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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Herb-Medicine Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Medica Arteriana (Med-Art) Community Development Journal: Jurnal Pengabdian Masyarakat Indonesian Journal of Medical Sciences and Public Health Jurnal Pandu Husada

Nenny Triastuti

Faculty Of Medicine, Muhammadiyah University Of Surabaya

Author-ID : 627751

Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Pengaruh Pola Makan dan Aktivitas Fisik Terhadap Penurunan Kadar Gula Darah Pada Pasien Diabetes Melitus Tipe 2 di Klinik Aulia Jombang Himmah, Siti Cholishotul; Irawati, Detty Nur; Triastuti, Nenny; Salim, Nabil
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 7, No 1 (2020): February
Publisher : APKKM (Muhammadiyah Medical and Health Education Association)

Latar Belakang : Diabetes melitus di Indonesia merupakan salah satu penyakit tidak menular dengan kematian tertinggi. Diabetes melitus tipe 2 ditandai dengan kerja insulin yang tidak efektif, sehingga tidak berfungsi optimal dalam mengatur metabolisme glukosa. Penyakit ini dapat disebabkan dari beberapa faktor salah satunya adalah gaya hidup yang tidak sehat, diantaranya latihan fisik dan pola makan yang tidak baik. Tujuan :Â Untuk mengetahui pengaruh pola makan dan aktivitas fisik pada penurunan kadar gula darah pada pasien diabetes melitus tipe 2. Metode : Penelitian ini menggunakan rancangan analitik Cross sectional. Populasi dalam penelitian ini adalah seluruh peserta yang mengikuti Prolanis di Klinik Aulia Jombang. Teknik pengambilan sampel dalam penelitian ini adalah purposive sampling. Sampel pada penelitian ini adalah peserta yang mengikuti Prolanis di Klinik Aulia Jombang, yang juga merupakan pasien diabetes melitus tipe 2. Instrumen yang digunakan adalah data primer berupa kuesioner dan data sekunder berupa rekam medis pasien.Hasil : Hasil analisis dengan mann-whitney test menunjukkan signifikansi pengaruh pola makan dan aktivitas fisik terhadap penurunan kadar gula darah (p kurang dari 0,05). Kesimpulan : Menunjukkan bahwa terdapat pengaruh yang signifikan polaimakan dan aktivitas fisik terhadap penurunan kadar gula darah

Hubungan Pemberian Anestesi Regional Dengan Kelancaran ASI Pada Ibu Post Partum Sectio Caesarea Di Rumah Sakit Muhammadiyah Gresik Rahmatika, Vina; Ghufron, Musa; Triastuti, Nenny; Rochman, Syaiful
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 7, No 2 (2020): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.7.2.2020.42-48

The Relationship between Regional Anesthesia and Breastfeeding Smoothness in Post Partum Sectio Caesarea Mothers at Muhammadiyah Hospital GresikBackground: The birth rate by caesarean section method is getting higher. Risk data for 2013 shows the method of birth with the operation method of 9.8 percent of the total 49,603 births during 2010 to 2013. Being in practice the mother must be given anesthetic before the surgery begins. This anesthesia will later affect the pain that will occur after SC.Objective: The purpose of this study was to determine the correlation between regional anesthetic drugs and the smoothness of breast milk in women born in sectio caesarea at Muhammadiyah Gresik Hospital.Method: Method with Cross Sectional approach. The population in this study mothers who gave birth in a caesarean section at Muhammadiyah Hospital Gresik in December 2019 to January 2020. The sampling technique in this study is probability / random simple sampling. The sample in this study was a portion of mothers who gave birth in a caesarean section at Muhammadiyah Gresik Hospital. The instrument used was primary data collection in the form of questionnaires and secondary data in the form of patient medical records.Result: The data obtained in this study were processed using spearman correlation statistics. From the statistical test the Correlation coefficient value was 0.807, and obtained P-Value equal to 0,000 this value is less than 0.05.Conclusion: The conclusion of this study is that there is a correlation between the administration of a regional anesthetics and the smoothness of breast milk in mothers of post partum caesarea at Muhammadiyah Gresik Hospital.

