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FORMULATION OF OINTMENT OF ANTIBACTERY ETHANOL EXTRACT OF TORCH GINGER (Etlingera elatior) AGAINST BACTERIA STAPHYLOCOCCUS AUREUS Ainil Fithri Pulungan; Debi Dinha Octora Sitepu; Devi Mariana Sinaga
Jurnal Penelitian Farmasi & Herbal Vol 1 No 1 (2018): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v1i1.30

One of the causes of infection was bacteria, such as Staphylococcus aureus. Torch ginger has been widely used to treat dwaseases caused by bacteria. Torch ginger has been studied to have antibacterial activity against Staphylococcus aureus bacteria. The purpose of thwas study was to formulate an ointment preparation of ethanol extract of torch ginger and to see if the ointment preparations had antibacterial activity against Staphylococcus aureus bacteria. The research method used in thwas research was experimental True, covering the stages: making of ethanol extract of kecombrang flower with maceration method using 96% ethanol solvent, ointment formulation made with ointment base: vaseline, adeps lanae, and propylene glycol. Made in three concentrations of extracts namely: F I with 100 mg, F II with 200 mg, and F III with 300 mg. Furthermore, the evaluation of the preparation of evaluation of physical stability and homogeneity, and test of antibacterial activity against Staphylococcus aureus bacteria with diffusion method to use Kirby odor dwasc paper. The results showed that the ointment had good physical stability and homogeneity for 30 days of storage at room temperature. The antibacterial activity test of the ointment shows that the inhibitory diameter F I has an average of 16.45 mm, F II has an average of 18.60 mm and F III has an average of 21.12 mm. Based on the results obtained it can be concluded that the preparation of the ethanol extract of torch ginger has an inhibitory power to Staphylococcus aureus bacteria. In the next research was expected to pay attention to the growing area of torch ginger and to compare the antibacterial activity between petal flowers and flower seeds using Staphylococcus aureus bacteria.

UJI IMUNOMODULATOR DARI EKSTRAK ETANOL DAUN WARU (HIBISCUS TILIACEUS) DENGAN METODE HIPERSENSITIVITAS TIPE LAMBAT Yanna Rotua Sihombing; Debi Dinha Octora
Jurnal Penelitian Farmasi & Herbal Vol 1 No 2 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v1i2.63

Immunomodulator is a compound that can increaase the imuno system. One of the plants that have immunomodulator’s activity is Waru Leaf (Hibiscus tiliaceus). the purpose of this research was to test the effect of immunomodulator by extract of Waru Leaf ethanol on rat male. The activity of immunomodulator was determined by using digital pletysmometer by measuring the differences between the last leg swelling’s volume and the first leg swelling’s volume. The treatment group were divided into 5 groups. Each group consistof 5 rats CMC-Na 0,5% (negative control), Stimuno® 32,5 mg/kgBW (positive control), dose of EEDW 50, 100 and 200 mg/kgBW, and bacteria E.coli as antigen. The results slowed that distribution of EEDW dose 200 mg/kgBW can give the effect of immunostimulant by swelling enthancement compared by CMC-Na 0,5 %. EEDW 200 mg/kgBW that have activity comparable with Stimuno® 32,5 mg/kgBW. Thus, it is concluded that of Waru Leaf extract has immunomodulator effects on delayed-type hypersensitivity response of rat male.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PIRDOT (SAURAUIA VULCANI KORTH.) TERHADAP BAKTERI SALMONELLA THYPI Debi Dinha Octora; Romauli Anna Teresia Marbun; Rahmadona Koto
Jurnal FARMASIMED (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Indonesia is known for the many plants that are used as traditional medicine for disease prevention, including the leaves of the pirdot (Saurauia vulcani Korth) family Actinidiaceae. This study aims to determine the antibacterial activity of ethanol extract of pirdot leaves (Saurauia vulcani Korth). The results of the characterization of pirdot leaf simplicia powder were obtained 3.99% water content, water soluble extract 12.15%, ethanol soluble extract 8.89%, total ash content 9.97%, insoluble ash content in acids 3.17%. The results of phytochemical screening tests contained the chemical compounds of steroids / triterpenoids, flavonoids, glycosides, tannins and saponins. Ethanol extract of pirdot leaf has antibacterial activity against Salmonella typhi bacteria. The treatment consisted of 4 concentrations, pirdot leaf extract with 3 repetitions, each blank (DMSO), 50 mg / ml, 100 mg / ml, 150mg / ml, 200 mg / ml. After that, it was incubated for 24 hours at 37oC. Inhibition zone diameter observations were made using calipers. The results obtained showed that administration of pirdot leaf extract at concentrations of 50 mg / ml, 100 mg / ml, 150 mg / ml and 200 mg / ml can inhibit the growth of Salmonella typhi bacteria. The results of the antibacterial activity test of pirdot leaf ethanol extract against Salmonella typhi bacteria obtained the highest inhibitory concentration of 200 mg / ml with a diameter of 20.48 mm.

