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MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan

APKKM
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Published by Universitas Muhammadiyah Semarang

ISSN : 24070505 EISSN : - DOI : https://doi.org/10.26714/magnamed

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this journal is all the field of medicine such as: -Internal medicine (including Pulmonary medicine and cardiovascular medicine) -Surgery (including urology, orthopaedic and traumatologic, plastic surgery, neurosurgery) -Anesthesia and Emergency Medicine -Neurology -Dermatology -Obstetric and Gynecologic -Forensic and Medicolegal -Clinical Pathology -Anatomical Pathology -Psychiatric -Ophthalmology -Otolaryngology -Pediatric -Radiology -Microbiology and parasitology -Basic Science of Medicine (including biochemistry, physiology, anatomy and Histology) -Public health and Health Management

Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran

Articles 10 Documents

Search results for , issue "Vol 1, No 5 (2018): February" : 10 Documents clear

Kolangitis Akut pada Penderita Tumor Klatskin Muhamad Ayus Astoni; Syadra Bardiman; Mitayani Purwoko
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

Acute cholangitis in patients with Klatskin tumor Tumor Klatskin merupakan suatu kolangiokarsinoma tipe ekstrahepatik yang bersifat ganas dan timbul dari epitel duktus koledokus dan kedua percabangannya. Seorang wanita usia 47 tahun mengalami keluhan badan panas sejak 1 hari sebelum masuk rumah sakit. Satu hari sebelum masuk rumah sakit, pasien mengalami demam tinggi terus- menerus, tidak disertai dengan menggigil. Keluhan disertai nyeri hebat di perut kanan atas sampai ke ulu hati, nafsu makan menurun, mual setiap hendak makan, BAK berwarna seperti teh, BAB biasa, dan mata terlihat kuning. Satu minggu sebelum masuk rumah sakit, keluhan nyeri perut makin sering timbul disertai demam, mual, kadang-kadang muntah bila makan, dan nafsu makan makin turun. Hasil MRI menunjukkan kesan lesi hipointens dengan tepi yang irreguler di distal CBD sepanjang ±2 cm dengan dilatasi sedang CBD di bagian proksimalnya dan dilatasi ringan IHBD serta tak tampak dilatasi pada duktus pankreatikus, mengesankan massa di distal CBD yang menyebabkan obstruksi, curiga Klatskin Tumor Type 1 (berdasarkan Bismuth Classification). Pasien menolak dilakukan tindakan pembedahan maupun kemoterapi. Pasien mengaku merasa dalam kondisi baik, keluhan nyeri perut sangat jarang, nafsu makan sudah meningkat. Klatskin tumor is an malignant extrahepatic type of cholangiocarcinoma and arises from the choledocus ducte pithelium and its two branches. A 47-year-oldwoman has afever since one day before being hospitalized. One day before being admitted to the hospital, the patient experienced a persistent high fever, not accompanied by shivering. Complaints accompanied by severe pain in the right upper abdomen to the epigastrium, decreasedappetite, nausea, urine coloredliketea, normal bowelmovements, and eyes look yellow. One week before being hospitalized, complaintsof abdominal pain often came with fever, nausea, sometimes vomiting when eating, and appetite decreased. The MRI results showed hypointense lesions with irregular edges in the distal CBD of ±2 cm with moderate CBD dilatation in the proximal part and mild IHBD dilatation and no visible dilatation of the pancreatic ducts, impressive distal CBD mass causing obstruction, suspicious of Klatskin Tumor Type 1 (basedonBismuthClassification). Patient refused surgeryor chemotherapy. Patient claimed to feel in good condition, complaints of abdominal pain was veryrare, appetite has increased.

