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UJI AKTIVITAS ANTIOKSIDAN TERONG BELANDA (SOLANUM BETACEUM CAV.) DENGAN METODE FRAP Inayah, Nurul; Kosman, Rachmat; Syarif, Sukmawati
Jurnal Ilmiah As-Syifaa Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.428 KB)

Abstract

Test Antioxidant Activity of Dutch eggplant (Solanum betaceum Cav.) with FRAP method. This study aims to measure and determine the antioxidant activity Dutch eggplant (Solanum betceum Cav.) with FRAP method. Dutch eggplant was analyzed qualitatively by using the metod FRAP with FRAP reagent. Quantitatively mix with the sample solution was analyzed by FRAP method Uv-Vis spectrophotometer at a wavelength 596 nm. By using trolox as a reference standard. The results obtained in this research that Dutch eggplant has antioxidant activity with an total value of antioxidant activity, 0,9353 µmol Trolox/gr sample.
UJI AKTIVITAS EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) SEBAGAI INHIBITOR ENZIM α-GLUKOSIDASE DENGAN MENGGUNAKAN ELISA READER Sukmawati Syarif; Nurnaningsih Nurnaningsih; Mamat Pratama
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.506

Abstract

Kersen leaves (Muntingia calabura L) contain metabolites such as alkaloids, anthrax, polyphenols, tannins, saponins and are rich in flavonoid components such as flavones, flavonones, flavan and biflavan which have antidiabetic activity. According to a study conducted by Apriyanti (2016), the ethanol extract of kersen (Muntingia calabura L) at a dose of 250 mg / kg BB significantly reduced blood glucose levels in male wistar rats. In this study aimed at determining IC50 ethanol extract of Muntingia calabura L as an inhibitor of α-glucosidase enzymes using ELISA reader. The method was divided into 3 category is 1 (sample extract), 2 (blank) and 3 (akarbose). Each group added 25 µL α-glucosidase solution (0.25 units / mL then measured using ELISA reader 405 nm. The results showed that the ethanol extract of kersen (Muntingia calabura L) had activity as an inhibitor of α-glucosidase enzyme with IC50 34,197 µg / mL and can be categorized as active.
UJI AKTIVITAS ANTIOKSIDAN VARIAN JUS DELIMA (Punicagranatum L.) DENGAN METODE FRAP A. Muflihunna; Sukmawati Syarif; Dian Rahmawati
As-Syifaa Jurnal Farmasi Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.761 KB) | DOI: 10.33096/jifa.v6i2.44

Abstract

A research test the antioxidant activity of pomegranate juice (Punicagranatum L.) with the FRAP method to measure and determine antioxidant activity. Pomegranate juice was analyzed qualitatively by using the metod FRAP with FRAP reagent. Quantitatively mix with the sample solution was analyzed by FRAP method UV-VIS Spectrophotometer at a wavelength 596 nm. By using trolox as a reference standard. From the research result that sample A and sample B sample C has antioxidant activity with an total value of antioxidant activity, sample A = 6.1243 μmol TR/g sample, sample B = 6.0913 μmolTR/g sample and sample C = 2.9651 μmolTR/g sample.Key words :  Pomegranate juice, antioxidant activity, FRAP, Trolox Uv-Vis Spectrophotometer.
FORMULASI DAN EVALUASI MASKER GEL PEEL-OFF EKSTRAK ETANOL KULIT BUAH APEL (Phyrus mallus L) SEBAGAI ANTIOKSIDAN A. Muflihunna; Sukmawati Syarif; A. Mumtihanah Mursyid
Jurnal Kesehatan The 1st Alauddin Pharmaceutical Conference and Expo (ALPHA-C) 2019
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v0i0.11355

