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ANALYSIS OF IMMUNOEXPRESSION OF ESTROGEN RECEPTOR BETA AND EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) ON TESTICULAR SEMINOMAS NONRECURRENCE AND RECURRENCE Ridwan, Antonius Janes; Suryanti, Sri; Hassan, Abdul Hadi; Hernowo, Bethy S
Journal of Medicine and Health Vol 1, No 2 (2015)
Publisher : Maranatha Christian University

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The most common malignancy of testis is seminoma with prognosis that is not always good because of high recurrence rate and death cases. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a glycoprotein adhesion molecules which plays a role in tumor cell invasion and metastasis as evidenced by immunohistochemistry method in several types of tumor cells and tissue that shows the correlation to the clinical progessivity.This study was conducted by observational descriptive analytics with each seven cases of seminoma nonrecurrences and recurrences diagnosed histopathologically from Dr.Hasan Sadikin Hospital, Advent Hospital and St.Borromeus Hospital in Bandung. This study shows that immunoexpression of estrogen receptor beta is not higher in testicular seminoma recurrence compared with nonreccurence. There was no higher imunoexpression of EMMPRIN receptor on testicular seminoma recurrence compared with nonrecurrence; besides, there was no relationship between immunoexspression of estrogen receptor beta and EMMPRIN in testicular seminoma nonrecurrence and recurrence.In conclusion, immunoexpression estrogen receptor beta expressed in all testicular seminoma, so that the patient could be given an alternative therapy and immunoexspression EMMPRIN, cannot be used to predict a recurrence in patients with seminoma who has received complete therapy.Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Keywords: EMMPRIN, Estrogen Receptor Beta, Seminoma Testis nonrecurrence and recurrence

Characteristics of Renal Cell Carcinoma in Dr. Hasan Sadikin General Hospital Bandung, 2010â2014 Putra, Dicky Suryana; Suryanti, Sri; Sihombing, Aaron Tigor
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

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Background: Data characteristics for renal cell carcinoma are mostly derived from developed countries. However, data from developing countries, specifically in Indonesia have not been fully described. This study aimed at describing renal cell carcinoma (RCC) characteristics based on age, gender, and histopathology type in Dr. Hasan Sadikin General Hospital Bandung.Methods: This was a descriptive study conducted in AugustâOctober 2015. The data were collected from histopathology medical records of patients who had been diagnosed with RCC at Department of Pathology Anatomy Dr. Hasan Sadikin General Hospital Bandung, from 2010 to 2014. Total sampling was used as sampling method. Only RCC records that had complete variables; which were age, gender, and histopathological type; included in this study.Results: There were 25 cases of renal cell carcinoma discovered in this study, 17 cases discovered in men and 8 cases discovered in women. The histopathology type found in this study was clear cell renal cell carcinoma (12 cases), papillary renal cell carcinoma (8 cases), chromophobe renal cell carcinoma (3 cases), and carcinoma of the collecting ducts of bellini (2 cases). There were no cases found below the age range 2â29 years old and above the age range 70â79 years old.Conclusions: Men have higher incidence than women with the ratio of 2:1. Peak incidence is found on the age range 50â59 years old. The most common histopathology type is clear cell renal cel carcinoma.[AMJ.2016;3(4):644â8]Â DOI:Â 10.15850/amj.v3n4.953

Five Years Facts of Bladder Cancer at West Javaâs Top Referral Hospital, in Indonesia Perix, Vivien Kate; Suryanti, Sri; Sihombing, Aaron Tigor
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

