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Jurnal Kesehatan Islam : Islamic Health Journal
Published by Universitas Islam Malang
ISSN : 2303022X     EISSN : 26158345     DOI : -
Core Subject : Health, Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health
Jurnal Riset Kedokteran Islam berisi informasi tentang hasil kegiatan penelitian, pemikiran konseptual dan kajian bidang ilmu kedokteran dan kedokteran. Jurnal ilmiah ini diterbitkan oleh Fakultas Kedokteran Universitas Islam Malang. Jurnal ini diterbitkan dengan frekuensi 2 kali setahun, yaitu pada bulan Maret dan bulan September.
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Articles 7 Documents
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Search results for , issue "Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal" : 7 Documents clear
Pengaruh Ekstrak Etanol 96% Bawang Dayak (Eleutherine Palmifolia (L.) Merr.) Terhadap Pertumbuhan Methicillin Resistant Staphylococcus Aureus (MRSA) Feriandri Utomo; Laura Nurul Alfiola
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16102

Abstract

The number of Methicillin Resistant Staphylococcus aureus (MRSA) continues to increase.The antibiotics used to treat MRSA infections is vancomycin, but the number of Staphylococcius aureus bacteria that are resistant to vancomycin has also increased. Dayak onion as a medicinal plant which has been used for a long time, has antibacterial compounds namely flavonoids, tannins, terpenoids, and quinones.The purpose of this study was to analyze the effect of 96% ethanol extract of Dayak onion with concentrations of 12.5%, 25%, 50% on the growth of MRSA compared to vancomycin, and to determine the phytochemical content of MRSA antibacterial compounds in Dayak onions.The study design used a post test only with control group by giving 0.9% NaCl to the negative control group. MRSA growth in this study was assessed from the size of the inhibition zone by the Kirby-Bauer method. Data analysis using One-Way ANOVA , then continued post hoc test. The results of this study indicated that Dayak Onion had weak anti-bacterial activity against MRSA, so it is not effective as an anti-bacterial MRSA because an average inhibition zone of <15mm is formed in all concentration groups (10.88mm at 12,5 % concentration, 12.35mm at 25 % concentration, and 14.35mm at 50% concentration). The average diameter of the inhibition zone in the treatment group of Dayak onion extract with 12,5 % concentration was significantly lower (p value <0.05) than the average diameter of the inhibition zone in the treatment group with 50 % concentration of the Dayak onion extract. The average diameter of the inhibitory zone in the treatment group of all concentrations of Dayak onion extract was significantly lower (p value <0.05) than the average diameter of the inhibition zone in the Vancomycin treatment group. The average inhibition zone formed in the vancomycin treatment group was 22.29 mm, so it was still effective as an anti-bacterial MRSA. This study also found the presence of flavonoid compounds, terpenoids, tannins, and quinones in Dayak onions. Therefore, it can be concluded that the 96% ethanol extract of Dayak onion which contains phytochemical anti-bacterial compounds has weak activity in inhibiting the growth of MRSA, so it is not effective as anti-bacterial for MRSA.
Pengaruh Kualitas Tidur dan Aktivitas Fisik pada Pasien Hipertensi di Puskesmas Ngajum, Kabupaten Malang Fitria Nugraha Aini; Dewi Martha Indria; Rizky Setia Firdaus; Ardhita Okky Riyana Dewi; Roziq Siroj Ramadhan; Cornellia Agnes Fransiska Putri
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16105

