Budhi Setianto
Departement of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

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QT dispersion, a simple tool to predict ventricular tachyarrhythmias and/or sudden cardiac death after myocardial infarction Yuniadi, Yoga; Munawar, M; Setianto, Budhi; Rachman, Otte J.
Medical Journal of Indonesia Vol 14, No 4 (2005): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.204 KB) | DOI: 10.13181/mji.v14i4.201

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Recent studies showed contradictive results of the relation between QT dispersion and the occurrence of ventricular tachyarrhythmias and/or sudden cardiac death. In addition, beta adrenoreceptors blocking agents, which are known to decrease the incidence of lethal arrhythmias after myocardial infarction, administered to the majority of patients in those studies population. Since β -blocker as secondary prevention drug was underutilized at National Cardiovascular Center Harapan Kita, this study was performed to find out the relation between QT dispersion and ventricular tachyarrhythmias and/or sudden cardiac death after previous myocardial infarction. The QT interval duration, QT dispersion and clinical variables of 36 postinfarction patients with history of sustained ventricular tachyarrhythmias and/or sudden cardiac death (event group) were compared with 75 postinfarction patients without such events (control group). QT dispersion differed significantly between study groups and was increased in the event group (115 ± 41 msec vs 81 ± 25 msec, p < 0.001). Corrected maximal QT interval duration was also prolonged in the event group (534 ± 56 vs 501 ± 35 msec, p < 0.001). Regression analysis showed that increasing QT dispersion was related to the occurrence of ventricular tachyarrhythmias and/or sudden cardiac death with OR of 3.2, 4, and 5.8 for cut-off point of 80, 90, and 100 msec respectively. The  QT dispersion could predict the occurrence of ventricle tachyarrhythmias and/or sudden cardiac death in patient with AMI. This study confirmed that the QTd remain useful in free of beta blocking agents state. (Med J Indones 2005; 14: 230-6)Keyword: QT dispersion, Acute myocardial infarction, Sudden death.
Electrophysiological characteristics and radiofrequency ablation of right atrial flutter Yuniadi, Yoga; Munawar, Muhammad; Rachman, Otte J.; Setianto, Budhi; Kusmana, Dede
Medical Journal of Indonesia Vol 16, No 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.905 KB) | DOI: 10.13181/mji.v16i3.274

Abstract

This study aimed to elaborate the electrophysiology characteristics and radiofrequency ablation (RFA) results of atrial flutter (AFL) which has not been established in Indonesia. Three multipolar catheters were inserted percutaneously and positioned into coronary sinus (CS), His bundle area and around tricuspid annulus. Eight mm ablation catheter was used to make linear ablation at CTI of typical and reverse typical AFL. Bidirectional block was confirmed by conduction time prolongation of more than 90 msec from low lateral to CS ostium and vice versa, and/or by means of differential pacing. Thirty AFL from 27 patients comprised of 19 typical AFL, 5 reverse typical AFL and 6 atypical AFL enrolled the study. Mean tachycardia cycle length (TCL) were 261.8 ± 42.84, 226.5 ± 41.23, and 195.4 ± 9.19 msec, respectively (p = 0.016). CTI conduction time occupied up to 60% of TCL with mean conduction time of 153.0 ± 67.37 msec. CS activation distributed to three categories which comprised of proximal to distal, distal to proximal and fusion activation. Only nine of 27 patients had no structural heart disease. RFA of symptomatic typical and reverse typical AFL demonstrated 96% success and 4.5 % recurrence rate during 13 ± 8 months follow up. Typical AFL is the predominant type of AFL in our population. The majority of AFL cases suffered from structural heart disease. RFA was highly effective to cure typical and reverse typical AFL. (Med J Indones 2007; 16:151-8) Keywords: atrial flutter, electrophysiology, ablation
Age, body posture, daily working load, past antihypertensive drugs and risk of hypertension: A rural Indonesian study Basuki, Bastaman; Setianto, Budhi
Medical Journal of Indonesia Vol 10, No 1 (2001): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (653.464 KB) | DOI: 10.13181/mji.v10i1.5

