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Effect of reperfusion injury from distant ischemia to small intestine Moenadjat, Yefta; Ramdhani, Aris; Jeo, Wifanto Saditya; Suharto, Wuryantoro; Werdhani, Retno Asti
Medical Journal of Indonesia Vol 28, No 1 (2019): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5843.677 KB) | DOI: 10.13181/mji.v28i1.1468

Abstract

BACKGROUND The ileum is the most vulnerable part of the small intestine that plays an important role as the motor of multisystem organ failure. Villous damage is demonstrated after ligation of supply artery in mice; however, there is no study on the ileum after distant ischemic organs. Thus, this study was aimed to find out ileal villous changes following reperfusion injury, the protective effects of ischemic hypothermia and ischemic preconditioning.METHODS An experimental study conducted enrolled 21 subjects of Oryctolagus cuniculus. Ischemia is induced by ligation of the femoral artery for 4 hours. Eight hours after ligation was released, ileum and duodenal specimens were taken through laparotomy. H&E stained specimens were examined for histomorphological changes. Villi change scores, tissue level of hypoxia-inducible factor-1α (HIF-1α), malondialdehyde (MDA), and occludin were statistically analyzed in four treatment groups, namely ischemia, ischemic hypothermia, ischemic preconditioning, and control.RESULTS Intestinal villi changes were found following ischemic-induced arterial ligation. Ileal villi changes showed differences with the duodenum and controls as indicated by the villi damage scores, increased tissue HIF-1α and MDA, and decreased occludin levels. Ileal villi changes in the ischemic and ischemic hypothermia groups showed significant changes with controls; whereas the ischemic preconditioning group showed no significant differences.CONCLUSIONS Ischemia at a distance leads to both histomorphological and biochemical damage of the ileal villi and disrupts the integrity of the intestinal mucosal barrier. In addition, the study showed a protective effect of ischemic preconditioning.
UPAYA PENGELOLAAN FATIGUE PADA PENERBANG DENGAN AKTIVITAS FISIK, LATIHAN FISIK DAN WAKTU TIDUR Retno Wibawanti; Amilya Agustina; Maria Melania Muda; Retno Asti Werdhani
Majalah Kedokteran Indonesia Vol 69 No 12 (2019): Journal of The Indonesian Medical Association Majalah Kedokteran Indonesia Volu
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v69i12.169

Abstract

Fatigue adalah kondisi fisiologis yang ditandai dengan penurunan kapabilitas performa fisik dan mental akibat kehilangan tidur atau terjaga berkepanjangan, perubahan irama sirkadian dan beban kerja yang dapat mengganggu kewaspadaan dan kemampuan personil penerbangan dalam mengoperasikan pesawat atau tugas penerbangan dengan selamat. Insiden atau kecelakaan penerbangan dapat timbul akibat kesalahan di tingkat individu (penerbang atau awak pesawat lainnya), dimana fatigue menjadi salah satu faktor penyebab utama.International Civil Aviation Organization (ICAO) telah merekomendasikan Fatigue Risk Management System (FRMS) kepada negara-negara anggotanya, termasuk Indonesia. FRMS ini merupakan suatu sistem adalah suatu sistim pengawasan dan pengelolaan faktor-faktor risiko terkait kelelahan berbasis bukti, yang dilakukan secara berkesinambungan. Di Indonesia saat ini belum banyak maskapai yang menerapkan FRMS. Sebagai upaya lain untuk mengelola fatigue di penerbang, maka dibutuhkan panduan langkah-langkah praktis untuk mengelola faktor risiko fatigue di penerbang, khususnya terkait aktivitas fisik, aktivitas di waktu senggang atau istirahat dan pengaturan waktu tidur.Buku Panduan Praktis Pengelolaan Fatigue bagi Penerbang dengan Aktivitas Fisik, Latihan Fisik dan Waktu Tidur ditargetkan untuk menjadi acuan pengelolaan fatigue bagi penerbang, maskapai dan dapat menjadi rekomendasi bagi pemangku kebijakan untuk dapat dijadikan bagian dari prosedur keselamatan penerbangan di Indonesia.
MODUL KONSULTASI DAN RUJUKAN DOKTER KELUARGA Retno Asti Werdhani
Majalah Kedokteran Indonesia Vol 68 No 12 (2018): Journal of The Indonesian Medical Association Majalah Kedokteran Indonesia Volu
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v68i12.203

