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INDONESIA
Jurnal Penelitian Kesehatan
Published by Forum Ilmiah Kesehatan
ISSN : 20863098     EISSN : 25027778     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Health Research "Forikes Voice" is a medium for the publication of articles on research and review of the literature. We accept articles in the areas of health such as public health, medicine, nursing, midwifery, nutrition, pharmaceutical, environmental health, health technology, clinical laboratories, health education, and health popular.
Arjuna Subject : -
Articles 21 Documents
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Search results for , issue "Vol 11 (2020): Nomor Khusus Mei-Juni 2020" : 21 Documents clear
Intervensi Musik dan Relaksasi Untuk Pasien Hipertensi : A Literature Riview Silvia Nurvita; Mateus Sakundarno Adi
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk301

Abstract

Hypertension was a non-communicable disease whose mortality and morbidity rates increase globally. Therapy of pharmacological and non-pharmacological hypertension was difficult to achieve because it required public awareness. Music and relaxation interventions presented as additional solutions to complement pharmacological and non-pharmacological therapies in the treatment of hypertension. Purpose of this study was to describe the effect music intervention and relaxation for reducing blood pressure in hypertensive patients. The research method was literature review from electronic databases such as Google Scholar, Science Direct, Pubmed, Sage and selected 5 articles published from 2017-2018. Results were all articles reviewed showed decrease in blood pressure due to music and relaxation interventions in hypertension patients. The conclusion that music and relaxation interventions have been shown to have a major effect on reducing blood pressure in patients with hypertension. It hoped that hypertension patients could to implement music and relaxation interventions. Keywords: intervention; music and relaxation; hypertension ABSTRAK Hipertensi merupakan penyakit tidak menular yang angka kematian dan kesakitan penderitanya terus meningkat secara global. Penanganan hipertensi secara farmakologi dan nonfarmakologi sulit tercapai karena membutuhkan kesadaran masyarakat. Intervensi musik dan relaksasi hadir sebagai solusi tambahan untuk melengkapi terapi farmakologi dan nonfarmakologi dalam penyembuhan penyakit hipertensi. Tujuan penelitian untuk menggambaran besar efek intervensi musik dan relaksasi dalam menurunkan tekanan darah pada pasien hipertensi. Metode penelitian adalah literature review dari data elektronik seperti Google Scholar, Science Direct, Pubmed, Sage dan terpilih 5 artikel yang dipublikasi dari tahun 2017 – 2018. Hasil penelitian semua artikel yang ditinjau terbukti kombinasi intervensi musik dan relaksasi menimbulkan efek penurunan tekanan darah pada pasien hipertensi. Kesimpulannya adalah intervensi musik dan relaksasi terbukti memiliki efek besar dalam menurunkan tekanan darah pada pasien hipertensi. Sehingga diharapkan pasien hipertensi dapat mengimplementasikan intervensi musik dan relaksasi secara teratur untuk penyembuhan penyakit hipertensi. Kata kunci: intervensi; musik dan relaksasi; hipertensi
Hubungan Antara Perilaku Beresiko dengan Kekerasan pada Remaja Hamil: “A Systematic Review” Irma Permata Sari; Setyowati Setyowati; Titin Ungsianik
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk306