Analisis Nilai Clothing Time, Prothrombine Time dan Activated Partial Thromboplastine Time pada Remaja Obes Nelly Nelly; Mansyur Arief; Ilham Jaya Patellongi
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

Analysis of the Value of Clothing Time, Prothrombine Time and Activated Partial Thromboplastine Time in Obese AdolescentsLatar belakang: Berdasarkan estimasi WHO, obesitas menjadi masalah kesehatan di dunia. Selain karena insidennya meningkat,juga karena obesitas menimbulkan berbagai komplikasi penyakit metabolik dan vaskuler seperti sindrom metabolik, penyakit jantung, stroke dan gangguan pembekuan darah. Mengingat insiden obesitas pada saat ini telah mengalami pergeseran dari dewasa ke usia anak dan remaja serta berbagai komplikasi yang ditimbulkan oleh obesitas itu sendiri maka dianggap perlu dilakukan deteksi dini adanya gangguan hemostasis pada obesitas usia anak dan remaja untuk mencegah komorbiditas obesitas dikemudian hari.Metode: Desain penelitian ini adalah cross sectional study yang dilakukan di SMA Katolik Rajawali Makassar dengan menggunakan sampel siswa yang berumur sekitar 10-18 tahun. Dilakukan pemeriksaan antropometrik dan pemeriksaan nilai Clothing Time (TT), Prothrombine Time (PT) dan Activated Partial Thromboplastine Time(aPTT). Obesitas dinyatakan berdasarkan Kategori IMT yang ditentukan berdasarkan ambang batas Z-Score sedangkan kategori lingkar pinggang ditentukan berdasarkan Waist Circumfrence for Hong Kong Chinese Children (2008). Data dianalisis dengan independent t-test untuk menilai perbedaan nilai CT, PT dan aPTT pada remaja obes dan berat badan normal sedangkan uji korelasi pearson digunakan untuk melihat adanya hubungan antara IMT dan LP dengan nilai CT, PT dan aPTT pada remaja obes. Subyek adalah siswa siswi SMA Katolik Rajawali Makassar dengan rerata umur 15 tahun terdiri dari 33 orang laki-laki (22 obesitas,11 normal) dan 16 perempuan (5 obesitas,11 normal).Hasil: Didapatkan perbedaan bermakna antara nilai CT, PT dan aPTT pada remaja obes dan berat badan normal. Nilai rata-rata CT, PT dan pada kelompok normal adalah masing-masing aPTT 11±1,23; 13,86 ± 0,63 detik ; 32,90 + 1,77 detik dan pada kelompok obes adalah nilai CT,PT dan aPTT adalah 9 ±1,7; 13,11 + 0,59 detik dan 31,92+3,82 detik. Selain itu, terdapat korelasi negatif antara nilai CT,PT dan LP pada remaja obes namun tidak ditemukan adanya korelasi antara IMT dan LP dengan nilai aPTT pada remaja obes. Nilai CT, PT dan aPTT pada remaja obes cenderung memendek dibandingkan dengan berat badan normal.Simpulan: Semakin tinggi nilai IMT dan LP, maka nilai CT, PT dan aPTT semakin memendek. Background: Based on World Health Organization estimation, obesity has been a world health problem. Aside from the increased incident, also because obesity causes various vascular and metabolic disease complications such as metabolic syndrome, heart disease, stroke and blood coagulation disorder. Considering that the obesitysyndrome now has shifted from adults to kids and adolescent along with the complications of obesity, it is necessary to get an early detection in haemostaticdisorder in kids and adolescent obesity to prevent obesity co morbidity in the future. Method: The design of the research is cross sectional study which was carried out the population of Katolik Rajawali High School student in Makassar, ranging in age from ten to eighteen years old. An anthropometric examination was done, as well as examination of Clothing Time (TT), Prothrombine Time (PT) and Activated Partial Thromboplastine Time (PTT) value. Obesity is declare based on Body Mass Index (BMI) Category which was determined based on Z-Score threshold whereas waist line category was determined based on Waist Circumference (WC) for Hong Kong Chinese Children (2008). Data was analyzed using an independent t-test to assess the difference in CT, PT and aPTT value in obese adolescent and normal weight whereas the Pearson correlation test was used to see the relation between BMI and WC with CT, PT and aPTT in obese adolescent. Subjects were the high school students with the average age of 15 years old, consisting of 33 boys (22 obese, 11 normal) and 16 girls (5 obese, 11 normal). Result: The results showed significance different between CT, PT and aPTT value in obese adolescent and normal weight. The mean CT, PT and aPTT in the normal group were each 11 ± 1.23; 13.86 ± 0.63 seconds; 32.90 + 1.77 seconds and in the obese group the CT value, PT and aPTT were 9 ±1.7; 13.11 + 0.59 seconds and 31.92 + 3.82 seconds. Besides that, there was a negative correlation between CT, PT and WC value in obese adolescent but there was no correlation between BMI and WC with aPTT value in obese adolescent. Clothing Time, PT and aPTT value in obese adolescent tends to shorten compared to normal weight. Conclusion: The higher BMI and WC values, the shorter CT, PT and aPTT values. Keywords : Obesity, adolescent,CT, PT,aPTT

