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All Journal Jurnal Fisika Edukasi Jurnal Penelitian Hasil Hutan CHEMPUBLISH JOURNAL Chimica et Natura Acta Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Penelitian Hasil Hutan Jurnal Ilmiah Wahana Pendidikan Molekul: Jurnal Ilmiah Kimia
Darwati, Darwati
Universitas Padjadjaran
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Energy Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Social Sciences Other

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Journal : Molekul: Jurnal Ilmiah Kimia

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Terpenoids from the Stem bark of Aglaia elaeagnoidea and their cytotoxic activity against HeLa and DU145 Cancer Cell lines Dini Oktaviani; Winda Sukmawati; Kindi Farabi; Desi Harneti; Nurlelasari Nurlelasari; Darwati Darwati; Rani Maharani; Tri Mayanti; Agus Safari; Unang Supratman
Molekul Vol 17 No 1 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.1.5594

Abstract

Aglaia is the largest genus of the Meliaceae family which contains terpenoid compounds. This type of compounds showed a diverse structures and biological activities that can be found in natural resources. Aglaia elaeagnoidea is a species from Aglaia genus that only has a few previous research. This study was aimed to isolate and determine the chemical structure of terpenoid compounds from the ethyl acetate extract of A. elaeagnoidea stem bark. Ethyl acetate extracts were separated and purified by various chromatographic techniques to obtain compounds 1-5. Compounds 1-5 were identified their chemical structures by spectroscopic methods (IR, MS, and NMR) and comparison with previous reported spectral data. Compounds 1 and 2 were identified as eudesmane-type sesquiterpenoids, 5-epi-eudesm-4(15)-ene-1β,6β-diol (1) and 6α-Hydroxy-eudesm-4(15)-en-1-one (2). Compounds 3-5 were identified as dammarane-type triterpenoids, 20S,24S-epoxy-25-hydroxydammarane-3-one (3), 20S,24S-epoxydammarane-3α,25-diol (4), and 3α-epi-cabraleahydroxy lactone (5). These compounds are first time reported from this plant. Compounds 1-5 were tested for cytotoxicity against HeLa cervical cancer cell and DU145 prostate cancer cell and as a result, compound 4 (20S,24S-epoxydammarane-3α,25-diol) showed the stronger activity compared to other compounds.
Co-Authors Agus Safari Anni Anggraeni Desi Harneti Putri Huspa Dini Oktaviani Euis Julaeha Hardjoeno Hardjoeno Hideo Hayashi Julinton Sianturi Khalijah Awang Kindi Farabi Kindi Farabi Mokhammad Khukaim Barkhowa Nurlelasari Nurlelasari Nurlelasari Nurlelasari Rani Maharani Rani Maharani Samirah Samirah Sri Adi Sumiwi Tati Herlina Tiara Prima Amalya Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Unang Supratman Unang Supratman Winda Sukmawati Windarwati Windarwati