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All Journal Jurnal Sains dan Teknologi Farmasi Molecular and Cellular Biomedical Sciences (MCBS) JSFK (Jurnal Sains Farmasi & Klinis) Ensiklopedia of Journal Jurnal Ners Jurnal Riset Indragiri Journal of Pharmaceutical and Sciences. Borneo Journal of Pharmacy

Armenia, Armenia

Fakultas Farmasi Universitas Andalas

Author-ID : 701114

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Dampak Terapi Sitikolin, Sosiodemografi dan Komorbiditas Terhadap Nilai GCS Pasien Stroke di RSUP dr. M. Djamil Padang Abdillah, Rahmad; Armenia, Armenia; Anggadireja, Kusnandar
Jurnal Sains dan Teknologi Farmasi Vol 19 No Supl1 (2017): Vol 19 Supplement 1, December 2017
Publisher : Fakultas Farmasi Universitas Andalas

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Kesadaran pasien adalah salah satu luaran penting dalam penanganan stroke, penurunan kesadaran pada pasien stroke dapat memperburuk prognosis dan salah satu faktor mortalitas pada pasien stroke. Penelitian ini dilakukan untuk mengetahui dampak terapi sitikolin, sosiodemografi (usia, jenis kelamin,dan pekerjaan)dankomorbiditas pasien stroke terhadap Glasgow Coma Scale (GCS). Sebanyak 82 pasien stroke berpartisipasi dalam penelitian ini. Dari tiga karakteristik sosiodemografi tersebut hanya umur dan jenis perkerjaan yang mempengaruhi nilai GCS (p<0,05). Namun tidak terdapat pengaruh variasi dosis sitikolin dan komorbiditas terhadap nilai GCS pasien stroke (p>0,1). Ditemukan dampak interaksi antara jenis stroke danvariasi dosis sitikolin, jenis stroke, terapi sitikolin, kejadian stroke berulang, danjenis stroke, serta komorbiditasdankejadian stroke berulang, terhadap nilai GCS (p<0,05).

Isolation, Characterization, Proliferation and Differentiation of Synovial Membrane-derived Mesenchymal Stem Cells (SM-MSCs) from Osteoarthritis Patients Marlina Marlina; Rizki Rahmadian; Armenia Armenia; Wahyu Widowati; Rizal Rizal; Hanna Sari Widya Kusuma; Satrio Haryo Benowo Wibowo; Wahyu Setia Widodo; Ika Adhani Sholihah
Molecular and Cellular Biomedical Sciences Vol 4, No 2 (2020)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v4i2.100

Background: Mesenchymal stem cells (MSCs) are the cells which have high renewal capacity and and are capable for differentiating into some types of cells. MSCs can be obtained from several tissues including bone marrow, synovial membrane, blood, adipose tissue and periosteum. The proliferation and self-repair ability of MSCs are the advantages to use as stem cells-based therapy of various diseases. The aim of this study was to determine the differentiation, characterization and proliferation of synovial membrane-derived MSCs (SM-MSCs).Materials and Methods: The cells proliferation capacity was determined by cell counting using trypan blue, characterization of MSCs (cluster of differentiation (CD)90, CD11b, CD73, CD34, CD19, CD45, CD105 and human leukocyte antigen-DR isotype (HLA-DR)) using flow cytometry analysis, and differentiation capability into three lineage cells was determined with red alcian blue, oil red O and alizarin staining.Results: The type culture of SM-MSCs was adherent and showed positive CD44, CD105, CD73, CD90 and negative of CD19, HLA-DR, CD11b, CD45, CD34 surface marker. Based on the result, SM-MSCs P3 showed differentiation potency into adipogenic, chondrogenic, and osteogenic lineage cells. The population doubling time of SM-MSCs has increased from P3 to P8. The population doubling time of SM-MSCs P3 was 1.69 days and SM-MSCs P8 was 3.64 days.Conclusion: The results indicated that SM-MCSCs from osteoarthritis patients are able to differentiate into osteocytes, chondrocytes, adipocytes and highly express of CD105, CD73, CD90, CD44 and negative for CD34, CD45, CD14, CD19.Keywords: synovial membrane, mesenchymal stromal cells, adipocyte, chondrocyte, osteocyte