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Background: Bladder cancer is the second most common genitourinary cancer and its incidence is rising 15% annually in Indonesia. Smoking is the leading risk factor of bladder cancer and two thirds of men in Indonesia smokes. This study was conducted to describe the characteristics of bladder cancer based on sex, age and histopathology type inÂ West Javaâs Top Referral Hospital, Indonesia. Methods: This study was a descriptive study conducted during theperiod of September to November 2015 using 372 histopathological medical records of patients who had primary and secondary bladder cancer at the Pathology Department, Dr. Hasan Sadikin General Hospital Bandung from January 2010 to December 2014. Data were collected using total sampling method based on the characteristics of age, sex histopathology type, and staging of bladder cancer.Results: Out of the 372 cases, 298 cases were male and 38 cases were female with a male to female ratio of 7.8:1. The age group with the highest incidence was the 50â59 years old group. Infiltrating urothelial carcinoma was the most common histopathology type (71.1%) in primary cancers, 66.1% of cases was muscle invasive while 33.9% was non muscle invasive. Staging pT1 had the most number of cases. The most common site of origin for secondary neoplasm was cervix with adenocarcinoma as the most common histopathology type. Conclusions: Bladder cancer is more common in male than female and peaks at the sixth decade of life. Infiltrating urothelial carcinoma is the most common histopathology type. [AMJ.2017;4(1):94â9]Â DOI:Â 10.15850/amj.v4n1.1028

THE EFFECT OF USING RING THEORY MOBILE APPLICATION ON STUDENT INVOLVEMENT AND REASONING ABILITY Suryanti, Sri; Sutaji, Deni
Journal on Mathematics Education Online First
Publisher : Department of Doctoral Program on Mathematics Education, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22342/jme.12.2.5398.%p

This study aims to determine the influence of the use of ring theory mobile application on student involvement in learning and the students reasoning ability. The subject of research is sixth-semester students who take the subject of Ring Theory that is 30 people. The research instrument used is observation sheet, student involvement questionnaire, and test questions to know students reasoning ability. The research method used is descriptive quantitative to know the involvement of students, while to know the effect on students reasoning ability used independent sample t-test with SPSS 15.0. The results showed that the use of ring theory mobile application caused a very positive engagement, from the overall indicator of student involvement in learning, gets an average scoreÂ 4.74 (score range 1-5). Also, there was a significant influence of the use of ring theory mobile application on students reasoning ability, which is 0.721

Hubungan CXC Chemokine Receptor 4 (CXCR4) dan Matrix Metalloproteinase 9 (MMP 9) dengan Kemampuan Metastasis Adenokarsinoma Prostat Murtiyani, Sri; S. Hernowo, Bethy; Suryanti, Sri
Jurnal Kedokteran YARSI Vol 27, No 1 (2019): JANUARI - APRIL 2019
Publisher : Lembaga Penelitian Universitas YARSI

Karsinoma prostat merupakan keganasan kedua terbanyak pada laki-laki dan merupakan penyebab kematian kelima diseluruh dunia. Faktor prognosis utama pada adenokarsinoma prostat adalah metastasis yang menyebabkan tingginya angka kematian. Keadaan ini disebabkan karena pada kasus adenokarsinoma prostat yang metastasis pilihan terapi belum mendapatkan hasil yang memuaskan karena terdapat faktor resisten terhadap terapi radiasi dan kemoterapi. CXCR4 dan MMP 9 merupakan petanda imunohistokimia yang berfungsi dalam proses migrasi, chemotaxis dan detachment yang memegang peranan terhadap terjadinya metastasis pada adenokarsinoma prostat. Tujuan penelitian ini adalah mencari hubungan imunoekspresi CXCR4 dan MMP 9 dengan metastasis pada adenokarsinoma prostat. Penelitian ini menggunakan desain potong lintang dan observasional analitik. Sampel diambil dari blok parafin yang tersedia di Departemen Patologi Anatomi RSUP Dr. Hasan Sadikin Bandung pada periode 2010-2016. Jumlah sampel sebanyak 52 sampel, dibagi menjadi 2 kelompok, yaitu kelompok metastasis 26 sampel dan kelompok non metastasis 26 sampel. Keseluruhan sampel dilakukan pulasan imunohistokimia CXCR4 dan MMP 9.Hasil penelitian ini menunjukkan bahwa 71% sampel mengekspresikan CXCR4 kuat dengan proporsi terbesar pada kelompok metastasis (nilai p=0,000) dan 56% sampel mengekspresikan MMP 9 lemah pada kelompok metastasis (nilai p=0,55).CXCR4 dapat digunakan sebagai faktor prediksi metastasis pada adenokarsinoma prostat.

