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EKSTRAK CACING TANAH SEBAGAI INOVASI PENYEMBUHAN ULKUS DIABETIK BERBASIS INDUKSI DENSITAS AKSON Mardiati, Ni Putu Jeny; Yunitasari, Arinda Nur; Sari, Dwi Astika; Saraswasta, I Wayan Gede; Putra, Fetreo Negeo; Kristianto, Heri
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Reduction of nerve growth factor expression in diabetic ulcer affects overall wound healing. Earthworm (Pheretima aspergillum) can stimulate schwann cell proliferation and migration to support axonal elongation. The objective of this study is to compare wound healing functions in diabetic ulcer of rats using earthworm extract, hydrogel, and conventional dressing. This study applied a true-experimental posttest only controlled group design. 21 days after treatment, the group receiving earthworm extract had a significantly higher percentage of wound contraction and axonal density compared to the control group (p<0.05). These results show that earthworm extract can promote wound healing in diabetic ulcer.Â Keywords: Diabetic Ulcer, Earthworm (Pheretima aspergillum), Wound Contraction, Peripheral Nerve Regeneration.

Efektifitas Ekstrak Bunga Cengkeh (Syzygium aromaticum) terhadap Jumlah Pembuluh Darah Kapiler pada Proses Penyembuhan Luka Insisi Fase Proliferasi Fatimatuzzahroh, Fatimatuzzahroh; Firani, Novi Khila; Kristianto, Heri
Majalah Kesehatan FKUB Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Brawijaya

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Tindakan pembedahan merupakan salah satu tindakan medis yang penting dalam pelayanan kesehatan. Tindakan tersebut melibatkan luka insisi atau penyayatan jaringan. Hingga saat ini, penanganan luka insisi pada umumnya menggunakan povidone iodine 10 % yang secara klinis dapat menimbulkan parut. Ekstrak bunga cengkeh mengandung 16-23 % minyak atsiri yang terdiri dari 64-85 % eugenol. Eugenol mengandung senyawa aktif seperti polifenol, flavonoid, saponin dan tannin yang saat ini banyak dikembangkan sebagai terapi komplementer dalam proses penyembuhan luka, khususnya luka insisi. Tujuan penelitian ini adalah untuk mengetahui efektivitas ekstrak bunga cengkeh (Syzygium aromaticum) terhadap jumlah pembuluh darah kapiler pada proses penyembuhan luka insisi fase proliferasi. Desain penelitian menggunakan true experiment post-test design dengan menggunakan 25 ekor tikus yang dibagi menjadi 5 kelompok yang terdiri dari 3 kelompok perlakuan yang diberi ekstrak bunga cengkeh (dosis 20 %, 40 % dan 60 %) diberikan dalam bentuk cair dan 2 kelompok kontrol yang diberi povidone iodine dan normal saline. Perawatan luka dilakukan selama 14 hari pada luka insisi seluas 4 cm lalu diukur jumlah pembuluh darah kapiler pasca perawatan luka insisi. Analisis data menggunakan ANOVA menunjukkan adanya perbedaan yang signifikan kelompok ekstrak bunga cengkeh 60 % dibandingkan kelompok kontrol dengan nilai signifikansi p sebesar 0,001 (p < 0,05). Kesimpulan penelitian ini yaitu perawatan luka insisi dengan ekstrak bunga cengkeh (Syzygium aromaticum) dosis 60 % mempengaruhi jumlah kapiler pada tikus putih (Rattus norvegicus) galur Wistar.Â Kata kunci :Â Ekstrak bunga cengkeh, Jumlah pembuluh darah kapiler, Luka insisi

Pengaruh Pemberian Ekstrak Kuncup Bunga Cengkeh (Syzygium aromaticum) terhadap Peningkatan Ketebalan Epitelisasi Luka Insisi pada Tikus Putih (Rattus novergicus) Galur Wistar Pratiwi, Arum Desi; Ratnawati, Retty; Kristianto, Heri
Majalah Kesehatan FKUB Vol 2, No 3 (2015)
Publisher : Faculty of Medicine Universitas Brawijaya