The Level of Effectiveness Use of Quinoline Drugs in COVID-19: A Literature Review M.Dedi Dermawan Dermawan; Afrita Amalia Laitupa; Muslim Andala Putra; Nenny Triastuti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4998

ABSTRACT Chloroquine is the first line of medicine in the treatment of malaria. Besides being antimalaria, the chloroquine also can be used as the anti-inflammation in the medicine of arthritis rheumatoid arthritis and lupus erythematosus discoid. Hydroxychloroquine sulfate is 4-aminoquinolin with hydroxylated chloroquine analog, having the same pharmacokinetic as chloroquine which is given orally in hydroxychloroquine sulfate form, processed by gastrointestinal absorption and very faster kidney elimination. The effectiveness of chloroquine and hydroxychloroquine towards COVID-19 in the in vitro experiment showed it could inhibit the duplication of the SARS-CoV-2 virus. The chloroquine function is to stop COVID-19 infection with (EC50) 1,13 μM and (CC50) larger than 100 μM. Meanwhile, the hydroxychloroquine function is to inhibit the attachment and entry of the virus into the host’s cell by enzymatic activation which is the lysosome acidification disorder and antigen presentation as the result of pH increase. Based on the clinical study, the 10 of 12 patients who have lopinavir/ritonavir therapy by virology, the chloroquine group showed RT-PCR negative on day 7, 10, and 14 in compare to lopinavir/ritonavir that showed RT-PCR negative on day 14. On the 9th day, 60% of the patients of chloroquine group showed the CT scan of Lungs image normal instead of the lopinavir/ritonavir at 25%. In the day 14 based on the CT test result, the pulmonary improvement increased twice rather than chloroquine group (Rate Ratio 2.21). It proved that the chloroquine role showed the result of the medicine has a significant effect by cleaning the virus or other clinical matters. The purpose of this literature review is to know the effectiveness quinoline class of drugs which is chloroquine and hydroxychloroquine in COVID-19 disease.Keywords: effectiveness, chloroquine, COVID-19Correspondence: dedydermawan555@gmail.com

Role Of Inhaled Nitric Oxides In Pregnancy With Eisenmenger Syndrome Muhammad Anas; Nenny Triastuti; Muhammad Perdana Airlangga
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 1 (2020)
Publisher : Universitas Muhammadiyah Surabaya

ABSTRACTEisenmenger Syndrome (ES) is congenital heart disease with pulmonary hypertension and shunting turning from right to left. The resistance of pulmonary vascular more than 7.5 mmHg/L/min. The right ventricle and pulmonary artery always enlarge. During pregnancy, there will be hemodynamic changes that will affect the ES. It can be understood the possible dangers that can occur, like right heart failure; an increase in pulmonary arteries or the aggravation of pulmonary hypertension because there is no decrease in pulmonary resistance; A sudden decrease in venous return in supine hypotension syndrome can cause a relative increase in pulmonary arterial pressure so as to aggravate pulmonary hypertension and reverse shunting.Physiological effects of inhaled nitric oxide (INO) therapy cause selective pulmonary vasodilation: Hypoxia alveoli causes reversible vasoconstriction, thereby increasing pulmonary wedge pressure. INO can lower it. Moderate cardiac output and systematic arterial pressure are not affected; Selective in pulmonary because it is activated by hemoglobin; Selective vasodilation in the ventilated area, local hypoxia alveoli constricts the surrounding vascular tissue and redistributes blood flow to the ventilated lungs better and higher intraalveolar oxygen pressure. INO enhances this mechanism by increasing blood flow through a well-ventilated lung; Bronchodilators; Pulmonary surfactant, The combination of high concentrations of inspired oxygen and high concentrations of INO reduces the minimum surfactant surface tension.Keywords: Inhalation Nitric Oxides, Pregnancy, Eisenmenger Syndrome