Abstract

Adolescents behaviour high risk is one of important problem in health care especially in their growth now and later. Adolescents behaviour in reproduction system could be happen in around the world, such as free sex that could be the end with without marriage or marriage earlier. In a moment, adolescents haven't ready yet to get married are impacted to violence while they're pregnant. Violence is the second place of being dead. That's why we would like to know the causes of suicide while they're pregnant. The aim of this research was identify some researches that identified causes of violence in pregnant adolescents with used systematic review from articles that had been published. Database that we used were proquest, sciencedirect, and pubmed in the last 5 years with Prisma statement. Based on researched we got 426 of three database and also another researches of articles focus on the main problem research we got eight articles. Conlusion : caused of violence in pregnant adolescents were risk behaviours, such as drug abuse, alcohol consumption, smoked, history of sexual intercourse, sexual coercion, and partner risked behaviour. Recommendation: obtained so that the searched results of this article could be further synthesized into health education materials in the prevention of violence in pregnant adolescents. Keywords: violence in adolescents; behaviour high risk; pregnant adolescents ABSTRAK Perilaku remaja dalam kesehatan reproduksi terjadi diseluruh dunia seperti seks bebas yang berakhir dengan kejadian remaja hamil diluar nikah atau terpaksa dinikahkan dini. Ketidaksiapan remaja memasuki pernikahan dengan segala permasalahannya dapat menyebabkan kekerasan selama remaja hamil. Oleh sebab itu perlu digali apa penyebab kekerasan yang terjadi pada remaja hamil. Tujuan mengidentifikasi beberapa penelitian yang sudah meneliti penyebab kekerasan pada remaja hamil dengan menggunakan metode systematic review dari artikel yang telah dipublikasikan. Pencarian database yang digunakan yaitu ProQuest, ScienceDirect, dan PubMed 5 tahun terakhir dengan menggunakan Prisma Statement. Hasil penelurusan artikel didapatkan 426 dari tiga database, pencarian artikel difokuskan pada masalah penelitian didapatkan delapan artikel. Kesimpulan: perilaku berisiko remaja yang dapat menyebabkan terjadinya kekerasan pada remaja hamil, yaitu penyalahgunaan obat terlarang, konsumsi alkohol, merokok, riwayat melakukan hubungan seksual, pemaksaan seksual dan perilaku berisiko pasangan. Rekomendasi: kecukupan informasi telah didapat, sehingga hasil-hasil penelusuran artikel ini dapat disintesa lebih lanjut menjadi bahan edukasi kesehatan dalam pencegahan kekerasan pada remaja hamil. Kata kunci: kekerasan pada remaja; perilaku berisiko; remaja hamil
Pengaruh Variasi Dosis Ekstrak Terong Belanda Terhadap Konsentrasi Spermatozoa Pada Mus Muscullus Yang Dipapar Timbal Asetat Abadiyah Zakiah; Reny I’tishom; Siti Khaerunnisa
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk319

Abstract

Infertility is a 10-15% problem experienced by men around the world. One of the causes of infertility in men is caused by an increase in reactive oxygen species (ROS) by toxic substances such as heavy metal lead (Pb). This research was conducted to find the potential of Dutch eggplant fruit (Solanum betaceum) in various doses to increase the concentration of mice spermatozoa (Mus muscullus) exposed to lead acetate. Dutch eggplant has a good phenolic content as an antioxidant to prevent free radicals. The study design used was Posttest only control group design with a sample of 40 male mice. The treatment time in all groups is 35 days. Mice were divided into 5 groups that were given oral treatment. The control group was given 75 mg/kgBW of lead acetate treatment. The treatment group was given lead acetate 75mg / KgBB and Dutch eggplant extract at various doses of 100 mg/kgBW (P1), 200 mg/kgBW (P2), and 400 mg/kgBW (P3). The results showed that Dutch eggplant extract (Solanum betaceum) with various doses could significantly increase spermatozoa concentration. The optimal dose of Dutch eggplant extract (Solanum betaceum) in mice exposed to lead is 100 mg/kg/day in the treatment group (P1). Keywords: tamarillo; spermatozoa concentration ABSTRAK Infertilitas merupakan masalah 10-15% yang dialami pria di seluruh dunia. salah satu penyebab infertilitas pada pria disebabkan oleh peningkatan reactive oxygen species (ROS) oleh bahan toksik seperti logam berat timbal (Pb). Penelitian ini dilakukan untuk menemukan potensi buah terong belanda (Solanum betaceum) dalam berbagai dosis terhadap peningkatan konsentrasi spermatozoa mencit (Mus musculus) yang dipapar timbal asetat. Terong belanda mempunyai kandungan fenolik yang baik sebagai antioksidan untuk mencegah radikal bebas. Desain penelitian yang digunakan Posttest only control group design dengan sampel 40 mencit jantan. Waktu perlakuan pada semua kelompok yaitu 35 hari. Mencit dibagi menjadi 5 kelompok yang diberikan perlakuan secara oral. Kelompok kontrol diberikan perlakuan timbal asetat 75mg/KgBB. Kelompok perlakuan diberikan timbal asetat 75mg/KgBB dan ekstrak terong belanda dengan berbagai dosis 100mg/KgBB (P1), 200mg/KgBB (P2), dan 400mg/KgBB (P3). Hasil penelitian menunjukkan bahwa ekstrak terong belanda (Solanum betaceum) dengan berbagai dosis mampu meningkatkan konsentrasi spermatozoa secara signifikan. Dosis optimal pemberian ekstrak terong belanda (Solanum betaceum) pada mencit yang dipapar timbal adalah 100 mg/kgBB/hari pada kelompok perlakuan (P1). Kata kunci: terong belanda; konsentrasi spermatozoa
Potensi Ekstrak Solanum betaceum sebagai Agen Protektif Sel Leydig pada Mencit yang Dipapar Timbal Asetat Anak Agung Istri Dalem Cinthya Riris; Reny I’tishom; Siti Khaerunnisa
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk313