Abstract

Antioxidants are substances that can fight the dangerous effects of free radicals or Reactive Oxygen Species (ROS) that are formed as a result of oxidative metabolism, which is the result of chemical reactions and metabolic processes that happen in the body. Antioxidant compounds can function as free radical scavengers, complex formers with metal antioxidants and function as reducing compounds. Peel-off mask is a cosmetic product that functions as a dead skin peel mechanically containing synthetic polymers that are quite safe and effective. The purpose of this study is to formulate and evaluate peel off gel masks from apple peel waste (Phyrus mallus L) as one of the stable free antiradicals. The peel off gel mask formulation was made through several stages, namely optimization, formulation and evaluation. This variation is done to optimize the effective base concentration to meet the criteria for the physical properties of the peel off mask pharmaceutically and can survive in shelf life through stability testing. The evaluation is based on physical parameters including organoleptic examination, homogeneity, viscosity measurement, determination of flow type,pH measurement, spreadability and drying time. The results of this study are apple peel extract can be formulated into peel off mask preparations with a PVA base of 2.5% and 5%. The peel off mask formulation of several variations of the PVA base concentration was concluded to be pharmaceutically stable based on the following parameters: In the pH test, PVA 2.5%=6.49; PVA 5%=6.47, In the dispersion test, the PVA spread value is 2.5%=6.7; PVA 5%=6.0, In the viscosity test, the value of PVA viscosity is 2.5%=28.27; PVA 5%=121.07.From all tests fulfilling the pharmacutics requirements and after the forced conditions did not experience significant changes
Peningkatan Pemahaman Mengenai Menstruasi Melalui Penyuluhan Serta Pemeriksaan Golongan Darah Di Usia Dini Sukmawati Syarif; A. Muflihunna; Zainal Abidin; Masdiana Tahir
LOYALITAS: Jurnal Pengabdian Kepada Masyarakat Vol 3 No 2 (2020): November 2020
Publisher : IAI Darussalam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30739/loyal.v3i2.397

Abstract

Menstruation is a physiological change in a woman's body that occurs periodically and is influenced by reproductive hormones either FSH-Estrogen or LH-Progesterone. In women, this usually occurs every month between teens to menopause, and lasts around 7-28 days. Knowing the characteristics of menstruation early is a very important thing to know because it is an early learning about the reproductive system and their health. Blood type is an inherited antigen on the surface of red blood cells. The two most important types of blood classification to know are the classification of ABO and Rhesus (Rh factor). Blood type examination is an activity that is sometimes overlooked by the community, in this case the needs of the Blood Type are carried out for clinical purposes such as: blood transfusions, preventing transfusion complications, and for pregnant women. According to empirical data obtained in 2017 the level of understanding of menstruation and blood type in primary schools is very low. For this reason, efforts are made to provide education and information as well as checks on children from an early age as a starting point for character building in improving education and knowledge in general and specifically regarding health
POTENSI SENYAWA FLAVONOID DAUN AFRIKA (Vernonia amygdalina Del.) ASAL TERNATE SEBAGAI ANTIOKSIDAN Sukmawati Sukmawati; Harira Hadi; Aminah Aminah
As-Syifaa Jurnal Farmasi Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.555 KB) | DOI: 10.33096/jifa.v9i2.278

Abstract

African Leaf (Vernonia amygdalina Del.) belonging Asteraceae family. The African leaf contain flavonoids, alkaloids, saponins, terpenoids, tannins, glycosides, indole alkaloids, anthraquinones and luteolin. This study aimed to measure the potencyl of flavonoid compounds of African leaf (Vernonia amygdalina Del.) origin Ternate using DPPH and FRAP. Extraction by maceration method using ethanol 96%. The compounds identification in African leaf extract contains flavonoids. The absorbance was measured at the maximum wavelength of 515 nm. DPPH scavenging showed that ethanol extract has weak antioxidant activity based on AAI 0.454 value. This potency is lower in comparasion with quersetin which has a value of AAI 6,315 and for FRAP methods, the absorbance was measured at the wavelength of 720 nm with the antioxidant capacity is 14,846 mgQE / gram.
ANALISIS KADAR KUERSETIN PADA EKSTRAK ETANOL DAUN MIANA (Plectranthus scutellarioides (L.) R.Br.) SECARA HPLC (High Performance Liquid Chromatography) Sukmawati Sukmawati; Harti Widiastuti; Miftahuljanna Miftahuljanna
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.556 KB) | DOI: 10.33096/jifa.v11i1.462

Abstract

One of the medicinal plants that people often use as a medicine is the Miana leaves (Plectranthus scutellarioides (L.) R.Br.). The Miana leaves are empirically used to treat coughs, heart disease, worm medicines, antimicrobials, antioxidants, antiseptics, bronchitis, hemorrhoids, tuberculosis, and other pharmacological activities. The miana leaves contain secondary metabolite compounds of flavonoids, steroids, tannins, and saponins. One of the most critical flavonoids is quercetin. This study aimed to determine the quercetin content of ethanol extract of miana leaves by HPLC (High Performance Liquid Cromatography). The extraction method by maceration using 96% ethanol. Determination of quercetin content in miana leaf ethanol extract by HPLC with C18 column, maximum wavelength of 369.11 nm with mobile phase methanol : aquabides (59:41) flow rate of 1 mL/minute. The results showed retention time for quercetin as a comparison of 4,183 minutes, a sample of 4.563 minutes, and an additional sample of 4,363 minutes. The average content of quercetin in miana leaf ethanol extract was 3.122 mg/g or 0,312%.
ANALISIS KANDUNGAN β-KAROTEN PADA JENIS SAWI PUTIH (Brassica pekinensia L) DAN JENIS SAWI HIJAU (Brassica Juncea L coss) SECARA SPEKTROFOTOMETRI UV-VIS Sukmawati Syarif; Milka Flaning
As-Syifaa Jurnal Farmasi Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (202.481 KB) | DOI: 10.33096/jifa.v5i1.69