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Luka insisi merupakan hasil dari prosedur invasif yang biasa dilakukan untuk prosedur pemeriksaan atau pengobatan suatu penyakit. Ekstrak kuncup bunga cengkeh (Syzygium aromaticum) mengandung eugenol, vitamin A,C, dan E, tanin, saponin, dan senyawa flavonoid yang berperan dalam proses penyembuhan luka yang melibatkan proses epitelisasi. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak kuncup bunga cengkeh terhadap peningkatan ketebalan epitelisasi luka insisi pada tikus putih (Rattus novergicus) galur Wistar. Penelitian ini menggunakan desain true experimental laboratory.Â Pada 25 ekor tikus Wistar yang dibagi secara random dalam 5 kelompok diberi perlukaan dengan model insisi. Kelompok perlakuan diberikan ekstrak kuncup bunga cengkeh dengan dosis 20 %, 40 %, dan 60 % dalam sediaan cair. Kelompok kontrol positif diberikan povidone iodine dan kelompok negatif diberikan normal saline. Ketebalan epitelisasi luka insisi pada hari ke-14 diamati dengan metode histologi. Analisis menggunakan uji one way ANOVA yang dilanjutkan dengan uji post hoc Tukey. Hasil penelitian menunjukkan bahwa pemberian ekstrak kuncup bunga cengkeh dosis 60 % berpengaruh pada peningkatan ketebalan epitelisasi secara signifikan sebesar 105,18 Âµm (p < 0,05) atau 2 kali lipat dibandingkan keempat kelompok lainnya. Kesimpulan dari penelitian ini adalah ekstrak cengkehÂ konsentrasi 60 % meningkatkan ketebalan jaringan epitel dibandingkan dengan kelompok lainnyaÂ Kata kunci : Ekstrak kuncup bunga cengkeh, Ketebalan epitel, Luka insisi.

THE EFFECT OF PHERETIMA ASPERGILLUM EXTRACT ON THE INCREASE OF HAIR FOLLICLES NUMBER IN DIABETIC ULCER GRADE II IN WISTAR RAT Kristianto, Heri; Sari, Dwi Astika
in process
Publisher : ETN Centre Indonesia

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Background: Diabetic ulcer is the result of serious microvascular complication of diabetes mellitus that is caused by vascular insufficiency, resulting in dry skin, loss of taste, and a decrease in the number of hair follicles. Earthworm (Pheretima aspergillum) has a bioactive component of IGF-1 (insulin like growth factor 1), which can stimulate cell growth and survival. IGF-1 is involved in hair follicle growth by regulating cell proliferation and migration through the cellular mechanism of its receptor (IGF - 1R). This study aimed to determine the effect of earthworm extract on the increase of hair follicles number in rats induced diabetic ulcer stage II. Methods: This study used a true experimental posttest only controlled group design. Samples were randomly selected, divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. Ulcer treatment is done for 21 days, on day 22, rats were euthanized. The numbers of hair follicles in skin tissue connecting to nervous fibers were identified using silver impregnation stain. Results: The results showed that the treatment groups that received earthworm extract had significantly higher number of hair follicles as compared to the control groups (p=0.000). The administration of earthworm extract via topical has an optimal effect on the increase of hair follicles numbers. Conclusion: It can be concluded that the extract of earthworm (Pheretima aspergillum) can increase the growth of hair follicles in rats diabetic models. Keywords: diabetic ulcer, earthworm (Pheretima aspergillum), hair follicles.

ANALISIS PERUBAHAN HEMODINAMIKA TUBUH PADA PASIEN HIPERGLIKEMIA DENGAN TERAPI REHIDRASI DI IGD RSUD DR. ISKAK TULUNG AGUNG Lutfi, Erik Irham; Wihastuti, Titin Andri; Kristianto, Heri
Jurnal Kesehatan Mesencephalon Vol 3, No 2 (2017): Jurnal Kesehatan Mesencephalon - Oktober 2017
Publisher : Jurnal Kesehatan Mesencephalon

