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All Journal Biosfer: Jurnal Tadris Biologi KOVALEN: Jurnal Riset Kimia Jurnal Kimia Mulawarman Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas (JFSK) Jurnal Kreativitas PKM BERNAS: Jurnal Pengabdian Kepada Masyarakat Bakti Cendana: Jurnal Pengabdian Masyarakat Jurnal Sains dan Edukasi Sains Jurnal Biosense Aptekmas : Jurnal Pengabdian Kepada Masyarakat Journal of The Indonesian Society of Integrated Chemistry
Maximus M Taek
Universitas Katolik Widya Mandira
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Journal : Jurnal Farmasi Sains dan Komunitas (JFSK)

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The Effect of Ethanol Extract of Marsilea crenata Presley Leaves on Rotenone-Induced Zebrafish Locomotor Activity Burhan Ma'arif; Faisal Akhmal Muslikh; Destiya Argo Pamuji Fihuda; Husnul Khotimah; Maximus M. Taek; Mangestuti Agil
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (420.717 KB) | DOI: 10.24071/jpsc.004576

Abstract

Neurodegenerative diseases are mostly experienced by postmenopausal women and are often caused by estrogen deficiency, so it is necessary to replace the hormone estrogen in the form of phytoestrogens. One of the plants that contain phytoestrogens is Marsilea crenata. The objective of this study is to see if giving rotenone-induced zebrafish a 96% ethanol extract of M. crenata leaves increases locomotor activity. This research was conducted by inducing 5 µg/L rotenone as a compound that will interfere with the locomotor activity of zebrafish. Next, treatment was given with 96% ethanol extract of clover in each group with a dose of 2.5; 5; 10; and 20 mg/mL to determine the effect of the extract on increasing locomotor activity of rotenone-induced zebrafish. Observations were made by looking at the quantity of zebrafish swimming every five minutes until day 28. The treatment of 96% ethanol extract of M. crenata leaves could significantly increase zebrafish motility at the optimum dose of 2.5 mg/mL, because every week the zebrafish locomotor activity increased compared to the negative control. M. crenata leaves extract is proven to prevent neurodegenerative diseases. However, further research needs to be done on the degenerative effects of rotenone every week.
Co-Authors Adilson de Castro Ruas Adri Gabriel Sooai Adrianus Ketmoen Alfry Aristo Jansen Sinlae Aloisius Masan Kopon Aloysius Djalo Ambrosius Faofeto Angela Nona Angeliana Desimaris Nita Anggelinus Nadut Anselmus Boy Baunsele Bare, Yohanes Burhan Ma'arif Christiani Dewi Q. M. Bulin Destiya Argo Pamuji Fihuda Erly Grizca Boelan Faisal Akhmal Muslikh Gerardus Diri Tukan Hildegardis Missa Husnul Khotimah Juvencio de Castro Ruas Lodowik Landi Pote Lusia Ina Dai M A Yohanita Nirmalasari Mangestuti Agil Maria Aloisia Uron Leba Maria Augustin Lopes Amaral Maria O. Krisdayanti Maria Vitriani Barek Sabon Noemia A. Ruas Paskalis Andrianus Nani Paulus Adrianus K. L. Ratumakin Priscilla M. A Hornay Sardina Ndukang Sari, Dewi Ratih Tirto Sisilia Daeng Bakka Mau Timba, Frederiksen Novenrius Sini Viany Cecilia Pah Yustina Dwisofiani Lawung