Abstract

Konsultasi dan Rujukan adalah salah satu bentuk pelayanan kedokteran integrasi dengan tenaga-tenaga kesehatan lain baik di tingkat yang sama maupun ke tingkat yang lebih tinggi dalam rangka mengoptimalkan penatalaksanaan pasien. Tujuannya adalah untuk meningkatkan keilmuan, meningkatkan hubungan dengan sejawat, rekan kerja, dan pasien, serta menjamin tatalaksana pasien secara komprehensif dan berkesinambungan. Proses konsultasi dan rujukan memungkinkan pelayanan kedokteran menjadi tidak terkotak-kotak. Namun hal ini membutuhkan koordinasi dan komunikasi efektif antar dokter, pasien dan tenaga kesehatan lain.
THE EFFECT OF SNACK INTERVENTION TOWARD WORKING DURATION AMONG HELPER WORKERS IN CONTAINER COMPANY Nove Maria; Setyawati Budiningsih; Dian Kusumadewi; Retno Asti Werdhani; Ance Adriani
Majalah Kedokteran Indonesia Vol 68 No 12 (2018): Journal of The Indonesian Medical Association Majalah Kedokteran Indonesia Volu
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v68i12.205

Abstract

Pendahuluan: Asupan gizi yang baik pada tenaga kerja dapat memengaruhi produktivitas kerja. Namun, banyak pekerja yang tidak memerhatikan kecukupan asupan gizi mereka, termasuk pekerja helper di perusahaan peti kemas. Berdasarkan data International Labor Office (ILO) tahun 2005, diet yang tidak seimbang dapat menurunkan produktivitas sampai 20%. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian makanan selingan terhadap lama pengerjaan pada pekerja helper di perusahaan peti kemas. Metode: Desain penelitian ini adalah pra-eksperimen yang dilakukan selama empat minggu. Sebanyak delapan belas responden yang merupakan pekerja helper diberikan makanan selingan satu kali sehari, sebesar 300 kkal selama empat minggu. Asupan makanan responden dicatat dengan food record setiap minggu (dua hari kerja dan satu hari libur) dan dianalisis dengan aplikasi Nutrisurvey serta perhitungan manualHasil: Terdapat perbedaan rerata yang bermakna pada lama pengerjaan total (berkurang dua jam delapan menit) sebelum dan sesudah intervensi (p < 0,001). Kesimpulan: Pemberian makanan selingan satu kali sehari selama empat minggu dapat mempersingkat lama pengerjaan pada pekerja helper.  
MATA-DATA: DATA VISUALIZATION IN APPROACHING EVIDENCE-BASED HEALTH POLICY Tanoto, Rodri; Khoe, Levina Chandra; Werdhani, Retno Asti
ASEAN Journal of Community Engagement Vol. 3 No. 1 (2019)
Publisher : UI Scholars Hub

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Abstract

Data and information is the key in implementing evidence-based health policy, which has been problematic in Indonesia. The communication between researchers and policy makers must be further strengthened, by encouraging data visualizations as the narrative tools to optimize those communications. Mata-Data (https://mata-data.com) aimed to present national data on health and its social determinants in dynamic data visualization, which was previously presented in tables only. This program were developed in several steps. First, data extraction and analysis from data bank and offical reports. Second, website development subcontracted to external consultants. Third, trial and feedback conducted using online forms, both in quantitative and qualitative data. Fourth, evaluation and dissemination. Several important findings were established. At first, the limitation of data types (mainly categorical and ordinal) means that the multivariate display of data in one graphic was unavailable. However, in general, the user experiences were favorable. The superiority of data visualizations was agreed by the users. Nevertheless, several concerns emerged. First, the use of mobile device was growing. Second, the need of user for reference points, instead of comparing between provinces. Last, the interest for geographically deeper data, especially on city-district level. In conclusion, it can be observed that this program has evolved into something specific for Indonesian context. Further analysis in various concerns is needed to further how Mata-Data can improve data communication in Indonesia.
Assessment of compliance to standard precautions among nurses using the Health Belief Model Rusli, Noer Triyanto; Mansyur, Muchtaruddin; Kekalih, Aria; Sulistomo, Astrid; Werdhani, Retno Asti
Universa Medicina Vol. 39 No. 3 (2020)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2020.v39.199-206

