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All Journal Jurnal Saintika Medika Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Tumbuhan Obat Indonesia Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Indonesian Journal of Biotechnology Caraka Tani: Journal of Sustainable Agriculture Jurnal Biologi Tropis PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM
Siti Rofida
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Tumbuhan Obat Indonesia

 1 
PHYTOCHEMISTRY PROFILE, EFFICACY, AND SAFETY OF GREEN TEA (Camellia sinensis (L.) Kuntze) FOR BREAST CANCER CHEMOPREVENTION: A SYSTEMATIC REVIEW Dwi Hartanti; Siti Rofida
Jurnal Tumbuhan Obat Indonesia Vol 14 No 2 (2021): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v14i2.4994

Abstract

ABSTRACT The consumption of tea (Camellia sinensis (L.) Kuntze), mainly green tea, is famous for various health benefits. This review summarizes the potential use of green tea and epigallocatechin gallate (EGCG) for breast cancer chemoprevention. The data were retrieved from the online publication on the Pubmed database and covered the phytochemistry, preclinical study, and clinical trial of green tea related to its use as a breast cancer chemopreventive agent. Catechins, particularly EGCG, are the chemopreventive bioactive constituents of green tea. Preclinical studies demonstrated that the anti-proliferative and induction of apoptosis potentials of green tea are mediated through several different mechanisms. However, no association between green tea intake and a lowered breast cancer risk in human studies, but it might be favorable for secondary cancer prevention. Keywords: green tea, epigallocatechin gallate, chemopreventive, breast cancer. ABSTRAK Konsumsi teh (Camellia sinensis (L.) Kuntze), terutama teh hijau, terkenal dengan berbagai manfaat kesehatannya. Ulasan ini merangkum potensi penggunaan teh hijau dan epigallocatechin gallate (EGCG) untuk kemoprevensi kanker payudara. Data diambil dari publikasi online di database Pubmed dan mencakup fitokimia, studi praklinis, dan uji klinis teh hijau terkait dengan penggunaannya sebagai agen kemopreventif kanker payudara. Katekin, terutama EGCG, adalah konstituen bioaktif kemopreventif teh hijau. Studi praklinis menunjukkan bahwa anti-proliferatif dan induksi potensi apoptosis teh hijau dimediasi melalui beberapa mekanisme yang berbeda. Namun, tidak ada hubungan antara asupan teh hijau dan penurunan risiko kanker payudara dalam penelitian pada manusia, tetapi mungkin menguntungkan untuk pencegahan kanker sekunder. Kata kunci: teh hijau, epigallocatechin gallate, kemopreventif, kanker payudara.
Co-Authors Ahmad Shobrun Jamil Amaliyah Dina Anggraeni Anak Agung Istri Sri Wiadnyani Aufa Fadnurrahim Dian Yuliartha Lestari Dinda Farida Dwi Hartanti Dwi Retno Nur Syahida Erfan Dani Septia Firdiansyah, Ahmad Firzannida Firzannida Fitriyastuti, Endah Hijriani, Nursela Ilham Niawan Saputra Lely Mauliana Lilik Yusetyani Lilik Yusetyani Maftuchah Maftuchah Mohammad Saifur Rahman Nursela Hijriani Nurul Amalia Azhari Nurwahdaniati Nurwahdaniati Nurwahdaniati Nurwahdaniati, Nurwahdaniati Rahman, Mohammad Saifur Sakti Bagaskara Salahudin Salahudin Saputra, Ilham Niawan Savana Sonia Savira Setyawati Soeharto Setyawati Soeharto, Setyawati Sofyan Arief Trimianti Hidahyatun Nazah Wawan Kurniawan