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All Journal Althea Medical Journal The Journal of Pure and Applied Chemistry Research Chimica et Natura Acta
Vycke Yunivita Kusumah Dewi
Department Of Pharmacology And Therapy, Faculty Of Medicine, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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Effectiveness of Allergic Rhinitis Management Related to WHO Guideline on Allergic Rhinitis and Its Impact on Asthma (ARIA) Atika Aziza; Arif Dermawan; Vycke Yunivita Kusumah Dewi
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.933 KB)

Abstract

Background: The standard procedure of Allergic Rhinitis (AR) Management in Indonesia is based on Allergic Rhinitis and Its Impact on Asthma (ARIA) World Health Organization (WHO) 2008 guideline; however, it needs some adjustment to get an effective use locally in Indonesia. The data related to the problem however did not exist in Indonesia. The study aimed to evaluate the effectiveness of AR patient management based on the ARIA WHO guideline in the Department of Otorhinolaryngology-Head and Neck Surgery Dr. Hasan Sadikin General Hospital Bandung.Methods: The study was conducted from September to October 2015 using quantitative descriptive design to observe the development of ARIA classification, total nasal symptom score (TNSS), and quality of life (QoL) during the first 6 months of therapy. The data were obtained from medical records of AR patients who visited the Rhinology-Allergy clinic Department of Otorhinolaryngology-Head and Neck Surgery Dr. Hasan Sadikin General Hospital within one year. Thirty three patients were included in the study using total sampling.Results: There was significant improvement (p<0.001) in ARIA classification, TNSS, and QoL between the initiation of therapy, the third, and the sixth month. In contrary, there was no significant difference in ARIA classification (p=0.109), TNSS (p=0.317), and QoL (p=1.000) between the third and the sixth month of therapy.Conclusions: Allergic rhinitis patient management based on the 2008 ARIA WHO guideline is effective. [AMJ.2016;3(4):538–44]Keywords: Allergic rhinitis, asthma, effectiveness, management DOI: 10.15850/amj.v3n4.651
ANALISIS GLIKOSIDA KARDIOAKTIF DIGOKSIN MENGGUNAKAN ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY (UPLC) Triana Nurul Meirina; Atu Purnama Dewi; Harold Eka Atmaja; Vycke Yunivita Kusumah Dewi; Rovina Ruslami
Chimica et Natura Acta Vol 2, No 1 (2014)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (777.149 KB) | DOI: 10.24198/cna.v2.n1.9142

Abstract

Digoksin merupakan glikosida kardioaktif, salah satu senyawa yang penting dalam terapi yang saat ini tersedia sebagai obat untuk pengobatan penyakit jantung. Penggunaan obat ini meningkat sejalan dengan bertambahnya penderita penyakit jantung. Oleh karena itu, perlu dilakukan penelitian dan monitoring penggunaan obat ini pada penderita penyakit jantung dalam proses terapi kesembuhan. Tujuan dari penelitian ini adalah untuk mengetahui metode analisis digoksin dengan menggunakan alat Ultra Performance Liquid Chromatography (UPLC). Digoksin yang digunakan adalah Fargoksin (Injection 0,25 mg/mL, ampoule/berbentuk cairan). Pengenceran digoksin dilakukan dengan penambahan pelarut metanol. Kolom yang digunakan adalah kolom BEH C18. Optimasi metode analisis yang dilakukan meliputi perbandingan pelarut yang digunakan, suhu kolom, dan laju alir. Setelah melakukan optimasi, diperoleh kondisi fasa gerak yang optimum adalah larutan air-asetonitril (72:28%), laju alir 0,3 mL/menit, waktu selama ± 6 menit, suhu kolom off, dan detektor yang digunakan adalah spektrofotometer UV dengan panjang gelombang 218 nm. Pengulangan analisis dengan menggunakan hasil yang diperoleh secara optimum dilakukan sebanyak sepuluh kali. Berdasarkan data tersebut, proses analisis dengan menggunakan UPLC dapat berlangsung lebih cepat dibandingkan dengan menggunakan HPLC.
A Validated Ultra Performance Liquid Chromatography Method for Quantification of Metformin in Human Plasma Vycke Yunivita Kusumah Dewi; Atu Purnama Dewi; Budi Setiabudiawan; Edhyana Sahiratmadja; Triana Nurul Meirina; Harold Eka Atmaja; Rovina Ruslami
The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (704.45 KB) | DOI: 10.21776/ub.jpacr.2018.007.003.414

Abstract

Metformin is oral hypoglycemic or blood sugar-lowering drug which is used for the first- line drug in the treatment of diabetes mellitus type 2. This study presented the validated  Ultra Performance Liquid Chromatography UltraViolet (UPLC-UV) method for the determination of metformin in human plasma. Metformin levels were measured using UPLC with a UV detector and liquid-liquid extraction method. Separation was carried out on an Acquity UPLC HSS T3 100mm × 2.1mm i.d. column (1.8μm particle size) using gradient elution of acetonitrile and phosphate buffer 0.02 M (0.6 mL/min) as mobile phase at 30°C. The analyte was monitored at 236 nm. No endogenous substances were found to interfere with the peaks of drug and internal standard. The value of percent deviation and the coefficient variation obtained respectively less than the percentage set in the FDA guidelines. The linearity factor values were more than 0.997 and LOD was 0.01µg/mL. UPLC with UV detector is able to analyze metformin in a short time with good precision and accuracy which is useful for bioequivalence and bioavailability studies.
Co-Authors Almira, R. Devina Fathia Arif Dermawan Atika Aziza Atmaja, Harold Eka Atu Purnama Dewi Atu Purnama Dewi Aziza, Atika Budi Setiabudiawan Dewi, Atu Purnama Dianwari, Vera Edhyana Sahiratmadja Gartika Sapartini Harold Eka Atmaja Harold Eka Atmaja Kamila, Tasya Meirina, Triana Nurul Miftahurachman Miftahurachman Miftahurachman Miftahurachman, Miftahurachman Nia Kania R. Devina Fathia Almira Rovina Ruslami, Rovina Tasya Kamila Teguh Marfen Djajakusumah Teguh Marfen Djajakusumah, Teguh Marfen Triana Nurul Meirina Triana Nurul Meirina Vera Dianwari Wulantika Nurhayati Wulantika Nurhayati, Wulantika Yundari, Yundari