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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Journal of Tropical Pharmacy and Chemistry JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Pengabdian Masyarakat (ABDIRA) Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Sains dan Kesehatan

Niken Indriyanti

Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4295845

Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Edukasi Penggunaan Suplemen Kesehatan yang Rasional di Samarinda Niken Indriyanti; Fahriani Istiqamah Jafar; Fika Aryati
Jurnal Pengabdian Masyarakat (abdira) Vol 2, No 1 (2022): Abdira, Januari
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v2i1.70

A phenomena increased use of health supplement in Samarinda community is lasting since COVID-19 pandemic. The people knowledge about health supplement consumption a are dominantly received from advertisement and published article on internet. However, not all of the informations are correct. Therefore, this community service program was a webinar and interactive discussion about the use of health supplement, in a zoom meeting media. The pretest and post test were used to evaluate the benefit of this program. From a total of 67 participants, 37 of them fill the pretest form, and 28 fill the posttest form. As many as 92% of participants believe that health supplements keeps body healthy, and 43% of them routinely consumed health supplements. After our explanation and discussion session, 86% participants stated that very much new information they received, ang 50% of them said that their way to use health supplement were not fully correct. As many as 93% participants satisfied to this community service program. It can be concluded that this education program was successful.

Drug-Herb Interaction between Metformin and Momordica charantia in Diabetic Mice Asri Dwi Endah Dewi Pramesthi; Mirhansyah Ardana; Niken Indriyanti
Molecular and Cellular Biomedical Sciences Vol 3, No 2 (2019)
Publisher : Cell and BioPharmaceutical Institute

Background: Bitter gourd has various metabolites, such as momordicosides, polypeptide-P, v-insulin, charantin, and vicine that have antidiabetic effect. It has synergistically effect while combined with oral diabetic drugs, such as metformin as glucose lowering agent. The aim of this study is to investigate the interaction of bitter gourd fruit juice and metformin as glucose lowering agent in mice.Materials and Methods: Alloxan-induced diabetic mice were treated with bitter gourd fruit juice, metformin, and the combination of those two for 21 days. Glucose level was checked on first and last day of treatment.Results: Furthermore, blood glucose levels measurement showed no significant difference between groups compared with negative control, which was p>0.05. The stomach of groups that treated with metformin and bitter gourd fruit juice histopathologically showed no significant differences.Conclusion: The use of bitter gourd once daily together with metformin is a better choice, while twice daily might induce hypoglycemia and mice death. There is no interaction between them on lowering blood glucose.Keywords: metformin, Momordica charantia, diabetes mellitus

Dampak Positif Fraksi Etil Asetat dari Kalanchoe pinnata terhadap Antibodi Anti-Smith dan Sel T Reg pada Mencit Lupus NIKEN INDRIYANTI; JUNAIDI KHOTIB; JOEWONO SOEROSO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.226 KB)

Kalanchoe pinnata (Lmk) Pers is a medicinal plant that has many activities, such as antioxidant, anti-infl ammation and immunosuppressant activities. Based on our previous study, aqueous extract of this plant leaves has a repairing eff ect on lupus nephritis model. The expected active compounds are flavonoids. Those compounds are separated in the ethyl acetate fraction. Therefore, this study observed the activity of the ethyl acetate fraction of Kalanchoe pinnata (Lmk) Pers on reducing the level of Anti- Smith autoantibody and the regulation function of CD4+CD25+ T reg in lupus mice. The experimental groups were a negative control group that received placebo, ethyl acetate fraction of Kalanchoe pinnata (Lmk) Pers (EF-KP) group and a positive control group that received cyclophosphamide. The anti-Sm level was measured by using indirect ELISA. The spleen cells were prepared for CD4+CD25+ T reg assay using fl ow cytometry. The result of this experiment was a reduction of anti-Sm antibody level. The decrease was suffi cient to stabilize lupus condition. The fl ow cytometry assay results showed the increase in the relative percentage of CD4+CD25+ T reg. This function can inhibit the reactivity of autoantigens, so it prevents tissue and organ damage from lupus. However, further research is needed to observe the complete mechanism.

