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Indonesian Journal of Science and Technology

Vol 8, No 2 (2023): (ONLINE FIRST) IJOST: September 2023

Idin Sahidin (Universitas Halu Oleo)
N. Nohong (Universitas Halu Oleo)
Marianti A. Manggau (Universitas Hasanuddin)
A. Arfan (Universitas Halu Oleo)
W. Wahyuni (Universitas Halu Oleo)
Iren Meylani (Universitas Halu Oleo)
M. Hajrul Malaka (Universitas Halu Oleo)
Nur Syifa Rahmatika (Universitas Halu Oleo)
Agung W. M. Yodha (Politeknik Bina Husada Kendari)
Nur Upik En Masrika (Universitas Khairun)
Abdulkadir Kamaluddin (Universitas Khairun)
Andini Sundowo (National Research and Innovation Agency (BRIN))
Sofa Fajriah (National Research and Innovation Agency (BRIN))
Rathapon Asasutjarit (Thammasat University)
Adryan Fristiohady (Universitas Halu Oleo)
Rina Maryanti (Universitas Pendidikan Indonesia)
Nur Indri Rahayu (Universitas Pendidikan Indonesia)
M. Muktiarni (Universitas Pendidikan Indonesia)

Publish Date
28 Dec 2022

The utilization of the stems, leaves, and hulls of peanuts (Arachis hypogea) is not as popular as the seeds. This study aimed to investigate the chemical contents and pharmacological activities of A. hypogaea stems in-vitro and in-silico. This study was also completed with bibliometric analysis. The methanol extract (ME) was reextracted by ethylacetate to get ethyl acetate extract (EAE). The chemical contents of EAE were analyzed by phytochemical screening, Liquid Chromatography-Mass Spectroscopy (LC-MS/MS), TPC (Total Phenolic Content), and TFC (Total Flavonoid Content). In-vitro and in-silico studies evaluated antioxidant potency, toxicity, and cytotoxicity toward MCF-7 cell lines. The results showed that EAE contained terpenoids, flavonoids, alkaloids, and phenolics which were supported by LC-MS/MS data. The EAE was categorized as a very strong antioxidant and moderately active in both cytotoxicity and toxicity.

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