ANALYSIS OF IMMUNOEXPRESSION OF ESTROGEN RECEPTOR BETA AND EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) ON TESTICULAR SEMINOMAS NONRECURRENCE AND RECURRENCE Ridwan, Antonius Janes; Suryanti, Sri; Hassan, Abdul Hadi; Hernowo, Bethy S
Journal of Medicine and Health Vol. 1 No. 2 (2015)
Publisher : Universitas Kristen Maranatha

The most common malignancy of testis is seminoma with prognosis that is not always good because of high recurrence rate and death cases. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a glycoprotein adhesion molecules which plays a role in tumor cell invasion and metastasis as evidenced by immunohistochemistry method in several types of tumor cells and tissue that shows the correlation to the clinical progessivity.This study was conducted by observational descriptive analytics with each seven cases of seminoma nonrecurrences and recurrences diagnosed histopathologically from Dr.Hasan Sadikin Hospital, Advent Hospital and St.Borromeus Hospital in Bandung. This study shows that immunoexpression of estrogen receptor beta is not higher in testicular seminoma recurrence compared with nonreccurence. There was no higher imunoexpression of EMMPRIN receptor on testicular seminoma recurrence compared with nonrecurrence; besides, there was no relationship between immunoexspression of estrogen receptor beta and EMMPRIN in testicular seminoma nonrecurrence and recurrence.In conclusion, immunoexpression estrogen receptor beta expressed in all testicular seminoma, so that the patient could be given an alternative therapy and immunoexspression EMMPRIN, cannot be used to predict a recurrence in patients with seminoma who has received complete therapy.Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Keywords: EMMPRIN, Estrogen Receptor Beta, Seminoma Testis nonrecurrence and recurrence

The Relationship between Body Mass Index (BMI) and Gleason Score of Indonesian Prostate Cancer Men in Hasan Sadikin General Hospital Abdurrahman, Fauzan; Suryanti, Sri; Sihombing, Aaron T
Journal of Medicine and Health Vol. 2 No. 2 (2018)
Publisher : Universitas Kristen Maranatha

The risk of high grade PCa in Asia in relation to BMI had positive or negative effect. The objective of this study is to know the relationship between BMI and Gleason score in Indonesian PCa patients. A cross sectional study was conducted in Hasan Sadikin General Hospital. The data were secondary data taken from medical records of prostate adenocarcinoma patients in Hasan Sadikin General Hospital. Ordinal data were analyzed using Chi square and correlation using Spearman. All calculation was done using SPSS 24. There were 95 Indonesian PCa patients. 78 patients is in normal BMI range. Of those 41 patients (52.6%) is in high level of Gleason score. 17 patients is in high BMI range. High Gleason score was found in 11 patients (P = 0.362; rs = 0.094). Conclusion, there is no relation between BMI in Indonesian PCa and Gleason score.Â Â Â Keywords : Prostate adenocarcinoma (PCa); BMI; Gleason score.

THE IMMUNOEXPRESSION PROFILE OF FGFR3 AND P53 IN PUNLMP AND UROTHELIAL BLADDER CARCINOMA AT HASAN SADIKIN GENERAL HOSPITAL Suryanti, Sri; Agustina, Hasrayati; Mulyati, Sri
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.551