Pengaruh Penggunaan Metode Experiential Learning terhadap Hasil Belajar Anatomi Bagi Mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Semarang Mega Pandu Arfiyanti; Arum Kartika Dewi
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

The Influence of the Use of Experiential Learning Methods on Anatomy Learning Outcomes for Students of the Faculty of Medicine, University of Muhammadiyah SemarangBackground: Anatomy is a basic science that must be mastered by students of the Faculty of Medicine as the basis for conducting a physical examination and clinical reasoning. Students' understanding of anatomy is still lacking because they think that anatomy is very difficult to learn. Anatomy active learning method is needed to improve students' understanding.Objectives: The study was to determine the effect of using experiential learning methods on student anatomy learning outcomes.Methods: This study is an experimental pretest posttest design study with a sample of all first year students of Unimus Medical Faculty which were divided into control and treatment groups by randomized sampling. Students in the treatment group were taught anatomy using the experiential learning method, while the control group was taught using the conventional method. The data taken is the mean difference in the pretest posttest scores of the control group and the treatment group.Results: Out of 110 students, only 94 students followed the entire study protocol, consisting of 47 students in the control group and 47 students in the treatment group. Based on the independent t test, the results obtained sig (2-tailed) 0.000, which means that the experiential learning method has an influence on the learning outcomes of anatomy.Conclusion: The experiential learning method is effectively used to improve the anatomy learning outcomes of students of the Faculty of Medicine, University of Muhammadiyah Semarang.Latar belakang: Anatomi merupakan ilmu dasar yang harus dikuasai oleh mahasiswa Fakultas Kedokteran sebagai dasar melakukan pemeriksaan fisik dan penalaran klinis. Pemahaman mahasiswa akan ilmu anatomi masih kurang karena menganggap anatomi sangat susah dipelajari. Metode pembelajaran aktif anatomi diperlukan untuk meningkatkan pemahaman mahasiswa.Tujuan: Penelitian mengetahui pengaruh penggunaan metode experiential learning terhadap hasil belajar anatomi mahasiswa.Metoda: Penelitian ini merupakan penelitian eksperimental pretest posttest design dengan sampel seluruh mahasiswa tahun pertama FK Unimus yang dibagi menjadi kelompok kontrol dan perlakuan dengan randomised sampling. Mahasiswa kelompok perlakuan diajarkan anatomi dengan metode experiential learning, sedangkan kelompok kontrol dengan metode konvensional. Data yang diambil adalah rerata selisih nilai pretest posttest kelompok kontrol dan kelompok perlakuan.Hasil: Dari 110 mahasiswa hanya 94 mahasiswa yang mengikuti seluruh protokol penelitian yang terdiri dari 47 mahasiswa kelompok kontrol dan 47 mahasiswa kelompok perlakuan. Berdasarkan uji independent t test di dapatkan hasil sig (2-tailed) 0.000 yang artinya metode experiential learning memiliki pengaruh terhadap hasil belajar anatomi.Simpulan: Metode experiential learning efektif digunakan untuk meningkat hasil belajar anatomi mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Semarang.

