnya  pembuangan  asam  urat,  atau kombinasi  keduanya. Asam urat merupakan hasil akhir metabolisme purin dalam tubuh. Penyakit gout merupakan gangguan inflamasi akut yang ditandai dengan pembengkakan pada sendi disebabkan kadar asam urat yang tinggi (hiperurisemia). Salah satu tanaman yang dapat digunakan sebagai obat tradisional untuk hiperurisemia adalah daun pandan wangi (Pandanus amaryllifolius Roxb.). Tujuan penelitian ini untuk mengetahui aktivitas antihiperurisemia ekstrak etanol dari daun pandan wangi terhadap kadar asam urat darah mencit jantan hiperurisemia.Tiga puluh ekor mencit dibagi menjadi enam kelompok yaitu kelompok kontrol normal, kelompok kontrol negative (diberi jus hati sapi 0,6 ml/20gBB), kelompok kontrol positif (alopurinol 13 mg/kgBB), kelompok dosis 200 mg/kgBB, kelompok dosis 400 mg/kgBB dan kelompok dosis 800 mg/kgBB.Penginduksian hiperurisemia dilakukan dengan menggunakan Makanan Diet Purin tinggi (MDPT) jus hati sapi segar. Pemeriksaan kadar asam urat menggunakan metode Point of Care Testing (POCT) dengan menggunakan alat digital EasyTouch®GCU. Hasil yang didapat ekstrak etanol dari daun pandan wangi (Pandanus amaryllifolius Roxb.) dosis 200mg/kgBB, 400mg/kgBBdan 800 mg/kgBB dapat menurunkan kadar asam urat darah pada mencit putih jantan secara signifikan (P<0,05). Potensi ekstrak etanol daun pandan wangi dosis 400 mg/kgbb dan 800 mg/kgBB setara dengan allopurinol dosis 13 mg/kgBB dalam menurunkan kadar asam urat mencit hiperurisemia (P>0,05).
Co-Authors Aida Mistawati Asnila Asnila Emma Susanti Erniza Pratiwi Ferdy Firmansyah Ferelina Santi Firstio Anfasa Mashudi Hazizah Hazizah Helmi Arifin Lisa Renita Musdalifah Musdalifah Muthui’ah Muthui’ah Nisa Aulia Nofriyanti Rahma Dona Rahmayati Rusnedy Shella Anggraini Siti Aisyah Rahmadani Syilfia Hasti Syilfia Hasti Titik Maryani