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All Journal Jurnal Kebijakan Publik Majalah Kedokteran Bandung The Indonesian Journal of Dental Research Majalah Obat Tradisional jurnal niara Dinamisia: Jurnal Pengabdian Kepada Masyarakat Politik Indonesia: Indonesian Political Science Review Jurnal Respirologi Indonesia JOELS: Journal of Election and Leadership jurnal administrasi politik dan sosial Jurnal Sosio-komunika
Harsini Harsini
Universitas Lancang Kuning
Humanities Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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DAYA ANTIFUNGI REBUSAN KULIT BATANG JAMBU METE (Anacardium occidentale L.) TERHADAP C. albicans PADA RESIN AKRILIK Lidyawita, Ria; Sudarsono, Sudarsono; Harsini, Harsini
Majalah Obat Tradisional Vol 18, No 1 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (389.14 KB) | DOI: 10.14499/mot-TradMedJ18iss1pp%p

Abstract

Kurangnya perawatan gigi palsu berakibat pada tingkat kepadatan koloni Candida albicans yang dapat menyebabkan denture stomatitis. Mikroba tersebut sering dijumpai pada pemakai gigi tiruan dan dijumpai sebanyak 86% dari penderita denture stomatitis. Pada kulit batang jambu mete terdapat tanin, asam galat dan asam anakardat, yaitu komponen fenolik dengan aktivitas antijamur terhadap C. albicans. Penelitian ini meliputi pengumpulan bahan, perebusan, freeze drying, identifikasi fitokimia asam anakardat dan asam galat, penetapan kandungan fenolik total dengan metode Folin Ciocalteu, dan uji daya antifungi terhadap C. albicans pada plat resin akrilik. Plat resin akrilik direndam dalam suspensi C. albicans selama 24 jam, dibilas dengan Phosphate Buffer saline (PBS), direndam disertai agitasi selama 3 menit dalam larutan hasil freeze drying rebusan kulit batang jambu mete konsentrasi 12,5%b/v, 25%b/v, dan 50%b/v dengan stok 20mg/mL, divibrasi dalam NaCl fisiologis yang kemudian diinkubasi pada Agar Sabouraud selama 48 jam, diamati dan dihitung persentase penghambatan pertumbuhan C. albicans. Analisis statistik dengan Anava, dilanjutkan uji Kruskal-Wallis untuk mengetahui perbedaan antar kelompok perlakuan. Hasil penelitian menunjukkan bahwa rebusan kulit batang jambu mete konsentrasi 12,5%b/v, 25%b/v, dan 50%b/v memiliki daya hambat terhadap pertumbuhan C. albicans yang berbeda bermakna, yaitu berturut – turut 69,69%, 82,66%, 94,14% dan kandungan fenolik total yang berbeda bermakna, yaitu berturut – turut 35,18%b/b EAG, 31,64%b/b EAG, 29,47%b/b EAG.
Anti-Inflammatory Activity of Ethanol Extract of Cashew Stem Bark (Annacardium Occidentale L.) on Rat Paw Edema Induced by Carrageenan Harsini, Harsini; Sutardja, Iwa; Martono, Sudibyo; Sunarintyas, Siti; Sudarsono, Sudarsono
The Indonesian Journal of Dental Research Proceeding Book
Publisher : The Indonesian Journal of Dental Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (19.124 KB)

