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All Journal Biosfer: Jurnal Tadris Biologi KOVALEN: Jurnal Riset Kimia Jurnal Kimia Mulawarman Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas (JFSK) Jurnal Kreativitas PKM BERNAS: Jurnal Pengabdian Kepada Masyarakat Bakti Cendana: Jurnal Pengabdian Masyarakat Jurnal Sains dan Edukasi Sains Jurnal Biosense Aptekmas : Jurnal Pengabdian Kepada Masyarakat Journal of The Indonesian Society of Integrated Chemistry
Maximus M Taek
Universitas Katolik Widya Mandira
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Journal : Biosfer: Jurnal Tadris Biologi

 1 
Berberine: A Potential Inhibitor of Dihydrofolate Reductase- Thymidylate Synthase (DHFR-TS) for Malaria Yohanes Bare; Dewi Ratih Tirto Sari; Angeliana Desimaris Nita; Maximus M Taek
Biosfer: Jurnal Tadris Biologi Vol 13, No 1 (2022): Biosfer: Jurnal Tadris Biologi
Publisher : UNIVERSITAS ISLAM NEGERI RADEN INTAN LAMPUNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/biosfer.v13i1.11145

Abstract

The goal of this study was to genetically link natural materials derived from Tinospora crispa L with Berberine to dihydrofolate reductase-thymidylate synthase (DHFR-TS). Method: The ligand berberine (CID: 2353) was obtained from Pubchem, while the protein DHFR-TS (PDB ID 2bl9) was obtained from Protein Data Bank. The ligands and proteins interacted with HEX 8.0.0.0 and were visualized with Discovery Studio. The researchers discovered a positive interaction between berberine and DHFR-TS, observed at four amino acid residues that bind to the protein TYR125, ILE121, LEU45, and MET54. Van der Waals interactions, hydrogen bonds, Pi-Sulfur, Pi-Alkyl, and Pi-Stalked interactions all contribute to strength and stability. In conclusion, berberine has the potential to act as a DHFR-TS inhibitor and thus prevent malaria.ABSTRAK: Tujuan penelitian ini adalah memanfaatkan bahan alam yang berasal dari Tinospora crispa L dengan kandungan utama Berberin dengan dihydrofolate reductase-thymidylate synthase (DHFR-TS) secara genetik. Metode, Ligan berberin (CID: 2353 ) diperoleh dari Pubchem sedangkan protein DHFR-TS (PDB ID 2bl9) diperoleh dari Protein Data Bank, ligan dan protein diinteraksikan menggunakan HEX 8.0.0.0 dan divisualisasikan menggunakan discovery studio. Ditemukan interaksi positif antara berberin dan DHFR-TS yang menunjukkan interaksi pada empat residu asam amino yang berikatan dengan protein. Mereka adalah TYR125, ILE121, LEU45 dan MET54. Beberapa interaksi yang dilakukan Van der Waals, ikatan hidrogen, Pi-Sulfur, Pi-Alkyl dan Pi-Stalked juga memberikan dukungan dalam rangka meningkatkan kekuatan dan stabilisasi. Kesimpulannya, berberin memiliki potensi fungsi sebagai penghambat DHFR-TS dan mengarah pada malaria.
Co-Authors Adilson de Castro Ruas Adri Gabriel Sooai Adrianus Ketmoen Alfry Aristo Jansen Sinlae Aloisius Masan Kopon Aloysius Djalo Ambrosius Faofeto Angela Nona Angeliana Desimaris Nita Anggelinus Nadut Anselmus Boy Baunsele Bare, Yohanes Burhan Ma'arif Christiani Dewi Q. M. Bulin Destiya Argo Pamuji Fihuda Erly Grizca Boelan Faisal Akhmal Muslikh Gerardus Diri Tukan Hildegardis Missa Husnul Khotimah Juvencio de Castro Ruas Lodowik Landi Pote Lusia Ina Dai M A Yohanita Nirmalasari Mangestuti Agil Maria Aloisia Uron Leba Maria Augustin Lopes Amaral Maria O. Krisdayanti Maria Vitriani Barek Sabon Noemia A. Ruas Paskalis Andrianus Nani Paulus Adrianus K. L. Ratumakin Priscilla M. A Hornay Sardina Ndukang Sari, Dewi Ratih Tirto Sisilia Daeng Bakka Mau Timba, Frederiksen Novenrius Sini Viany Cecilia Pah Yustina Dwisofiani Lawung