FORMULASI SEDIAAN SABUN MANDI PADAT EKSTRAK ETANOL BONGGOL NANAS (Ananas cosmosus L.) UNTUK KELEMBAPAN KULIT Debi Dinha Octora; Yuliana Situmorang; Romauli Anna Teresia Marbun
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.369

Tanaman nanas dapat diformulasikan menjadi sediaan sabun mandi padat karna berdasarkan penelitian sebelumnya bonggol nanas menggandung antioksidan tinggi karena memiliki senyawa flavonoid dan saponin. Senyawa yang mampu menangkal radikal bebas adalah antioksidan. Penelitian ini menggunakan metode quasi eksperimental. Pengumpulan sampel, pembuatan simplisia, pembuatan ekstraksi secara maserasi menggunakan pelarut etanol dan pembuatan sediaan sabun padat dengan ekstrak etanol bonggol nanas masing-masing dengan konsentrasi 3%, 4% dan 5%. Kemudian dilakukan uji sabun meliputi: pengukuran pH, ketingian busa sabun, dan uji kemampuan sediaan untuk melembabkan kulit pada responden sebanyak 10 orang selama Â± 1 jam dengan menggunakan alat skin analyzer. Ekstrak etanol bonggol nanas dapat diformulasikan menjadi sediaan sabun mandi padat dengan hasil uji pH menunjukan konsentrasi 5% lebih tinggi, hasil uji ketinggian busa menunjukan konsentrasi 5% lebih tinggi dan hasil pemeriksaan kelembaban kulit menunjukan konsentrasi 5% lebih lembab. Hasil penelitian menunjukan sediaan sabun mandi padat dari ekstrak etanol bonggol nanas (AnanasCosmosusL) untuk melembabkan kulit dengan variasi konsentrasi yang berbeda dapat diformulasikan menjadi sediaan sabun mandi padatdengan hasil uji pH menunjukan stabil pada kulit dan hasil pemeriksaan kelembaban kulit menunjukan konsentrasi 5% lebih lembab. Diharapkan untuk penelitian selanjutnya agar dapat membuat sediaan lain dari ekstrak etanol bonggol nanas (Ananas cosmosus L.) dalam bentuk sediaan lain seperti sabun cair, lotion, sabun transparan, krim dan sebagainya.

EVALUASI PENGGUNAAN OBAT GASTRITIS PADA PASIEN RAWAT INAP DI RS GRANDMED LUBUK PAKAM TAHUN 2020 Dini Mayasari; Delfi Mutiara Hutahean; Debi Dinha Octora
Jurnal FARMASIMED (JFM) Vol 4 No 1 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i1.577

Gastritis is a disease caused by the bacterium Helicobacter phylory, this first gastritis drug, namely Antacids, Omeprazole, and Ranitidine. The increasing number of Gastritis patients from 2019 to 2020 at Grandmed Lubuk Pakam Hospital is encouraging researchers to conduct this study. The purpose of this study was to determine the description of the use of Gastritis drugs and the rationality of the use of Gastritis medications in Gastritis patients at Grandmed Lubuk Pakam Hospital in 2019. This study was a descriptive (non-experimental) study with retrospective data collection taken from patient medical records. Gastritis at Grandmed Lubuk Pakam Hospital. Data were collected using a purposive sampling technique in accordance with the inclusion criteria and exclusion criteria using the Data Collection Sheet. The number of samples used in this study were 64 medical records of patients diagnosed with gastritis. Data analysis was performed using Univariat with the help of SPSS. Results of distribution of duration of treatment data for which most patients undergo treatment. And the number of Chronic Diseases suffered by Diarrhea patients is 20 patients (31.2%). All three have a significant relationship with patient care outcomes. While in the age range 31-60 years, 45 people (70.3%) affected by gastritis. and The results of evaluating the rationality of treatment for gastritis are the right indications (96.9%), (62 patients), 100% correct patients (64 patients), the right medication by (96.9%) (62 patients), and the correct dosage 100% correct (64).

ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT PACAR AIR LEAVES (IMPATIENS BALSAMINA L.) AGAINST PROPIONIBACTERIUM ACNE Debi Dinha Octora; Krismawati Waruwu
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1067

ABSTRAK Aktivitas antibakteri Impatiens balsamina L. telah dipelajari selama bertahun-tahun. Daun inai air mengandung flavonoid, saponin dan tanin yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. P. acnes merupakan salah satu jenis bakteri yang dapat menyebabkan infeksi pada jerawat. Salah satu tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol daun inai air dan konsentrasi yang paling efektif dalam menghambat bakteri P. acnes. Penelitian ini merupakan penelitian eksperimen murni. Daun inai air dimaserasi dengan pelarut etanol 96%. Uji aktivitas antibakteri dilakukan dengan metode difusi cakram. Penelitian dilakukan dengan 3 variasi konsentrasi yang berbeda. Hasil penelitian menunjukkan adanya aktivitas antibakteri pada setiap konsentrasi. Kesimpulannya ekstrak etanol daun inai dengan konsentrasi 25%, 50% dan 75% memberikan penghambatan pertumbuhan bakteri paling efektif dengan konsentrasi 25%, 50% dan 75% yang termasuk dalam kategori kuat. Saran diharapkan bagi peneliti selanjutnya untuk dapat menguji bakteri lain dan membuat formulasi dari ekstrak daun inai air. ABSTRACT The antibacterial activity of Impatiens balsamina L. has been studied for many years. Water henna leaves contain flavonoids, saponins and tannins which have the ability to inhibit bacterial growth. P. acnes is one type of bacteria that can cause infection in acne. One of the objectives of this study was to determine the antibacterial activity of the ethanol extract of henna water leaves and the most effective concentration in inhibiting P. acnes bacteria. This research is a pure experimental research. Water henna leaves were macerated with 96% ethanol as solvent. Antibacterial activity test was carried out by disc diffusion method. The research was conducted with 3 different concentration variations. The results showed that there was antibacterial activity at each concentration. The conclusion is that the ethanol extract of henna leaves with concentrations of 25%, 50% and 75% gave the most effective bacterial growth inhibition with concentrations of 25%, 50% and 75% which were included in the strong category. Suggestions are expected for further researchers to be able to test other bacteria and make formulations from water henna leaf extract.

Comparative Effect of Cinnamon Powder and Red Ginger Powder for Menstrual Pain Primary Dysmenorrhea in Adolescent Diah Evawanna Anuhgera; Riris Sitorus; Debi Dinha Octora
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol. 5 No. 1 (2022): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkf.v5i1.1365

Menstrual pain is a problem with interferes by women in every menstrual cycle. This can interfere with the activities of women such as dizziness, nausea, stomach cramps, and productivity of women. Several non-pharmacologic treatment can help reduce menstrual pain such as giving cinnamon and red ginger. The purpose of this study was to compare the effectiveness of cinnamon powder and red ginger to decrease menstruation in adolescents with primary dysmenorrhea. This type of research is a quasi-experimental type of time series design. The sample in this study were all first semester female students in the Nursing Study Program at the Lubuk Pakam Medistra Health Institute who experienced primary dysmenorrhea as many as 28 people. The sampling technique used is simple random sampling. In this study there were two groups, namely the control group with the administration of ginger powder while the intervention group with the administration of cinnamon powder. The process was given an intervention for 3 days and the use of the research instrument to measure menstrual pain was the Numeric Rating Scale (NRS). Data analysis used independent t-test and Repeated Measured Anova test. The results showed that there was a difference in mean pain before and before cinnamon powder at 24 hours of intervention after (p<0.001) while red ginger drink powder showed no significant difference in mean pain before and before the intervention in the first 24 hours of intervention (p = 0.112). However, at 48 hours and 72 hours of intervention for the two groups, there was a significant difference in the decrease in mean menstrual pain in primary dysmenorrhea (p<0.001). Cinnamon drink powder is more effective than red ginger drink powder in reducing primary dysmenorrhea menstrual pain. Cinnamon and red ginger can be used as an effective non-pharmacological treatment intervention and obtained as a treatment for primary removal. Midwives can educate and apply the intervention of cinnamon and red ginger drinks to adolescents with primary dysmenorrhea.