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Abstract : Disease patterns change in the World led to significant increases of non infectious diseases, one of which is DM hyperglycemia with Indonesian rank fifth in the World. Uncontrolled DM hyperglycemia will lead an increase in osmolarity that will disrupt the bodys fluid and electrolyte balance. The primary management of hyperglycaemia according to ADA is by fluid rehydration therapy. Successful replacement of rehydration fluids can be seen by monitoring continuous and sustained of hemodynamics. This study aims is to analyze the changes in hemodynamics in hyperglycemia patients receiving rehydration therapy.This study included into comparative studies with a cohort approach. The number of samples in this study as many as 56 respondents. Date collection using consecutive sampling technique. From the result of the research based on the bivariate analysis test, there is no change in the hemodynamic variables with p value for each hemodynamic research variable more than 0.005 (p value of pulse frequency variable = 0,825, p value of respiratory frequency = 0,434, p value of systolic blood pressure = 0,534, p value of oxygen saturation = 0,007 and p value of consciousness = 0,368). Changes in osmolarity occur due to a decrease in blood glucose levels after fluid rehydration. This further proves that rehydration therapy is very effective in lowering blood glucose levels (hyperosmolarity) in the blood. Continuous osmolarity and hemodynamic examination is needed for hyperglycemic patients receiving rehydration therapy to determine the effect of rehydration therapy and to know the side effects of rehydration therapy so that prevention can be done to avoid problems causing emergency situations.Keywords : Rehydration Therapy, Osmolarity, HemodynamicsÂ Abstrak : Perubahan pola penyakit di dunia dengan angka penyakit tidak menular mengalami peningkatan. Penyakit tidak menular di Indonesia, yang meningkat salah satunya adalah penyakit DM dengan Indonesia berada pada peringkat ke lima di Dunia. DM Hiperglikemia yang tidak terkontrol akan menyebabkan peningkatan osmolaritas yang akan menganggu keseimbangan cairan dan elektrolit tubuh. Tatalaksana utama hiperglikemia menurut ADA adalah dengan terapi rehidrasi cairan. Keberhasilan penggantian cairan rehidrasi dapat dilihat dengan melakukan pemantauan secara berkesinambungan dan berkelanjutan. Penelitian ini bertujuan untuk menganalisis perubahan hemodinamika tubuh pada pasien hiperglikemia yang mendapatkan terapi rehidrasi. Penelitian ini termasuk kedalam penelitian komparatif dengan pendekatan cohort. Jumlah sampel dalam penelitian ini sebanyakÂ 56 responden dengan pengambilan data menggunakan teknik consecutive sampling. Dari hasil penelitian berdasarkan uji analisis bivariat tidak terlihat perubahan pada variabel hemodinamika tubuh dengan p value untuk masing-masing variabel penelitian hemodinamika lebih dari 0,005 (p value variabel frekuensi nadi = 0,825,Â p value frekuensi pernapasan = 0,434, p value variabel tekanan darah sistolikÂ = 0,534, p value variabel saturasi oksigen = 0,007 dan p value variabel kesadaran = 0,368). Perubahan osmolaritas terjadiÂ akibat adanya penurunan kadar glukosa darah setelah dilakukan rehidrasi cairan. Hal ini semakin membuktikan bahwa terapi rehidrasi sangat efektif dalam menurunkan kadar glukosa darah (hiperosmolaritas) di dalam darah. Pemeriksaan osmolaritas dan hemodinamika yang berkesinambungan sangat diperlukan bagi pasien hiperglikemia yang mendapatkan terapi rehidrasi untuk mengetahui efek terapi rehidrasi maupun untuk mengetahui efek samping dari terapi rehidrasi sehingga dapat dilakukan upaya pencegahan agar tidak menjadi permasalahan yang menimbulkan situasi kegawat daruratan.Kata kunci : Terapi Rehidrasi, Osmolaritas, Hemodinamika

ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN OUTCOME PASIEN CEDERA KEPALA YANG DIRUJUK DI IGD RSUD dr. ISKAK TULUNGAGUNG MELALUI PENDEKATAN MODEL INTERPERSONAL NURSINGHELDEGRAD E. PEPLAU Sasmito, Nanang Bagus; Wihastuti, Titin Andri; Kristianto, Heri
Jurnal Kesehatan Mesencephalon Vol 3, No 2 (2017): Jurnal Kesehatan Mesencephalon - Oktober 2017
Publisher : Jurnal Kesehatan Mesencephalon