Dampak Karakteristik Sosiodemografi dan Tingkat Kepatuhan Terapi Antihipertensi Terhadap HRQoL Pasien Gagal Jantung Kongestif Maryorie Rosa; Armenia Armenia; Dedy Almasdy
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Health Realted Qulity Of Life (HRQoL) is the patient perspective to their medication and illnes. The objective of study is to determine the impact of social demography characteristics, and medical adherence to the HRQoL of congestive heart failure patients in M. Djamil Hospital Padang. Data social demography, adherence, and HRQoL of 111 patients were collected by guided interview and completed by their medical record. We used T-test and one-way ANOVA, while 95% confidence intervals was taken for the significance. Patients who completed the education in senior high school possessed the best HRQoL score and the patients with lower level education had a worse HRQoL score (P<0,05). The best HRQoL score was showed by civil servant compared to other professions (P<0,05). While the worse HRQoL performed by the patient who had lower level of medication adherence (P<0,05). While the gender and age of the patients were not significantly affected the HRQoL score (P>0,1).

Hubungan Ketepatan Switch Therapy Terhadap Kesembuhan Luka, Lama Rawatan dan Biaya Pengobatan Antibiotik Pasien Appendisitis Lathvi Masyithah; Armenia Armenia; Almahdy Almahdy
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Antibiotic Switch therapy is defined by the switch of intravenous antibiotic therapy to oral form. This research aimed to learn about the relationship of switch therapy toward the value of wound healing, lenght of stay and the antibiotic expenditure. The data of this cross sectional study was collected from medical record and by direct investigation to patients for their macroscopis the wound healings value. T-test was used to compared the relationship of the patient wound healings value, lenght of stay and the antibiotic expenditure between the those with and accurate switch therapy and those without it. The result showed that there was no different of wound healing value between those groups of patients (P>0,1). On the other hand, lenght of stay and antibiotic expenditure of the patient with the accurate switch therapy was cuted on the patient with the accurate switch therapy. These indicated that accuracy of switch therapy will proceed a benefit outcome to the patient with appendicitis, especially to there lenght of stay and antibiotic expenditure as well.

Uji Toksisitas Subkronis Ekstrak Etanol Tali Putri (Cassytha filiformis L.) Terhadap Fungsi Ginjal Tikus Yori Yuliandra; Armenia Armenia; Annisa Nur Salasa; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Sub-chronic toxicity test of the deffated ethanolic extract of tali putri (Cassytha filiformis L.) on the rat renal function has been carried out. A number of 16 male rats aged 2-3 months, weighing ±250 g were used as experimental animals. The rats were divided into 4 groups which consisted of 1 control group and 3 extract-treated groups given 1.25, 2.5, and 5 mg/kg extract administrated intraperitoneally once a day for 14 days. The creatinine clearance, renal function, and the ratio of renal were calculated and analyzed by two-way ANOVA followed by Duncan’s test. The study showed that the creatinine clearance and renal function decreased significantly during treatment (p<0.05). The kidney weight ratio of groups treated with extract, especially with greater doses, showed a very significant increase as compared with control (p<0,01). These indicated that the ethanolic extract of C. filiformis on the doses of 1.25 – 5 mg/kg might decrease the renal function, althought it seemed to be relatively safe when used for 14 days.

Effect of Eleutherine americana Merr. bulb extract on blood pressure and heart rate in anesthetized hypertensive rats Yori Yuliandra; Rizki Oktarini; Armenia Armenia
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

The effect of ethanolic extract of Eleutherine americana Merr. on the blood pressure and heart rate has been investigated. A number of 25 Sprague-Dawley male rats were induced with prednisone 1.5 mg/kg in combination with saline solution 2.5% for 14 days to obtain hypertension model. The rats were anesthetized and prepared for the recording of blood pressure and heart rate. The rats were divided into five groups receiving 100, 200, and 400 mg/kg of the extract, vehicle control, and captopril 30 mg/kg as the reference. The treatment was administered three times with 30 minutes interval. The systolic (SBP), diastolic (DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded. The data were analyzed with two-way analysis of variance (ANOVA) followed by Duncan’s MRT (95% confidence interval). The study revealed that the extract exhibited a blood pressure lowering effect. The best antihypertensive activity of the extract was shown by the dose of 100 mg/kg. Meanwhile, HR was also affected inversely by the treatment, in which the lowest dose caused the highest increase. The study suggests that the extract of Eleutherine americana exhibits antihypertensive activity that may be potential for future development of drugs.