SEMINAR ANTIBAKTERI EKSTRAK ETANOL DAUN PACAR AIR (Impatiens balsamina L.) TERHADAP BAKTERI Propionibacterium acne Debi Dinha Octora; Asti Pratiwi; Krismawati Waruwu
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

The antibacterial activity of Impatiens balsamina L. has been studied for many years. Water henna leaves contain flavonoids, saponins and tannins which have the ability to inhibit bacterial growth. P. acnes is one type of bacteria that can cause infection in acne. One of the objectives of this study was to determine the antibacterial activity of the ethanol extract of henna water leaves and the most effective concentration in inhibiting P. acnes bacteria. This research is a pure experimental research. Water henna leaves were macerated with 96% ethanol as solvent. Antibacterial activity test was carried out by disc diffusion method. The research was conducted with 3 different concentration variations. The results showed that there was antibacterial activity at each concentration. The conclusion is that the ethanol extract of henna leaves with concentrations of 25%, 50% and 75% gave the most effective bacterial growth inhibition with concentrations of 25%, 50% and 75% which were included in the strong category.

ACTIVITY TESTS OF ANTIBACTERIAL CREAM OF BAY LEAF (Syzygium polyanthum) ETHANOL EXTRACT AGAINST BACTERIA Propionibacterium acnes Debi Dinha Octora; Delima Sari
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1659

Bay leaf (Syzygium polyanthum) is a plant that is widely used as a flavor enhancer. Based on research that has been done, bay leaves contain flavonoids, alkaloids, tannins, and saponins that have the ability to act as natural antibacterial agents. Improper use of antibiotics in the treatment of infections can cause resistance, so it is necessary to use antibiotics from natural ingredients that have an optimal working power and are relatively safe. P. acnes is one type of bacteria that can cause acne. The purpose of this research is to find out the effective antibacterial activity of bay leaf ethanol extract cream preparation against P. acnes bacteria. This research is an experimental research with 3 different concentration variations. The research results show that there is antibacterial activity at each concentration with an average diameter of the clear zone of 10.06 mm, 14.4 mm and 20.16 mm, the higher the concentration of EEDS, the higher the inhibitory power against P. acnes bacteria growth. The conclusion of the activity of salam leaves with a concentration of 5%, 10%, and 15% provides the most effective inhibition of bacterial growth with a concentration of 10%, 15% which is included in the strong category. Suggestions are expected to the next researcher to be able to test other bacteria and make a greater concentration than the previous research from EEDS.

Socialization of The Use of Melinjo Leaf Ethanol Extract (Gnetum gnemon L.) on Growth Salmonella typhi Bacteria Aminah Syarifuddin; Chandra Pranata; Novidawati Boru Situmorang; Debi Dinha Octora; Lili Ramadhani
JURNAL PENGMAS KESTRA (JPK) Vol. 3 No. 1 (2023): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jpk.v3i1.1149

Gnetum gnemon L. has antibacterial activity against Salmonella typhi because it contains flavonoids, saponins, tannins, alkaloids, and steroids. Where these compounds play an important role as an antibacterial. The purpose of this service is to provide information to the public regarding the benefits of melinjo leaves which can act as an antibacterial agent. This service activity is carried out in the form of socialization using lecture, question and answer, and demonstration methods. The number of participants in this community service activity was 20 pharmacists at Grandmed Lubuk Pakam Hospital. Based on the results of the PkM activities carried out, it can be stated that there has been an increase in public knowledge regarding the efficacy of melinjo leaves as an antibacterial substance. This can be proven by the increase in post-test scores when compared to pre-test scores. The average increase in the knowledge of PkM participants was 21.5. On the other hand, the highest post-test score obtained was 85, while the lowest post-test score was 60. Meanwhile, based on the PkM material that had been socialized, the PkM participants understood that the results of phytochemical tests on melinjo leaf Simplicia showed that melinjo leaf extract contains compounds alkaloids, flavonoids, steroids, saponins, and tannins. Meanwhile, the antibacterial test showed that the inhibition zones of various concentrations included a moderate concentration of 40%, a moderate category of 60%, and a strong category of 80%. The average diameter of the inhibition zone increased with each concentration of melinjo leaves.

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