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All Journal MEDISAINS Indonesian Applied Physics Letters Jurnal Ilmiah Sains Prosiding Seminar Nasional Unimus
Djony Izak Rudyardjo
Department Of Physics, Faculty Of Science And Technology, Universitas Airlangga, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Electrical & Electronics Engineering Engineering Health Professions Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Journal : MEDISAINS

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Evaluation of surface modified PLLA-collagen hollow fiber as vascular graft Mayasari, Dita Ayu; Widiyanti, Prihartini; Rudyardjo, Djony Izak
MEDISAINS Vol 17, No 2 (2019)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v17i2.5259

Abstract

Background: Cardiovascular disease as the first silent killer in the world is related to atherosclerosis plaque. Coronary artery bypass grafting as a gold standard for severe atherosclerosis needs alternative materials to replace the narrowed artery due to plaque. PLLA is one of the biodegradable polymers which is suitable for the vascular graft, but some of its weaknesses should be addressed.Objective: The aim of this research is to improve PLLA characteristics for a vascular graft candidate by using collagen and chitosan.Methods: This study was an experimental study that consisted of two steps, preparation of hollow fiber and evaluation of its characteristic. This research evaluated the effect of chitosan concentration against cytotoxicity and hemocompatibility using MTT assay and hemolytic test.Results: The result showed that chitosan could improve the biological characteristics of hollow fiber PLLA-collagen, non-toxic, and non-hemolytic.Conclusions: There is a good effect on the biological characteristics of PLLA-Collagen hollow fiber by adding chitosan on the surface of PLLA-Collagen hollow fiber.
Co-Authors - Aminatun - Siswanto - Winarno Aditya Budi Fauzi Adri Supardi Adri Supardi Andi Hamim Zaidan Arifianto, Deny Dani Gustaman Syarif Darmawan Darmawan Denny Afianto Dita Ayu Mayasari, Dita Ayu Fardatul Azkiyah Firman Maulana Ikhsan Heri Trilaksana Jan Ady Jan Ady Miftachul Nur Afifah Nuril Ukhrowiyah Prihartini Widiyanti Rezza Ruzuqi