Pengaruh Jenis Vaksin Covid-19 pada Kualitas Hidup Terkait Kesehatan (HRQoL) Masyarakat di Kota Padang dan Pariaman Boy Andre; Lailaturrahmi Lailaturrahmi; Almahdy A; Armenia Armenia
Jurnal Sains Farmasi & Klinis Vol 9, No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.277-284.2022

Covid-19 (Corona Virus Disease-2019) merupakan penyakit infeksi yang disebabkan oleh virus coronavirus 2 yang sangat mudah menular dan menyebabkan infeksi pada sistem pernafasan. Vaksinasi Covid-19 adalah salah satu upaya pencehagan penularan, dimana jenis vaksin yang diberikan kepada masyarakat ditetapkan oleh pemerintah. Tujuan penelitian ini adalah menganalisis pengaruh jenis vaksin Covid-19 terhadap kualitas hidup terkait kesehatan (HRQoL) di Kota Padang dan Pariaman. Penelitian dilakukan dengan menyebarkan dalam jaringan kuisioner generik WHOQOL-BREF yang berisi 26 pertanyaan pada bulan Juli – September 2022. Jenis vaksin merupakan variabel independen sedangkan data sosiodemografi responden yang meliputi jenis kelamin, usia, status perkawinan, pekerjaan, kota domisili, pendidikan terakhir, dan penyakit penyerta sebagai covariat. Kuisioner diolah secara statistik menggunakan SPSS versi 26 dengan analisis univariat. Vaksin Covid-19 yang diterima oleh responden yaitu Sinovac dan Sinopharm (inactivated virus), Moderna dan Pfizer (mRNA), serta Astra Zeneca (Non-Replicating Viral Vector). Kuisoner yang diisi secara lengkap oleh 418 responden didapatkan hasil dimana sebanyak 242 dan 81 responden menyatakan kualitas hidup terkait kesehatan mereka berstatus baik dan sangat baik, sedangakan 93 dan 2 repsonden menyatakan biasa dan buruk. Hasil uji statistik menunjukkan tidak terdapat pengaruh yang signifikan (p>0,05) antara jenis vaksin terhadap ke empat domain pada HRQoL. Namun, terdapat pengaruh yang signifikan (p<0,05) pada covariat yaitu status perkawinan, pekerjaan dan pendidikan terakhir terhadap semua domain pada HRQoL.

HUBUNGAN KARAKTERISTIK INDIVIDU DAN STATUS GIZI DENGAN KONDISI DIABETES MELITUS TIPE 2 DI WILAYAH KERJA PUSKESMAS ANAK AIR TAHUN 2022 Sepni Asmira; Fauzan Azima; Kesuma Sayuti; Armenia
JURNAL RISET INDRAGIRI Vol 2 No 1 (2023): Maret
Publisher : Lembaga Marwah Rakyat

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Prevalensi diabetes pada orang dewasa terus meningkat di tingkat nasional dan global. Ada beberapa faktor penentu diabetes sangat penting untuk tindakan pencegahan dan kontrol penderita diabetes. Tujuan penelitian ini untuk mengetahui Hubungan Karakteristik Individu dan Status Gizi Pada Pasien Diabetes Melitus Tipe 2 Di Wilayah Kerja Puskesmas Anak Air Tahun 2022. Penelitian ini merupakan analitik dengan desain penelitian cross sectional pada 42 responden, dengan analisis data dengan analisis univariat dan analisis bivariat dengan uji Chi-Square. Hasil penelitian didapatkan pengetahuan kurang 64,29%, asupan karbohidrat cukup 47,62 %, asupan lemak cukup 54,76%, protein cukup 45,24 %, aktivitas fisik kurang 73,80%, dan status gizi overweight 73,81%. Adanya hubungan pengetahuan, asupan karbohidrat, asupan lemak, aktivitas fisik, status gizi dengan kejadian DM tipe2 dan tidak terdapat hubungan antara protein dengan diabetes melitus tipe 2 . Pengetahuan, pola makan, aktivitas fisik dan status gizi sangat mempengaruhi kondisi DM Tipe 2. Diharapkan responden lebih aktif untuk melakukan aktivitas sehari-hari, menjaga asupan makanan, agar kondisi gula darah tetap terkontrol sehingga terhindar dari peningkatan kadar glukosa dalam darah.

