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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL ILMU KEFARMASIAN INDONESIA Borneo Journal of Pharmacy
RIKA SARI DEWI
Faculty Of Pharmacy, Pancasila University
Medicine & Pharmacology

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Uji Efek Anti-Inflamasi dan Analgesik Infusa Daun Senggani (Melastoma malabathricum L.) LESTARI RAHAYU; RIKA SARI DEWI; GUSRITA AYU
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.197 KB)

Abstract

Secara empiris penggunaan daun senggani mempunyai kemampuan sebagai anti-inflamasi dan analgesik. Penelitian ini bertujuan menguji efek anti-inflamasi dan analgesik dari infusa daun senggani. Pada uji anti-inflamasi menggunakan metode Winter, tikus dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif diberi air suling, kontrol positif diberi natrium diklofenak 1,8 mg/200 g bb, kelompok uji diberi infusa daun senggani 2,8 mL/200 g bb dengan konsentrasi 10%, 20% dan 40%. Setelah 30 menit diinduksi karagenan 1%, 0,2 mL/200 g bb. Pada pengujian analgesik menggunakan metode Sigmund, mencit dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif diberi air suling, kontrol positif diberi natrium diklofenak 0,26 mg/20 g bb, kelompok uji diberi infusa daun senggani 0,4 mL/20 g bb dengan konsentrasi 10%, 20% dan 40%. Setelah 30 menit diinduksi asam asetat 3%, 0,2 mL/20 g bb. Dari hasil ANOVA satu arah infusa daun senggani dengan dosis 2,8 mL/200 g bb dengan konsentrasi 10%, 20% dan 40% mempunyai efek sebagai anti-inflamasi dan infusa daun senggani dosis 0,4 mL/20 g bb dengan konsentrasi 10%, 20% dan 40% mempunyai efek sebagai analgesik. Infusa daun senggani dengan dosis 2,8 mL/200 g bb dengan konsentrasi 10%, 20% dan 40% mempunyai efek anti-inflamasi yang lebih rendah dibandingkan natrium diklofenak dan infusa daun senggani dosis 0,4 mL/20 g bb dengan konsentrasi 10%, 20% dan 40% mempunyai efek analgesik yang lebih rendah dibandingkan natrium diklofenak. Peningkatan dosis infusa daun senggani tidak memberikan peningkatan efek sebagai anti-inflamasi maupun analgesik.
Efek Anti-Agregasi Platelet Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight) Walp.) pada Mencit RIKA SARI DEWI; NI MADE DWI SANDHIUTAM; SULISTYO RAHARJO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.291 KB)

Abstract

Salam leaves (Syzygium polyanthum (Wight) Walp.) contains fl avonoids, volatile oil and phenolic acid that can inhibiting platelet aggregation induced by ADP (adenosine diphospate), arachidonic acid, epinephrine, thrombin, collagen and aff ecting the activity enzyme ectonucleotidase so it can be used as anti-platelet drug. The purpose of this study was to investigated 70% ethanol extract of salam leaves have anti-platelet aggregation eff ect and increase of dose can also increase anti-platelet aggregation. This study was performed in 5 groups, each group consisted of 5 mice there were: groups of positive control, normal control, 70% ethanol extract leaves doses (150, 300, 450) mg/ kg, each group is given orally once daily during 8 days and measurements of parameters at day-0 and day-9th. The results of this study was 70% ethanol extract of leaves of salam leaves doses (150,300, 450) mg/kgBW showed the eff ects prolong bleeding time, coagulation time, enhance the decreased plasma absorbance after the addition of ADP. From the measurement parameter bleeding time, coagulation time and measurement decreased plasma absorbance after the addition of ADP that 70% ethanol extract of salam leaves doses 150, 300 and 450 mg/kgBW have anti-platelet aggregation eff ect and increase of dose was able to increase the eff ect anti-platelet aggregation.
Efek Anti-Agregasi Platelet Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight) Walp.) pada Men RIKA SARI DEWI; NI MADE DWI SANDHIUTAMI; SULISTYO RAHARJO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.291 KB)

