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All Journal Majalah Kedokteran Bandung International Journal of Nasopharyngeal Carcinoma Cermin Dunia Kedokteran
Bogi Soeseno
Departemen Ilmu Kesehatan Telinga Hidung Tenggorok-Bedah Kepala Leher Fakultas Kedokteran Universitas Padjadjaran-RS Dr. Hasan Sadikin Bandung
Health Professions Medicine & Pharmacology Public Health

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Ketebalan Tunika Intima dan Media Arteri Karotis Komunis pada Karsinoma Nasofaring Pra dan Pascaradioterapi Sofyan, Ferryan; Samiadi, Dindy; Soeseno, Bogi; Boesoirie, M. Thaufiq; Lasminingrum, Lina
Majalah Kedokteran Bandung Vol 44, No 3 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1600.862 KB)

Abstract

Radioterapi eksternal merupakan pengobatan utama karsinoma nasofaring. Radioterapi  eksternal menyebabkan disfungsi endotel arteri karotis komunis yang menurunkan produksi nitrogen oksida dan prostasiklin di sel endotel sehingga terjadi penebalan dinding pembuluh darah. Tujuan penelitian ini untuk mengetahui perubahan ketebalan intima media dan diameter lumen arteri karotis komunis akibat radioterapi eksternal  pada penderita karsinoma nasofaring. Tipe penelitian adalah  studi deskriptif dengan rancangan pre-post design. Penelitian dilakukan di Departemen Telinga Hidung Tenggorok-Bedah Kepala Leher-Rumah Sakit Dr. Hasan Sadikin Bandung mulai Maret 2009–Februari 2010. Pada penelitian ini dilakukan pemeriksaan  ultrasonografi  gray scale praradioterapi, pascaradioterapi, dan 10 minggu pascaradioterapi.  Hasil penelitian ini menggunakan uji Fischer dan T berpasangan. Terdapat 25 subjek karsinoma nasofaring dan hasil penelitian ditemukan peningkatan ketebalan intima media sebesar 0,1 mm di intima media arteri karotis komunis kanan dan 0,09 mm di intima media arteri karotis komunis kiri (p<0,001), juga ditemukan pengurangan diameter lumen arteri karotis komunis kanan sebesar 0,384 mm dan 0,342 mm di arteri karotis komunis kiri (p<0,001).  Simpulan, radioterapi eksternal menunjukkan ketebalan intima media dan pengurangan diameter lumen arteri karotis komunis pada penderita karsinoma nasofaring. [MKB. 2012;44(3):179–85].Kata kunci: Diameter lumen, karsinoma nasofaring, ketebalan intima media, radioterapi eksternal                     Intima and Media Tunica Thickness of Common Carotid Artery in Nasopharyngeal Carcinoma Pre and Post External RadiotherapyExternal radiotherapy is the main treatment for nasopharyngeal carcinoma. External radiotherapy  can cause endothelial dysfunction of common carotid artery and reduces nitrogen oxide and prostacyclin by endothelial cell and cause thickening of the vessels walls. Purpose of this study was to find out changes in intima-media thickness and lumen diameter of common carotid artery due to radiotherapy in patients with nasopharyngeal carcinoma. This research was descriptive with pre and post design and performed from March 2009 to February 2010 in the Ear Nose Throat-Head Neck Surgery Department of Dr. Hasan Sadikin Hospital Bandung. Gray scale ultrasound examination was performed before, after and ten weeks after radiotherapy and calculated by using Fischer’s test and paired T test.  They were 25 subjects and was found out 0.1 mm additional thickness in right intima media and 0.09 mm in left intima media common carotid artery (p<0.001), also found reduction in lumen diameter of common carotid artery in which 0.384 mm in the right and 0.342 mm in the left (p<0.001). In conclusions, external radiotherapy can cause increase intima media thickness  and reduction lumen  diameter  in common  carotid artery  in patients with nasopharyngeal carcinoma. [MKB. 2012;44(3):179–85].Key words: External beam irradiation, intima media thickness, lumen diameter, nasopharyngeal carcinoma DOI: http://dx.doi.org/10.15395/mkb.v44n3.206
EFFECT OF SEA CUCUMBER OIL AND HONEY IN POST RADIOTHERAPY NASOPHARYNGEAL CARCINOMA PATIENTS Hendrawan, Wawan; Soeseno, Bogi; Basriyadi S, Tonny; Afriani Dewi, Yussy; Burhanuddin, Ade
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i02.3899