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BACKGROUNDThe application of Standard Precautions (SP) has become a significant challenge for healthcare workers, especially in developing countries, endangering their safety and increasing their exposure to blood-related pathogens. This study was aimed at exploring the factors related to nurses’ compliance with the practice of SP.METHODSA cross-sectional study was conducted on 120 nurses working at a hospital in Palembang. Health Belief Model components of the subjects were recorded through questionnaires. A 12-point observation form assessed the nurses’ SP compliance. Multiple logistic regression models were used to explore factors associated with nurses’ compliance.RESULTSThe results showed that 56.7% of participants had good compliance, although the five moments of hand hygiene still needed to be improved. The study revealed that the proportion of the operating room and emergency room nurses who complied with the SP was larger than the proportion of those who worked at the other wards (OR=2.57, 95% CI 1.51-4.36). The nurses who had received training also showed a larger proportion of compliance with SP than those who had not been trained (OR=2.70, 95% CI 1.07-6.79).CONCLUSIONNurses’ behavior to SP was significantly associated with the adequacy of the training and work unit. It is suggested that the practice of SP was also influenced by enabling factors and subjective norms. Adequate training of nurses, provision of infection prevention equipment, and assessment of occupational exposures need to be introduced.
PASCAOPERASI ADENOMA HIPOFISIS HUBUNGAN ANTARA DURASI AWITAN DENGAN LUARAN KLINIS VISUS DAN LAPANG PANDANG Renindra Ananda Aman,* Reki Setiawan,* Retno Asti Werdhani,* Samsul Ashari,* David Tandian,* Syaiful
NEURONA Vol. 37 No. 3 Juni 2020
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION PITUITARY ADENOMAS CAN CAUSE DECREASE OF VISUAL ACUITY VA NARROWING VISUAL FIELD VF SEVERAL STUDIES HAVE SHOWED THAT THE DURATION OF COMPLAINTS WERE RELATED SIGNIFICANTLY WITH CLINICAL OUTCOMES AS A NATIONAL REFERRAL CENTER HOSPITAL ALL PITUITARY ADENOMA PATIENTS WHO CAME TO OUR INSTITUTION WERE REFERRED FROM OPHTHALMOLOGISTS NEUROLOGISTS AND NEUROSURGEONS FROM OTHER INSTITUTIONS
Frekuensi Keteraturan Senam dan Penurunan Tekanan Darah Anggota Klub Jantung Sehat Pondalisa, Jakarta Tahun 2000 - 2005 Retno Asti Werdhani
Jurnal Kesehatan Masyarakat Nasional Vol. 1 No. 5 April 2007
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.954 KB) | DOI: 10.21109/kesmas.v1i5.292

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Prevalensi hipertensi di Indonesia meningkat bersamaan dengan meningkatnya usia. Untuk itu, upaya pencegahan hipertensi dan komplikasinya perlu dilakukan sejak dini jauh sebelum usia lanjut. Olahraga khususnya jenis aerobik diketahui dapat mengendalikan tekanan darah. Penelitian ini bertujuan mengetahui hubungan frekuensi dan keteraturan senam terhadap penurunan tekanan darah pada peserta program latihan. Desain studi yang digunakan adalah kohort retrospektif dengan metoda analisis Cox Regression. Penelitian dilakukan terhadap sumber data sekunder 132 anggota KJS Pondalisa yang merupakan salah satu sarana olahraga masyarakat, selama periode satu tahun keanggotaan. Hasil penelitian memperlihatkan bahwa tidak ada anggota yang melakukan senam 3xper minggu sesuai program dengan keteraturan senam anggota maksimum selama 15 minggu. Penelitian ini menemukan bahwa seluruh anggota KJS Pondalisa belum melakukan olah raga sesuai dengan anjuran. Efek frekuensi senam 2xper minggu terhadap penurunan tekanan darah tidak berbeda secara bermakna dengan efek frekuensi senam < 2xper minggu. Penurunan tekanan darah pada frekuensi senam 2xper minggu didapatkan bila dilakukan selama > 8 minggu berturut-turut.Kata kunci : Frekuensi, teratur, senam/olahraga, penurunan tekanan darahAbstractThe prevalence of hypertension in Indonesia increases with age. Health promotion is needed to prevent hypertension and its complications among those who have not yet reached old age. Sport especially aerobic type has been known to control blood pressure. The objective of the study is to evaluate the association among frequency and regularity of exercise with blood pressure reduction. A Retrospective cohort study and Cox Regression analysis was conducted using secondary data of members of KJS Pondalisa during the first year of membership. The result of study showed that there were no member doing exercise three times weekly as programmed. The maximum exercise’s regularity was 15 weeks. There is no statistically significant effect of two times weekly exersices on reduction of blood presure compared to frequency of less than two times weekly. Reduction of blood presure will be occured if the exercise is conducted for more than 8 weeks continuously.Keywords: Frequency, regular, exercise, blood pressure reduction
Immunization competence retention in medical students: a comparation between conventional lectures and lectures with simulations method Hartono Gunadi; Rini Sekartini; Retno Asti Werdhani; Ardi Findyartini; Muhammad Arvianda Kevin Kurnia
Paediatrica Indonesiana Vol 55 No 6 (2015): November 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.46 KB) | DOI: 10.14238/pi55.6.2015.339-44

