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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Indonesia JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Mandala Pharmacon Indonesia Jurnal Biomedika Majalah Farmasetika Health Information : Jurnal Penelitian Open Access Indonesian Journal of Medical Reviews Jurnal Sains dan Kesehatan Jurnal Multidisiplin Madani (MUDIMA)
Lucia VIta Inandha Dewi
Faculty Of Pharmacy, Setia Budi University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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Identifikasi Polimorfisme Gen N-Asetiltransferase 2 (NAT2) Pada Suku Batak Ezra Pasaribu; Jason Merari Paranginangin; Lucia Vita Inandha Dewi
Health Information : Jurnal Penelitian Vol 15 No 1 (2023): Supplemen
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia has various ethnic groups spread from Sabang to Merauke consisting of more than 300 ethnic groups, Research on the TB gene in Javanese (40%) Sundanese (15.50%), Malay (3.7%), Batak (3.6%), Madura (3%) and Betawi (2.88%). The aim is to determine the presence of polymorphisms in the NAT2 gene of healthy Batak subjects along with the types of polymorphisms and types of acetylators. The impact of NAT2 polymorphisms are drug toxicity, peripheral neuropathy. The method uses the RFLP method with a sample of 10 Batak tribes. Blood samples were isolated by DNA using the Wizard® Genomic DNA Purification Kit then RFLP PCR using restriction enzymes: Taq1, Kpn1, BamH1 and electrophoresis. The RFLP of the Kpn1 restriction enzyme used a 100bp marker. Taq1 obtained NAT2*4 and the mutant allele NAT2*6A. BamH1 obtained NAT2*4 and the mutant allele NAT2*7B. There are NAT2 gene polymorphisms in the Batak tribe, namely NAT2*4/*5B, NAT2*4/*6A, NAT2*4/*7B, NAT2*5B/*5B and NAT2*7B/*7B and the type of NAT2 gene polymorphism in the Batak tribe. namely medium acetylator NAT2*4/*5B (20%), NAT2*4/*6A (33.3%) and in NAT2*4/*7B (20%), slow acetylator NAT2*5B/*5B (13,3%) and NAT2*7B (13.3%). The types of acetylators in the Batak tribe of North Sumatra province are medium and slow acetylators.
The relationship between knowledge and community behavior in improving the immune system during the COVID-19 pandemic era in Barong Tongkok Village Stevania Windi; Lucia Vita Inandha Dewi; Inaratul Rizkhy Hanifah
Jurnal Ilmiah Farmasi Vol. 19 No. 1 (2023): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol19.iss1.art6

Abstract

Abstract Background: Within 2 years of the COVID-19 pandemic, stopping the spread of COVID-19 in the community can be done with adequate knowledge about immune system improvement behaviors and the use of health supplements to improve the body's immune system.Objective: This study aims to determine the relationship between the level of knowledge and community behavior in improving the immune system in Barong Tongkok Village in the era of the COVID-19 pandemic.Method: This study is a quantitative type with a cross-sectional method conducted in Barong Tongkok Village with a total sample of 356 respondents from 4,787 total populations. Analysis of results is carried out with univariate tests to concentrate and display data, while bivariate tests are statistical analyses of chi-square tests to see the relationship between two variables.Results: A univariate analysis revealed that the level of knowledge in the high category was 55.6% and the behavior of improving the immune system in the good category was 50.8%. The results of the bivariate test analysis with the chi-square test revealed a significant relationship between the level of knowledge and the behavior of improving the immune system (p = 0.000).Conclusion: There is a relationship between the level of knowledge and the behavior of improving the immune system in Barong Tongkok Village.Keywords: Level of knowledge, behavior, immune system, COVID-19 pandemic Intisari Latar belakang: Dalam kurun waktu 2 tahun lamanya pandemi COVID-19 telah berlangsung, penghentian penyebaran COVID-19 di masyarakat bisa dilakukan dengan pengetahuan yang memadai tentang perilaku peningkatan sistem imun dan penggunaan suplemen kesehatan untuk memperbaiki sistem imun tubuh.Tujuan: Studi ini bertujuan untuk mengetahui hubungan antara tingkat pengetahuan, dengan perilaku masyarakat dalam peningkatan sistem imun di Kelurahan Barong Tongkok di era pandemi COVID-19. Metode: Penelitian ini termasuk jenis kuantitatif dengan metode cross-sectional dilakukan di Kelurahan Barong Tongkok dengan jumlah sampel 356 responden dari 4.787 populasi masyarakat, analisis hasil dilakukan dengan uji univariat untuk mempersentasekan dan menampilkan data, sedangkan uji bivariat yaitu analisis statistika uji chi-square untuk melihat hubungan antara dua variabel.Hasil: Analisis univariat diperoleh bahwa tingkat pengetahuan dengan kategori tinggi sebesar 55,6%, dan perilaku peningkatan sistem imun dengan kategori baik sebesar 50,8%. Hasil analisis uji bivariat dengan uji chi-square diperoleh hubungan yang signifikan antara tingkat pengetahuan dengan perilaku peningkatan sistem imun (p=0,000).Kesimpulan: Terdapat hubungan antara tingkat pengetahuan dengan perilaku peningkatan sistem imun di Kelurahan Barong Tongkok.Kata kunci: Tingkat pengetahuan, perilaku, sistem imun, pandemi COVID-19
Development of Pocketbooks as an Education and Compliance Module for Diabetes Mellitus Patients at the Kaliwungu Health Center, Kudus, Indonesia Eka Fitriani; Rina Herowati; Lucia Vita Inandha Dewi
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 4 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i4.351