Objective: To obtain FGFR3 and p53 immunohistochemistry of PUNLM and UBC basic data profile. Material & Methods: This retrospective observational analytic study used a cross-sectional design on formalin-fixed paraffin-embedded (FFPE) from patients diagnosed as PUNLMP and UBC then performed FGFR3 and p53 immunohistochemical staining. Statistical analysis of immunoexpression data using SPSS 24.0. Results: There are three main immunohistochemistry pattern profiles of PUNLMP and UBC in this research data, i.e. FGFR3+ p53+, FGFR+ p53- and FGFR3- p53+. There were no Cis sample obtained. FGFR+ was showed in PUNLMP, LG-PUC, HG-PUC, IUBC (pT1, pT2, pT3, pT4) with decreased percentage sequentially. As many as 51 of 54(94.44%) IUBC samples showed combination pattern with p53+ while 3 other samples were p53-. Conclusion: The FGFR3 and p53 immunohistochemistry profile, separately or as a pattern of combination, is in accordance with the oncogenesis molecular pathway of UBC.

THE IMMUNOEXPRESSION PROFILE OF FGFR3 AND P53 IN PUNLMP AND UROTHELIAL BLADDER CARCINOMA AT HASAN SADIKIN GENERAL HOSPITAL Suryanti, Sri; Agustina, Hasrayati; Mulyati, Sri
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.551

Objective: To obtain FGFR3 and p53 immunohistochemistry of PUNLM and UBC basic data profile. Material & Methods: This retrospective observational analytic study used a cross-sectional design on formalin-fixed paraffin-embedded (FFPE) from patients diagnosed as PUNLMP and UBC then performed FGFR3 and p53 immunohistochemical staining. Statistical analysis of immunoexpression data using SPSS 24.0. Results: There are three main immunohistochemistry pattern profiles of PUNLMP and UBC in this research data, i.e. FGFR3+ p53+, FGFR+ p53- and FGFR3- p53+. There were no Cis sample obtained. FGFR+ was showed in PUNLMP, LG-PUC, HG-PUC, IUBC (pT1, pT2, pT3, pT4) with decreased percentage sequentially. As many as 51 of 54(94.44%) IUBC samples showed combination pattern with p53+ while 3 other samples were p53-. Conclusion: The FGFR3 and p53 immunohistochemistry profile, separately or as a pattern of combination, is in accordance with the oncogenesis molecular pathway of UBC.

INFILTRATING UROTHELIAL CARCINOMA ALONG THE URINARY TRACT OF A YOUNG ADULT Suryanti, Sri; Kharisma, Yuktiana; Tigor, Aaron
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.707

Objective: To present a rare case of infiltrating urothelial carcinoma along the urinary tract on a young adult. Case(s) Presentation: A 39 year old Asian male patient with > 20 pack-year smoking history, came to the hospital with a chief complaint of hematuria and flank pain since two weeks ago. Physical examination revealed Eastern Cooperative Oncology Group (ECOG) Performance Status 1, the right kidney was palpated, no tenderness on fist percussion. Abdominal ultrasound (USG) revealed 1.5 cm and 0.5 cm masses located in the urinary bladder. The CT scan show mass in the bladder was exophytic, > 3 cm in size, and occupying lesion was located on the right posteroinferior and left lateral bladder wall accompanied with dilatation of pelvic calyces and right ureter. Histopathology of the specimen revealed low-grade infiltrating urothelial carcinoma of bladder and right ureter. The pathological stage was pT2NxMx, The patient refused neoadjuvant chemotherapy and surgery. Four months after TURBT, he came with weakness and right flank pain. The patient consent to surgery and underwent the right nephroureterectomy. Histopathology of the specimen showed infiltrating urothelial carcinoma of right kidney, ureter, Gerota fascia with lymphovascular invasion (pT3NxMx). Discussion: Urothelial carcinoma (UC) is commonly arising in the urinary bladder, but it can develop along the urinary tract. Cigarette smoke contains a lot of carcinogenic agents and stimulates DNA damage. Conclusion: Upper tract urothelial carcinoma (UTUCs) is subset of UC with a poor prognosis. Cigarette smoking is the main risk factor that induces DNA damage.

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