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Background Immunization is recognized as one of the strategies to reduce vaccine preventable diseases. Competency related to immunization are consequently important for medical students and the medical school needs to assure the competence acquisition. Objective To assess competence related to immunization and its retention following lectures with simulations compared to lectures only. Methods A quasi-experimental study was conducted to the 5th year students of University of Indonesia Medical School during the Child Adolescent Health Module in 2012-2013. The intervention group had lectures with simulations and the control group had lectures only. Immunization knowledge was assessed with a 30 multiple choice question (MCA) items performed before and after the module. Competence retention was assessed by MCQ (knowledge) and OSCE (skills) 2-6 months afterwards. Results Sixty eight subjects for each group with similar characteristics were analyzed. There was significant difference after module MCQ score between two groups. Competence retention in 2-6 months after module completion was better in intervention group, both for the knowledge (median MCQ score of 70.00 (range 37-93) vs. mean score of 58.01 (SD 12.22), respectively; P<0.001) and skill (OSCE mean scores of 75.21 (SD 10.74) vs. 62.62 (SD 11.89), respectively; P < 0.001). Proportion of subjects in the intervention group who passed both the MCQ and OSCE were also significantly greater. Conclusion Lectures with simulations are proved to be more effective in improving medical students’ immunization competence as well as its retention compared to lectures only approach.
Inter-Professional Collaboration in Prevention and Management Problems of Infant and Toddler Nutrition Retno Asti Werdhani
Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Vol 3, No 1 (2020): January
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.54167

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One of the functions of the primary care/family physician in case management is as a care coordinator/coordinator of the patient’s management1. McDonald defines a care coordinator as a patient’s management activity in healthcare that involves two or more participants (including patients) to improve the quality of health services. The definition emphasizes the need for collaboration between doctors and various parties including patients, families, and other health workers in managing health problems2. This paper emphasizes coordination and collaboration between health workers and families, which aims to increase knowledge and perceptions of families and communities to prevent malnutrition events such as failure to thrive, or obesity in children in the management of the first 1000 days of life.Management of the first 1000 days of life and growth and development monitoring needs doctors who motivate as well as parenting guidance to be able for caring and feeding the baby, as well as directly monitor the growth and development of their children. Many perceptions and stigmas develop in community can affect parenting parents towards their children. Accordingly, the function of the family physician is expected to have the ability as a care coordinator to support the successful management of the first 1000 days of life. This service requires collaboration between doctors and other healthcare professionals. This is in line with a spirit of partnership and cross-sector cooperation3. Primary care/family physician responsible for providing health services sustainably and comprehensively to individuals, families, and the community, in collaboration with other health workers. Primary care/family physicians manage various resources for the benefit of patients and families. Health services in primary care services provide primary to tertiary prevention services4, which doctors cannot do alone. Primary care/family physician is not only responsible for primary prevention and screening, however, must also be prepared to manage health problems in the first 1000 days of life, growth, and development, including facilitating referral and reconciliation. This responsibility proves the importance of collaboration practice in primary care services.