Abstract

Abstract Introduction: Nasopharyngeal carcinoma is one of the most commonly found cases of head and neck malignancy. The most common side effects of radiotherapy is skin damaged. Until now, there is no standard therapy that has been given to post radiotherapy patient in Hasan Sadikin Hospital. Sea cucumber and honey can accelerate the healing process of the wound caused by radiotherapy. Objective: This study was conducted to compare the effects of the use topical sea cucumber oil and honey in patient with nasopharyngeal carcinoma post radiotherapy. Method: The study was conducted at Radiotherapy Clinic in Hasan Sadikin Hospital from may until September 2015 with patients who experienced skin damaged level two or more based on the criteria of Radiation Therapy Oncology Group (RTOG). This was an experimental study. Subjects were selected consecutively between the two groups: sea cucumber oil group and honey group. The draft analysis was done using Randomized Controlled Trial (RCT). Result: 30 patients were divided equally into two groups, sea cucumber group and honey group. Most of the nasopharyngeal carcinoma patients were >45 years old, the ratio man to woman was 2-3:1, with the BMI was <18.5. All subjects in this study experienced recovery rate up to level 1 (p=1.0), after one week of treatment. In the 2nd week after treatment all patients in the sea cucumber group achieved recovery up to level 0, and in the honey group as much as 2 patients only experienced the recovery rate to level 0, while the remaining 13 subjects remained at level 1 (p=0.0001). It was found that the wound healing process occurs better in sea cucumber oil group than the honey group (p=0.0001). Conclusion: Sea cucumber oil accelerates the healing process of the skin tissue damaged in patients with nasopharyngeal carcinoma after radiotherapy, faster than with honey.
Pengaruh Pemakaian Pipa Nasogastrik pada Kejadian Otitis Media Efusi Kamaludin, Deden; Boesoirie, Thaufiq S.; Soeseno, Bogi; Purwanto, Bambang
Majalah Kedokteran Bandung Vol 43, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Otitis media merupakan peradangan lapisan mukoperiosteum di telinga tengah tanpa melihat penyebab atau patogenesisnya. Angka kejadiannya bervariasi, di Bandung dan sekitarnya mencapai 6,9%. Penyebab otitis media karena terganggunya fungsi tuba eustakius dapat ditimbulkan oleh pemakaian pipa nasogastrik (PNG). Dilakukan penelitian analisis observasional untuk melihat pengaruh PNG pada kejadian otitis media efusi pada penderita rawat inap di Departemen Ilmu Kesehatan Telinga, Hidung, Tenggorok-Bedah Kepala dan Leher Rumah Sakit Hasan Sadikin. Sebanyak 34 orang subjek didapatkan dalam periode Januari 2007 yang memenuhi kriteria inklusi diikutsertakan dalam penelitian. Pada 34 subjek dilakukan pemeriksaan fisik THT dan timpanometri sebelum dan selama pemasangan PNG. Pemeriksaan timpanometri diulang tiap 24 jam sampai PNG dilepas. Timpanogram dibaca dan data yang diperoleh dianalisis menggunakan uji Friedman untuk membandingkan nilai tengah tekanan dan compliance antara sebelum dan sesudah pemasangan PNG. Uji Spearman correlation untuk mengetahui hubungan tekanan dengan compliance di telinga tengah. Besarnya kejadian ganguan otitis media efusi diuji dengan uji binomial. Terjadi penurunan puncak tekanan dan compliance di telinga tengah sampai hari ke-3 (p=0,197), sedangkan pada hari ke-4–ke-7 terjadi peningkatan kembali. Simpulan, penggunaan PNG tidak berpengaruh pada tingkat otitis media efusi, tetapi pada penurunan puncak tekanan (daPa) dan compliance (mmho) telinga tengah. [MKB. 2011;43(1):42–8].Kata kunci: Compliance, otitis media, pipa nasogastrik, tekanan, telinga tengah, tuba eustakiusThe Effect of Using Nasogastric Tube on Incidence of Otitis Media with Effusion Otitis media is an inflammation of the middle ear mucoperiosteal without reference to its cause or pathogenesis. The incidence rate in Bandung area was 6.9%. Otitis media caused by Eustachian tube dysfunction might be induced by the use of nasogastric tube (NGT). An observational analytic was conducted to know the effect of NGT on incidence rate of otitis media with effusion in hospitalized patients at Department of Otolaryngology-Head and Neck Surgery, Dr. Hasan Sadikin Hospital. There were 34 subjects in January 2007 were included in this study. Before NGT insertion all subjects had physical examination and tympanometry. Every 24 hours tympanometry was performed till exertion the NGT. Tympanogram was collected and analysed statistically by Friedman test to compared median value of pressure before and after NGT insertion, and that of compliance. Spearman correlation test to identify correlation between peak pressure and compliance in the middle ear, and binomial to test hypotesis. There was decreasing pressure and compliance in middle ear until day 3 (p=0.197) and increased on day -4 and -7. In conclusion, the incidence rate of otitis media with effusion is not affected by using of NGT. The using of NGT is associated with reduced peak middle ear pressure (daPa) and peak compliance (mmho). [MKB. 2011;43(1):42–8].Key words: Compliance, eustachian tube, middle ear, pressure, nasogastric tube, otitis media DOI: http://dx.doi.org/10.15395/mkb.v43n1.43
Deteksi Dini dan Diagnosis Karsinoma Nasofaring Wijaya, Frita Oktina; Soeseno, Bogi
Cermin Dunia Kedokteran Vol 44, No 7 (2017): THT
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.593 KB) | DOI: 10.55175/cdk.v44i7.748

Abstract

Karsinoma nasofaring adalah karsinoma sel skuamosa epitel permukaan nasofaring, merupakan karsinoma nomor satu di bidang THT-KL Indonesia. Gejala karsinoma nasofaring sering tidak spesifik, sehingga sering terdiagnosis pada stadium lanjut. Diagnosis didapat dari anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang, di antaranya pemeriksaan endoskopi, radiologi, dan serologi. Diagnosis dini akan membuat hasil terapi lebih baik.Nasopharyngeal carcinoma is squamous cell carcinomas derived from epithelial surface of the nasopharynx. It is the most frequent carcinoma in ORL-HNS in Indonesia. The symptoms are usually non-specific, patients are often diagnosed at an advanced stage. Diagnosis is obtained by history, physical examination, and ancillary tests including endoscopy, radiology, and serology. Early diagnosis will result in better outcome.
Co-Authors Afriani Dewi, Yussy Bambang Purwanto Basriyadi S, Tonny Burhanuddin, Ade Deden Kamaludin Desyandri Desyandri Dindy Samiadi Ferryan Sofyan Lina Lasminingrum M. Thaufiq Boesoirie Thaufiq S. Boesoirie Wijaya, Frita Oktina