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Abstract : Head injuries will affect more serious disorder compared with other organ traumatic. Lack of nurse competences, particularly on identify the early sign of critical head injuries and misunderstood of onset head injuries happened with the patient, will cause delays to give precise treatment and decision for the patient, such as giving reference to other hospital. The objective of this study is to analyze the influencing factor related to outcome of head injury patient in RSUD dr. Iskak Tulungagung using Interpersonal Interpersonal Nursing Model by Heldegrad E. Peplau approach. This research used analytical analytics comparative with cross-sectional approch. The data collected by purposive sampling and finally 78 respondent were included in this research. With regard to outcome of head injury patient whose referenced in, the bivariat analysis result showed conditions patients a head injury (p-value 0,005), assistance referral (p-value 0,042), the distnace referral (p value 0,020), and time referral (p value 0,006). In addition, the regression analysis showed variable pattients condition the most dominant relating to outcome patients a head injury referred (p value 0,001 and OR 16.184). The decrease of GCS value for patients who reference at other hospital indicated the deterioration of their condition. Hence, the values of GCS was important indication to be noticed.When in every phase in interpersonal nursing implementation well in patients referred to a head injury, so outcome head injuries with the glasgow outcome scale would be good.Key Word : Outcome Patient Head Injuries, Referrals, Interpersonal Nursing.Â Abstrak : Cedera kepala akan memberikan gangguan yang sifatnya lebih kompleksbila dibandingkan dengan trauma pada organ tubuh lainnya. Minimnya kompetensi yang dimiliki perawat dalam mengenali tanda dini kegawatan cedera kepala dan tidak memahami onset cedera kepala yang dialami oleh korban memberi dampak pada keterlambatan tindakan segara yang harus diberikan kepada pasien cedera kepala, salah satunya dalam membuat keputusan rujukan.Beberapa hal yang dapat mengurangi dampak dari pelaksanaanrujukan pasien yang tidak optimal, perlu disusun manajemenrujukan pasien gawat darurat yang berfungsi sebagai kerangka acuan bagi petugas kesehatan terlebih lagiperawat. Salah satu teori model keperawatan yang menunjang dan mengembangkan pelaksanaan rujukan adalah teori interpersonal relations in nursingdari Heldegard E Peplau. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berhubungan dengan outcome pasien cedera kepala yang dirujuk di IGD RSUDdr. Iskak Tulungagung melalui pendekatan model interpersonal nursing Heldegrad E. Peplau. Metode dalam penelitian ini adalah analitik komparatif dengan pendekatan cross-sectional. Jumlah sampel sebanyak 78 responden dengan menggunakan purposive sampling. Dari analisis bivariat faktor yang berhubungan dengan outcome pasien cedera kepala yang dirujuk adalah tingkat kesadaran pasien cedera kepala (p value 0,005), pendampingan saat merujuk (p value 0,042), jarak rujukan (p value 0,020) dan faktor waktu yang ditempuh (p value 0,006). Hasil analisis uji regresi logistik menunjukkan faktor kondisi pasien yang paling dominan berhubungan dengan outcome pasien cedera kepala yang dirujuk (p value 0,001 dan nilai OR 16.184). Pasien cedera kepala mengalami penurunan nilai GCS pada saat dirujuk merupakan petunjuk bahwa terjadi perburukan kondisi pasien, sehingga nilai GCS menjadi parameter yang penting utnuk diperhatikan. Sehingga apabila dalam setiap fase dalam interpersonal nursing dapat dilaksanakan dengan baik pada pasien cedera kepala yang dirujuk, maka outcome cedera kepala dengan penilaian glasgow outcome scale akan baik.Kata Kunci : Outcome Pasien Cedera Kepala, Rujukan, Interpersonal Nursing.