Abstract

Lead exposure as environmental pollution can cause male reproductive problems. Provision of natural antioxidants can be an alternative solution to protect male reproductive function. This research was conducted to investigate the potential of Solanum betaceum extract as a protective agent for Leydig cells in mice exposed to lead acetate. The entire research process with a replication unit of 40 male mice. Mice were divided into five groups with each treatment given orally. The negative control group (K0) only gets aquadest for 35 days, the positive control group (K1) gets aquadest day 1-3, day 4-35 get lead acetate at a dose of 0.075 mg/kg BW/day, the treatment group (P1), (P2 ), and (P3) only given Solanum betaceum extract at day 1-3 with sequential doses of 100 mg/ kg BW /day, 200 mg/ kg BW /day, and 400 mg/ kg BW /day, then 4-35 days were given Solanum extract betaceum and after 1 hour given lead acetate. The results of this study indicate that there were significant differences between groups with p
Peningkatan Kepuasan Pasien dan Keluarga Terhadap Pelayanan Keperawatan Dengan Melibatkan Keluarga Dalam Pemberian Kebutuhan Dasar di Unit Perawatan Intensif: Literature Review Uswatun Hasanah; Ratna Sitorus; Agung Waluyo
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk303

Abstract

Intensive care unit (ICU) is an important part of the management of the disease of a hospital that handles illnesses with complex cases both acute and chronic. Various diseases that arise because these cases become a challenge for health workers to think more about how to overcome health problems that exist from the other side outside of medical treatment, one of which is by involving families to participate in treatment. Generally in intensive care units, the family is not actively involved in caring for patients in a meaningful way. The family-centered care model makes the family active in working with and participating in the care team. The purpose of this study to describe, analyze and compare the influence of family involvement in providing basic needs to patient and family satisfaction in the intensive care room. This literature review was a search of online databases such as EBSCO-host, ScienceDirect, ProQuest, SAGE. Search for articles published from 2014-2019 received 13 relevant articles. The result by involving families in care at the ICU can increase family satisfaction with nursing services. Involving families in care accompanied by nurses provides many benefits for patient recovery. Therefore, involving families in the care team at the ICU can be applied to accelerate the recovery process of patients, reduce daycare and can increase family satisfaction with the services provided. Keywords: family satisfaction; family involvement; intensive care unit; family needs
Hubungan Antara Pengetahuan Kesehatan Reproduksi dan Sikap Seksualitas Dengan Perilaku Pacaran Pada Pelajar SLTA Eny Pemilu Kusparlina
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk317

Abstract

Courtship behavior risk among adolescents, especially students is increasing. During the courtship, students not only get to know each other but they already have kisses even sexual intercourse.This study aims to determine and analyze the relationship between knowledge of reproductive health and sexuality attitude with courtship behavior in high school students at the city of Madiun. This study was an analytic survey with cross sectional approach. This research was conducted at SMAN 6 Madiun, SMAN 4 Madiun, SMKN 2 Madiun and SMKN 3 Madiun. This population was studied at the class X and XI the number of 2209 students, with the sample was 172 students. Sampling tecnic used simple random sampling. Chi-Square is used as bivariate analysis. The results showed reproductive health knowledge of respondents classified as good (83%), sexual attitudes of respondents classified as negative (59%) and the courtship behavior of respondents classified as not at risk (51%). Statistical analysis showed there is a relationship between knowledge of reproductive health (p = 0.002) and sexuality attitude (p = 0.006) with courtship behavior in high school students at the city of Madiun. Keywords: reproductive health knowledge; sexuality attitude; behaviour courtship ABSTRAK Perilaku pacaran yang berisiko dikalangan remaja khususnya pelajar semakin meningkat. Selama berpacaran pelajar tidak hanya berusaha mengenal lawan jenisnya, tetapi sudah sampai berciuman bahkan saling berhubungan seksual. Tujuan penelitian ini untuk mengetahui dan menganalisis hubungan antara pengetahuan kesehatan reproduksi dan sikap seksualitas dengan perilaku pacaran pada pelajar SLTA di Kota Madiun. Penelitian ini menggunakan metode survei analitik dengan pendekatan cross sectional. Penelitian ini dilaksanakan di 4 SLTA Kota Madiun. Populasi dalam penelitian ini adalah pelajar kelas X dan kelas XI sebanyak 2209 siswa, dengan jumlah sampel sebanyak 172 siswa. Pengambilan sampel menggunakan simple random sampling. Analisis bivariat menggunakan Chi-Square. Hasil penelitian menunjukkan pengetahuan kesehatan reproduksi responden tergolong baik (83%), sikap seksualitas responden tergolong negatif (59%) dan perilaku pacaran responden tergolong tidak berisiko (51%). Hasil uji statistik menunjukkan ada hubungan antara pengetahuan kesehatan reproduksi (p=0,002) dan sikap seksualitas (p=0,006) dengan perilaku pacaran pada pelajar SLTA di Kota Madiun. Kata kunci: pengetahuan kesehatan reproduksi; sikap seksualitas; perilaku pacaran
Kajian Literatur Dampak Posisi Tubuh Pada Bayi Prematur Terhadap Saturasi Oksigen Selama Weaning Ventilasi Non-Invasif Ayu Ferissa; Yeni Rustina
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk304

