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All Journal Jurnal Saintika Medika Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Tumbuhan Obat Indonesia Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Indonesian Journal of Biotechnology Caraka Tani: Journal of Sustainable Agriculture Jurnal Biologi Tropis PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM
Siti Rofida
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Annona squamosa L. Rofida, Siti; Firdiansyah, Ahmad; Fitriyastuti, Endah
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.154 KB) | DOI: 10.33508/jfst.v2i1.693

Abstract

Cause of cardiovascular disease risk factors, one of which is a high cholesterol levels in serum. Mortality caused by cardiovascular disease as 17.3 million people. Annona squamosa L. or commonly referred custard apple is a plant from family Annonaceae and have been used for insecticide, antitumor, antidiabetic, antioxidant, anti-inflammatory, and antihyperlipidemia. The leaves of Annona squamosa L. contains acetogenin, diterpene, flavonoids, lignin, hydroxyl ketones, and benzoquinazolin. The aims of this study is to determine the optimum dose to reduce levels of LDL on hyperlipidemic rats. In this study, hyperlipidemic rats were divided into 5 groups, negative control group (normal feed), positive control group (normal feed and simvastatin at a dose of 0.9 mg/KgBW), treatment group 1 (normal feed and ethanol extract leaves of Annona squamosa L. at a dose of 0.25 mg/gBB, treatment groups 2 (normal feed and ethanol extract leaf of Annona squamosa L. at a dose of 0.75 mg/gBB, treatment groups 3 (normal feed and ethanol extract leaf of Annona squamosa L. at a dose of 1 mg/gBB). The results of identification by thin-layer chromatography on ethanol extract leaf of Annona squamosa L indicates the presence of flavonoids. The results showed that the ethanol extract leaves of Annona squamosa Linn. On hyperlipidemia rats, can lower LDL cholesterol levels at doses of 0.25 mg/gram BB.
STUDI ETNOBOTANI DAN ETNOFARMAKOLOGI UMBI BINAHONG (Anredera cordifolia (Ten) Steenis) Rofida, Siti
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 1 (2010): April-September 2010
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (419.473 KB) | DOI: 10.22219/far.v1i1.429

Abstract

Pengetahuan penggunaan tumbuhan sebagai obat tradisional hanyalah berdasarkan empiris. Perubahan pola pengobatan modern ke pengobatan tradisional, menyebabkan kebutuhan terhadap obat yang berasal dari bahan alam menjadi meningkat. Bahan alam yang digunakan sebagai obat sebaiknya berpegangan kepada pedoman bahwa bahan obat tersebut tidak menimbulkan keracunan baik akut maupun kronis dan terbukti bisa menyembuhkan penyakit atau berkhasiat sebagai obat serta dapat diperoleh secara kontinu. Secara empiris masyarakat kota Malang menggunakan umbi binahong (Anredera cordifolia (Ten) Steenis) untuk mengobati nyeri pada gigi yang disertai dengan pembengkakan yang keluar nanah, gastritis akut, nyeri kepala, panas dalam yang disertai sariawan, mengobati luka bekas operasi, mengurangi nyeri setelah operasi dan lain-lain. Ciri-ciri morfologi umbi binahong berbentuk silindris dengan tekstur permukaan yang tidak rata, panjangnya antara 4-7 cm dengan diameter 0,5-2 cm dan berdaging lunak. Secara anatomis tampak jaringan dasar (parenkim), berkas pengangkutan (xylem dan floem) dan benda ergastrik berupa amilum. Tumbuhan ini mudah tumbuh di dataran rendah maupun dataran tinggi. Kata kunci: obat tradisional, umbi, Anredera cordifolia (Tenn) Steenis,.
PERANAN MIKROBA ENDOFIT UNTUK PENGEMBANGAN OBAT ANTI KANKER Rofida, Siti
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2991.12 KB) | DOI: 10.22219/far.v1i2.1173

