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All Journal International Journal of Biosciences and Biotechnology Indonesian Journal of Pharmaceutical Science and Technology WIDYABHAKTI Jurnal Ilmiah Populer Manuju : Malahayati Nursing Journal Jurnal Ilmiah Medicamento Jurnal Pengabdian kepada Masyarakat COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Usadha
Puguh Santoso
Fakultas Farmasi Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Skrining Fitokimia, Formulasi dan Antioksidan Sediaan Granul Effervescent Ekstrak N-Butanol Buah Dewandaru (Eugenia uniflora L.) Puguh Santoso; Debby Juliadi; Ni Nyoman Wahyu Udayani; I Putu Pasek Jaya Separsa; Ida Ayu Gede Syntya Mahayani; I Gede Yodhi Trismawan
Malahayati Nursing Journal Vol 5, No 2 (2023): Volume 5 Nomor 2 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v5i2.7509

Abstract

ABSTRAK Kandungan metabolit sekunder tanaman yang berkhasiat obat sebagai acuan pemanfaatan untuk membuat sebuah produk, Dewandaru (Eugenia uniflora L), merupakan salah satu tanaman daerah tropis yang belum banyak di gali dan di manfaatkan secara ilmiah. Tujuan penelitian ini  mengetahui metabolit sekunder, uji mutu fisik sediaan effervescent dan uji antioksidan ekstrak buah buah Dewandaru. Metode penelitian eksperimenal ini menujukkan bahwa hasil metabolit sekunder ekstrak n- butanol buah Dewandaru menunjukkan adanya senyawa alkaloid, tannin, flavonoid, dan saponin, hasil uji mutu fisik sdiaan effervescent menunjukkan mutu fisik yang baik di semua jenis pengujian, Pada pengujian pH, sediaan memiliki pH 6. Dari hasil penelitian yang telah dilakukan maka dapat disimpulkan bahwa sediaan granul effervescent memiliki mutu fisik yang baik, uji antioksidan formula effervescent mendapatkan hasil 21,196 ppm.  Termasuk antiosidan yang sangat kuat. Kata Kunci: Antioksidan, Efervescent, Mutu Fisik, Skrining  ABSTRACT The content of secondary metabolites of plants that have medicinal properties as a reference for use to make a product, Dewandaru (Eugenia uniflora L), is one of the tropical plants that has not been widely explored and used scientifically. The purpose of this study was to determine secondary metabolites, test the physical quality of effervescent preparations and test the antioxidants of Dewandaru fruit extracts. This experimental research method showed that the results of secondary metabolites of the n-butanol extract of Dewandaru fruit showed the presence of alkaloids, tannins, flavonoids, and saponins, the results of the physical quality test of effervescent preparations showed good physical quality in all types of tests. 5. From the results of the research that has been done, it can be concluded that the effervescent granule preparation has good physical quality, the antioxidant test of the effervescent formula obtained 21.196 ppm results. Including very strong antioxidants. Keywords: Antioxidant, Effervescent, Physical Quality, Screening
Identifikasi Senyawa Flavonoid dan Aktivitas Antioksidan Ekstrak Etanol Buah Dewandaru (Eugenia uniflora L.) Puguh Santoso; Fitria Megawati; Ni Wayan Cintya Purnama Sari; Ni Kadek Linda Paramita
Usadha Vol 2 No 1 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.4588

Abstract

Indonesia is a country with abundant natural wealth. Almost all kinds of plants can grow in this country. Most have been used since ancient times to treat various diseases. One of the efficacious plants used as medicine is the Dewandaru fruit (Eugenia uniflora L.). This study aims to identify the presence of flavonoid compounds in the Dewandaru fruit (Eugenia uniflora L.) and test the in vitro activity of the ethanol extract of the Dewandaru fruit. Dewandaru fruit extract (Eugenia uniflora L.) was prepared using the maceration extraction method with 96% ethanol solvent. The extraction process was carried out three times. The extract obtained was concentrated in a rotary evaporator at 40-45 °C and then dried in an oven at 40°C. The extracts obtained were identified by means of ultraviolet visible spectrophotometry thin-layer chromatography. obtained showed a positive reaction in the pre-test of flavonoids seen from the separation of red and from the separation of orange stains on thin-layer chromatography. The results of the in vitro test for the antioxidant activity of the ethanol extract of Dewandaru fruit showed an IC50 activity of 53.44 ppm.
Efek Ekstrak Etanol Buah Dewandaru (Eugenia uniflora L) terhadap Penurunan Kadar Glukosa Darah dan Perbaikan Sel Beta Pankreas pada Mencit yang Diinduksi Aloksan Ade Dwi Karisma Maharani; Puguh Santoso; Ni Nyoman Wahyu Udayani
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7384

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from impaired insulin secretion. Dewandaru fruit (Eugenia uniflora L.) contains flavonoids which act as free radical scavengers and reduce oxidative stress. This study aims to prove that the administration of ethanol extract of dewadaru fruit at doses of 200 mg/KgBW and 400 mg/KgB can reduce blood glucose levels and repair damage to pancreatic β cells in alloxan-induced male white mice (Rattus norvegicus) wistar strain diabetes mellitus. This study used 32 mice aged 2-3 months weighing 25 grams intraperitoneally induced by alloxan (0.5 ml/kg). Mice were divided into four treatment groups, namely K- (alloxan), K+ (glibenclamide), P1 (dose of dewadaru fruit extract 200 mg/kgBB), P2 (dose of dewadaru fruit extract 400 mg/kgBB) Quantitative data by calculating blood glucose levels and the number of pancreatic β cells were analyzed using Paired T-Test. P2 is the dose of dewadaru fruit extract 400 mg/kg BW. In the repair of pancreatic β cells it was stated that the average damage to pancreatic β cells at a dose of 200 mg/KgBB was 67.5 and at a dose of 400 mg/KgBW was 89.1. This study proves that the ethanol extract of dewadaru fruit is able to lower blood glucose and inhibit the rate of damage to pancreatic β cells in mice with diabetes mellitus. Keywords: dewadaru, diabetes mellitus, blood glucose, pancreatic β cells
Co-Authors Ade Dwi Karisma Maharani Agus Adrianta Debby Juliadi Dewa Ayu Ika Pramitha Erna Cahyaningsih Fitria Megawati Gusti Ayu Putu Eka Darmayanti I Gede Yodhi Trismawan I Gusti Agung Ayu Kusuma Wardani I Gusti Agung Ayu Kusuma Wardani I Made Agus Sunadi Putra I Putu Pasek Jaya Separsa I Putu Tangkas Suwantara Ida Ayu Gede Syntya Mahayani Ketut Agus Adrianta Ni Kadek Linda Paramita Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Sintya Ni Nyoman Wahyu Udayani Ni Putu Dewi Agustini Ni Wayan Cintya Purnama Sari Putra, I Made Agus Sunadi Putu Era Sandhi K.Yuda Putu Era Sandhi Kusuma Yuda Putu Windra Gunawan Sasadara, Maria Malida Vernandes