Abstract

Aim: This article aimed of the impact of positioning on oxygen saturation during the weaning process of non-invasive ventilation in preterm infant. Method: This review articles sourced from online database using Medline, Sciencedirect, Cumulative Index to Nursing and Allied Health Literature (CINAHL). Result: This review discussed 3 subtopics were: 1. Body position impacted of phyisiological stabilitation, 2. Influenced of body position againts pulmonary function, 3. Body position againts variance of vital signs. Conclusion: Based on 3 subtopics, several factors that factors were affected by birth weight and gestational age, providing prone and quarter/semi-prone positions were safe and recommended, in accelerating the weaning process and contributing to extubation success. Supine position can be an alternative, if the baby was contraindicated giving prone or quarter prone positions. . Keywords: premature infant; prone position; supine position; oxygen saturation; ventilator weaning ABSTRAK Tujuan dari penulisan ini adalah untuk mereview dampak pemberian posisi tubuh pada saturasi oksigen selama proses weaning ventilasi non-invasif pada bayi prematur. Metode: Telaah artikel dengan menggunakan online database Medline, Sciencedirect, Cumulative Index to Nursing and Allied Health Literature (CINAHL). Hasil: Dari hasil telaah artikel, didapatkan subtema pembahasan yaitu: 1. Posisi tubuh memengaruhi stabilitas fisiologis, 2. Posisi tubuh memberikan dampak pada fungsi paru, 3. Posisi tubuh terhadap variasi tanda-tanda vital. Keimpulan: dari hasil pembahasan tiga subtema dampak pemberian posisi tubuh terhadap saturasi oksigen diperoleh faktor yang memengaruhi berat lahir dan usia gestasi, pemberian posisi prone dan posisi quarter/semi-prone aman dan direkomendasikan, dalam mempercepat proses weaning dan berkontribusi dalam kesuksesan ekstubasi. Posisi supine bisa menjadi alternatif, jika bayi mengalami kontraindikasi pemberian posisi prone atau quarter prone. Kata kunci: bayi prematur; posisi pronasi; posisi supinasi; saturasi oksigen; penyapihan ventilasi mekanik
Faktor Resiko Kejadian Multi Drug Resistant Tuberculosis (MDR TB) di Surakarta, Jawa Tengah Nita Yunianti Ratnasari
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk312