Laporan Kasus: Penanganan Efek Samping Pseudoefedrin pada Pasien ISPA Anak: Case Report: Handling Pseudoephedrine Side Effects in Pediatric ISPA Patients Agata Tika Sari; Niken Indriyanti
Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 2 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Abstract Flu with various symptoms can be caused by infection or allergies. This case report focuses on the management of pseudoephedrine side effects in pediatric ISPA patients receiving polypharmacy therapy. An 8-year-old female patient came to the doctor to practice coughing, colds and fever for 2 days. The patient was then given Puyer containing amoxicillin 200 mg and Puyer for symptomatic symptoms containing paracetamol 200 mg, mebhydrolin napadisylate 50 mg 1/3 tablet, amboroxol 6 mg, dexamethasone 0.5 mg 1/3 tablet, pseudoephedrine HCL 60 mg and triprolidine. HCL 2.5 mg 1/4 tablet with the use of 3×1 for 15 powders. After drinking the powder, the patient complained of heart palpitations. abstrak flu dengan berbagai gejalanya dapat disebabkan oleh infeksi ataupun alergi. Laporan kasus ini berfokus pada penanganan efek samping pseudoefedrin pada pasien ISPA anak yang mendapatkan terapi polifarmasi. Pasien anak perembuan umur 8 tahun datang ke dokter praktek mengeluhkan batuk, pilek, dan demam sudah 2 hari. Pasien tersebut kemudian diresepkan puyer dengan kandungan amoxicillin 200 mg dan puyer untuk gejala simptomatis dengan kandungan parasetaml 200 mg, mebhydrolin napadisylate 50 mg 1/3 tablet, ambroxol 6 mg, dexamethasone 0.,5 mg 1/3 tablet, pseudoefedrin HCL 60 mg dan triprolidine HCL 2,5 mg 1/4 tablet dengan aturan pemakaian 3×1 untuk 15 puyer. Setelah minum puyer tersebut pasien mengeluhkan jantung berdebar-debar.

Ekstrak Daun Cocor Bebek (Kalanchoe pinnata) untuk Terapi Preventif Lupus pada Mencit yang Diinduksi dengan 2,6,10,14 Tetramethylpentadecane Niken Indriyanti; Afrillia Nuryanti Garmana
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 3 (2011): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Cocor bebek Plants (Kalanchoe pinnata) has been observed to have a potent immunosuppressant compounds in BALB/c mice with Delayed Type Hypersensitivity test (DTH). Compounds are efficacious immunosuppression can be used for treatment of autoimmune diseases such as lupus. The purpose of this study was knowing the class of compounds in leaf extracts cocor bebek and test whether the extract can prevent the occurrence of lupus in test animals. Methods: In this study the identification of classes of compounds present in Cocor bebek leaf extracts and testing imunnosupression activities from test animals BALB/c mice induced lupus using 2,6,10,14 tetramethylpentadecane (TMPD). Parameters measured lupus glomerulonephritis which was known by the presence of proteinuria using a test strip supported by data on changes in weight. Results: Extracts of cocor bebek leaves positive contain tannins, flavonoids, saponins and steroid / triterpene. Mice given the extract of Cocor bebek leaves every day until the 3rd month after not having induced proteinuria, while untreated mice had proteinuria up to +2 (proteinuria levels> 30 mg / dL). Key words : Cocor bebek, BALB/c mice, lupus, TMPD, glomerulonefritis ABSTRAK Tanaman cocor bebek (Kalanchoe pinnata) telah diteliti memiliki senyawa yang berkhasiat immunosupresan pada mencit BALB/c dengan uji Delayed Type Hypersensitivity (DTH). Senyawa yang berkhasiat imunosupresan dapat digunakan untuk penanganan penyakit autoimun, misalnya lupus. Tujuan penelitian ini adalah Mengetahui golongan senyawa dalam ekstrak daun cocor bebek dan menguji apakah ekstrak tersebut dapat mencegah terjadinya lupus pada hewan uji. Metode : Pada penelitian ini dilakukan identifikasi golongan senyawa yang ada dalam ekstrak daun cocor bebek dan pengujian aktivitas imunosupresannya terhadap hewan uji mencit BALB/c yang diinduksi lupus menggunakan 2,6,10,14 tetramethylpentadecane (TMPD). Parameter lupus yang diukur adalah glomerulonefritis yang diketahui dengan adanya proteinuria menggunakan strip test didukung dengan data perubahan berat badan. Hasil : Ekstrak daun cocor bebek positif mengandung tanin, flavonoid, saponin dan steroid/triterpen. Mencit yang diberi ekstrak daun cocor bebek setiap hari sampai bulan ke-3 setelah diinduksi tidak mengalami proteinuria, sedangkan mencit yang tidak ditreatmen mengalami proteinuria sampai +2 (kadar proteinuria >30 mg/dL). Kata kunci : cocor bebek, mencit BALB/c, lupus, TMPD, glomerulonefritis.