Abstract

Introduction: Cashew stem bark (Anacardium occidentale L.) was traditionally used to cure inflammation in the oral cavity. Phenolic substances such as phenol and anacardic acid that have anti-inflammatory effect was found in cashew stem bark. The aim of this study was to investigate the anti-inflammatory activity of the ethanol extract of cashew stem bark and indometazine as Non-steroid anti-inflammatory drug. Materials and Methods: Cashew stem bark was collected from Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia. Extraction was done by maceration method using ethanol as solvent. Anti-inflammatory activity of 40 mg/kg bw, 80mg/kg bw, 160mg/kg bw dosage of cashew stem bark extract was monitored and indometazine 10 mg/kg bw was used as positive control. Edema volume determination on rat paw was counted as area under cure (AUC) value and anti-inflammatory percentage. Result: This study result showed that total phenolic content on cashew stem bark was 12.25 ± 0.26% w/w gallic acid equivalent (GAE). The anti-inflammatory activity of cashew stem bark extract in this study were 9.985±6.483% for 40mg/kg BW, 15.576±6.754% for 80mg/kg bw, 25.87±19.7% for 160mg/kg bw and 56.85 ±15.52% for Indometazine 10 mg/kg bw. Analysis of Variance (ANOVA) method was applied on the results and showed significant anti-inflammatory activity of ethanol extract on cashew stem bark (p<0.05). Conclusion: In conclusion, ethanol extract of cashew stem bark has anti-inflammatory activity. However, its’ activity is lower than indometazine.
Mainstreaming Regional Budget (APBD): Issues and Challenges in Riau Province in 2015 Yandra, Alexsander; Nasution, Sri Roserdevi; Harsini, Harsini; Wekke, Ismail Suardi
Jurnal Politik Indonesia: Indonesian Political Science Review Vol 3, No 1 (2018): General Issue: Indonesian Politics
Publisher : Political Science Program, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.67 KB) | DOI: 10.15294/jpi.v3i1.11510

Abstract

This research explores issues related to mainstreaming the 2015 Regional Budget (APBD) of Riau Province amounted IDR 10.7 trillion. Based on the data obtained from the Riau Finance and Asset Management Board (BPKAD), Riau could only spend APBD 37.58% of APBD until October 2015. Meanwhile, the Ministry of Home Affairs of the Republic of Indonesia calculated Riau spent only 59.6% throughout 2015 and it wast the lowest regional spending in Indonesia. This poor expenditure rate demonstrates a problem in the implementation of Riaus APBD which was inneficient and not yet relevant. An assessment by government expenditure theory reveals that these problems indicate a gap in APBD allocation that affect on the non-performance regional development as targeted in mid-term regional development plan (RPJMD). This APBD seems to perform only a budget plan, not an implemented budget policy yet.
Relationship Risk Factors and Laten Tuberculosis Infection (LTBI) in HIV Patients Irwandi, Delvan; Harsini, Harsini; Reviono, Reviono
Jurnal Respirologi Indonesia Vol 39, No 2 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

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Abstract

Introduction: In 2014 globally 9.6 million people are infected with TB, including 1.2 million people living with HIV. HIV positive patients have a risk of Tuberculosis (TB), infection or latent TB infection (LTBI) about 5-8% per year and the risk of developing active TB 3 times higher than the immunocompetent individuals. The impact of HIV infection on the immune system is the destruction of lymphocyte T CD4 and declining nutritional status. Nutritional status can be assessed by clinical signs, anthropometry and biochemical indicators such as serum albumin levels. Methods: Cross-sectional observational epidemiological research in RS Dr. Moewardi, Surakarta, to patients with HIV, from April to May 2017 to observe the association of risk factors with LTBI in HIV patients. The first step is patient and family anamnesis, history of past and family illness, duration of antiretroviral therapy, Cluster of Differentiation 4 (CD4) count, BMI count, serum albumin concentration, immunologic Tuberculin Skin Test (TST) for LTBI diagnosis. Results: Total of 93 people meet the criteria. There was no association close contact history with active tuberculosis patients with ITBL in HIV (p = 0.5, OR 1.268; 95% CI 1.139-1.411); no association of BMI classification with LTBI in HIV (P=1.000; OR=0.894; 95%CI=0.326-2.457), no association of serum albumin grade with ITBL in HIV (P=0.19; OR=1.284; 95%CI=1.147-1.436); there was a significant association of CD4 classification with LTBI in HIV (P=0.033; OR=3.560; 95%CI=1.214-10.433), there was no association between duration of antiretroviral therapy with LTBI in HIV (P=0.636; OR=0.969; 95% CI=0.244-3.848). Conclusions: HIV patients with advanced CD4 and severe immunosuppressive CD4 classification (CD4+
Pengaruh Faktor Risiko terhadap Waktu Timbulnya Efek Samping Kanamisin pada Tuberkulosis Resistan Obat Wati, Martha Ratna; Reviono, Reviono; Putranto, Wachid; Sutanto, Yusup Subagio; Harsini, Harsini
Majalah Kedokteran Bandung Vol 50, No 2 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.161 KB) | DOI: 10.15395/mkb.v50n2.1297