Abstract

Analysis content of β-carotene for Sawi hijau (Brassica juncea L coss) and sawi putih (Brassica pekinensia L) By Spectrophotometri Visible. A heve applied of research about contentof β-carotene in two quality  of sawi namely sawi hijau (Brassica juncea L coss) and sawi putih (Brassica pekinensia L). For to Analysis and senelles content β-carotene in sawi. Sawi sample to be extraction in demarcation by acetone. The result of extraction to extract agein with petroleum eter and applied safonification with KOH 15 %. Qualitative analysis applied with Chromatography method in thin layer using petroleum eter:Benzen (9:1). The result it showing there are spot which same on two samples and β-carotene pure as the compere. While Quantitative analysis with spectrofotometri visible using β-carotene pure as compere showing that the content of β-carotene sawi hiaju 99,23 mg/g and sawi putih 40,91 mg/g.Key Word : β-Karoten, Brassica pekinensia L,  Brassica juncea L coss
EFEK ANTIHIPERLIPIDEMI INFUS DAUN SAMBILOTO (Andrograpidis paniculata) PADA HEWAN COBA KELINCI ( Orictolagus cuniculus) DENGAN PARAMETER KOLESTEROL DAN TRIGLISERIDA Sukmawati Syarif; Aulia Wati; Hendra Herman
As-Syifaa Jurnal Farmasi Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i2.133

Abstract

This research is done to know whether infuse of sambiloto leaf can reduce cholesterol and trigliserida value in the blood or not. For reducing cholesterol and trigliserida value in the blood, we want to know the most effective concentration of infuse of sambiloto leaf ( Andrograpidis paniculata).In this research, the method is used is draw up samples, substancions, experimental animals, treatment with experimental animal and measuring cholesterol and trigliserida value.All sample can reduce cholesterol and trigliserida value at concentration 10%, 15%, or 20%, sample with concentration 15% and 20% reduce cholesterol value is better than sample with concentration 10%. Sample with concentration 15% and 20% have reducing effect of trigliserida value same with simvastatin.Analyze using ANAVA (analys variant) with continuing test using LSD at belief standart 0,05, in conclusion, infuse of Sambiloto leaf can reduce not only cholesterol but also trigliserida value in male rabbits.Key Word : Antihiperlipidemi, Andrograpidis paniculata, cholesterol and trigliserida.
ANALISIS KANDUNGAN POLIFENOL DALAM RUMPUT LAUT Eucheuma sp DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE Rachmat Kosman; Pirman AP; Sukmawati Syarif
As-Syifaa Jurnal Farmasi Vol 1, No 2 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i2.95

Abstract

Seaweed are one of resource foreign exchange of state and earning source for coastal area society. Besides can be used direct upon which food, some result processing of seaweed like gelatinous, carrageenan and alginate represent the compound which important enough in industry. A lot of research proving that seaweed is substance of food which important, like some among other thing is anticancer, antioxidant, preventing cardiovascular, and as diet food. As for content of chemistry compound anticipated by a sharing to cause the effect is compound polyphenol. Referring to above the mentioned, and to know furthermore hit the content polyphenol in Eucheuma sp seaweed, is hence done by analysis research polyphenol in Eucheuma sp seaweed. This research benefit is to give the erudite evidence and information about existence of content polyphenol of Eucheuma sp seaweed. This research is done by using method of spectrofotometric UV-Visible and as reagent used by Folin Ciocalteu and Na2CO3 yield the blue colour, then read by absorbance at 670 nm. As standard condensation used by acid tannat with the concentration 0,25; 0,5; 1,0; 2,0; 4,0; and 8,0 ppm. From research result indicate that the Eucheuma sp seaweed contain the polyphenol with the rate polyphenol of Eucheuma sp I as much 0,054 mg/100g and Eucheuma sp II as much 0,053 mg/100g.Key Words :  Polifenol, Euchema sp and Spectrofotometri UV-Vis.