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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Biotechnology Indonesian Journal of Cancer The Indonesian Biomedical Journal Medical Laboratory Technology Journal Jurnal Gizi Klinik Indonesia Majalah Kedokteran Neurosains Jurnal Pandu Husada

Teguh Aryandono

Division Of Surgical Oncology, Department Of Surgery, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia

Author-ID : 402405

Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Clinical aspects of gastrointestinal lymphoma Teguh Aryandono, Teguh Aryodono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 02 (1995)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.936 KB)

Diagnosis sebagian besar limtoma gastrointestinal hanya dapat ditegakkan dengan laparotomi. Duapuluh empat penderita limtoma gastrointestinal primer diteliti. Penderita dikelompokkan menurut umur, jenis kelamin, keluhan, adanya simtom B (demam, penurunan berat badan, dan keringat malam), lokasi tumor, tindakan bedah, diagnosis histopatologis menurut International Working Formulation, dan terapi.Dari 16 orang penderita laki-laki, umur antara 6,5 - 76 tahun dengan rerata 44,7 tahun, lama keluhan pada 10 penderita tidak Iebih dari 6 bulan, hanya terdapat 8 penderita dengan simtom B.Lima betas penderita dengan keluhan massa pada abdomen, 5 dengan gangguan pola pencernaan, 4 dengan obstruksi, dan sakit perut pada 10 penderita. Biopsi laparotomi dikerjakan pada 16 penderita dan reseksi hanya dapat dikerjakan pada 6 penderita. Dua penderita dilakukan apendektomi karena gejala yang mirip dengan apendisitis. Menurut International Working Formulation, 17 penderita dengan derajat keganasan sedang, 5 dengan derajal keganasan tinggi dan 2 dengan derajat keganasan rendah. Hanya 9 penderita mendapat kemoterapi dengan sikiotostamid, vinkristin dan prednisolon dan hanya 3 penderita mendapatkan 3 siklus atau IebihÂ kemoterapi.Key Words : gastrointestinal lymphoma -- laparotomy -- chemotherapy -- working formulation.

Sensitivity and specificity test of fine needle aspiration biopsy in determining thyroid nodule diagnosis Teguh Aryandono, Ahmad Aryono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 42, No 01 (2010)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.363 KB)

Based on guideline of the American Association of Clinical Endocrinologist, fine needle aspiration (FNA) is believedas effective method to differentiate between benign and malignant thyroid nodule. At Dr. Sardjito Hospital,during2004 â 2008 there were 12 cases of false negative from 14 cases of thyroid malignancy. The high false negativevalue raised question about the role of FNA in determining thyroid nodule diagnosis. The purpose of this study is tofind out sensitivity and specificity of FNA in determining thyroid nodule diagnosis at Dr. Sardjito Hospital Yogyakarta.Patients underwent FNA and surgery for thyroid nodule were collected between January 2004 until December2008. The result of FNAwas compared to histopathological result then sensitivity and specificity test were performedrespectively. The fine needle aspiration was conducted to 120 patients. It consist of 23 men and 97 women, mostly41 â 50 years old. The results of FNA were four of malignancy, 74 of benign, and 42 of follicular neoplasm.Histopathological result showed malignant in 23 patients and benign in 97 patients. The FNA at Dr. Sardjito Hospitalshowed 14.29%of sensitivity, 96.86%of specificity, 50%of PPV, 83.78% of NPV, 4.55 of LR +0.884 of LR-,18.92% of prevalence, and 86.49% of accuracy. The thyroid FNA at Dr. Sardjito Hospital showed low value ofsensitivity and high value of specificity. Futhermore, the thyroid FNA showed minimal role in determining thyroidnodule diagnosis.Keywords : thyroid nodule-diagnosis-fine needle aspiration-sensitivity-specificity

Sarkoma jaringan lunak regio humeri. Penanganan dengan amputasi lengan atas Teguh Aryandono, Teguh Aryodono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 01 (1996)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.124 KB)

