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All Journal Prosiding Seminar Biologi Current Biochemistry Journal PROSIDING SEMINAR KIMIA Reswara: Jurnal Pengabdian Kepada Masyarakat Community Empowerment Jurnal Nuansa Akademik: Jurnal Pembangunan Masyarakat Proceeding Biology Education Conference Jurnal Pengabdian Masyarakat Kedokteran Gemakes: Jurnal Pengabdian Kepada Masyarakat Prosiding Seminar Nasional Pengabdian Kepada Masyarakat
Dwi Endah Kusumawati
Program Studi Sarjana Farmasi, Universitas Islam Sultan Agung, Semarang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Current Biochemistry Journal

 1 
Aktivitas Antibakteri Isolat Bakteri Endofit dari Tanaman Miana (Coleus scutellariodes [L.] Benth.) terhadap Staphylococcus aureus dan Escherichia coli Dwi Endah Kusumawati; Fachriyan Hasmi Pasaribu; Maria Bintang
Current Biochemistry Vol. 1 No. 1 (2014)
Publisher : IPB University

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Abstract

Coleus scutellarioides [L.] Benth. known as medicinal plant which contains antidiarhea and antimicrobial compounds. Extraction of bioactive compound from plants is not efficient because it needs a large biomass, therefore the one of appropiate ways is using endophytic bacteria. The purpose of this research was to isolate and test of antibacterial activity of endophytic bacteria from Coleus scutellarioides [L.] Benth. against two pathogenic bacteria i.e Eschericia coli and Staphylococcus aureus. A total of 22 isolates of endophytic bacteria were obtained from Coleus scutellarioides [L.] Benth. Based on antibacterial activity test, 13 isolates of endophytic bacteria were able to inhibit the growth of E. coli and 15 isolates were able to inhibit S. aureus, whereas endophytic bacteria which can inhibit both types of pathogens are 10 isolates.
Analysis of Metabolite Compound Profiles of Miana Leaves Endophytic Bacteria (Coleus scutellariodes) using GC-MS Dwi Endah Kusumawati; Ukhradiya Magharaniq Safira Purwanto; Maria Bintang; Fachriyan Hasmi Pasaribu
Current Biochemistry Vol. 8 No. 2 (2021)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.8.2.2

Abstract

Exploration of bioactive compounds from endophytic bacteria as novel source of antibacterial need to be explored, as an alternative to substitute synthetic antibiotics. Based on previous studies, DM6 was a potential isolate that showed antibacterial activity. The isolate has been identified as Brevibacillus sp. based on 16S rRNA analysis. This study aimed to identify antibacterial compounds produced by DM6 isolate using GC-MS. The GC-MS results showed that the chloroform extract of DM6 isolate contained : 1-Octadecene (CAS).alpha.-Octadecene, Hexanedioic acid, dioctyl ester (CAS) Dioctyl adipate, Phenol, 3,5-bis(1,1-dimethylethyl)- (CAS) 3,5-Di-tert-butylphenol, and 1,4-diaza-2,5-dioxobicyclo[4.3.0]nonane. Adipic acid/hexanedioic acid and phenols are also known to contained in the leaves of Coleus scutellariodes. This indicated that endophytic bacteria were able to synthesize antibacterial compounds which similar with the host plant.
Antibacterial Test of Endophytic Bacteria Isolated from Jawer Kotok (Coleus scutellarioides L. Benth) Against Bacillus cereus and Salmonella enteritidis Dwi Endah Kusumawati; Maria Bintang
Current Biochemistry Vol. 10 No. 1 (2023)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.10.1.2

Abstract

The use of synthetic antibiotics in small doses and long term against pathogenic bacteria can cause negative effects, such as resistance of pathogens and killing of good bacteria. We needs an innovation to substitute the use of synthetic antibiotics with natural antimicrobial compounds. Jawer kotok (Coleus scutellarioides L. Benth) has been used as medicinal plant and shown to be efficacious as antimicrobial because it contains flavonoids, tannins, alkaloids and saponins. Endophytic bacteria are symbiotic microorganisms that live in healthy plant tissue without harming to the host plant and may produce natural antimicrobial compounds which similar to the host plant. The aim of this study are to isolating endophytic bacteria from jawer kotok and screening their antibacterial activity against two pathogenic bacteria, namely Bacillus cereus and Salmonella enteritidis. A total of 22 bacterial isolates were obtained from C scutellarioides [L.] Benth. Based on antibacterial activity test, nine isolates shown antibacterial activity against B. cereus and S.enteritidis. BJ7 is the most potential isolate because it shown the biggest inhibition. It great possible that endophytic bacteria from jawer kotok may synthesize the same antimicrobial compounds like their host plant.
Co-Authors Amy Mutiasari Asih Puji Lestari Chintiana Nindya Putri Chintiana Nindya Putri Desriani Desriani Dina Fatmawati Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Maria Bintang Maria Bintang MARIA BINTANG Maria Bintang Maria Bintang Mifta Triwahyuni Neneng Hasanah Nita Tiara Luthfiah Purwanto, Ukhradiya Magharaniq Safira Putri, Chintia Nindya Siti Zubaidah Syamsul Falah Wilda Fhitriany Usman Wiwit Amrinola