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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Biotechnology Indonesian Journal of Cancer The Indonesian Biomedical Journal Medical Laboratory Technology Journal Jurnal Gizi Klinik Indonesia Majalah Kedokteran Neurosains Jurnal Pandu Husada
Teguh Aryandono
Division Of Surgical Oncology, Department Of Surgery, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Medical Laboratory Technology Journal

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MiR-21 and mRNA PTEN Expression Levels and Biomarker Potential in Breast Cancer Dinna Rakhmina; Sofia Mubarika Haryana; Teguh Aryandono
Medical Laboratory Technology Journal Vol. 7 No. 1 (2021): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (802.167 KB) | DOI: 10.31964/mltj.v7i1.364

Abstract

MiR-21 has been linked to tumorigenesis, development, and metastasis in tumor pathogenesis. All human cancers, including breast cancer, have increased expression of MiR-21, which is the only miRNA that has increased expression. PTEN expression was found to be reduced in the majority of solid tumors, including breast cancer. Since lymph node metastatic factors, estrogen receptor status, tumor grade, and tumor node metastasis (TNM) all decreased PTEN expression, the PTEN expression profile may be a very useful prognostic marker in breast cancer. PTEN inhibits PIP3 (phosphatidylinositol 3,4,5-triphosphate) activity by having protein phosphatase and lipid phosphatase activity that is the polar opposite of PI3K (Phosphatidyl Inositol 3-Kinase). The aim of this research was to see how often miR-21 and mRNA PTEN were expressed at different stages of breast cancer and whether they could be used as prognostic markers. This type of research is an observational study with a cross-sectional design. The sample size of 43 people came from breast cancer patients. Analysis of miR-21 expression and mRNA PTEN using Real-Time qPCR. The results showed that miR-21 expression increased 1.32 times at an advanced stage compared to an early stage, while mRNA PTEN expression decreased 1.33 fold at an advanced stage compared to an early stage. According to the findings, miR-21 expression in the blood plasma of breast cancer patients was upregulated at an advanced stage compared to an early stage and downregulated mRNA PTEN expression. MiR-21 which is increased at an advanced stage has the potential to be a poor prognostic marker at the stage of breast cancer. The change in miR-21 expression can be a good candidate as a molecular prognostic marker and for future research the role of miR-21 in breast cancer progression will further enrich the scientific repertoire, especially in the health and clinical fields.
Co-Authors . Irianianiwati . Supomo . Supomo Addin Trirahmanto Ahmad Ghozali Ahmad Hamim Sadewa Akbar Satria Fitriawan Anwar, Sumadi Lukman Aprilia Indra Kartika Aprilia Indra Kartika Arif Faisal Bambang Karsono Benny, Yohanes Cita Herawati DENNI JOKO PURWANTO, DENNI JOKO Dewajani Purnomosari Dewi Sahfitri Tanjung Dewi Sahfitri Tanjung Didik Setyo Heiyanto Dinna Rakhmina Dwi Nur Indah Sari Dwianingsih, Ery Kus Hardyanto Soebono Haryono, Samuel J. Heru Pradjatmo Ibnu Purwanto Indwiani Astuti Indwiani Astuti Irianiwati Widodo Ishandono Dachlan Iwan Dwiprahasto Iwan Dwiprahasto Karsono, Ramadhan Lenny Sari, Lenny Lina Choridah Mae Sri Hartati Wahyuningsih Marsetyawan Soesatyo Marsetyawan Soesatyo Meutia Srikandi Fitria Oktriani R Paulus Sudiharto Paulus Sudiharto Risky Oktriani Sa’adah N Siti Nur Chasanah Siti Nur Chasanah Soeripto Soeripto Sofia Mubarika Sofia Mubarika Sofia Mubarika H Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Susetyowati Susetyowati Susetyowati Susetyowati, Susetyowati Tirta wardana Torizal GF Wardana T Yohanes Benny Yohanes Widodo Wirohadidjojo Ysrafil . Yulia Pratiwi