Abstract

Indonesia has about 210 million inhabitans and most of them live in rural areas, therefore in rural community it is estimated that a big number of hypertensive people can be found. However, few rural community-based studies have been conducted to identify hypertensive risk factors. This study aims to identfy some risk factors related to hypertension in rural areas. The data for this study came from the result of the field study done by the second year medical students of the Faculty of Medicine, University of Indonesia, Jakarta. The study was conducted on July 12, 2000 at 10:00 AM to 1:00 PM in a rural area, the Cijeruk subdistrict in Bogor regency. The subjects were selected randomly using neighborhood cluster. Interviews and blood pressure were taken at the houses of the subjects. The results of this study showed that people aged 40 years or over had an increase risk to suffer hypertension compared to the 17-39 year old group, and the risk was most prominent among the 55-59 year group (adjusted odds ratio = 21.62; 95% confidence intervals (CI) = 4.10-113.97). Compared to the subjects with normal body posture, those who were obese had more than 6.3-folds increase in the risk to be hypertensive (adjusted OR = 6.33: 95% CI = 2.62-15.29). In addition, those who discontinued antihypertensive drugs had almost 12-fold increase in the risk to be hypertensive relative to subjects who never take antihypertensive drugs (adjusted OR = 11.92; 95% CI = 4.61 -30.80). This study concluded that special attention should be taken to the elderly aged 40 years and over, to some one who discontinued antihypertensive drugs, and whom had light daily working load to prevent hypertension. (Med J Indones 2001; 10:29-33)Keywords: hypertensive, risk factor, adjusted odds ratio, elderly.
Effect of enhanced external counterpulsation therapy on myeloperoxidase in lowering cardiovascular events of patients with chronic heart failure Rampengan, Starry H.; Setianto, Budhi; Posangi, Jimmy; Immanuel, Suzanna; Prihartono, Judo; Siagian, Minarma; Kalim, Harmani; Inneke, Sirowanto; Abdullah, Murdani; Waspadji, Sarwono
Medical Journal of Indonesia Vol 22, No 3 (2013): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (911.558 KB) | DOI: 10.13181/mji.v22i3.584

Abstract

Background: Chronic heart failure (CHF) is a slowly progressive disease with high morbidity and mortality; therefore, the management using pharmacological treatments frequently fails to improve outcome. Enhanced external counterpulsation (EECP), a non-invasive treatment, may serve as alternative treatment for heart failure. This study was aimed to evaluate the influence of EECP on myeloperoxidase (MPO) as inflammatory marker as well as cardiac events outcome.Methods: This was an open randomized controlled clinical trial on 66 CHF patients visiting several cardiovascular clinics in Manado between January-December 2012. The subjects were randomly divided into two groups, i.e. the group who receive EECP therapy and those who did not receive EECP therapy with 33 patients in each group. Myeloperoxidase (MPO) as inflammatory marker was examined at baseline and after 6 months of observation. Cardiovascular events were observed as well after 6 months of observation. Unpaired t-test was use to analyze the difference of MPO between the two groups, and chi-square followed by calculation of relative risk were used for estimation of cardiovascular event outcomes.Results: MPO measurement at baseline and after 6 months in EECP group were 643.16 ± 239.40 pM and 422.31 ± 156.26 pM, respectively (p < 0.001). Whereas in non EECP group, the MPO values were 584.69 ± 281.40 pM and 517.64 ± 189.68 pM, repectively (p = 0.792). MPO reduction was observed in all patients of EECP group and in 13 patients (48%) of non-EECP group (p < 0.001). Cardiovascular events were observed in 7 (21.21%) and 15 (45.45%) of patients in EECP and non-EECP groups, respectively (p = 0.037).Conclusion: EECP therapy significantly decreased the level of MPO as inflammatory marker and this decrease was correlated with the reduction of cardiovascular events in CHF patients. (Med J Indones. 2013;22:152-60. doi: 10.13181/mji.v22i3.584)Keywords: CHF, cardiovascular events, EECP, myeloperoxidase
Perbedaan Kadar Adiponektin, Asimetrik Dimetilarginin Plasma, dan Respons Vasodilatasi Arteri Brakialis antara Dewasa Muda dengan Riwayat Bayi Berat Lahir Rendah dan Normal Purnomowati, Augustine; K.S. Kariadi, Sri Hartini; Achmad, Tri Hanggono; C. Mose, Johanes; Setianto, Budhi
Majalah Kedokteran Bandung Vol 44, No 1 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (929.954 KB)

