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All Journal Jurnal Farmasi Udayana Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Chemical Science CARADDE: Jurnal Pengabdian Kepada Masyarakat FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL FARMASI GALENIKA Jurnal Ilmiah Farmako Bahari Jurnal Sains dan Teknologi Farmasi Indonesia
Diah Lia Aulifa
Padjadjaran University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Journal : Jurnal Sains dan Teknologi Farmasi Indonesia

 1 
AKTIVITAS ANTIBAKTERI EKSTRAK N- HEKSAN, ETIL ASETAT, DAN ETANOL Morus alba L. TERHADAP BAKTERI PENYEBAB KARIES GIGI Diah Lia Aulifa; Yessi - Febriani; Maria Selviana Rendo
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 4, No 2 (2015)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (825.622 KB) | DOI: 10.58327/jstfi.v4i2.48

Abstract

AbstrakFraksi etil asetat ekstrak metanol kulit akar dan ekstrak etanol daun murbei (Morus alba L.) diketahui mempunyai aktivitas antibakteri terhadap bakteri Streptococcus mutans. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri ekstrak n-heksan, etil asetat, dan etanol buah murbei terhadap bakteri Streptococcus mutans dan Streptococcus sanguinis. Simplisia buah murbei diekstraksi menggunakan kepolaran bertingkat dengan pelarut n-heksan, etil asetat, dan etanol dengan metode maserasi. Pada simplisia dan ekstrak dilakukan skrining fitokimia, karakterisisasi simplisia dan uji aktivitas antibakteri dengan metode difusi agar. Penentuan Kadar Hambat Minimum (KHM) dilakukan terhadap ekstrak paling aktif dengan metode difusi Agar dan diidentifikasi menggunakan Kromatografi Lapis Tipis (KLT). Hasil uji aktivitas antibakteri menunjukkan ekstrak paling aktif adalah ekstrak etil asetat dengan nilai KHM 8 mg/ml dan 9 mg/ml terhadap bakteri Streptococcus mutans dan Streptococcus sanguinis. Hasil analisis statistika untuk taraf α = 0,05 menunjukkan adanya perbedaan daya hambat antara kontrol dengan ekstrak etanol dan etil asetat. Hasil skrining fitokimia pada ekstrak etil asetat menunjukkan adanya senyawa golongan flavonoid, fenolat, kuinon, monoterpen dan seskuiterpen. Hasil identifikasi dengan KLT menunjukkan bahwa pada ekstrak etil asetat terdapat 10 spot dengan masing-masing Rf 0,04; 0,08; 0,16; 0,36; 0,48; 0,74; 0,78; 0,86 dan 0,94.  Kata kunci: buah murbei (Morus alba L.), Streptococcus mutans, Streptococcus sanguinis, KHM, Antibakteri.  AbstractEthyl acetate fraction of methanol extract of the root bark and ethanol extract of mulberry leaves (Morus alba L.) was known to have an antibacterial activity against Streptococcus mutans. The aims of this research is to know the antibacterial activity of n-hexane, ethyl acetate, and ethanol extract against Streptococcus mutans and Streptococcus sanguinis. Mulberry fruit was extracted by a maceration method using gradient polarity solvents (n-hexane, ethyl acetate and ethanol). The phytochemical screening and characterization of crude drugs and extract were carried out, and identified by Thin Layer Chromatography (TLC). The antibacterial activity and the minimum inhibitory concentration (MIC) of the most active extract were determined using the agar diffusion method. The antibacterial activity showed the most active extract was ethyl acetate extract with MIC value 8 mg/ml and 9 mg/ml against Streptococcus mutans and Streptococcus sanguinis. The statistical analysis for level α = 0.05 showed differences inhibition between the control with ethyl acetate and ethanol extracts. The phytochemical screening of ethyl acetate extract showed flavonoid, phenolat, quinone, and monoterpene and sesquiterpene groups. The identification using TLC showed 10 spot with Rf 0.04; 0.08; 0.16; 0.36; 0.48; 0.74; 0.78; 0.86 and 0.94 respectively in the ethyl acetate extract.  Keywords: mulberry fruit (Morus alba L.), Streptococcus mutans, Streptococcus sanguinis, MIC, Antibacterial
AKTIVITAS ANTI-INFLAMASI EKSTRAK ETANOL Ficus virens dan Ficus adenosperma Sani Nurlaela Fitriansyah; Diah Lia Aulifa; Riki - Nugraha
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 4, No 2 (2015)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (910.5 KB) | DOI: 10.58327/jstfi.v4i2.44