Hubungan Jenis Kelamin dan Gambaran Klinis Celah Bibir Non Sindromik di CLP Center FK UMM Ruby Riana Asparini; Erika Yuli Susanti; Gita Sekar Prihanti
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

Relationship between Sex and Clinical Features of Non-Syndromic Cleft Lip at CLP Center FK UMMBackground: Non-syndromic cleft lip is a type of cleft that is not accompanied by abnormalities in the head and neck. There are sex differences in the timing of palate closure.Objective: To determine the relationship between sex and clinical features of non-syndromic cleft lip (with or without cleft palate) at CLP Center FK UMM (2016-2017).Method: CrossSectional. Data on sex and clinical features of non-syndromic cleft lip were obtained from the CLP Center FK UMM as many as 241 out of 271. Data analysis used the chi-square test with conditionsexpectedcount less than five not more than 20%. If it does not meet the requirements use the non-parametric Mann Whitney test.Results: The results of the chi-square test data analysis did not meet the requirements so that a non-parametric Mann Whitney test was carried out which showed p = 0.152 (p> 0.05), which means that there is no sex relationship and clinical features of cleft lip (with or without cleft palate). ) non-syndromic.Conclusion: There is no sex relationship and the clinical picture of cleft lip (with or without cleft palate) is non-syndromic.Latar Belakang: Celah bibir non sindromik merupakan jenis celah yang tanpa disertai kelainan pada kepala dan leher. Terdapat perbedaan jenis kelamin terhadap waktu penutupan langit-langit.Tujuan: Mengetahui hubungan jenis kelamin dan gambaran klinis celah bibir (dengan atau tanpa celah langit-langit) non sindromik di CLP Center FK UMM (tahun 2016-2017). Metode: CrossSectional. Data jenis kelamin serta gambaran klinis celah bibir non sindromik yang diperoleh dari CLP Center FK UMM sebanyak 241 dari 271. Analisis data menggunakan uji chi-Squaredengan syaratexpectedcountkurang dari lima tidak lebih dari 20%. Jika tidak memenuhi syarat menggunakan uji non parametrikMann Whitney. Hasil: Hasil analisis data uji chi-Squaretidak memenuhi syarat sehingga dilakukan uji non parametrikMann Whitney yang menunjukkan p=0,152 (p>0,05), yang berarti tidak ada hubungan jenis kelamin dan gambaran klinis celah bibir (dengan atau tanpa celah langit-langit) non sindromik. Kesimpulan: Tidak terdapat hubungan jenis kelamin dan gambaran klinis celah bibir (dengan atau tanpa celah langit-langit) non sindromik.

Pengaruh Konsumsi Kopi Terhadap Peningkatan Tekanan Darah Nurlatifah Almaida Amaluddin; Ummu Kalzum Malik
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

The Effect of Coffee Consumption on Increased Blood PressureLatar belakang: Kopi merupakan minuman yang sejak lama digemari masyarakat Indonesia. Kopi dapat mempengaruhi tekanan darah karena kandungan polifenol, kalium dan kafein. Polifenol dan kalium bersifat menurunkan tekanan darah, sedangkan kafein bersifat meningkatkan tekanan darah.Tujuan: Penelitian ini untuk mengetahui adakah perubahan status tekanan darah setelah diintervensi yang diberikan dalam penelitian ini yaitu kopi.Metoda: Desain penelitian merupakan penelitian observasional analitik dengan metode cross sectional study. Besar sampel yang digunakan sebanyak 96 laki-laki, dengan usia 20-40 tahun melalui tehnik purposive sampling.Hasil: Uji statistik dengan menggunakan uji Kolmogorov Smirnov, untuk pengaruh jenis kopi terhadap peningkatan tekanan darah didapatkan nilai p = 1.000, pengaruh jumlah kopi terhadap peningkatan tekanan darah didapatkan nilai p = 1.000 dan pengaruh frekuensi kopi terhadap peningkatan tekanan darah nilai p = 1.000.Simpulan: tidak terdapat pengaruh konsumsi kopi terhadap peningkatan tekanan darah. Background: Coffee is a drink that has been popular in indonesian people. Coffee may affect blood pressure because it contains of polyphenol, potassium and caffeine. Polyphenol and potassium is decreases blood pressure, while caffeine is increases blood pressure.Objective: To know is there any change in the status of blood pressure after the intervention of a given in this research namely coffee. Kind of this research is the observational analytic with the method is cross sectional study, which is done in the coffee shop in the Makassar city. Sample of this research is 96 man, consist of 20-40 years old. The research purposive sampling technique.Result: The statistical tests by using test kolmo gorov smirnov, the influence of kinds of the coffee on the increased. Blood pressure obtained value of P = 1.000, the influence of the number of coffee on the increase blood pressure obtained value of P = 1.000, and the influence of the frequency of coffee on the increase blood pressure obtained value of P = 1.000.Conclusion: There is no influence of consumption coffee on increased blood pressure.