Abstract

Salam leaves (Syzygium polyanthum (Wight) Walp.) contains flavonoids, volatile oil and phenolic acid that can inhibiting platelet aggregation induced by ADP (adenosine diphospate), arachidonic acid, epinephrine, thrombin, collagen and aff ecting the activity enzyme ectonucleotidase so it can be used as anti-platelet drug. The purpose of this study was to investigated 70% ethanol extract of salam leaves have anti-platelet aggregation eff ect and increase of dose can also increase anti-platelet aggregation. This study was performed in 5 groups, each group consisted of 5 mice there were: groups of positive control, normal control, 70% ethanol extract leaves doses (150, 300, 450) mg/ kg, each group is given orally once daily during 8 days and measurements of parameters at day-0 and day-9th. The results of this study was 70% ethanol extract of leaves of salam leaves doses (150,300, 450) mg/kgBW showed the effects prolong bleeding time, coagulation time, enhance the decreased plasma absorbance after the addition of ADP. From the measurement parameter bleeding time, coagulation time and measurement decreased plasma absorbance after the addition of ADP that 70% ethanol extract of salam leaves doses 150, 300 and 450 mg/kgBW have anti-platelet aggregation eff ect and increase of dose was able to increase the eff ect anti-platelet aggregation.
The effectiveness of avocado (Persea americana M.) leaves infusion as urinary stones dissolving in rats Ni Made Dwi Sandhiutami; Rika Sari Dewi; Alya Fariha
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.121 KB) | DOI: 10.12928/pharmaciana.v12i2.21833

Abstract

Urolithiasis is a pathological condition marked by the formation of urinary stones (calculi) in the urinary tract. Avocado leaf (Persea americana M.) contains substances that play crucial roles in the solubility of calcium in urinary stones, such as flavonoids, alkaloids, saponins, and magnesium. Empirically, avocado leaves are used to make urinating easier and break stones in the urinary tract. This study aims to determine the effect of avocado leaf infusion to dissolve urinary stones in white male rats. According to the experiment, 24 male white rats were divided into four groups; the negative control group (not given infusion), the 1 g/kg BW dose group, the 2 g/kg BW dose group, and the 3 g/kg BW dose group of avocado leaves infusion. The infusion was administered orally for seven consecutive days after 28 days of planting black silk thread as the stone core in the urinary tract. Then, the stone formed is taken. The weight and volume are measured. The urinary stones were tested qualitatively in terms of calcium and oxalate. The results showed that there were significant differences among treatment groups in weight and volume of urinary stones. The effect of bladder stone dissolving was best in the 3 g/kg BW group. The qualitative test also shows that urinary stones contain the same calcium and oxalate as urinary stones that form in humans. Avocado leaves infusion can have a urinary stone dissolving effect on white male rats. Increasing the dose of avocado leaves infusion increases its effectiveness as a urinary stone dissolution.
Anti-Inflammatory and Analgesic Activity of Musa balbisiana Peels In Vivo Ni Made Dwi Sandhiutami; Sondang Khairani; Rika Sari Dewi; Zainur Rahman Hakim; Anita Rahmi Pradani
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3169

Abstract

Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inflammatory test, respectively, was 51.35%, 74.15%, and 74.01%. The results of the percentage inhibition of the analgesic test in mice for groups II, III, IV, and V were 55.25%, 38.52%, 44.53%, and 49.31%, and the percentage of effectiveness for the analgesic test, respectively, followed by 69.71%, 80.59%, and 89.24%. Based on the results, it can be concluded that the decoction of the MBP has an anti-inflammatory and analgesic effect.
Co-Authors Alya Fariha Anita Rahmi Pradani GUSRITA AYU Lestari Rahayu NI MADE DWI SANDHIUTAM Ni Made Dwi Sandhiutami Sondang Khairani SULISTYO RAHARJO Zainur Rahman Hakim