Abstract

Diabetes mellitus (DM) is a chronic disease that requires long-term treatment. Management of DM patients is one of them by providing education. This study aimed to determine the product trial of developing a pocketbook as an educational module using the assessment parameters of experts and DM patients who meet the eligibility criteria at Kaliwungu Health Center, Kudus. This study used qualitative and quantitative analysis. Qualitative analysis in the form of suggestions and input from experts, and quantitative analysis in the form of assessment scores. The method used in this research is research and development. Product development with Borg and Gall procedures. Product trials of pocket book development as a DM patient education module at Kaliwungu Health Center, Kudus, using expert parameters including media experts at 100%, material expert I with a value of 84%, material expert II with a value of 92.3%, material expert III with a value of 100%, expert practitioners with a value of 100% and DM patients with an average value of 80.5% in the category worth using with revision.
Analysis of Drug Management and Improvement Strategies Using the Hanlon Method in Pharmaceutical Installations RSUD Dr. Moewardi in 2022 Hamra Sakaria; Tri Wijayanti; Lucia Vita Inandha Dewi
Jurnal Multidisiplin Madani Vol. 4 No. 5 (2024): May 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i5.9379

Abstract

Drug management at RSUD Dr.Moewardi in previous research showed that drug management in the Pharmacy Installation at Dr. Moewardi is not yet efficient. Dr. Moewardi Hospital Pharmacy Installation which includes the selection, planning, procurement, distribution and use stages in 2022, determine priority drug management problems based on the Hanlon method and find out strategies for improving drug management in the RSUD Pharmacy Installation Dr.Moewardi in 2022. Secondary data was obtained from interviews with the Head of the Pharmacy Installation at RSUD Dr. Moewardi. The results of research on drug management at IFRSUD Dr. Moewardi who did not meet the standards at the selection stage for suitability of drug items available at Fornas (82.80%) and FRS (81.41%) at the procurement stage, percentage of drug procurement fund allocation (17.27%) Frequency of late payments (448X) percentage of suitability of drug planning(87.16%) at the distribution stage accuracy of drug quantity data on stock cards (95%) ITOR(15.078 times) percentage of expired drugs (0.04%), percentage of dead stock (13%) and at the usage stage the number of drug items per prescription sheet (3.6), the percentage of generic drug use (72.85%) and the average waiting time for compounded drugs was (61.76 minutes) and non-mixed (28.68 minutes)
Analisis Efektivitas Biaya Pengobatan Golongan Statin dalam Manajemen Penyakit Jantung Koroner Di RSUD Kota Madiun 2021/2022 Emiliya Dwi Agustin; Lucia Vita Inandha Dewi; Inaratul Rizkhy Hanifah
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.363