The management of soft tissue sarcoma of the extremities is very complicated, particularly if the tumor is large and has infiltrated into the deep structures. Forequarter amputation is still one best choice for either curative or palliative purposes, although this operation is very mutilated.This report is aimed at presenting the benefit of forequarter amputation in patients with soft tissue sarcomas in the humeri region. Two patients with extrasceletal myxoid chondrosarcoma and pleomorphic rhabdomyosarcoma in the humeri region were managed with forequarter amputation and neoadjuvant chemotherapy. The patients condition and quality of life were better after the amputation.Key Words : soft tissue sarcoma - forequarter amputation - neoadjuvant chemotherapy - extrasceletal myxoid chondrosarcoma - pleomorphic rhabdomyosarcoma

Sensitivity and specificity test of fine needle aspiration biopsy in determining thyroid nodule diagnosis Ahmad Aryono Teguh Aryandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 42, No 01 (2010)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.363 KB)

Based on guideline of the American Association of Clinical Endocrinologist, fine needle aspiration (FNA) is believedas effective method to differentiate between benign and malignant thyroid nodule. At Dr. Sardjito Hospital,during2004 – 2008 there were 12 cases of false negative from 14 cases of thyroid malignancy. The high false negativevalue raised question about the role of FNA in determining thyroid nodule diagnosis. The purpose of this study is tofind out sensitivity and specificity of FNA in determining thyroid nodule diagnosis at Dr. Sardjito Hospital Yogyakarta.Patients underwent FNA and surgery for thyroid nodule were collected between January 2004 until December2008. The result of FNAwas compared to histopathological result then sensitivity and specificity test were performedrespectively. The fine needle aspiration was conducted to 120 patients. It consist of 23 men and 97 women, mostly41 – 50 years old. The results of FNA were four of malignancy, 74 of benign, and 42 of follicular neoplasm.Histopathological result showed malignant in 23 patients and benign in 97 patients. The FNA at Dr. Sardjito Hospitalshowed 14.29%of sensitivity, 96.86%of specificity, 50%of PPV, 83.78% of NPV, 4.55 of LR +0.884 of LR-,18.92% of prevalence, and 86.49% of accuracy. The thyroid FNA at Dr. Sardjito Hospital showed low value ofsensitivity and high value of specificity. Futhermore, the thyroid FNA showed minimal role in determining thyroidnodule diagnosis.Keywords : thyroid nodule-diagnosis-fine needle aspiration-sensitivity-specificity

Sarkoma jaringan lunak regio humeri. Penanganan dengan amputasi lengan atas Teguh Aryodono Teguh Aryandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 01 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.124 KB)

Clinical aspects of gastrointestinal lymphoma Teguh Aryodono Teguh Aryandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 02 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.936 KB)

Diagnosis sebagian besar limtoma gastrointestinal hanya dapat ditegakkan dengan laparotomi. Duapuluh empat penderita limtoma gastrointestinal primer diteliti. Penderita dikelompokkan menurut umur, jenis kelamin, keluhan, adanya simtom B (demam, penurunan berat badan, dan keringat malam), lokasi tumor, tindakan bedah, diagnosis histopatologis menurut International Working Formulation, dan terapi.Dari 16 orang penderita laki-laki, umur antara 6,5 - 76 tahun dengan rerata 44,7 tahun, lama keluhan pada 10 penderita tidak Iebih dari 6 bulan, hanya terdapat 8 penderita dengan simtom B.Lima betas penderita dengan keluhan massa pada abdomen, 5 dengan gangguan pola pencernaan, 4 dengan obstruksi, dan sakit perut pada 10 penderita. Biopsi laparotomi dikerjakan pada 16 penderita dan reseksi hanya dapat dikerjakan pada 6 penderita. Dua penderita dilakukan apendektomi karena gejala yang mirip dengan apendisitis. Menurut International Working Formulation, 17 penderita dengan derajat keganasan sedang, 5 dengan derajal keganasan tinggi dan 2 dengan derajat keganasan rendah. Hanya 9 penderita mendapat kemoterapi dengan sikiotostamid, vinkristin dan prednisolon dan hanya 3 penderita mendapatkan 3 siklus atau Iebih kemoterapi.Key Words : gastrointestinal lymphoma -- laparotomy -- chemotherapy -- working formulation.

