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All Journal INDONESIAN JOURNAL OF PHARMACY JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Kefarmasian Indonesia Pharmaceutical Sciences and Research (PSR)
Fadlina Chany Saputri
UNIVERSITAS INDONESIA
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Pharmaceutical Sciences and Research (PSR)

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Pengembangan Metode Induksi Tukak Lambung Saputri, Fadlina Chany; Sari, Santi Purna; Munim, Abdul
Majalah Ilmu Kefarmasian Vol. 5, No. 2
Publisher : UI Scholars Hub

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Scientific evaluation on pharmacological activity of medicinal herbs required repro-ducible and valid method-induced ulcer models in animal. In this study, the method of antiulcerogenic effect was investigated using several inducers. The male white Sprague-Dawley rats divided into five groups which were orally administrated water, indomethacin (48 mg/kg bw), aspirin-HCl (150 mg/kg bw), 96% ethanol (1 ml/200 g bw), and 80% ethanol (1 ml/200 g bw), respectively. The result of this study showed that the group was induced with 80% ethanol demonstrated the highest ulcer index. Histological examination of the stomach showed abnormality of mucosa cells on the aspirin-HCl, 96% ethanol, and 80% ethanol-induced gastric ulcer model in rats.
Uji Aktivitas Anti-Inflamasi Minyak Atsiri Daun Kemangi (Ocimum americanum L.) pada Tikus Putih Jantan yang Diinduksi Karagenan Saputri, Fadlina Chany; Zahara, Rita
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Kemangi (Ocimum americanum L.) is an aromatic plant that contains citral and known as anti-inflammatory agents. The aim of this study was to determine the anti-inflammatory activity of the essential oil kemangi leaves on carrageenan-induced rat. The male rats were divided into six groups, each consisting of four rats. Group I as negative control was given 0.5% CMC solution, group II as positive control was given diclofenac sodium, group III was given sitral, groups IV, V and VI were given 40 mg/200 g BW, 80 mg/200 g BW, and 160 mg/200 g BW essential oil of Ocimum americanum L., emulsified in 0.5% CMC solution. After 30 minutes of test substance administration, left paw of rats injected by 0.2 mL of carrageenan to induce edema. Edema volume was measured using pletismometer every hour for six hours. The result showed that at dose 160 mg/200 g BW gives the best effect in inhibited the inflamation response 44,83%. There was significant difference (p < 0.05) at dose 160 mg/200 g BB to negative control. From this study can be concluded that essential oil kemangi leaves has anti-inflammatory activity.
Pengaruh Pemberian Minyak Atsiri Daun Kemangi (Ocimum americanum L.) Terhadap ~ Motilitas Usus Mencit Putih Jantan Sriyani, Dewi; Saputri, Fadlina Chany
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Kemangi (Ocimum americanum L.) is a well known plant that contains essential oils with citral as a major compound. Citral is reported to have beneficial effect on intestinal motility. In the present study, we investigated the effect of essential oil of kemangi leaves (Ocimum americanum L.) on male DDY mices intestinal motility. Thirty mices were divided into six groups and each group was pretreated with 0,2 ml of 0,5% CMC (negative control), 1 mg/kg BW of atropine sulfate (positive control), 5 mg/kg BW of citral (comparative control), and three dose variation of volatile oil of kemangi leaves (25 mg/kg BW; 50 mg/kg BW; 100 mg/kg BW) orally. All mices were given charcoal meal suspension 0,2 ml orally, and the animals were sacrificed. The percentage ratio and inhibition were analysed by measure the intestinal transit of charcoal. The results showed that the essential oil of kemangi leaves dose 100 mg/kg BW significantly (p < 0.05) reduced intestinal transit in mice with the percentage ihibition value of 59,79%. This value is not significant different (p > 0.05) compared with citral and atropine sulfate. It is concluded that the essential oil of kemangi leaves has potential effect as antispasmodic agent.
Co-Authors Abdul Mun&#039;ím Abdul Munim Berna Elya Dewi Sriyani Dewi Sriyani, Dewi Effionora Anwar Effionora Anwar Hariyanti Hariyanti Hayun, Hayun Iis Irawatty Dewi Muhammad Hanafi Mun'im, Abdul Nur Rahmawati Rita Zahara Rita Zahara, Rita Santi Purna Sari Santi Purna Sari SITI MARDIYANTI Suswidiantoro, Vicko Tri Nofi Yani Yesi Desmiaty, Yesi