Abstract

Kanamisin adalah obat untuk terapi tuberkulosis resistan obat (TB RO) yang menimbulkan efek samping gangguan pendengaran, gangguan fungsi ginjal, dan gangguan elektrolit terutama hipokalemia. Penelitian bertujuan menilai kesintasan waktu timbulnya efek samping dan pengaruh faktor risiko usia, riwayat terapi streptomisin serta berat badan terhadap efek samping akibat pemberian kanamisin pasien TB RO. Penelitian kohort retrospektif dari data rekam medis pasien TB RO dari Januari 2011 sampai April 2017 di RSUD Dr. Moewardi Surakarta. Analisis pengaruh faktor risiko terhadap efek samping menggunakan uji cox regression. Dari 238 pasien didapatkan gangguan pendengaran 143 pasien, gangguan fungsi ginjal 147 pasien, dan hipokalemia 169 pasien. Usia lebih dari 40 tahun hazard ratio (HR) 2,419 (IK: 95%; 1,716–3,409; p= 0,000) dan jenis kelamin perempuan HR: 1,549 (IK: 95%; 1,089–2,202; p= 0,015) berisiko terjadi gangguan pendengaran. Usia lebih dari 40 tahun HR: 1,892 (IK: 95%; 1,353–2,646; p= 0,000) dan jenis kelamin perempuan HR: 1,667 (IK: 95%; 1,179–2,357; p= 0,004) berisiko terjadi gangguan fungsi ginjal. Riwayat streptomisin sebelumnya dan indeks massa tubuh (IMT) tidak berisiko timbul efek samping akibat pemberian kanamisin. Pengawasan ketat timbulnya efek samping gangguan pendengaran dan gangguan fungsi ginjal pasien usia lebih dari 40 tahun dan perempuan pada pengobatan TB RO.Kata kunci: Efek samping, gangguan fungsi ginjal, gangguan pendengaran, kanamisin, TB resistan obat Effects of Risk Factors on the Onset of Kanamycin’s Adverse Events in Drug Resistant TuberculosisKanamycin is a therapy for drug-resistant tuberculosis (TB) which may cause hearing loss, impaired kidney function, and electrolyte disorders, especially hypokalemia. The objective of this study was to assess patient survival and the effects of risk factors such as age, previous history of streptomycin therapy, and weight on adverse events due to kanamycin administration in patients with drug resistant TB. A retrospective cohort study was conducted in TB patients by using medical records from January 2011 to April 2017 in Dr. Moewardi Hospital Surakarta. Cox regression analysis was used to analyze the relation between risk factors and adverse events. Of 238 patients, 143 patients experienced hearing loss, 147 patients experienced impaired kidney function, and 169 patients had hypokalemia. Age over 40 and female gender had higher risks for hearing loss and impaired kidney function (HR: 2.419 (95% CI: 1.716–3.409; p= 0,000) and HR: 1,892 (95% CI: 1.353–2.646; p=0,000); HR: 1.549 (95%CI: 1.089–2.202; p=0,015), and HR: 1.667 (95% CI: 1.179–2.357; p=0.004)), respectively. History of streptomycin and body mass index (BMI) were not risk factors for  kanamycin’s adverse events. Therefore, closed monitoring on hearing loss and impaired kidney function is necessary for drug resistant TB patients aged over 40, and female patients. Key words: Adverse events, drug resistant tuberculosis, hearing loss, impaired kidney function, kanamycin
LEVEL OF CONFORMITY EXAMINATION OF URIC ACID LEVELS IN PLEURAL FLUID, RATIO OF URIC ACID LEVELS IN PLEURAL FLUID WITH SERUM TO DISTINGUISH EXUDATES AND TRANSUDATES Sigit, Indarto; Sutanto, Yusup Subagio; Harsini, Harsini
Jurnal Respirologi Indonesia Vol 40, No 2 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i2.100