The effect of combination of hemofilter, pre- and intraoperative methylprednisolone administration on systemic inflammatory response syndrome (SIRS) post open heart surgery . Supomo; Teguh Aryandono; Marsetyawan Soesatyo; Paulus Sudiharto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 1 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Systemic inflammatory response syndrome (SIRS) occurs in almost all patients whom undergo open heart surgery causes the increase its morbidity and mortality. The effect of pre- and intraoperative methylprednisolone administration combined with hemofilter application in cardiopulmonary bypass machine in the reduction of SIRS incidence remains controversial. This study aimed to evaluate the effect pre- and intraoperative methylprednisolone administration combined with hemofilter on SIRS incidence after open heart surgery. This was an experimental study using prospective randomized open-blinded evaluation (PROBE) design. Ninety-five patients from Dr. Sardjito General Hospital, Yogyakarta, and Dr. Cipto Mangunkusumo General Hospital, Jakarta, who had open heart surgery within the period of December 2011 to May 2012 were enrolled in this study. The patients were randomly allocated into two groups i.e. Group A (48 patients) received pre-; intra-; and postoperative methylprednisolone (15; 5 and 5 mg/kg BW, respectively) and hemofilter and Group B (47 patients) just received intra- and postoperative methylprednisolone (15 and 5 mg/kg BW). The SIRS incidence was evaluated in 3; 24; 48 and 72 hours post surgery. This study showed that the SIRS incidence in Group B at 3 (OR= 0.12; 95%CI=0.03-0.39; p< 0.001) and 24 (OR= 0.38; 95%CI=0.14-0.996; p< 0.031) hours postoperative were significantly higher than that in Group A. In conclusion, pre- and intraoperative methylprednisolone administration combined hemofilter significantly decrease the SIRS incidence post open heart surgery.

The effect of mitomycin-c in keloid fibroblast cultures Ishandono Dachlan; Teguh Aryandono; Mae Sri Hartati Wahyuningsih; Hardyanto Soebono; Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 3 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACTKeloid occurs due to hyperactivity of keloid fibroblast (KF) in proliferation, migration, collagen deposition, together with low rates of collagen degradation. These are under the responsibility of TGF-b. Mitomycin C (MC) is used for treating keloid by a topical application during surgery at the level of 0.02% to 0.08%. Unfortunately, the lowest effective level of MC for keloid has not been determined yet. We aimed to determine the lowest effective level of MC in the suppression of KF activities. Various levels of MC diluted in growth medium were administered on KF that were isolated from six patients. After 24 hours and 72 hours of incubation, cellular proliferation, collagen deposition, cellular migration and level of TGF-b, were analyzed. Application of 120 uM MC on KF culture for 24 hours could significantly reduce TGF-b production from 1265.74 ± 274.81 pg/mL to 265.17 ± 12.20 pg/mL; proliferation index from 100% to 84.01 ± 12.91%; inhibit cellular migration to 64.38 ± 3.66%; but reduce collagen depositions from 100% to only 91.13 ± 10.19%. The lowest MC level is on 30 uM or equal with 0.001%. In conclusion, the lowest level of MC can suppress the activities of KF is 0.001%. Moreover, due to low activity in inhibiting collagen deposition, MC would be better as an adjuvant drug for keloid surgery.