Effects of Ginger Extract (Zingiber officinale L) on Glycogen Levels Liver on Mice with Hyperglycaemia Nenny Triastuti; Achmad Basori; Sunarni Zakaria
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 1, No 01 (2017)
Publisher : Universitas Muhammadiyah Surabaya

This study aims to prove the effect of ginger extract on rat liver glycogen levels in hyperglycemic. The design of this study is the post-test only control group design with independent variables (free) include a high-fat diet, injections of streptozotocin, the ethanol extract of ginger doses of 300, 400, 500 mg / kg and the dependent variable (dependent) include blood glucose levels ( GTTO II), glycogen levels. Based on this study, the results of different test GTTO end shows significant differences between negative control group and a positive control, a positive control and P1. Besides, also, there is a significant difference between P1 to P2. This suggests that, dosing higher ginger extract can increase the amount of glycogen levels to near normal. Effect of ginger extract on levels of glycogen in the liver of mice were exposed to a high-fat diet and STZ

EFEKTIVITAS PEMBERIAN EKSTRAK DAUN YAKON “SMALANTHUS SONCHIFOLIUS” SEBAGAI TERAPI ANTIHIPERGLIKEMIA PADA MENCIT (MUS MUSCULUS) YANG DIINDUKSI STREPTOZOTOCIN Nenny Triastuti; Detty Nur Irawati; Yelvi Levani; Aldo Dwi Prastya
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 3, No 2 (2020): Herb-Medicine Journal Juli 2020
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v3i2.7578

Abstract Diabetes mellitus is an endocrine metabolite disorder characterized by hyperglycemia. This disorder is caused by demage to pancreatic beta cells or insulin resistance. According to WHO, an estimated 300 million people wordwide suffer from diabetes mellitus by 2025. The use medical drug must of course consider side effects including hypoglycemia, gastrointestinal disorders and impaired kidney function. Smalanthus sonchifolius is known to have anti-inflamatory, antioxidant and antidiabetic effects. Flavonoids as antioxidant and antidiabetic effects through several channels such as reducing apoptosis of beta pancreatic cells, promoting insulin secretion, glucose regulation on hepatocytes, reducing insulin resistance, reducing inflammation and oxidative stress on skeletal muscule cells and adipose tissue, and increasing glucose uptake in skeletal cells, This research uses a true experimental approach using the “Randomized pre and post test control group designI”. The population in this study were 28 male mice which would be divided into 4 groups, each group consisting of 7 individuals. 1 group as a control, and 3 treatment group with the administration of yakon extract each dose 200mg/KgBB, 300mg/KgBB, and 500mg/KgBB for 7 days. Of the four groups after streptozotocin induction, the highest average glucose value was 220,71mg/dl at K and the smallest value at P3 was 208,29mg/dl. While changes in the average glucose value after administration of the extract decreased, the largest value reached 50 at P3 and the smallest value at P1 which was only 36,71. Whereas in K it increased by 0,43 Key word: Diabetes Mellitus, Smalanthus sonchifolius, glucose

PKM PEMASANGAN ALAT FILTRASI AIR UNTUK PENINGKATAN KESEHATAN GINJAL MASYARAKAT DESA TUBAN Rinza Rahmawati Samsudin; Ponidi Ponidi; Nenny Triastuti
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 1 No. 3 (2020): Volume 1 Nomor 3 Tahun 2020
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v1i3.1132