Abstract

Tuberculosis is a disease of global concern. In accordance with the 2030 Sustainable Development Goals, WHO for a reduction in tuberculosis deaths by 90% and a decrease in incidence by 80% in 2030. In 2015 there were 10.4 million new tuberculosis cases or 142 cases / 100,000 population, with 480,000 multidrug resistant cases . It is estimated that more than 55% of Multi-Resistant Tuberculosis (MDR TB) TB patients have not been diagnosed or received good and correct treatment. The design used was a case control study. Data collection was carried out at the Surakarta Center for Community Lung Health (BBKPM) in August to December 2018. Case population was all patients who received OAT resistance in 2016-2018 and proved to be resistant, as well as controlling all patients who experienced OAT resistance from 2016- 2018 and proven sensitive to OAT. Each sample consisted of 34 cases and 34 controls. Data collection techniques were carried out by observing and recording data on TB 01 form and medical records of MDR TB patients from 2016 to 2018. Variables used in this study consisted of special respondents, including age, sex, marital status, education level, occupation, approve treatment, type of financing and distance perception. Total sample in this study were 68 people. The results of the analysis displayed 4 independent variables that proved to be significant as MDR-TB predictors, namely occupation [p = 0.034; OR 1,170 (0,390-3,512)]; marital status [p = 0.033; OR 0.864 (0.299-2.495)]; regularity of taking medication [p = 0.038; OR 2,097 (1,625-2705)] and the distance [p = 0.046; OR 0.316 (0.097-1.030)]. MDR TB incidence still needs related studies related to the causes. Expected amount can be increased as much as possible. Risk factors for MDR TB events are divided into physical factors (occupation, marital status and distance) and psychological factors (regularity of taking medication). Keywords: risk factors; multi drug resistance; tuberculosis ABSTRAK Tuberkulosis merupakan penyakit yang menjadi perhatian global. Sesuai dengan Tujuan Pembangunan Berkelanjutan 2030, WHO menargetkan untuk menurunkan kematian akibat tuberkulosis sebesar 90% dan menurunkan insidens sebesar 80% pada tahun 2030. Pada tahun 2015 terdapat 10,4 juta kasus baru tuberkulosis atau 142 kasus/100.000 populasi, dengan 480.000 kasus multidrug-resistant. Diperkirakan pula lebih dari 55% pasien Multi Drug Resistant Tuberculosis (MDR TB) belum terdiagnosis atau mendapat pengobatan baik dan benar. Desain yang digunakan adalah case control study. Pengambilan data dilakukan di Balai Besar Kesehatan Paru Masyarakat (BBKPM) Surakarta pada bulan Agustus sampai Desember 2018. Populasi kasus adalah semua penderita yang diuji resistensi OAT pada tahun 2016-2018 dan terbukti resisten, sedangkan populasi kontrol adalah semua penderita yang diuji resistensi OAT dari tahun 2016-2018 dan terbukti sensitif terhadap OAT. Adapun jumlah sampel masing-masing terdiri dari 34 kasus dan 34 kontrol. Teknik pengumpulan data dilakukan dengan metode observasi dan pencatatan data form TB 01 serta rekam medis pasien TB MDR mulai tahun 2016 sampai 2018. Adapun variabel yang digunakan dalam penelitian ini terdiri dari karakteristik responden, meliputi usia, jenis kelamin, status marital, tingkat pendidikan, pekerjaan, kepatuhan berobat, jenis pembiayaan serta persepsi jarak. Total sampel dalam penelitian ini sebanyak 68 orang. Hasil analisis menunjukkan terdapat 4 variabel bebas yang terbukti berpengaruh secara signifikan sebagai prediktor MDR-TB yaitu pekerjaan [p= 0,034; OR 1,170 (0,390-3,512)]; status marital [p = 0,033; OR 0,864 (0,299-2,495)]; keteraturan minum obat [p = 0,038; OR 2,097 (1,625-2,705)] dan jarak [p = 0,046; OR 0,316 (0,097-1,030)]. Kejadian MDR TB masih membutuhkan kajian mendalam terkait faktor penyebabnya. Sehingga diharapkan jumlah penderita dapat ditekan semaksimal mungkin. Faktor resiko kejadian MDR TB terbagi menjadi faktor fisik (pekerjaan, status marital dan jarak) serta faktor psikologis (keteraturan minum obat). Kata kunci: faktor resiko; multi drug resistance; tuberkulosis
Efektifitas Pemberian Ekstrak Terong Belanda (Solanum betaceum) Terhadap Peningkatan Berat Testis Mencit (Mus musculus) yang Dipapar Timbal Asetat Nurul Jannatul Wahidah; Reny I'tishom; Siti Khaerunnisa
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk318

Abstract

Male infertility with unknown definite etiology can be associated with lead exposure. Lead that accumulates in the body can cause oxidative stress and spermatogenesis disruption. To minimize the impact of lead exposure, it is necessary to use conventional methods with natural materials. One of them is the use of Solanum betaceum which have been proven to have secondary metabolic components that are antioxidants. This study aims to prove the effect of Dutch Eggplant (Solanum betaceum) extract to testicular weight of mice (Mus musculus) exposed to lead. This research was an true experimental research using male Mus musculus. Mice were 40 and divided into five groups randomly. Each group was consist of 8 mices. 1st group was negative control (K0), 2nd group was positive control (K1), 3rd group was exposed to lead + Solanum betaceum extract 100mg / KgBB (P1), 4th group was exposed to lead + Solanum betaceum extract 200mg / KgBB (P2), 5th group was exposed to lead + Solanum betaceum extract 400mg / KgBB (P3) for 35 days. Data were analyzed with One Way Anova and continued with T-Test. The results of this study prove that Dutch Eggplant (Solanum betaceum) extract significantly increase the testicular weight in mice exposed by lead acetate (p
Efektivitas Ekstrak Rumput Kebar (Biophytum petersianum Klotzch) dalam Meningkatkan Tebal Epitel Tubulus Seminiferus Pada Mencit (Mus musculus) Jantan Model Diabetes Melitus Magfira Febrianty Lacindung; Bambang Purwanto; Reny I’tishom
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk310

