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JFL : Jurnal Farmasi Lampung

jfl
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Published by Universitas Tulang Bawang

ISSN : 23552506 EISSN : 25984896 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.

Arjuna Subject : -

Articles 7 Documents

Search results for , issue "Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung" : 7 Documents clear

ANALISIS JENIS DAN KADAR SAPONIN EKSTRAK METANOL DAUN KEMANGI (Ocimum basilicum L.) DENGAN MENGGUNAKAN METODE GRAVIMETRI Mauritz Pandapotan Marpaung; Romelan Romelan
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Kemangi plant (Ocimum basilicum L.) is a plant that has benefits such as overcoming nausea, abdominal bloating, fever, essential oils, vegetable pesticides, fresheners and as a medicine. Kemangi leaves contain phytochemical compounds such as tannins and saponins. The purpose of this research is to analyze the type and content of saponin on kemangi leaf extract by color test and gravimetric method. Samples of kemangi leaves were obtained from Betung area, Banyuasin regency, South Sumatera. Analysis of saponin content, kemangi leaf extract was done by using reflux extraction with methanol solvent. The results showed that the results of the color test, the type of saponin contained from kemangi leaf extract is saponin steroid and the saponin content produced from kemangi leaf extract was 3.11 ± 0.0795%. Keywords: Kemangi leaf, saponin, gravimetry

FRAKSI ETANOL RIMPANG TEMU PUTIH (Curcuma zedoaria (Christm.) Rosc.) SEBAGAI ANTIFUNGI TERHADAP Candida albicans dan Trichophyton rubrum Yuli Wahyu Trimulyani; Nurma Suri; Niken Dwi Astarina
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Traditional medicine is used as natural because it has small effects and more economical than the synthetic drugs. One example of the plants used as a Traditional medicine are Curcuma zedoaria. The study to examine the activity fraction of Curcuma zedoaria rhizome ethanol extract agains Candida albicans and Trichophyton rubrum. The simplisia of Curcuma zedoaria rhizome was extracted with ethanol 70% using a maceration method. Thick extracts were then fractionated using saveral solven such as n-heksane, chloroform and ethanol. The testing method used disc antifungi activity with the concentration of 6.25%, 12.5%, 25%, 50%, 75%, ketokonazol as the positive control and aquades as the resolvent. The test compounds Thin Layer Chromatography (TLC) method with eluen chloroform: methanol: water (2:3:5(v/v/v)) and phase uses G60F254 had been done. The result showed that Curcuma zedoaria rhizome significantly inhibit of C. albicans and T. rubrum the best inhibit zone diameter that are concentration of 75% for both of them with a diameter 8.98 mm in C. albicans and 11.66 mm in T. rubrum. Minimum Inhibitory Concentration (MIC) C. albicans is obtained on concentration of 6.25% and T. rubrum is concentration on of 12.5%. The TLC results showed a compound of flavonoids (Rf 0.88), saponins (Rf 0.74), tannins (Rf 0.86). Minimum Inhibitory Concentration (MIC) in C. albicans and T. rubrum are fungistatik and Minimum Bactericidal Concentration (MBC) are not fungisid for both of them. The ethanol fraction of Curcuma zedoaria rhizome has an activity as an antifungal against C. albicans and T. Rubrum with flavonoids, tannins and saponins. Keywords: Antifungi, Candida albicans, Curcuma zedoaria, Fungistatic, Trichophyton rubrum.

PENGARUH FRAKSI AIR DAUN KEDONDONG BANGKOK (Spondias dulcis) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT PUTIH JANTAN Ramadhan Triyandi; Nopiyansyah Nopiyansyah; Robi Wira Pratama
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Ambarella Bangkok fruit (Spondias dulcis) is fruits from Anacardiaceae family. Ambarella plant is known containing secondary metabolite compounds such as alkaloid, flavonoid, saponin and tannin. Flavonoid is a polyphenol compound which work as antioksdant. Ambarela Bangkok leaf containing rich antioksidant which can be use as prevention of cancer, heart disease, cholesterol, diabetes, and premature aging. The purpose of this research is to look effect from water fraction from Ambarela leaf (spondias dulcis) to decrease diabetes disease from white male mice. In this research ambarela leaf is extracted by maseration with 70% alcohol. After the extract obtained then fractionation prosen be held. From the fraction wich ocurred, then made three variant of dose those are 175.5 mg/kgW, 351 mg/kgW and 702 mg/kgW. From those three dose, the 702mg/ kgW dose has the best effect from another dose. Positive control used glibenclamide and negative control used aquadest. The result of this research shows that water fraction from Ambarela leaf can decrease diabetes desease from the white male mice. The the greater fraction concentration, the greater the concentration of the fraction then the decrease of blood glucose level in mice is getting better. The 702mg/kgW dose has an average value of decline 94.3 mg/Dl. The result of analisys shows that watter fraction of ambarella Bangkok leaf can decrease the blood glucose level in male white mice. Key word : Spondias dulcis, water fraction of Ambarela leaf , Blood glucose level

ANALISIS KANDUNGAN BORAKS PADA KERUPUK NASI YANG DIJUAL DI PASAR TRADISIONAL KABUPATEN TANGGAMUS SECARA SPEKTROFOTOMETRI UV-Vis Samsuar Samsuar; Akhmad Rokiban; Suparsi Suparsi
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