Abstract

Sleep quality affects overall health and quality of life, including blood pressure. Increased blood pressure or hypertension is one of the factors causing cardiovascular disease that is often found in primary health care. Based on Riskesdas data in 2018, 25.8% of the Indonesian population suffers from hypertension. This study aims to determine the effect of sleep quality and level of physical activity with the incidence of hypertension in patients at the Ngajum Public Health Center, Malang Regency. Method: The research design used is a case control study. This research was conducted on 60 respondents in the working area of the Ngajum Health Center, Ngajum District, Malang Regency in December 2019. Sampling was carried out using the purposive sampling method. The research instrument used a sleep quality questionnaire adopted from the Pittsburgh Sleep Quality Index (PSQI) and a physical activity questionnaire adopted from the Global Physical Activity Questionnaire (GPAQ). Results: The case group consisted of 30 hypertensive patients and the control group consisted of 30 non-hypertensive patients. In the hypertension group, 23.3% of patients had good sleep quality and 76.7% had poor sleep quality. In the group of non-hypertensive patients, 73.3% had good sleep quality and 26.7% had poor sleep quality (p≤0.05). Meanwhile, the level of physical activity in hypertensive patients was 60.0% who had high activity, 6.7% had moderate activity, and 33.3% had low activity. Then in the control group there were 70.0% who had high activity, 20.0% had moderate activity, and 10.0% had low activity (p≤0,05). Conclusion: Based on the results of the study, it can be concluded that the quality of sleep and activity had a significant effect on the incidence of hypertension in patients at the Ngajum Public Health Center, Ngajum District, Malang Regency.
Efek Ekstrak Bunga Melati (Jasminum Sambac) dengan Metode Elektrik terhadap Efek Knockdown pada Nyamuk Aedes Aegypti Stadium Dewasa Rizky Noni Amalia; Anung Putri Illahika; Aida Musyarrofah; Fathiyah Safithri
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16078

Abstract

Abstract. Dengue Hemorrhagic Fever (DHF) is caused by the Dengue virus (DENV) which is transmitted by mosquitoes. One of the factors that cause high number of dengue infections in Indonesia is due to poor vector management. Chemical-based insecticides used to control mosquitos can cause human health problems and mosquito resistance. Jasmine flower (Jasminum sambac) can be used as an alternative because it contains flavonoids, alkaloids, saponins, and tannins that can act as natural insecticides. Objective: Proving the effect of jasmine flower extract (Jasminum sambac) with the electric method has a knockdown effect on adult stage Aedes aegypti mosquitoes. Method: True Experimental Post Test Only Control Group Design. In each test group, 20 adult Aedes aegypti were used with four replications. In this study, the test group consisted of malathion as positive control, aquades as negative control, and jasmine flower extract (Jasminum sambac) at concentrations of 5%, 10%, 15%, 20%, and 25%. Data was analyzed using Kruskal Wallis test, Post Hoc Mann Whitney test, Spearman correlation test and Probit test. Results and Discussion: Kruskal Wallis test obtained a significance value (P) <0.05. Post hoc mann whitney test showed knockdown effect at concentrations of 15%, 20% and 25%. The results of the Spearman correlation test (P = 0.019 and R = 0.440) showed a sufficient correlation between the con­centration of jasmine flower extract and the knockdown effect. LC50 was obtained by probit test at a concentration of 12.839%. The results showed that the content of jasmine flower extract had an insecticidal effect with the electric method. Conclusion: Jasmine flower extract (Jasminum sambac) applied using the electric method has a knockdown effect on adult Aedes aegypti at concentrations of 15%, 20% and 25%.
Butenedioic Acid of Soursop Leaves (Annona muricata) Water Extract as Dipeptidyl-peptidase 4 (DPP4) Inhibitor Dini Sri Damayanti; Nurdiana Nurdiana; HMS. Chandra Kusuma; Djoko Wahono Soeadmadji
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16106

Abstract

The aim of the study was to prove the potential of Soursop Leaves Water Extract (SLWE) content as DPP4 inhibitor an in silico method. The extraction process of soursop leaves uses water solvent with the infusion method. Withdrawal of the active compounds using acetone solvent. Identification using the GCMS method. Molecular docking of SLWE active compounds, Linagliptin as a control and DPP4 protein target  using  Autodoc Vina application. 2D visualization using LigPlot. Validation of affinity of active compounds of Annona muricata Leaves  using the measurement results of free binding energy, the number  similarity of bond position to active site ot  the protein target, and the number of hydrogen bond compared to controls. To determine the potential effect as a drug and toxicity using the 5 rules of Lipinski and ADME. The results of molecular docking found that the active SLWE compounds that have affinity close to control is butenedioic acid. It has the ∆G of  -7 kcal / mol, binds 53% of amino acid residues of DPP4 and has one hydrogen bond. Based on 5th rules of Lipinski and ADMET, Buetenoic acid has the potential to be developed as DPP4 inhibitor drugs which is administered orally and had a non-toxic effect. The the Conclusion Butenedioic acid, the active compound found from SLWE is potential as DPP4 inhibitors.
Pengaruh Ekstrak Buah Labu Siam (Sechium edule) terhadap Ketebalan Dinding Aorta Tikus Putih (Rattus norvegicus strain wistar) Model Aterosklerosis Desy Andari; Aulia Wiraldi Putra; Meddy Setiawan
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16079