The effect of hemofilter, preoperative and intraoperative methylprednisolone on complications after open heart surgery . Supomo; Teguh Aryandono; Marsetyawan Soesatyo; Paulus Sudiharto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 4 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Complications after open heart surgery may threaten patient’s survival rate. Theintraoperative methylprednisolone administration alone shows controversial resultson open heart surgery complications. Similarly, the intraoperative and preoperativemethylprednisolone administration as well as the use of hemofilter in open heart surgeryis still controversial. This study aimed to evaluate the effect of hemofilter, preoperativeand intraoperative methylprednisolone administration on complications following openheart surgery. This was a Prospective Randomized Open-Blinded Evaluation (PROBE)experimental study. Ninety-five patients who had open heart surgery in Dr. SardjitoGeneral Hospital, Yogyakarta, and Integrated Cardiac Care of Dr. Cipto MangunkusumoGeneral Hospital, Jakarta within the period of December 2011 to May 2012 wereinvolved in this study. The patients were divided into two groups i.e. group A, 48 patientsreceived methylprednisolone 15mg/kg intraoperatively, methylprednisolone 5mg/kgpreoperatively, and hemofilter, while group B, 47 patients received methylprednisolone15mg/kg intraoperatively alone. From the total 95 patients, we found 26 (27.4%)patients experienced complications i.e. 19 in group B (40.4%) and 7 in group A(14.6%). The differences of the complications were statistically significant (p<0.05;OR=3.97; 95%CI=1.476-10.71). Complications risk decreased by 63.9% in the groupA compared to the group B with the hazard ratio of 3.2. In conclusion, the application ofhemofilter, preoperative and intraoperative methylprednisolone might decrease the risk ofcomplications after open heart surgery.

Implementation of Medical Genetics in Medical Education Curriculum Teguh Aryandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 4 (2016): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Primary care physicians should be aware that genomics has arrived at the doorstep of their practice. Genetic knowledge, skills, and attitudes are important to primary care physicians providing support and management to patients and families with (higher risks of) genetic conditions. At least one in ten patients seen in primary care has a disorder with a genetic component, including hereditary cancer.Primary care physicians must be able to advise patients on genetic and genomic manifestations of the associated diseases and disorders, to outline a primary pedigree to deliver the necessary information: the disease which the patients are at risk of, and to decide whether to refer the patients to genetic services.There is more and more evidence to the importance of clinical emphasis in the genetics classes, probably proceeding to a third-year refresher program in the longitudinal curriculum. An enhanced educational experience to improve genetics and genomics knowledge should be better structured in the imminent future.Keywords: primary care physicians, hereditary cancer, genetic curriculum, genetic services

Co-Authors . Irianianiwati . Supomo . Supomo Addin Trirahmanto Ahmad Ghozali Ahmad Hamim Sadewa Akbar Satria Fitriawan Anwar, Sumadi Lukman Aprilia Indra Kartika Aprilia Indra Kartika Arif Faisal Bambang Karsono Benny, Yohanes Cita Herawati DENNI JOKO PURWANTO, DENNI JOKO Dewajani Purnomosari Dewi Sahfitri Tanjung Dewi Sahfitri Tanjung Didik Setyo Heiyanto Dinna Rakhmina Dwi Nur Indah Sari Dwianingsih, Ery Kus Hardyanto Soebono Haryono, Samuel J. Heru Pradjatmo Ibnu Purwanto Indwiani Astuti Indwiani Astuti Irianiwati Widodo Ishandono Dachlan Iwan Dwiprahasto Iwan Dwiprahasto Karsono, Ramadhan Lenny Sari, Lenny Lina Choridah Mae Sri Hartati Wahyuningsih Marsetyawan Soesatyo Marsetyawan Soesatyo Meutia Srikandi Fitria Oktriani R Paulus Sudiharto Paulus Sudiharto Risky Oktriani Sa’adah N Siti Nur Chasanah Siti Nur Chasanah Soeripto Soeripto Sofia Mubarika Sofia Mubarika Sofia Mubarika H Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Sofia Mubarika Haryana Susetyowati Susetyowati Susetyowati Susetyowati, Susetyowati Tirta wardana Torizal GF Wardana T Yohanes Benny Yohanes Widodo Wirohadidjojo Ysrafil . Yulia Pratiwi

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