Abstract

Adiponektin mempunyai efek antiaterogenik, antiinflamasi, sensitizer insulin, dan berperan penting dalam mengatur pertumbuhan janin. Hipoadiponektinemia dapat menyebabkan disfungsi endotel. Risiko penyakit kardiovaskular meningkat pada subjek dengan riwayat bayi berat lahir rendah (BBLR). Penelitian ini bertujuan menganalisis perbedaan kadar adiponektin, asimetrik dimetilarginin (ADMA) plasma dan respons vasodilatasi arteri brakialis melalui tes flow mediated brachial artery (FMBA) antara dewasa muda dengan riwayat BBLR dan bayi berat lahir normal (BBLN), serta korelasi kadar adiponektin dengan fungsi endotel pada BBLR. Penelitian kohor retrospektif dilakukan periode November 2009–Januari 2010 berasal dari Growth Study Cohort Tanjungsari Kabupaten Sumedang. Sebanyak 134 subjek dipilih secara simple random, terdiri atas 67 BBLR dan 67 BBLN yang karakteristik umumnya sama. Analisis multivariat melalui Hotelling’s trace menunjukkan FMBA, kadar ADMA, dan adiponektin berbeda bermakna (p<0,001) antara BBLR dan BBLN. Analisis simultaneous confidence interval menunjukkan kadar adiponektin plasma dan FMBA bermakna lebih rendah (p=0,015 dan p<0,001) pada BBLR dibandingkan dengan BBLN. Korelasi tidak bermakna antara kadar adiponektin dan ADMA (r=-0,16; p=0,176) dan FMBA (r=0,13; p=0,281) BBLR. Kecil peran adiponektin pada disfungsi endotel, mungkin variabel lain berperan, seperti tumor necrosis factor α. Simpulan, terdapat perbedaan kadar adiponektin plasma dan FMBA antara dewasa muda dengan riwayat BBLR dan BBLN, tetapi kecil peran adiponektin pada disfungsi endotel dewasa muda dengan riwayat BBLR. [MKB. 2012;44(1):1–6].Kata kunci: Adiponektin, asimetrik dimetilarginin, BBLR, tes flow mediated brachial arteryDifferences of Plasma Adiponectine, Asymmetric Dimethylarginine and Brachial Artery Vasodilatation Response in Young Adult with Low and Normal Birth Weight HistoryBeside an anti-atherosclerotic, anti-inflammation effect, and a sensitizer insulin, adiponectin also play an important role in fetal growth. Hypoadiponectinemia may lead to endothelial dysfunction. Low birth weight (LBW) has increase risk of cardiovascular disease. The aim of this study was to analyze the differences of plasma adiponectin, asymmetric dimethylarginine (ADMA) level and vasodilatation response of brachial artery by doing flow mediated brachial artery (FMBA) test between young adults with LBW and normal birth weight (NBW), and the role ofadiponectin level in endothelial function of the LBW. This was a retrospective cohort study during November 2009– January 2010, 134 subjects were randomly selected from the Growth Study Cohort of Tanjungsari Sumedang. They consisted of 67 LBW and 67 NBW young adults, with similar basic characteristics. A multivariate analysis via Hotelling’s trace showed that there was a significant difference (p<0.001) for FMBA, ADMA, and adiponectin level, but simultaneous confidence interval measurements indicated that the rate of FMBA and the level of plasma adiponectin were significantly lower (p<0.001, p=0.015, respectively) in LBW compared to NBW. The correlation between adiponectin and ADMA level (r=-0.16, p=0.176), and FMBA (r=0.13, p=0.281) in LBW were not significant, suggesting a small role of plasma adiponectin in endothelial dysfunction of young adults with LBW, other variables could play a role such as tumor necrosis factor α. In conclusions, the level of plasma adiponectin and FMBA are different between LBW and NBW, but the role of adiponectin may be small in endothelial dysfunction in young adults with LBW. [MKB. 2012;44(1):1–6].Key words: Adiponectin, asymmetric dimethylarginine, flow mediated brachial artery, LBW test DOI: http://dx.doi.org/10.15395/mkb.v44n1.72
Literature Review: Hubungan Personal Hygiene dengan Kejadian Penyakit Kulit Pekerja Pengangkut Sampah di TPA Rokhiya, Naily Aniqotur; Asih, Akas Yekti Pulih; Setianto, Budhi
MEDIA KESEHATAN MASYARAKAT INDONESIA Vol 20, No 6 (2021): MKMI
Publisher : Fakultas Kesehatan Masyarakat, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/mkmi.20.6.443-450