Masyarakat Dahor memenuhi kebutuhan air minum dari air tanah dengan cara membuat sumur gali disekitar perbukitan kapur. Pada umumnya air yang mengalir pada daerah batuan kapur memiliki tingkat kesadahan yang tinggi. Program kegiatan yang dilaksanakan diantaranya pertemuan kesepahaman antara mitra dan tim pengusul untuk memadukan persepsi atas program, pertemuan dengan kepala desa dan perangkat desa untuk menyampaikan persiapan pelaksanaan pengabdian, penyuluhan tentang pentingnya konsumsi air layak minum, penyuluhan kesehatan tentang pentingnya mengetahui gejala, pencegahan dan pengobatan terhadap penyakit akibat mengkonsumsi air yang tidak layak minum, proses pemasangan alat filtrasi air dan penyuluhan cara maintenance/perawatan rangkaian alat pengolah air sumur layak minum. Pemasangan alat filtrasi air yang berlokasi di penampung induk Desa Dahor dilakukan oleh dosen teknik lingkungan dan disaksikan langsung oleh perangkat Desa Dahor, bahkan tidak sedikit dari warga desa yang ikut membantu memasang alat filtrasi air tesebut. Terpasangnya alat filtrasi air diharapkan dapat meningkatkan kualitas air layak minum dan kualitas kesehatan masyarakat di desa Dahor Tuban.

Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus) Andre Bagaskara; Nenny Triastuti; Nurma Yuliyanasari; Yudith Annisa Ayu Rezkitha; Muhammad Anas; Ricky Indra Alfaray
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 9, No 1 (2022): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.9.1.2022.01-09

Background:Putri Malu plants (Mimosa pudica linn) contain flavonoid compounds that are useful as hepatoprotectors. Putri Malu plants extract can be usefull to prevent problem such as Ibuprofen-induced hepatic damage., but study that focus on this topic remain scarce in Indonesia. Objective: To prove the extracted content of the leaves of the Putri Malu plant (Mimosa pudica linn) as a hepatoprotector of hepatic damage in mice (Mus musculus) induced by Ibuprofen. Method: This randomized post-test control group design was conducted at the Experimental Animal Laboratory, Faculty of Veterinary Medicine, Universitas Airlangga. A total of 28 mice were treated with four condition then underwent SGOT and SGPT blood laboratory tests. Results: Group P1 (placebo) had SGOT and SGPT levels averaging 23.87 mg/dl and 13.45 mg/dl, group P2 (ibuprofen dose 7 mg/KgBW) had SGOT and SGPT levels of 29.13 mg/dl and 19.10 mg/dl, group 3 (Putri Malu extract 35 mg/KgBW) had SGOT and SGPT of 24.05 mg/dl and 13.56 mg/dl, and group 4 (ibuprofen dose 7 mg/KgBW and Putri Malu extract of 35 mg/KgBW) showed SGOT and SGPT levels of 28.23 mg/dl and 18.35 mg/dl. The four groups had different mean SGOT and SGPT levels (P 0,000). Conclusion:Leaf extract of the Putri Malu plants (Mimosa pudica linn) has a chemical effect of heaptoprotector as shown by the decrease in SGOT and SGPT level.

Usage of Inhaled Nitric Oxides in Cases of Eisenmenger Syndrome Nenny Triastuti; Muhammad Perdana Airlangga; Muhammad Anas
Indonesian Journal of Medical Sciences and Public Health Vol 1 No 1 (2020)
Publisher : Future Science

Eisenmenger Syndrome is congenital heart disease with pulmonary hypertension and shunting turning from right to left. The resistance of pulmonary vascular more than 7.5 mmHg/L/min. The right ventricle and pulmonary artery always enlarge. Physiological effects of inhaled nitric oxide therapy cause selective pulmonary vasodilation: Hypoxia alveoli causes reversible vasoconstriction, thereby increasing pulmonary wedge pressure. Inhaled nitric oxide can lower it. Moderate cardiac output and systematic arterial pressure are not affected; Selective in pulmonary because it is activated by hemoglobin; Selective vasodilation in the ventilated area, local hypoxia alveoli constricts the surrounding vascular tissue and redistributes blood flow to the ventilated lungs better and higher intraalveolar oxygen pressure. Inhaled nitric oxide enhances this mechanism by increasing blood flow through a well-ventilated lung; Bronchodilators; Pulmonary surfactant, The combination of high concentrations of inspired oxygen and high concentrations of Inhaled nitric oxide reduces the minimum surfactant surface tension.