Aktivitas Ekstrak Etanol dan Fraksi Akar Singawalang (Petiveria alliacea L.) Terhadap Jamur Penyebab Ketombe dengan Metode Broth Microdilution Niken Indriyanti; I Ketut Adnyana; Elin Yulinah Sukandar
Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 2 (2013): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Dandruff was an anomaly of scalp caused by abnormal growth of Pityrosporum ovale. Ketoconazole and sulfuric compounds known as antifungal, include antifungal against Pityrosporum ovale. One of medicinal plant that has polysulfide compounds was Singawalang (Petiveria alliacea L.). Activity of ethanol extract and fraction of singawalang roots tested using microdilution broth method appropriate to Clinical and Laboratory Standard Institute (CLSI) standard, then growth profiles determined by colony count. Microdilution test results showed that Singawalang roots extract has antifungal activity against Pityrosporum ovale with Minimum Inhibition Concentration (MIC) 16 Î¼g/mL and Minimum Fungicidal Concentration (MFC) 64 Î¼g/mL. Fraction that has highest activity against Pityrosporum ovale was n-hexane fraction of Singawalang roots with MIC 16 Âµg/ml dan MFC 128 Î¼g/mL. The higher activity of the extract predicted that there were some polysulfide compounds have synergic activity. Key words : singalawang roots, polysulfide, Pityrosporum ovale ABSTRAK Ketombe adalah suatu keadaan anomali pada kulit kepala disebabkan jamur Pityrosporum ovale dalam jumlah diatas normal. Selama ini antijamur yang digunakan adalah ketokonazol. Selain itu, senyawa sulfur juga diketahui aktif terhadap jamur. Salah satu tanaman yang telah diteliti mengandung senyawa polisulfida adalah tanaman singawalang (Petiveria alliacea L.). Penelitian aktivitasnya terhadap Pityrosporum ovale dilakukan dengan Broth Microdilution sesuai standar Clinical and Laboratory Standard Institute (CLSI). Konsentrasi Hambat Minumum (KHM) terkecil ada pada ekstrak dan fraksi n-heksan, yaitu 16 Î¼g/mL, seperempat dari aktivitas ketokonazol. Konsentrasi Fungisidal Minimum (KFM) terkecil ekstrak adalah 64 Î¼g/mL, dan pada fraksi n-heksan ekstrak etanol akar singawalang dengan konsentrasi 128 Î¼g/mL. Diduga aktivitas antijamur lebih kuat pada ekstrak karena adanya kombinasi aktivitas beberapa senyawa polisulfida yang bekerja sinergis. Kata kunci : Akar singawalang, polisulfida, Pityrosporum ovale