Abstract

AbstrakTelah banyak dilaporkan dari beberapa ekstrak spesies Ficus sp [famili Moreaceae] memiliki aktivitas biologi diantaranya aktivitas anti-inflamasi. Walaupun demikian, aktivitas anti-inflamasi ekstrak daun Ficus adenosperma dan ekstrak daun Ficus virens belum banyak diteliti. Ekstraksi dilakukan terhadap daun Ficus adenosperma dan Ficus virens dengan metode maserasi menggunakan etanol. Ekstrak dipekatkan dengan rotavapor dan terhadap masing-masing ekstrak dilakukan pengujian skrining fitokimia dan aktivitas anti-inflamasi. Aktivitas anti-inflamasi diuji menggunakan metode induksi karagenan 1%. Dosis ekstrak yang digunakan adalah 250 mg/KgBB dan 500 mg/KgBB. Ekstrak etanol daun Ficus adenosperma dan daun Ficus virens memiliki kandungan metabolit sekunder flavonoid, fenol dan steroid, dan mempunyai aktivitas anti-inflamasi untuk model inflamasi akut. Ekstrak etanol daun Ficus virens memiliki nilai inhibisi radang pada 250 mg/KgBB sebesar 63,3% dan pada 500 mg/KgBB sebesar 76,7%. Aktivitas anti-inflamasi untuk model inflamasi akut dari ekstrak etanol daun Ficus virens lebih baik daripada ekstrak etanol daun Ficus adenosperma. Kata Kunci: Ficus adenosperma, Ficus virens, Anti-inflamasi Abstract It has been widely reported from several extract of species Ficus sp [family Moraceae] have biological activity such as anti-inflammatory activity. Nevertheless, the anti-inflammatory activity of leaves extract Ficus adenosperma and Ficus virens have not been reported. Extraction was performed with maceration method and used ethanol. The extract were evaporated using rotary evaporator and tested phytochemical screening and anti-inflammatory activity. The anti-inflammatory activity was used the carrageenan 1 % induced method. Extract doses were used 250 mg/KgBW and 500 mg/KgBW. Ethanol extract leaves of Ficus adenosperma and Ficus virens contain flavonoids, phenols and steroids and have anti-inflammatory activity in a model of acute inflammation. The percent inhibition of inflammatory activity from ethanol extract leaves of Ficus virens at 250 mg/KgBW was 63,3% and at 500 mg/KgBW was 76,7%. Anti-inflammatory activity for an acute model from ethanol extract leaves of Ficus virens, is better than ethanol extract leaves of Ficus adenospermae.  Keywords: Ficus adenosperma, Ficus virens, Antiinflamatory
Co-Authors Alya Puteri Agustina Pribadi Angela Alysia Elaine Anisa Pebiansyah Asilla Mauri Ramdini Kamaludin Audry Rahma Dewayani Augustina, Yeni Ayu Permatasari Bernap Dwi Putra Sitinjak Diffa Hauna F. Pakhrul Diki Prayugo Wibowo Febriani, Yessi Firman Firman Fitriansyah, Sani Nurlaela Halwa Aulia Nurdin Hesti Riasari Husna Muharram Ahadi Jutti Levita Kaila Keyshia Mei Kevin Gabriel Maria Selviana Rendo Maya Andani Natashya Parameswari Natasya Prameswari Nyai Ayu Sylfia Stannia Puspitasari Helmi Oktavia Sabetta Permatasari, Ayu Riasari, Hesti Riezki Amalia Riki - Nugraha Rizky Prasiska Wulandari Sabiq Salmandhiya Harits Salsabil Ghaliya Sani Nurlaela Fitriansyah Siti Uswatun Hasanah Sunani Sunani Winingsih, Wiwin Wiwin Winingsih Yessi - Febriani Yessi Febriani Yunitasya Guspira