THE EFFECTS OF EARTHWORMSâ€™ (PHERETIMA ASPERGILLUM) ETHANOL EXTRACT TOWARD THE IMPROVEMENT OF NERVE FIBERS DENSITY IN DIABETIC ULCERS CARE DEGREE II OF RATS WISTAR Kristianto, Heri; Mardiati, Ni Putu Jeny
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Background. Diabetic ulcer is a chronic complication of diabetes mellitus which lead to infection and lowerÂ extremity amputation. Earthworm (Pheretima aspergillum) has bioactive substance of IGF-1 (insulin likeÂ growth factor 1) to promote Schwann cell proliferation, survival, and migration into the distal end in theÂ injured nerve area to support axonal re-growth.Objective. To investigate the effect of earthworm extract (Pheretima aspergillum) on the enhancement of nervous fibers density in rats induced diabetic ulcer stage II.Methods. This study applied a true-experimental posttest only controlled group design. Samples were divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. The patterns of nervous fibers connecting to hair follicles were identified using silver impregnation stain.Results. The result shows the groups receiving earthworm extract have significantly higher nervous fibers density compared to the control groups (p=0.000). The administered of earthworm extract via topical has an optimal effect on improving nervous fibers density.Conclusion. Earthworm extract promote regeneration of peripheral nerve in rats model of diabetic.

THE EFFECT OF PHERETIMA ASPERGILLUM EXTRACT ON THE INCREASE OF HAIR FOLLICLES NUMBER IN DIABETIC ULCER GRADE II IN WISTAR RAT Kristianto, Heri; Sari, Dwi Astika
Jurnal Luka Indonesia Vol 2 No 2 Juni 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.23

Background: Diabetic ulcer is the result of serious microvascular complication of diabetes mellitus that is caused by vascular insufficiency, resulting in dry skin, loss of taste, and a decrease in the number of hair follicles. Earthworm (Pheretima aspergillum) has a bioactive component of IGF-1 (insulin like growth factor 1), which can stimulate cell growth and survival. IGF-1 is involved in hair follicle growth by regulating cell proliferation and migration through the cellular mechanism of its receptor (IGF - 1R). This study aimed to determine the effect of earthworm extract on the increase of hair follicles number in rats induced diabetic ulcer stage II. Methods: This study used a true experimental posttest only controlled group design. Samples were randomly selected, divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. Ulcer treatment is done for 21 days, on day 22, rats were euthanized. The numbers of hair follicles in skin tissue connecting to nervous fibers were identified using silver impregnation stain. Results: The results showed that the treatment groups that received earthworm extract had significantly higher number of hair follicles as compared to the control groups (p=0.000). The administration of earthworm extract via topical has an optimal effect on the increase of hair follicles numbers. Conclusion: It can be concluded that the extract of earthworm (Pheretima aspergillum) can increase the growth of hair follicles in rats diabetic models. Keywords: diabetic ulcer, earthworm (Pheretima aspergillum), hair follicles.

PHENOMENOLOGY.STUDY : THE MEANING OF THE EXPERIENCE OF NURSES PERFORM EMERGENCY PHASE OF BURN CARE IN THE EMERGENCY ROOM Artawan, I Kadek; Winarni, Indah; Kristianto, Heri
Jurnal Keperawatan Vol 8, No 1 (2017): Januari
Publisher : University of Muhammadiyah Malang