Aktivitas Antifungi Fraksi Etilasetat Akar Singawalang (Petiveria alliacea L.) terhadap Aspergillus niger Niken Indriyanti
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Aspergillus niger is a mold that can infect respiratory tract in certain condition. Azoles are used to solve this infection. Drug development on antifungal drugs still continued, one of the resorce is from plant. A plant that widely studied as antifungi is singawalang (Petiveria alliacea L.). Activity of ethanol extract and fraction of singawalang roots on Aspergillus niger tested by microdilution broth method appropriate to Clinical and Laboratory Standard Institute (CLSI) standard. Microdilution test results showed that Singawalang roots extract has antifungal activity against Aspergillus niger with Minimum Inhibition Concentration (MIC) 32 Î¼g/mL and Minimum Fungicidal Concentration (MFC) 1048 Î¼g/mL. Fraction that has high activity against Aspergillus niger was ethylacetate fraction of Singawalang roots with MIC 128 Âµg/ml dan MFC 512 Î¼g/mL. The higher activity of the extract than the fraction was predicted as the impact of multiple compounds that have synergic activity. The growth profile of Aspergillus niger showed unconstant result and tends to descend. However, further research needed to ensure this effect. Keywords: antifungal, microdilution, singawalang (Petiveria alliacea L.), Aspergillus niger ABSTRAK Aspergillus niger merupakan kapang penginfeksi saluran pernafasan pada kondisi tertentu. Obat-obat golongan azol biasa digunakan untuk mengatasi infeksi ini. Pengembangan obat antifungi saat ini terus dilakukan, termasuk dari tanaman. Salah satu tanaman yang telah banyak diteliti memiliki efek antifungi adalah tanaman singawalang (Petiveria alliacea L.). Pengujian dilakukan dengan Broth Microdilution sesuai standar Clinical and Laboratory Standard Institute (CLSI). Ekstrak akar singawalang menghambat pertumbuhan Aspergillus niger dan memiliki KHM 32 ppm dan KFM 1048 ppm. Hasil dan Fraksi Ekstrak Akar Singawalang Terhadap Aspergillus niger pada fraksi etilasetat ekstrak etanol akar singawalang adalah Konsentrasi Hambat Minimum (KHM) 128 Î¼g/mL dan Konsentrasi Fungisidal Minimum (KFM) 512 Î¼g/mL. KHM ekstrak yang lebih tinggi diduga karena senyawa yang bekerja sinergis. Profil pertumbuhan Aspergillus niger tidak konstan dan cenderung menurun mirip efek fungisida sehingga penelitian lanjutan diperlukan untuk memastikan efek tersebut. Kata Kunci: Antifungi, mikrodilusi, singawalang (Petiveria alliacea L.), Aspergillus niger

Minireview: Prospect of Doxycycline in Systemic Lupus Erythematosus Treatment Niken Indriyanti; Joewono Soeroso
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 5 (2019): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i5.173

Doxycycline has non-antibiotic effects which are necessary for lupus treatment, such as immunosuppressive, anti-inflammatory, and anti-depressive effects. This widely used drug is a promising one to be developed as lupus drug since doxycycline has no data of its microbial resistance and it is safe for maternity. The other benefit is that doxycycline has lower side effects than the current drugs for lupus treatment. It gives excellent chances for women with lupus to be pregnant and have healthy babies. This article contains the compilation data of doxycycline target sites beyond its beneficial activities for lupus and also its limitations. Finally, this data will be a background for doxycycline in lupus drug development.

Nephrotoxicity Risk of Cyclophosphamide in Lupus Model Niken Indriyanti
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.289

Cyclophosphamide is one of the standard therapies for lupus, especially lupus nephritis based on its immunosuppressive effect. However, cyclophosphamide is also known as a nephrotoxic agent. Therefore, this research was aimed to measure the effect of cyclophosphamide at the dose that comparable to the human dose of 1 mg/kg BW on the kidney of lupus mice induced by means of 2,6,10,14-tetramethylpentadecane (TMPD). In this research, the IL-6 as a pro-inflammatory cytokine was tested by using flow cytometry method. In addition, the structural damage of the kidney tissues was assessed by means of Moroni’s kidney organ scoring method for lupus. The result showed that cyclophosphamide reduced the IL-6 significantly with the value of 36.72±22.79% for the TMPD-treated group; 32.59±9.97% for the cyclophosphamide group; and 30.25±4.48% for the naïve group. Moreover, the damages of the kidney tissues on the cyclophosphamide group were more severe than the TMPD-treated group. In conclusion, despite its anti-inflammatory effect which is useful for lupus, cyclophosphamide has a severe nephrotoxic effect which harms the patient. The effects may be a cause of the long interval use of cyclophosphamide. It can be a consideration for the further research and the next revision of the guideline for lupus nephritis treatment.