Abstract

Background: Uric acid can be used as a biomarker to distinguish transudates from pleural fluid exudates. Uric acid is soluble in liquid media, elevated levels of uric acid in blood plasma become a predisposing factor for uric crystal deposits in tissues and body fluids. Increased permeability due to changes in capillary pleural pressure in the formation of transudates is a cause of increased levels of uric acid in pleural fluid. The aim of the study was to analyze the examination of pleural fluid uric acid levels and the ratio of uric acid levels to pleural fluid to serum to distinguish exudates and transudates in pleural effusion. Methods: A cross sectional diagnostic test with a cross sectional study design in pleural effusion patients at RSUD Dr. Moewardi Surakarta in July-August 2019. Subjects were examined for pleural fluid levels, serum uric acid ratio, and pleural fluid analysis. Results: A total of 30 pleural effusion patients were included in this study. The level of agreement between the uric acid pleural fluid against Light criteria was in the moderate category and statistically significant (Kappa = 0.595; P=0.001). The level of agreement between the ratio of uric acid to pleural fluid and serum to Light's criteria was weak and not statistically significant (Kappa = 0.200; p = 0.195) Conclusion: The level of concordance between pleural fluid uric acid with Light criteria is in the medium category and statistically significant. There is no match between the ratio of serum pleural fluid uric acid levels with Light criteria. (J Respir Indo. 2020; 40(2): 82-6)
TRANSPARANSI DALAM PROSES SELEKSI CALON ANGGOTA PANITIA PENGAWAS (PANWAS) PEMILU TAHUN 2017: STUDI KASUS DI KABUPATEN BENGKALIS, KABUPATEN ROKAN HILIR, KOTA DUMAI, DAN KOTA PEKANBARU nasution, sri roserdevi; harsini, harsini; kusumawardhani, fajarwaty
Jurnal Niara Vol. 11 No. 1 (2018)
Publisher : FAKULTAS ILMU ADMINISTRASI UNIVERSITAS LANCANG KUNING

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.928 KB) | DOI: 10.31849/nia.v11i1.1523

Abstract

This study aims to determine and analyze the selection process of candidate members of the Election Supervisory Committee (Panwas) Election in two districts and two cities in the province of Riau. The selection takes place in mid-2017, in response to Law No. 15 of 2011 on General Election. Moreover, Riau will hold the Elections to the Regions in 2018 and Legislative Election and the Presidential and Vice Presidential Election in 2019. The existence of Panwas is a necessity in the effort to make the election more qualified and produce leaders in accordance with the conscience of the people. But please note how transparency in the selection process of candidates for Panwas members who have a very big mandate in the nation's democratic process. Selection of Panwas member candidates should fulfill the element of transparency as a proof of the implementation of good governance.The method used in this research is qualitative research methods. Data collection is done by using primary data in the form of in-depth interviews to the informants.Purposive sampling is chosen to be a technique in getting informants in accordance with this research. In addition, secondary data derived from the Election Supervisory Agency and mass media documents also support and sharpen the case studies as the analytical blades in this study.
EFEKTIVITAS LEMBAGA KESWADAYAAN MASYARAKAT (LKM) DALAM PENGENTASAN KAWASAN KUMUH DI KECAMATAN RUMBAI KOTA PEKANBARU Putri, Lusi Dwi; nasution, sri roserdevi; harsini, harsini
Jurnal Niara Vol. 11 No. 1 (2018)
Publisher : FAKULTAS ILMU ADMINISTRASI UNIVERSITAS LANCANG KUNING

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (65.769 KB) | DOI: 10.31849/nia.v11i1.1784