Abstract

Penyakit Jantung Koroner (PJK) menjadi salah satu prevalen dengan angka yang cukup tinggi di Indonesia. Pengobatan utama yang digunakan di RSUD Kota Madiun adalah golongan HMG-CoA Reduktase Inhibitor atau Statin, yaitu atorvastatin dan simvastatin. Penggunaan obat jangka panjang, biaya perawatan rumah sakit, frekuensi kunjungan ke dokter dan biaya pengobatan PJK menjadi beban yang signifikan. Tujuan dari studi ini adalah mengetahui cost effective antidislipidemia golongan statin pada penyakit jantung koroner. Pendekatan metode yang digunakan adalah deskriptif non-interventional, yaitu dengan mengumpulkan data secara retrospektif dari rekam medik dan billing pasien. Subyek penelitian  sejumlah 64 pasien PJK yang menerima terapi simvastatin dan atorvastatin. Efektivitas pengobatan diukur berdasarkan jumlah pasien yang mencapai target penurunan LDL sebesar 18 – 55% dan peningkatan HDL 5-15%, sementara biaya yang diukur adalah biaya medis langsung yang diperoleh dari data billing selama pasien dirawat dalam satu periode rawatan. Pendekatan farmakoekonomi yang digunakan adalah Cost Effectiveness Analysis dengan menghitung nilai ACER, ICER dan analisis sensitivitas. Hasil penelitian menunjukkan rata-rata biaya total atorvastatin dan simvastatin sebesar Rp. 7.874.384 dan Rp. 6.828.385 dengan persentase efektivitas sebesar 94,28% dan 79,31%. Atorvastatin lebih cost effective dengan nilai ACER yang lebih rendah yaitu Rp. 8.352.125, sementara simvastatin sebesar Rp.8.609.740. Sehingga dapat disimpulkan bahwa antidislipidemia yang paling cost-effective adalah atorvastatin dan untuk menambah 1 efektifitas diperlukan biaya sebesar Rp. 6.987.241,15.
Uji Kualitas Hidup Pasien Post Vaksinasi Covid-19 Dengan Pendekatan SF 36 Dan SF 12 joverly endey; Gunawan Pamudji Widodo; Lucia Vita Inandha Dewi
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.482

Abstract

Pesantnya penyebaran COVID-19 dan bahaya yang akan muncul jika tidak segera ditangani maka salah satu cara yang sangat mungkin untuk mencegah penyebaran virus ini adalah dengan mengembangkan vaksin. Namun, vaksinasi COVID-19 menimbulkan beberapa efek samping jangka panjang dan jangka pendek. Penelitian ini bertujuan untuk mengetahui gambaran sosiodemografi pada pasien pasca vaksinasi COVID-19, gambaran kualitas hidup dengan pendekatan SF 36 dan SF-12, serta membandingkan keduanya. Penelitian ini merupakan desain penelitian deskriptif non eksperimental dengan rancangan cross-sectional. Penelitian ini dilakukan di Puskesmas Kecamatan Banjarsari, Kota Surakarta. Penelitian dekstriptif menggambarkan kualitas hidup masyarakat pasca vaksinasi COVID-19 yang terjadi di Puskesmas Kecamatan Banjarsari, Kota Surakarta. Karakteristik responden penelitian didominasi pasien laki-laki sejumlah 46 pasien (51,69%) dengan kategori umur 17-24 tahun (Remaja Akhir) 42 pasien (47,19%), pendidikan terakhir SMA 47 pasien (52,81 %), status pernikahan belum menikah 51 pasien (57,30%), status pekerjaan pegawai swasta 30 pasien (33,71%), tingkat penghasilan lainnya di luar rentang UMR (1,9 juta) – 3,5 juta sebanyak 40 pasien (44,94% ) dengan mendapatkan vaksin booster pada bulan Februari 2023 77 pasien (86,52%). Kualitas hidup pasien pasca vaksinasi booster COVID-19 dengan kuesioner SF-36 diperoleh hasil kategori baik sebanyak 62 pasien (69,66%). Kualitas hidup pasien pasca vaksinasi booster COVID-19 dengan kuesioner SF-12 diperoleh hasil kategori baik sebanyak 67 pasien (72,28%). Tidak ada perbedaan hasil antara Kuesioner SF-36 dan SF-12 karena hasil dari pengukuran kualitas hidup pasien pasca vaksinasi booster COVID-19 masuk kategori baik dengan nilai Mann Whitney sig. 0,671 > 0,05.
Co-Authors Asa Puspagiri Setiyasih D. Andang Arif Wibawa Dyah Susilowati Eka Fitriani Eka Umayasari Emiliya Dwi Agustin Eunike Yuvita Purbosari Ezra Pasaribu Gunawan Pamudji Widodo Hamra Sakaria Inaratul Rizkhy Hanifah Jason Merari Paranginangin joverly endey KETUT WIRIANA Lukman Hakim Mamik Ponco Rahayu Marisa Stifani Mandala Ngatidjan Ngatidjan RATNA AGUNG SAMSUMAHARTO Rina Herowati Sismindan Sismindan Soni Prabowo Putra Stevania Windi Tika Novita Sari Tri Wijayanti