Abstract

Natural product that has developed as anticancer drugs are consists from secondary metabolites that has isolated from plant, ocean plant and microorganisms. To maintain its productivity, must be concerned to the cultivation of the medicinal plants. Medicinal plants need time to grow and producing secondary metabolites that would be isolated, so that the production of secondary metabolites compound from plant is very limited.             The plants that infected by endophytic fungi be able to grow faster than the normal plants. Endophytic fungi also have ability producing secondary metabolites compound that produced by the host plant. Taxol, podophyllotoxin and camptothecin are compounds that proved has anticancer activity. Endophytic fungi have also proved increasing the production of the compound.
EVALUATION OF SST-2 ROLE IN LVH REGRESSION OBTAINED IN HYPERTENSIVE MICE MODELS AFTER BLOCKING RENIN-ANGIOTENSIN SYSTEM Yusetyani, Lilik; Rofida, Siti; Lestari, Dian Yuliartha; Kurniawan, Wawan; Hijriani, Nursela; Saputra, Ilham Niawan; Soeharto, Setyawati; Rahman, Mohammad Saifur
Journal of Tropical Life Science Vol 9, No 1 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Soluble ST2, is a protein which acts as a decoy receptor for interleukin-33, and served as biomarker associated with left ventricular hypertrophy (LVH).  Few data exist in evaluating the effects of anti-hypertensive agents on the role-played form ST2 on regression of LVH. This study was designed to compare the effects of captopril and valsartan on blood pressures, plasma renin and soluble ST2 levels and regression of LVH in hypertensive mice models. Twenty-four male mice (Mus musculus L), were divided into four groups, namely aquadest/control, L-NAME, L-NAME + captopril and L-NAME + valsartan groups respectively. Mice blood pressures were measured on day 14th after induction with L-NAME extract 1.75 mg/25 g BW/day (pretreatment) and day 14th post treatment. Levels of plasma renin, sST2, and ventricular wall thicknesses reflecting LVHs, were measured on day 14th post treatment. Administration of L-NAME within 14 days resulted in making mice models to be hypertensive paralleled by an increase of Ventricular wall thickness. Treatment with captopril and valsartan lowered the blood pressures to normal level within the next 14 days. Valsartan and captopril treatment induced a significant decrease of plasma renin level. Valsartan, but not for captopril treatment prevented wall thickness increase (p < 0.05), while plasma sST2 was not able to mirroring this effect. Captopril and valsartan had similar effect in lowering plasma renin level and   blood pressure, but sST2 seems to be not involved in LVH regression obtained in hypertensive mice models after blocking renin-angiotensin system.
EFEK MUTAGENIK PERASAN BUAH MENGKUDU (MORINDA CITRIFOLIA L.) PADA BAKTERI SALMONELLA TYPHIMURIUM TA 1535 DENGAN METODE MUTASI BALIK Rofida, Siti
Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol 5, No 1 (2009): Januari 2009
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v5i1.1024

Abstract

EFEK MUTAGENIK PERASAN BUAH MENGKUDU (MORINDA CITRIFOLIA L.) PADA BAKTERI SALMONELLA TYPHIMURIUM TA 1535 DENGAN METODE MUTASI BALIK Siti Rofida
Saintika Medika Vol. 5 No. 1 (2009): Januari 2009
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v5i1.1024

Abstract

STUDI ETNOBOTANI DAN ETNOFARMAKOLOGI UMBI BINAHONG (Anredera cordifolia (Ten) Steenis) Siti Rofida
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 1 No. 1 (2010): April-September 2010
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v1i1.429

Abstract

Pengetahuan penggunaan tumbuhan sebagai obat tradisional hanyalah berdasarkan empiris. Perubahan pola pengobatan modern ke pengobatan tradisional, menyebabkan kebutuhan terhadap obat yang berasal dari bahan alam menjadi meningkat. Bahan alam yang digunakan sebagai obat sebaiknya berpegangan kepada pedoman bahwa bahan obat tersebut tidak menimbulkan keracunan baik akut maupun kronis dan terbukti bisa menyembuhkan penyakit atau berkhasiat sebagai obat serta dapat diperoleh secara kontinu. Secara empiris masyarakat kota Malang menggunakan umbi binahong (Anredera cordifolia (Ten) Steenis) untuk mengobati nyeri pada gigi yang disertai dengan pembengkakan yang keluar nanah, gastritis akut, nyeri kepala, panas dalam yang disertai sariawan, mengobati luka bekas operasi, mengurangi nyeri setelah operasi dan lain-lain. Ciri-ciri morfologi umbi binahong berbentuk silindris dengan tekstur permukaan yang tidak rata, panjangnya antara 4-7 cm dengan diameter 0,5-2 cm dan berdaging lunak. Secara anatomis tampak jaringan dasar (parenkim), berkas pengangkutan (xylem dan floem) dan benda ergastrik berupa amilum. Tumbuhan ini mudah tumbuh di dataran rendah maupun dataran tinggi. Kata kunci: obat tradisional, umbi, Anredera cordifolia (Tenn) Steenis,.
PERANAN MIKROBA ENDOFIT UNTUK PENGEMBANGAN OBAT ANTI KANKER Siti Rofida
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 1 No. 2 (2011): Oktober 2010 - Maret 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v1i2.1173

Abstract

Natural product that has developed as anticancer drugs are consists from secondary metabolites that has isolated from plant, ocean plant and microorganisms. To maintain its productivity, must be concerned to the cultivation of the medicinal plants. Medicinal plants need time to grow and producing secondary metabolites that would be isolated, so that the production of secondary metabolites compound from plant is very limited. The plants that infected by endophytic fungi be able to grow faster than the normal plants. Endophytic fungi also have ability producing secondary metabolites compound that produced by the host plant. Taxol, podophyllotoxin and camptothecin are compounds that proved has anticancer activity. Endophytic fungi have also proved increasing the production of the compound.
ANALISIS KUALITATIF OBAT TRADISIONAL SEBAGAI AGEN PENINGKATAN IMUNITAS TUBUH DALAM MELAWAN COVID-19 DI SURAT KABAR ONLINE INDONESIA Amaliyah Dina Anggraeni; Salahudin Salahudin; Ahmad Shobrun Jamil; Siti Rofida
JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama Vol 8, No 2 (2021): JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jkm.v8i2.684