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Latar belakang: Kejadian penyakit kulit seringkali dialami oleh petugas pengangkut sampah. Didasari dengan perilaku personal hygiene yang tidak dilakukan secara baik oleh tiap petugas pengangkut sampah setelah melakukan pekerjaan. Penelitian ini bertujuan untuk menganalisis hubungan personal hygiene dengan kejadian penyakit kulit pada pekerja pengangkut sampah di TPA.Metode: Metode yang digunakan dalam penulisan literature review ini adalah tradisional literature review. Sumber data yang digunakan berasal dari google scholar dan portal garuda dalam rentang waktu 2015-2020. Kata kunci yang digunakan yaitu “Personal Hygiene dengan penyakit kulit pekerja pengangut sampah di TPA”. Setelah dilakukan screening didapatkan sebanyak 12 artikel rujukan.Hasil: Hasil penelitian ini menunjukkan bahwa terdapat aspek aspek personal hygiene yang memiliki hubungan dengan kejadian penyakit kulit yaitu kebersihan kulit, rambut, tangan, kaki, dan kuku. Secara umum juga menyebutkan bahwa personal hygiene memiliki hubungan dengan kejadian penyakit kulit.Simpulan: Simpulan literature review ini adalah perilaku Personal Hygiene yang buruk dapat menyebabkan kejadian penyakit kulit pada pekerja pengangkut sampah di TPA. Kejadian tersebut dapat mengganggu aktifitas pekerja pengangkut sampah dalam bekerja. Kejadian tersebut dapat dihindari dengan melakukan kegiatan Personal Hygiene dengan baik mulai dari perawatan rambut sampai dengan perawatan kulit.Kata kunci: Kejadian Penyakit Kulit; Pengangkut Sampah; Personal Hygiene ABSTRACTTitle: Literature Review: Association of Personal Hygiene with Incidence of Skin Diseases in Transporting Waste Workers in LandfillBackground: The incidence of skin diseases is often experienced by garbage collectors. Based on personal hygiene behavior that is not carried out properly by each garbage collector after doing work. This study aims to analyze the relationship of personal hygiene with the incidence of skin diseases in workers who transport waste at the TPA. Method: The method used in writing this literature review is a traditional literature review. The data sources used are from Google Scholar and the Garuda Portal in the 2015-2020 period. The keywords used are "Personal Hygiene with skin diseases of workers carrying waste at the TPA". After screening, 12 reference articles were obtained.Result: The results of this study indicate that there are aspects of personal hygiene that have a relationship with the incidence of skin diseases, namely the cleanliness of the skin, hair, hands, feet, and nails. In general, it is also stated that personal hygiene has a relationship with the incidence of skin diseases.Conclusion: The conclusion of this literature review is that poor Personal Hygiene behavior can cause skin diseases to occur in waste transport workers at the TPA. This incident can disrupt the activities of waste transport workers at work. This incident can be avoided by doing good Personal Hygiene activities, from hair care to skin care.Keywords: Skin Diseases; Garbage Collectors; Personal Hygiene