Pengujian Kualitas Aspek Mikrobiologi Air Minum Isi Ulang Indah Puspitasari; Niken Indriyati; Victoria Yulita Fitriani; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 1 (2015): Proceeding of Mulawarman Pharmaceuticals Conferences (Prosiding Seminar Nasional Kefa
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Beberapa tahun terakhir ini usaha air minum isi ulang telah berkembang pesat di di Indonesia, khususnya di Kota Samarinda. Setiap usaha air minum wajib melakukan pemeriksaan mutu produk sesuai dengan peraturan yang berlaku. Penelitian ini dilakukan untuk memperoleh gambaran kualitas aspek mikrobiologi air minum isi ulang yang dijual di tiga depo air minum isi ulang di Samarinda. Pengujian mikrobiologis dilakukan meliputi pemeriksaan angka cemaran bakteri dengan metode angka lempeng total (ALT), pemeriksaan mikrobiologis dengan Most Probable Number (MPN), serta pemeriksaan bakteri koliform dan bakteri patogen, seperti Escherichia coli, Salmonella thyposa, dan Staphylococcus aureus. Hasil penelitian menunjukkan bahwa tidak ada satupun sampel yang melebihi batas yang dipersyaratkan dalam air minum serta sampel yang diuji tidak mengandung Escherichia coli dan Salmonella thyposa, namun 2 sampel mengandung bakteri Staphylococcus aureus.

Co-Authors Afrillia Nuryanti Garmana Agata Tika Sari Akhmad Ifda Hanip Alexander Mansyuria Andi Asti Ainun Annisa Annisa Antadini Antadini Arsyik Ibrahim Asri Dwi Endah Dewi Pramesthi Bella Sasmiyandri Debby Putri Mutiara Yusuf Dewi Mayasari Dewi Rahmawati Dewi Rahmawati Dewi Rahmawati Elin Yulinah Sukandar Eni Ayu Putri Erika Heldina Erwin Samsul Fahriani Istiqamah Jafar Fika Aryati Fika Aryati Frety Aula Nur Islamika Hafifah Sarwanda Hajrah Hajrah Hajrah Hajrah Halimathussadiah Halimathussadiah Halimatusya’ Diah Hifdzur Rashif Rija’i I Ketut Adnyana Indah Puspitasari Joewono Soeroso JOEWONO SOEROSO Jorgi Imanuel Emor Jufriyanto Pasang Junaidi Khotib Kawareng, Andi Tenri Kiki Fitria Anggraeni Kiki Riski Amelia Andi Kornelius Yustico Trimedya Purba Maharani Adelia Zeline Maria Almeida Maria Saena Puru Meilanie Dwi Anggraeni Meilina Purnama Ningrum Mirhansyah Ardana Muhammad Faisal Mukti Priastomo Nabila Nur Rahma Hidayat Nilam Sari Nur Aini Buring Incau Nur Masyithah Z Nur Masyithah Zamruddin Nur Masyithah Zamruddin Nur Mita Nurul Fitriani Nurul Syafitri AR Pabely Nahwan Maulana Pabely Nahwan Maulana Pakendek Fefryani Putri Anggreini Ragil Sekar Ayuni Raisa Fadilla Renaldi Adi Saputra Rida Wahda Maulida Tahir Risna Agustina Rolan Rusli Sabaniah Selfia Selfia Suparningtyas, Juniza Firdha Tiya Nur Aini Velita Rosari VICTORIA YULITA FITRIANI Vita Olivia Siregar Widya Vergiana Oktrinorma Wilujeng Ayu Wisnu Cahyo Prabowo

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