Hubungan Pola Asuh Orang Tua dengan Kesiapan Toilet Training Pada Anak Usia Toddler Aidatul Fitri Mail; Romdzati Romdzati
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

The Relationship of Parenting Patterns with Toilet Training Readiness in Toddler Age ChildrenBackground: One of the child development tasks at toddler age is toilet training. Toilet training is a process of teaching children to control urination and defecation correctly and regularly. The readiness of toilet training in toddler age children is not only influenced by physical, psychological, mental, and parental readiness but can also be influenced by parenting patterns applied to children. There are three kinds of parenting styles including authoritarian, permissive, and democratic.Objective: This study aims to determine the relationship between parenting patterns and toilet training readiness for toddlers in Yogyakarta.Methods: This study is a non-experimental study with a correlational design through a cross-sectional approach. The sample in this study were 44 respondents with sampling through purposive sampling technique. Statistical test using chi-square with a=0.05.Results: This study shows that most parents apply democratic parenting, as many as 30 respondents (68.2%) with toilet training readiness as many as 22 respondents (73.3%). Correlation using chi-square test results obtained p value = 0.040.Conclusion: Based on data analysis, a significant value of p = 0.040 <0.05 was obtained, which means that there is a relationship between parenting patterns and toilet training readiness in toddler age children.Latar Belakang: Salah satu tugas perkembangan anak pada usia toddler adalah toilet training. Toilet training adalah suatu proses pengajaran kepada anak untuk mengontrol buang air kecil dan buang air besar secara benar dan teratur. Kesiapan toilet training pada anak usia toddler tidak hanya dipengaruhi oleh kesiapan fisik, psikologis, mental, dan orang tua tetapi bisa juga dipengaruhi oleh pola asuh orang tua yang diterapkan ke anak. Pola asuh orang tua ada tiga macam diantaranya otoriter, permisif, dan demokratis.Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan pola asuh orang tua dengan kesiapan toilet training pada anak usia toddler Yogyakarta.Metode: Penelitian ini merupakan penelitian non-eksperimen dengan desain correlational melalui pendekatan cross-sectional. Sampel dalam penelitian ini sebanyak 44 responden dengan pengambilan sampel melalui teknik purposive sampling. Uji statistic menggunakan chi-square dengan a=0,05.Hasil: Penelitian ini menunjukkan sebagian besar orang tua menerapkan pola asuh demokratis yaitu sebanyak 30 responden (68,2%) dengan kesiapan toilet training sebanyak 22 responden (73,3%). Korelasi menggunakan uji chi-square didapatkan hasil nilai p=0,040.Kesimpulan: Berdasarkan analisis data diperoleh nilai signifikan p=0,040 < 0,05 yang berarti ada hubungan pola asuh orang tua dengan kesiapan toilet training pada anak usia toddler.

Perkembangan Sel Limfosit B Dan Penandanya Untuk Flowcytometry Yelvi Levani
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

B Cell Lymphocyte Development And Its Marker For Flowcytometry Sel limfosit B merupakan bagian dari respon imunitas adaptif yang berperan penting untuk pertahanan tubuh melawan patogen. Perkembangan sel limfosit B dimulai dari sel punca hematopoietik di sumsum tulang belakang dan organ limfoid sekunder dengan melalui berbagai tahapan proses maturasi dan seleksi. Sel limfosit B matur dapat menghasilkan berbagai macam antibodi yang spesifik untuk patogen. Di tiap perkembangannya, sel limfosit B memiliki ekspresi molekul yang berbeda pada permukaannya dan dapat diketahui dengan pemeriksaan flowcytometry. Pemeriksaan sel limfosit B yang sesuai dengan tahapan perkembangannya dapat digunakan untuk membantu diagnosis penyakit defisiensi imun kongenital, leukemia, limfoma dan penyakit autoimun. B lymphocyte cells are part of the adaptive immune response that plays an important role in the body's defense against pathogens. The development of B lymphocyte cells starts from hematopoietic stem cells in the spinal cord and secondary lymphoid organs through various stages of the maturation and selection process. Mature B lymphocyte cells can produce a variety of antibodies that are specific for pathogens. In each development, B lymphocyte cells have different molecular expressions on their surface and can be identified by flowcytometry examination. Examination of B lymphocyte cells according to their stage of development can be used to help diagnose congenital immune deficiency diseases, leukemia, lymphoma and autoimmune disease.

