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Journal of Pharmaceutical and Medicinal Research Sekolah Tinggi Ilmu Farmasi Makassar Perintis Kemerdekaan Street KM 13.7 90242 Makassar-Indonesia
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Journal of Pharmaceutical and Medicinal Sciences
Published by Sekolah Tinggi Ilmu Farmasi Makassar
ISSN : 25282824     EISSN : 2580328X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical and Medicinal Sciences (JPMS) pISSN 2528-2824; eISSN 2580-328X dedicated to publish original research papers, original research notes, invited topical reviews, mini-reviews, editorial commentary and news. Medicinal resources about exchange of information and understandings about people's use of plants, fungi, animals, microorganisms, minerals, their biological and pharmacological effects based on the principles established through international conventions. Pharmaceutical including drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 4 No 1 (2019)" : 5 Documents clear
Penetapan Kadar Fenolik Total, Flavonoid Total, dan Uji Aktivitas Antioksidan Ekstrak Daun Benalu Petai (Scurrula atropurpurea Dans.) Beserta Penapisan Fitokimia Wirasti Wirasti
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 1 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.893 KB) | DOI: 10.32814/jpms.v4i1.73

Abstract

Tumbuhan dalam dunia kesehatan dapat digunakan sebagai salah satu pendekatan terapi bahan alam yang ampuh untuk pengobatan berbagai penyakit dikarenakan mengandung antioksidan. Antioksidan yang tinggi umumnya berkorelasi dengan kandungan flavonoid ataupun fenolik yang tinggi pula. Tujuan penelitian ini adalah untuk mengetahui kadar senyawa fenolik total, flavonoid total, dan aktivitas antioksidan ekstrak etanol daun benalu petai (Scurrula atropurpurea Dans.). Fenolik total ditentukan dengan metode folin-ciocalteu, kadar flavonoid total secara kolorimetri menggunakan AlCl3, dan aktivitas antioksidan menggunakan metode penangkapan radikal bebas DPPH. Hasil penelitian menunjukkan bahwa ekstrak daun S. Atropurpurea memiliki aktivitas antioksidan kategori sangat kuat (IC50 = 23.48±0.04 µg/ml). Hal ini juga ditunjang dengan tingginya kandungan fenolik total sebesar 198,08±1,44 mg GAE/g ekstrak, dan flavonoid total sebesar 148,05±4,44 mg QE/g esktrak. Sehingga dapat disimpulkan bahwa daun S. Atropurpurea berpotensi sebagai sumber antioksidan alami.
Uji Difusi dan Iritasi Krim Solid Lipid Microparticle Ekstrak Etanol Daun Kersen (Muntingia calaura L.) Amriani Sapra; Radhia Riski; Nurul Hidayah
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 1 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (646.272 KB) | DOI: 10.32814/jpms.v4i1.74

Abstract

The extract of kersen leaves (Muntingia calabura L) contains flavanoid compounds as polar antioxidants which have difficulty to diffuse through the skin. Solid lipid microparticle is a drug delivery system to improve the availability of water-soluble compounds at site of action. The aim of this study was to determine diffusion profile and irritant effect of solid lipid microparticle cream loaded ethanol extract of kersen leaves. Diffusion of solid lipid microparticle cream loaded ethanol extract of kersen leaves was carried out using Whatman no.1 membrane and circumcision by franz diffusion methods while irritation test was performed on Albino rabbits (Orytoglagus cuniculus). The results of showed profil using Whatman membrane No. 1 are better than circumcision and the irritation test results the cream do not cause irritating effects on the skin.
UJI TOKSISITAS EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) MENGGUNAKAN METODE BRINE SHRIMP LETHALITY TESt (BSLT) PADA LARVA UDANG (Artemia salina Leach Sitti Rahimah Rachman; Fadillah Maryam; Bertha Ayu Limbong
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 1 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.409 KB) | DOI: 10.32814/jpms.v4i1.82

Abstract

Brine Shrimp Lethality Test (BSLT) is one of the initial screening methods for testing cytotoxic compounds. Previous studies have scientifically proven that Averrhoa bilimbi L leaves have antioxidant effects so that the basis of the aim of this study is to determine the toxicity effects of ethanol extracts of starfruit starfruit shrimp (Artemia salina L.) using the BSLT method. Testing was done using several variations of concentration, namely 10 μg / mL, 250 μg / mL, 500 μg / mL, 750 μg / mL, and 1000 μg / mL. Based on observations and analysis of data obtained that the ethanol extract of Averrhoa bilimbi L leaves gives a moderate toxic effect with LC50 value of 367,282 ± 33.81 µg / mL.
Kadar Kurkumin Dari Ekstrak Beberapa Rimpang Suku Zingiberaceae Riza R Yustinianus; Jeanny Wunas; Yusnita Rifai; Naimah Ramli
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 1 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (805.888 KB) | DOI: 10.32814/jpms.v4i1.93

Abstract

Research about curcumin content in extract of some rhizomes from zingiberaceae Family had been done. This research aimed to determine the content of curcumin in turmeric rhizome extract (Curcuma domestica Val.), Curcuma xanthorriza Roxb, Curcuma mangga Val., Curcuma zedoaria (Berg) Rosc. and Curcuma aeruginosa Roxb. using thin layer chromatography densitometry (TLC-densitometry) method based on the area of the rhizomes extract and curcumin standard. Each sample was extracted by soxhlet with acetone as solvent. Content of curcumin in the extracts was obtained using TLC with the silica gel GF254 as stationary phase and chloroform: methanol (95 : 5) as mobile phase and was analyzed using TLC-densitometer and measured at 420 nm. Results showed that curcumin content from each extract was found in C. domestica, C. xanthorrhiza, C. aeruginosa, C. mangga, C. zedoaria were 11.33, 5.95, 2.80, 1.80 and 0.60%.
Pemisahan dan Karakterisasi Senyawa dari Ekstrak Etanol Umbi Talas Safira (Colocasia esculenta Schott var. antiquorum) Karla Fransiska; Burhanuddin Taebe; Risfah Yulianty; Lukman Muslimin
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 1 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (608.058 KB) | DOI: 10.32814/jpms.v4i1.94

Abstract

Research on the separation and characterization of chemical compounds from taro tuber (Colocasia esculenta Schott var. antiquorum) has been done. The maceration results of 850.00 g simplicial with 70 % ethanol solvent obtained 102.16 g brown viscous extract. The result of chemical components identification showed that the ethanol extract of taro tuber was positive for alkaloids, flavonoids, and terpenoids. Separation and purification of the ethanol extract were done by a liquid-liquid partition, thin layer chromatography and two-dimensional chromatography with a combination of n-hexane and ethyl acetate (2:8) as mobile phase. We found 4 bands (I-IV) with maximum wavelength were 407.0, 268.50, 253.00, and 209.50 nm. The presence of absorption at a wavelength of 268.50 nm and 253.00 nm indicating the presence of a class of flavonoids. The infrared spectrum showed that the isolates had typical groups such as O-H, C=O, C-C, C-O, and C=C.

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