The use of additional subtance for food is to increase or to maintain nutritional value and quality of storability. Our govermment prohibits the use of borax as an additives subtance for food as appointed in Permenkes No.033, 2012. Borax is a chemical compound in white colorless crystalline with a chemical formula Na2B4O7.10H2O. Rice crackers are crackers made from rice with spices and flavor enhancer. In manufacturing crackers Borax is sometimes added to get savory crackers and to make them swelling. The purpose of this study is to find out the borax content on rice crackers in traditional markets Tanggamus district by using the qualitative method. It uses the flame test, cucurmin reagen test and ammonia steam test. It also applies quantitative test by using spectophotometry UV-Vis. There are 8 samples which were taken in tradisional markets Tanggamus district. The result of determination of the maximum length waves is 543 nm. This method has been validated before being used for the samples. The resulf of the research shows a curve with linear calibration,with the regression equalition y = 0,539x + 0,009 and correlation coefficient (r) = 0,9979. The average recorvery or accuracy value is 104,71 %. The precision or the result of standartd deviation and standard deviation relative or coeffecient of variation (CV) is 0,219%. The LOD acquistion value is 0,069 µg/ml and the LOQ is 0,320 µg/ml. The validation of the test shows that all methods have been done are valid, so it can be used to test the borax assay on the samples. Based on the analysis on 8 samples of rice crackers, quanlitative obtained sample testing shows 6 detected containing borax, then the result of quantitative obtained the level of borax ranged from 46,75 µg/g until 107 µg/g. Keywords : borax, rice crackers, Spectrofometry UV-Vis

Optimasi Zeolit Alam Lampung (ZAL) Sebagai Penstabil Sediaan Antibakteri Esktrak Buah Mengkudu (Morinda citrifolia L.) Laila Susanti; Lilik Koernia Wahidah; Pratika Viogenta
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Noni fruit extract has been widely known as an antibacterial, but plant extracts are easily degraded by light, pH and temperature, thus reducing the antibacterial activity, zeolite is added to maintain the stability of the noni extract. This study uses an experimental method that is by comparing the inhibition zones that occur between noni fruit extract and noni + ZAL fruit extract and to test the stability of the preparation, the sample is heated at 40oC and then tested for antibacterial activity again. The statistical test results show the value of Asymp. Sig (0.003)

FRAKSI ETANOL RIMPANG JERINGAU (Acorus calamus L.) SEBAGAI ANTIBAKTERI RERHADAP Staphylococcus aureus DAN Escherichia coli Pratika Viogenta; Nopiyansyah Nopiyansyah; Fitri Fitri
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Acorus calamus L. (jeringau) rhizomes are one of the medicinal plants used as traditional medicine in Indonesia. This plant were used as an antibacterial. The purpose of this research were to prove the inhibition jeringau rhizome on the selected microorganisme including two bacterial trains Staphylococcus aureus and Escherichia coli. The rhizomes of jeringau were extracted with maceration method using ethanol 70 % and fractionation process using solvent v/v (ethanol, n-hexane and chloroform). The antibacterial activity used the cup plate method with the concentration 20%, 40%, 60%, 80%, and 100%, positive control using ampicillin and negative control using aquades. The test were continved by determining the minimum inhibitor concentration (MIC). Research was obtained zone diameters of 0 mm (negative control), 35.37 mm (positive control), 23.33 mm (concentration 20%), 25.52 mm (40%), 27.11 mm (60%), 30.09 mm (80%), and 33.16 mm (100%) against Staphylococcus aureus. Inhibitory zone diameters 0 mm negative control, 36.68 mm positive control, 22.53 mm (concentration 20%), 25.85 mm (40%), 28.08 mm (60%), 29.73 mm (80%), and 32.21 mm (100%) against Escherichia coli. The minimum inhibitory concentration (MIC) value in both bacterial were 2%. The results showed that all fraction concentrations could inhibit the growth of Staphylococcus aureus and Escherichia coli. Keywords : Rhizome Jeringau, Staphylococcus aureus, Escherichia coli.

AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL 70% DAUN ASHITABA (Angelica keiskei) SECARA IN VIVO DENGAN PENGINDUKSI KARAGENAN Haka As'ada; Yardi Saibi; Hendri Aldrat
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Ashitaba leaves (Angelica keiskei) or also known as tommorow's leaf is plant that known to have various health benefit, one of them is as an anti-inflammatory activity. The anti-inflammatory activity of ashitaba leaves has been known through in vitro assays. This study aims to determine the anti-inflammatory activity of 70% ethanol extract of ashitaba leaves through in vivo assay. Anti-inflammatory activity was performed on white male rat of Sprague dawley strain with induction method of edema on rat's foot using 1% carrageenan 0.2 ml. Rats were divided into 5 groups. The negative control group was given a 0.5% Na-CMC suspension, a positive control group was given sodium diclofenac suspension of 5.14 mg / kgBW, and the test group was given 70% ethanol extract of ashitaba leaves at a dose of 1000; 2000; and 4000 mg / kgBW suspended in 0.5% Na-CMC. The results showed that in that dose range the 70% ethanol extract of ashitaba leaves had anti-inflammatory activity that did not depend on the dose. Percentage of edema of 70% ethanol extract of ashitaba leaves dose 1000; 2000; 4000 mg / kgBB was significantly different with negative control (p ≤ 0,05) and had percentage of edema inhibition respectively 83,95%, 79,01%, and 80,25%. The results of this study showed that 70% ethanol extract of ashitaba leaves have anti-inflammatory activity. Keywords: Ashitaba, Angelica keiskei, tommorow's leaf, anti-inflammatory, carrageenan.

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Contact Name
Laila Susanti

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laila.susanti@utb.ac.id

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Location
Kota bandar lampung,

Lampung

INDONESIA