Abstract

Background: Administration of antioxidants has been proven to reduce the production of free radicals in the body. One of the natural ingredients that contain antioxidants are Kebar grass. Kebar grass (Biophytum petersianum Klotzch) contains three types of chemical compounds that could potentially impact spermatogenesis. Those are flavonoids, saponins and tannins so it needs to investigate the effect on the testicles with a model of diabetes mellitus (DM). Purpose: Analyzed the Effectivness of Biophytum petersianum Klotzch extract to the epithelium thickness of the seminiferous tubules of mice (Mus musculus) model of diabetes mellitus. Methods: This research was a post test only control group design using Balb / C 45 male tail number, divided 5 groups were randomly selected. K-: DM mice group was given CMC Na 1% for 21 days. K +: DM mice group was given CMC Na 1% + metformin 2 mg / gBW for 35 days. (P1, P2, P3): DM group of mice given doses of 67.5 kebar seaweed extract, 135, 270 mg / kg + metformin 2 mg / gBW 35 days. Valid to 45 surgery and sampling and examination of thickness of seminiferous tubule epithelium. Results: The observation of thick epithelium of the seminiferous tubules was significant difference (p = 0.005) with a mean negative control group (K) 65 235 ± 5012, positive control(K +) 71 216 ± 12 514, (P1) 76 756 ± 6144, (P2) 80 660 ± 4140, (P3) 81 418 ± 7319. Conclusion Extract grass kebar (Biophytum petersianum Klotzch) efectivness in improving a thick epithelium of the seminiferous tubules in male mice model of diabetes mellitus. Keywords: kebar grass; diabetes mellitus; thick epithelium of the seminiferous tubules ABSTRAK Latar belakang : Pemberian antioksidan terbukti dapat menurunkan produksi radikal bebas di tubuh. Salah satu bahan alami yang mengandung antioksidan adalah rumput kebar. Rumput kebar (Biophytum petersianum Klotzch) mengandung tiga jenis senyawa kimia yang berpotensi memberikan pengaruh terhadap proses spermatogenesis, yaitu flavonoid, saponin dan tannin sehingga perlu dijadikan penelitian untuk melihat potensi pada testis dengan model diabetes melitus. Tujuan : Menganalisis efektivitas pemberian ekstrak rumput kebar (Biophytum petersianum Klotzch) terhadap tebal epitel tubulus seminiferus pada mencit (Mus musculus) jantan model diabetes melitus. Metode : Penelitian ini merupakan penelitian eksperimental dengan post test only control group design menggunakan mencit Balb/C jantan sejumlah 45 ekor, dibagi 5 kelompok dipilih secara acak. K- : kelompok mencit DM diberikan CMC Na 1% selama 21 hari. K+ : kelompok mencit DM diberikan CMC Na 1% + metformin 2 mg/gBB selama 35 hari. (P1, P2, P3) : kelompok mencit DM diberikan ekstrak rumput kebar dosis 67,5, 135, 270 mg/kgBB + metformin 2 mg/gBB 35 hari. Hari ke 36 dilakukan pembedahan dan pengambilan sampel dan melakukan pemeriksaan tebal epitel tubulus seminiferus. Hasil : Hasil pengamatan tebal epitel tubulus seminiferus didapatkan ada perbedaan yang signifikan (p=0,005) dengan rerata kelompok kontrol negatif (K-) 65.235 ± 5.012, kontrol positif (K+) 71.216 ± 12.514, ( P1) 76.756 ± 6.144, (P2) 80.660 ± 4.140, (P3) 81.418 ± 7.319. Kesimpulan : Ekstrak rumput kebar (Biophytum petersianum Klotzch) efektif dalam meningkatkan tebal epitel tubulus seminiferus pada mencit jantan model diabetes melitus . Kata kunci: rumput kebar; diabetes melitus; tebal epitel tubulus seminiferus

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