STUDI FENOMENOLOGI: MAKNA PENGALAMAN PERAWATDALAM MERAWAT PASIEN LUKA BAKAR FASE EMERGENCY DIINSTALASI GAWAT DARURAT RSUP SANGLAHPhenomenology.Study : The Meaning of the Experience of Nurses Perform EmergencyPhase of Burn Care in the Emergency RoomI Kadek Artawan1, Indah Winarni2, Heri Kristianto31,2,3Program Studi Magister Keperawatan Gawat Darurat Fakultas KedokteranUniversitas BrawijayaJalan Veteran Malang 651451e-mail : kadekartawan27@gmail.comABSTRAKLuka bakar merupakan salah satu jenis trauma dengan masalah yang kompleks. Permasalahanpada luka bakar menimbulkan kebingungan dan kesulitan pada perawat dalam memberikanperawatan. Perawat juga menjadi kewalahan dalam melakukan tindakan keperawatan dalammerawat pasien luka bakar. Kompleknya masalah luka bakar juga menimbulkan perubahan emosiperawat dalam memberikan perawatan sehingga berdampak pada distres emosional dan perawatanyang kurang optimal pada pasien. Adapun tujuan penelitian ini adalah mengeksplorasi maknapengalaman perawat melakukan perawatan luka bakar fase emergency di IGD. Desain penelitianmenggunakan kualitatif fenomenologi interpretatif. Data dikumpulkan dengan melakukaninterview mendalam (in depth interview) pada 7 partisipan dengan panduan wawancara semiterstruktur. Kemudian dianalisis menggunakan analisishermeneutics menurut Streubert &Carpertner.Penelitian ini menghasilkan beberapa tema dalam merawat pasien luka bakar faseemergency. Tema-tema tersebut yaitu; 1)memiliki kesigapan dalam memberikan perawatan 2)berkolaborasi menentukan keselamatan pasien, 3) melayani dalam situasi kacau balau, 4)mengalami tekanan batin dalam bekerja.Merawat sebagai sebuah perjuangan merupakan makapengalaman perawat dalam memberikan perawatan luka bakar fase emergency. Makna initerbentuk karena penuh perjuangan dalam memberikan perawatan dengan situasi yang banyaktekanan, pelayanan yang terbatas, tetapi dapat memberikan perawatan optimal dan mampumenstabilkan kondisi pasien.Kata Kunci: Pengalaman perawat, luka bakar, emergencyABSTRACTBurns is one type of traumahave a complex problem. Problems in burns cause confusion anddifficulty in nurses in providing care. Nurses also be overwhelmed in a nursing action in treatingburn patients. Complexity of the problem of burns also cause emotional changes of nurses inproviding care so the impact on emotional distress and less than optimal care for patients. Thepurpose of this study is to explore the meaning of the experience of nurses perform emergencyphase of burn care in the ER. The study design using qualitative interpretive phenomenology. Datawere gathered through in-depth interviews (in-depth interviews) at 7 participants with a semistructuredinterview guide. Then analyzed using analysis of hermeneutics according Streubert &Carpertner. The study produced several themes in treating burn patients. These themes namely; 1)had the alacrity in providing care, 2) collaborating determine patient safety, 3) caring inovercrowding situation, 4) feeling high stressor in work. Nursing as a struggle is the experience ofnurses in providing emergency treatment of burns phase. This meaning is formed because of strifein providing care to the situation that a lot of pressure, limited service, but it can provide optimalcare and is able to stabilize the patient's condition.Keywords : Nurse experiences, burn, emergency

THE EFFECT OF PHERETIMA ASPERGILLUM EXTRACT ON THE INCREASE OF HAIR FOLLICLES NUMBER IN DIABETIC ULCER GRADE II IN WISTAR RAT Kristianto, Heri; Sari, Dwi Astika
Jurnal Luka Indonesia Vol 2 No 2 Juni 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.23

Background: Diabetic ulcer is the result of serious microvascular complication of diabetes mellitus that is caused by vascular insufficiency, resulting in dry skin, loss of taste, and a decrease in the number of hair follicles. Earthworm (Pheretima aspergillum) has a bioactive component of IGF-1 (insulin like growth factor 1), which can stimulate cell growth and survival. IGF-1 is involved in hair follicle growth by regulating cell proliferation and migration through the cellular mechanism of its receptor (IGF - 1R). This study aimed to determine the effect of earthworm extract on the increase of hair follicles number in rats induced diabetic ulcer stage II. Methods: This study used a true experimental posttest only controlled group design. Samples were randomly selected, divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. Ulcer treatment is done for 21 days, on day 22, rats were euthanized. The numbers of hair follicles in skin tissue connecting to nervous fibers were identified using silver impregnation stain. Results: The results showed that the treatment groups that received earthworm extract had significantly higher number of hair follicles as compared to the control groups (p=0.000). The administration of earthworm extract via topical has an optimal effect on the increase of hair follicles numbers. Conclusion: It can be concluded that the extract of earthworm (Pheretima aspergillum) can increase the growth of hair follicles in rats diabetic models. Keywords: diabetic ulcer, earthworm (Pheretima aspergillum), hair follicles.

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