GAMBARAN KEPATUHAN DIET DAN KONTROL GULA DARAH PADA PASIEN DIABETES MELITUS TIPE 2 SETELAH KONSELING GIZI DI PUSKESMAS AIR DINGIN TAHUN 2022 Sepni Asmira; Fauzan Azima; Kesuma Sayuti; Armenia Armenia
Ensiklopedia of Journal Vol 5, No 3 (2023): Vol. 5 No. 3 Edisi 2 April 2023
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion and insulin resistance. The 2018 health profile survey showed that the highest prevalence of type 2 DM was in the working area of the Air Dingin Health Center, including high compared to other puskesmas in the Koto Tangah sub-district with 442 cases of DM. The aim of the study was to find out the description of dietary compliance and blood sugar control in type 2 DM patients at the Air Cold Health Center after nutritional counseling in 2022. This type of quasi-experimental research used the One Group Pretest Posttest design. Samples were taken using total sampling. The total sample was 37 people who met the inclusion and exclusion criteria. Data on blood sugar levels were measured using a glucometer. The data normality test used the Shapiro-Wilk test and the analysis used the Wilocoxon test. The results showed that there was a decrease in the average blood glucose level. There is a significant effect on blood sugar levels, there is no significant effect on adherence in terms of the amount of food on total energy and carbohydrates and there is a significant effect on adherence to protein and fat, there is a significant effect on adherence in terms of the type of food and there is a significant effect on adherence in terms of schedule Meals before and after nutritional counseling.

Penggunaan Obat Berpotensi Hepatotoksik Pada Pasien Sirosis Hati: Suatu Telaahan Ariesta Kirana Efmisa; Armenia Armenia; Dedy Almasdy
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Liver cirrhosis is a pathological liver disease characterized by the formation of scar tissue and regenerative nodules in liver cells. This condition leads to changes in the shape and size of the liver, accompanied by increased pressure in the veins and reduced blood flow in the portal vein. Liver cirrhosis is the seventh leading cause of death. Drugs are the main cause of liver damage. More than 900 drugs, toxins and herbs are reported to cause liver damage. The purpose of this review article is to summarize the results of previous studies on the use of hepatotoxic drugs in patients with liver cirrhosis. Data sources for this study were identified through searching Google Scholar, PubMed and Science Direct using the keywords "hepatotoxic drugs" and "liver cirrhosis" in articles published between 2011-2022. Finally, 10 articles were obtained and analyzed. The results of this review article show that liver cirrhosis patients are still often prescribed potentially hepatotoxic drugs. Some commonly prescribed drugs include paracetamol, omeprazol, ranitidine, ceftriaxon, ciprofloxacin, atorvasatin, metformin, and amiodarone.

Co-Authors Abdillah, Rahmad Almahdy A Almahdy Almahdy Anggadireja, Kusnandar Annisa Nur Salasa Ariesta Kirana Efmisa Boy Andre Dedy Almasdy Dwisari Dillasamola Fauzan Azima Friardi Ismed Fuji Araswati Hanna Sari Widya Kusuma Helmice Afriyeni Ika Adhani Sholihah Lailaturrahmi Lailaturrahmi Lathvi Masyithah Marlina . Maryorie Rosa Mike Esfika Rahmi Yosmar Rizal Rizal Rizki Oktarini Rizki Rahmadian Rosiana Rizal Satrio Haryo Benowo Wibowo Sayuti, Kesuma Sepni Asmira Wahyu Setia Widodo Wahyu Widowati Yori Yuliandra

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