Abstract

LKM is the spearhead of the success of slums in urban poverty alleviation programs, especially in the area of Sri Meranti Village, Rumbai, Pekanbaru. This study aims to determine the performance of the LKM in Sri Meranti Village, Rumbai, Pekanbaru.. The assessment takes place in 2018 (2017 performance audit) by comparing with secondary data that has been obtained in the LKM performance assessment results at the end of 2015 and the end of 2016. Qualitative research is the method chosen in this study. Data retrieval is done using primary data and secondary data related to the results of LKM performance appraisal compared during the last 3 (three) years work process. Data collection techniques are interviews, direct observation to the field and document review
TRANSPARANSI PELAYANAN PUBLIK PADA DINAS PENANAMAN MODAL DAN PELAYANAN TERPADU SATU PINTU (DPMPTSP) KOTA PEKANBARU harsini, harsini
Jurnal Niara Vol. 10 No. 2 (2018)
Publisher : FAKULTAS ILMU ADMINISTRASI UNIVERSITAS LANCANG KUNING

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (80.41 KB) | DOI: 10.31849/nia.v10i2.1903

Abstract

The purpose of this research is to analyze the transparency and to analyze the factors that inhibit the creation of transparency of public service to the investment service and integrated service one door of Pekanbaru City. In this study using qualitative data analysis, that is by conducting data analysis through surveys, interviews and through information obtained in the field. Based on the results of research that the transparency of information service has not been fully transparent in the provision of services to the community. Priority interest of service users has not been fully prioritized. This can be seen from the management of public service that has not been published to the public, such as the cost and service time that is still not kept on the customer, and this is caused by the lack of resources available in the field of IMB management
PROFESIONALISME APARATUR SIPIL NEGARA (ASN) DI KANTOR CAMAT BUKIT RAYA KOTA PEKANBARU prihati, prihati; harsini, harsini; nasution, sri roserdevi
Jurnal Niara Vol. 9 No. 1 (2016)
Publisher : FAKULTAS ILMU ADMINISTRASI UNIVERSITAS LANCANG KUNING

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.859 KB) | DOI: 10.31849/nia.v9i1.2014

Abstract

The Indonesian people are always faced with the problem of how to build a clean government and good (good governance and clean government ) . Bureaucracy is expected to be a motivator and as well as a catalyst of the passing of development, not able to perform its role as a modern bureaucracy not only promote the capacity to organize the tasks and functions of the organization , but also capable of responding to the aspirations of the public into the activities and programs of the organization and is able to bring new innovations aimed at facilitate the performance of the organization and as a part of the manifestation of the professional apparatus. In the perspective of public administration Indonesia known to a wide range of pathologies that make bureaucrats or officials are not professional in their duties and functions include low motivation to change and innovate. Given the urgency of the apparatus role in organizing role and function , it would need to be sought and formulated a strategic approach to build the new face of professional personnel that are reliable , responsive , flexible and innovative in providing services and procedural development implementation.This type of research is descriptive qualitative approach , data collection techniques using in-depth interviews and documentation . The selection of informants by using purposive sampling so didapatlah informants in accordance with the criteria. Further analysis of the data through the interpretation of ethics and EMIC is further elaborated in the study of governance in accordance with the governance discussion is being investigated.The results of the study of responsiveness and innovation apparatus Subdistrict Bukitraya well in order to give service to the community as well as in the implementation of the tasks that others have started to lead to the vision of districts Bukitraya namely the realization of the District Bukitraya The Professionals In The Governance and Service to Society , it's just not done optimally.
Co-Authors Alexsander Yandra, Alexsander Bima Ramadhan Saputra Dwi Herlinda Eka Eka Eny Samiasih Fajarwaty Kusumawardhani I Dewa Gde Mayun Permana Irwandi, Delvan Ismail Suardi Wekke Iwa Sutardja, Iwa Lusi Dwi Putri, Lusi Dwi Miftahur Rahmi Nurpeni, Nurpeni Prihati Prihati Putranto, Wachid Reviono Reviono Ria Lidyawita, Ria Sigit, Indarto Siti Sunarintyas Sri Roserdevi Nasution, Sri Roserdevi Sudibyo Martono Sulaiman Zuhdi Trio Saputra Wati, Martha Ratna Widia Astuti Yusup Subagio Sutanto