Abstract

COVID-19 menjadi pandemic di seluruh dunia saat ini. Pengobatan dan vaksin yang spesifik untuk penanganannya juga belum ditemukan. Namun, beberapa peneliti dunia tengah melakukan studi potensi pengobatan tradisional untuk menjadi alternative penanganan COVID-19. Pemberitaan media online termasuk di Indonesia juga tidak sedikit yang memberitakan potensi obat tradisional dalam melawan COVID-19. Penelitian ini bertujuan untuk mengetahui pengobatan tradisional yang dapat digunakan sebagai peningkatan imunitas tubuh untuk melawan COVID- 19. Penelitian ini merupakan penelitian kualitatif analisis konten terhadap konten media online nasional yang berkaitan langsung dengan pemberitaan dan pengkajian tentang obat tradisional sebagai obat untuk meningkatkan kekebalan tubuh menghadapi wabah Covid-19 di Indonesia. Analisis data menerapkan teknik coding berbuka, yaitu proses analisis data yang dilakukan berdasarkan pada konsep abstrak yang kemudian dijadikan sebagai dasar pengklasifikasian data yang berkaitan dengan topik penelitian ini. Analisis koding berbuka menggunakan software Nvivo 12 plus melalui fitur auto code, crosstab, hirarchy chart, dan word frequency. Penelitian ini menemukan bahwa penggunaan herbal dapat meningkatkan fungsi kekebalan tubuh. Kekebalan tubuh yang optimal dapat mencegah tubuh dari infeksi COVID-19 (penyakit Coronavirus-19). Keterbatasan penelitian ini adalah validitas data yang perlu dilakukan melalui triangulasi konten media online dan laporan ilmiah yang dibuat oleh para ahli dari berbagai laboratorium terkemuka. Oleh karena itu, penelitian selanjutnya perlu meninjau topik penelitian ini menggunakan teknik analisis triangulasi media online dan laporan penelitian yang dikeluarkan oleh laboratorium terkemuka di Indonesia.
Inhibitory activity of several extract of Piper betle Leaf against S. aureus Ahmad Shobrun Jamil; Siti Rofida; Dinda Farida; Dwi Retno Nur Syahida; Trimianti Hidahyatun Nazah
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.196 KB) | DOI: 10.12928/pharmaciana.v11i2.16999

Abstract

A high number of infections from year to year require infectious diseases to get serious attention. The antimicrobial compound exploration must be continued to anticipate the development of infectious diseases. The purpose of this study was to find out in vitro antimicrobial activity of n-hexane, ethyl acetate, and ethanol fractions of Piper betle green leaves against S. aureus, and profiles of secondary metabolite compounds contained in these three extracts. The antimicrobial activity test was carried out by disk diffusion test of the fraction of n-hexane, ethyl acetate, and ethanol at a concentration of 6,25, 12,5, and 18,75 µg/disk. Detection of secondary metabolite content was done by the Thin Layer Chromatography method with stain-view reagents. The highest antimicrobial activity was found in the ethyl acetate fraction and was significantly different from the activity in the ethanol and n-hexane fractions. However, the antibacterial activity of all fractions was lower compared to the positive control of amoxiclav 30µg/disk. The phytochemical screening results of secondary metabolites of each fraction were shown that the n-hexane fraction contained alkaloids, terpenoids, flavonoids, polyphenols, and anthraquinone; the ethyl acetate fraction contained terpenoids, polyphenols, and anthraquinone; while the ethanol fraction contained alkaloids, terpenoids, polyphenols, and anthraquinone. Based on the test results, it is concluded that all fractions of Piper betle leaf extract had high antimicrobial activity; meanwhile, the ethyl acetate fraction had the highest activities among others. Each fraction was proven to have a different composition of secondary metabolites.
Co-Authors Ahmad Shobrun Jamil Amaliyah Dina Anggraeni Anak Agung Istri Sri Wiadnyani Aufa Fadnurrahim Dian Yuliartha Lestari Dinda Farida Dwi Hartanti Dwi Retno Nur Syahida Erfan Dani Septia Firdiansyah, Ahmad Firzannida Firzannida Fitriyastuti, Endah Hijriani, Nursela Ilham Niawan Saputra Lely Mauliana Lilik Yusetyani Lilik Yusetyani Maftuchah Maftuchah Mohammad Saifur Rahman Nursela Hijriani Nurul Amalia Azhari Nurwahdaniati Nurwahdaniati Nurwahdaniati Nurwahdaniati, Nurwahdaniati Rahman, Mohammad Saifur Sakti Bagaskara Salahudin Salahudin Saputra, Ilham Niawan Savana Sonia Savira Setyawati Soeharto Setyawati Soeharto, Setyawati Sofyan Arief Trimianti Hidahyatun Nazah Wawan Kurniawan