Faktor yang Mempengaruhi Tingkat Kepatuhan Konsumsi Obat Antidiabetes Oral pada Pasien Diabetes Melitus Tipe 2 di RSUD Kabupaten Jombang Nenny Triastuti; Detty Nur Irawati; Yelvi Levani; Rizky Dwi Lestari
Medica Arteriana (Med-Art) Vol 2, No 1 (2020): Juni 2020
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.2.1.2020.27-37

Latar Belakang: Diabetes melitus (DM) tipe 2 merupakan penyakit kronik yang membutuhkan pengobatan jangka panjang seperti obat antidiabetes oral. Tingkat kepatuhan pasien dalam pengobatan dapat mempengaruhi kondisi penyakit. Tingkat kepatuhan pengobatan yang baik pada pasien DM akan mengurangi terjadinya risiko komplikasi seperti penyakit kardiovaskuler, nefropati, retinopati, neuropati dan ulkus pedis. Oleh karena itu penelitian ini dilakukan untuk mengetahui serta menganalisis faktor-faktor apa saja yang mempengaruhi tingkat kepatuhan konsumsi obat antidiabetes oral pada pasien diabetes melitus tipe 2 di poli penyakit dalam RSUD Kabupaten Jombang.Metode: Penelitian ini merupakan studi analitik observasional dengan menggunakan desain cross sectional. Penelitian ini dilaksanakan di Poli Penyakit Dalam RSUD Kabupaten Jombang dari bulan November hingga bulan Desember 2019. Sampel dari penelitian ini adalah pasien DM tipe 2 yang telah mendapatkan terapi obat antidiabetes oral di Poli Penyakit Dalam RSUD Kabupaten Jombang serta memenuhi kriteria inklusi. Instrumen penelitian berupa kuisioner. Analisis data bivariate menggunakan uji chisquare dengan menggunakan SPSS. Pengaruh dianggap signifikan bila p < 0,05.Hasil: Sebanyak 73 pasien FM berpartisipasi dalam penelitian ini. Sebagian besar pasien DM memiliki tingkat kepatuhan yang rendah (78,1%). Faktor-faktor yang berpengaruh terhadap ketidakpatuhan pasien pada pengobatan diantaranya adalah tingkat pengetahuan (p=0,000), motivasi pasien (p=0,011) dan sikap pasien (p=0,041). Sedangkan jenis kelamin (p=0,546) dan lama menderita diabetes (p=0,308) tidak berpengaruh terhadap tingkat kepatuhan dalam pengobatan DM.Kesimpulan: Dari penelitian ini didapatkan tingkat kepatuhan pasien DM dalam pengobatan antidiabetes oral masih kurang. Faktor yang berpengaruh terhadap tingkat kepatuhan pengobatan adalah pengetahuan, motivasi, sikap. Sedangkan faktor yang tidak berpengaruh dengan tingkat kepatuhan pengobatan adalah jenis kelamin dan lama menderita diabetes melitus (DM). Diharapkan dengan upaya meningkatkan pengetahuan, motivasi dan sikap pasien diabetes melitus (DM) maka dapat meningkatkan kepatuhan terhadap pengobatan oral antidiabates jangka panjang.

Co-Authors Achmad Basori Afrita Amalia Laitupa Aldo Dwi Prastya Andre Bagaskara Detty Nur Irawati Detty Nur Irawati Himmah, Siti Cholishotul Irawati, Detty Nur Kartika Prahasanti M.Dedi Dermawan Dermawan Mohammad hasan Muhammad Anas Muhammad Perdana Airlangga, Muhammad Perdana Musa Ghufron Muslim Andala Putra Nurma Yuliyanasari, Nurma Ponidi Ponidi Rahmatika, Vina Ricky Indra Alfaray Rinza Rahmawati Samsudin Rizky Dwi Lestari Rochman, Syaiful Salim, Nabil Sunarni Zakaria Tri Rosalia Nur Sholikah Yelvi Levani Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu yuli Wahyu Rahmawati

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