Hubungan Pola Makan Dan Gaya Hidup Dengan Angka Kejadian Hipertensi Pralansia Dan Lansia Di Wilayah Kerja Puskesmas I Kembaran Ajikwa Ari Widianto; Muhammad Fadhol Romdhoni; Dewi Karita; Mustika Ratnaningsih Purbowati
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

Relationship between diet and lifestyle with the incidence of hypertension in the pre-elderly and the elderly in the working area of Puskesmas I KembaranBackground: Hypertension is also known as The Silent Killer since it is a hidden killer which its prevalence is very high and tends to increase in the future. Besides, its high malignancy affects in the form of permanent disability and sudden death. Primary Health Care Center (Puskesmas ) I Kembaran obtained the second highest occurrence of hypertension reported by the Banyumas Health Office (Dinas Kesehatan Banyumas), consisted of 2287 cases. Many risk factors affect to hypertension, especially diet and lifestyle.Objective: Determine whether there was a correlation between diet and lifestyle to the occurrence of hypertension in pre-elderly and elderly in the working area of Puskesmas 1 Kembaran.Method: Analytic observational with Cross sectional approach and applied simple random sampling technique. This study was conducted by 50 pre-elderly and elderly respondents who participated PROLANIS (Chronic Disease Management Program) at Puskesmas 1 Kembaran. Questionnaire was implemented to measure the diet and lifestyle, while blood pressure was obtained by sphygmomanometer. Data analysis technique conducted was chi square test.Result: Chi square test to determine the correlation between diet and lifestyle to the occurrence of hypertension. The results of the analysis of diet variable obtained p = 0.003 and the lifestyle variable was p = 0.023.Conclusion: There was a correlation between diet and lifestyle to the occurrence of hypertension in pre-elderly and elderly in the working area of Puskesmas 1 Kembaran, where diet and lifestyle are not good trigger s a higher occurance of hypertension.

Dermatoglifi Pada Autisme Dan Sindrom Down di Palembang Altiara Risky Suciandari; Trisnawati Mundijo; Mitayani Purwoko
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

Dermatoglyphics on Autism and Down's Syndrome in PalembangDermatoglyphics is the study of fingerprint patterns, the number of tendrils and the number of triradius whose development is regulated by genetics. Chromosomal abnormalities that can affect the dermatoglyphic phenotype include Autism and Down's Syndrome. This study aims to determine the fingerprint pattern in patients with Autism and Down's Syndrome. This research is descriptive with a total sample of 76 patients, namely 46 patients with autism and 30 patients with Down's Syndrome who were taken by total sampling at YPAC, YBAM and Autism Clinic Anakku Palembang. From the research results, the loop pattern is the most common fingerprint pattern in Autism (57.2%) and in Down's Syndrome (80.7%). While the arch pattern is the least fingerprint pattern, namely Autism (3.7%) and Down's Syndrome (5.3%). The results of the study concluded that most people with Autism and Down's Syndrome in Palembang had a loop fingerprint pattern. Dermatoglifi adalah ilmu yang mempelajari pola sidik jari, jumlah sulur dan jumlah triradius yang perkembangannya diatur oleh genetik. Kelainan kromosom dapat mempengaruhi fenotip dermatoglifi diantaranya adalah Autisme dan Sindrom Down. Penelitian ini bertujuan untuk mengetahui pola sidik jari pada penderita Autisme dan Sindrom Down. Penelitian ini bersifat deskriptif dengan sampel penelitian berjumlah 76 penderita yaitu 46 penderita Autisme dan 30 penderita Sindrom Down yang diambil secara total sampling di YPAC, YBAM dan Klinik Autis Anakku Palembang. Dari hasil penelitian pola loop merupakan pola sidik jari terbanyak pada Autisme (57,2%) dan pada Sindrom Down (80,7%). Sedangkan pola arch merupakan pola sidik jari yang paling sedikit yaitu Autisme (3,7%) dan Sindrom Down (5,3%). Hasil penelitian disimpulkan penderita Autisme dan Sindrom Down di Palembang sebagian besar memiliki pola sidik jari loop.

Efek Pemberian Ekstrak Buah Kersen (Muntingia Calabura) terhadap Histopatologi Paru Tikus yang Dipapar Asap Rokok Ika Dyah Kurniati; Dyah Mustika Nugraheni
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): February
Publisher : Universitas Muhammadiyah Semarang

Effects of Giving Kersen Fruit Extract (Muntingia Calabura) on Lung Histopathology of Rats Exposed to Cigarette SmokeLatar belakang: Oksidan yang terkandung dalam asap rokok dapat menyebabkan terjadinya stres oksidatif. Buah kersen (Muntingia calabura) mengandung antioksidan diantaranya flavonoid. Penelitian ini bertujuan mengetahui efek proteksi ekstrak buah kersen terhadap kerusakan histologis alveolus paru tikus Sprague dawley yang terpapar asap rokok Metode: Tikus sejumlah dibagi 4 kelompok, kemudian di papar asap rokok 7 batang perhari dan ekstrak buah kersen (EBK) selama 4 minggu. Kelompok pertama sebagai kontrol (K1) diberi plasebo, kelompok kedua (K2) dipapar asap rokok saja, sedangkan sisanya merupakan kelompok Perlakuan 1 (P1) diberi EBK 100mg/kgBB/hari dan Perlakuan 2 (P2) diberi EBK 200mg/kgBB/hari. Perbedaan derajat kerusakan alveolus di analisis dengan Kruskal-Wallis Test.Hasil: Rerata derajat kerusakan alveolus pada kelompok kontrol (K1)sejumlah (69,44) kelompok perlakuan 1 (P1) sejumlah (80,00) dan kelompok perlakuan 2 (P2) sejumlah (79,63) sedangkan yang terendah yaitu pada kelompok kontrol paparan asap rokok (K2) sejumlah (61,11). Nilai P = 0.464, menunjukkan bahwa tidak terdapat perbedaaan yang bermakna derajat kerusakan alveolus antar kelompok, dimana rerata derajat kerusakan alveolus paru > 60% (kerusakan berat).Simpulan : Pemberian ekstrak buah kersen tidak berpengaruh terhadap gambaran mikroskopis paru tikus yang di papar asap rokok. Background: Oxidant which is contain in cigarette smoke increases oxidative stress. Kersen fruit (Muntingia calabura) contains antioxidants including flavonoids. The purpose of this study is to proves protecting effect of kersen fruit extract on the lung tissue.Method: Rats were divided into 4 groups that had been exposed 7 cigarrete smoke a day and given kersen fruit extract (KFE) for 4 weeks. The first group as the control group (K) was given a placebo, second group were exposed cigarrete smoke only, treatment group 1 (T1) and treatment group 2 (T2) were treated with 100 and 200mg/kgBodyWeight/ day KFE, respectively. The difference in the degree of alveolar damages were analyzed.Results: There were no significant differences in the degree of alveolar damages between groups. The average degree of alveolar damages was severe, where the alveolar damages were> 60%.Conclusion: Kersen fruit has no effect on the histopathology of alveolar damage

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Anas

Contact Email magnamedica21@gmail.com

Phone +62271-716844

Journal Mail Official magnamedica21@gmail.com

Editorial Address FK UMS Kampus IV UMS Jl. Ahmad Yani, Gonilan, Kartasura, Gonilan, Kec. Kartasura, Kabupaten Sukoharjo, Jawa Tengah 57169. Telepon: (0271) 716844

Location Kota semarang, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Anas

Contact Email
magnamedica21@gmail.com

Phone
+62271-716844

Journal Mail Official
magnamedica21@gmail.com

Editorial Address
FK UMS Kampus IV UMS Jl. Ahmad Yani, Gonilan, Kartasura, Gonilan, Kec. Kartasura, Kabupaten Sukoharjo, Jawa Tengah 57169. Telepon: (0271) 716844

Location
Kota semarang,

Jawa tengah

INDONESIA