Abstract

Background: Atheroslerosis is a disease that formed due to cumulation of the fibrous tissues in vascular wall and gradually become thrombus. Chayote contains antioxidants such flavonoid, saponin, and ascorbic acid that could prevent the thickening of the vascular wall. Objective: To determine the effect of chayote extract on aortic vascular wall thickness in white rats with atherosclerosis model. Methods: True experimental with post-test only controlled group design. Sixteen white male rats divided into 4 groups: positive control group and 3 treatment groups that given chayote extract at different doses (20 mg/day, 40 mg/day, 80 mg/day). The H&E stained aortic preparate were observed with 400x magnification used optical microscope and vascular thickness were measured with optilab software. Data analized with one way ANOVA, post hoc, pearson and linear regression test. Result: There was significant effect of chayote extract to the aortic arch vascular wall thickness (ANOVA p=0,001) and the dose that started giving effect was 40 mg/day (Post Hoc test). There was very strong, significant, and reciprocally correlation between chayote extract and aortic wall thickness (R=-0,896). Chayote extract affected aortic wall thickness with the value of 80,4%. Conclusion: Chayote extract could prevent the thickening of aortic wall in atherosclerotic rats.
Pola Resistensi Bakteri Penyebab Infeksi Saluran Kemih (ISK) pada Pasien di Salah Satu Rumah Sakit Swasta di Jakarta Utara Periode 2019-2021 Maulin Inggraini; Reza Anindita; Euodia Naomi Septiana Siburian; Noor Andryan Ilsan
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16080

Abstract

Urinary Tract Infection (UTI) is an infectious disease of the urinary tract caused by bacteria. Treatment therapy for UTI is done by giving antibiotics. However, the use of antibiotics often poses a risk of bacterial resistance that causes UTIs which has an impact on increasing morbidity rates, resulting in high UTI treatment costs. This study aims to determine the pattern of UTI bacterial resistance to antibiotics in UTI patients at a private hospital in North Jakarta for the 2019-2021 period. Cross sectional design, using a non-analytic retrospective approach conducted at a private hospital in North Jakarta for the 2019-2021 period. The sample of this study was secondary data totaling 159 urine of UTI patients taken by purposive sampling. The data is processed in tabular form and described to see a picture of UTI patients in a private hospital in North Jakarta for the 2019-2021 period. The results showed that there were more female UTI patients (68%) than men (32%), the most common bacteria causing UTI was E. colli (61.64%), the dominant antibiotic causing UTI bacterial resistance was ampicillin (67.92%). The conclusion of this study is that E. coli is the most dominant cause of UTI and ampicillin is the antibiotic that causes the most resistance to UTI bacteria.
Profil Health-Related Quality of Life (HRQOL) Masyarakat Surabaya Dewi Perwito Sari; Digdo Suryagama
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16101

Abstract

The development of a nation or state is determined by one of the factors, namely socially and economically productive human resources. Productive human resources are part of the health development plan that has been planned by the Ministry of Health of the Republic of Indonesia through the 2015-2019 Strategic Plan. Improving the quality of human life where health-related quality of life (HRQoL) is part of the main strategic plan. A large and healthy population of productive age supports the wheels of a country's development. Surabaya is one of the metropolitan cities with an estimated productive age population of 75.86% in 2019. This study aims to describe the HRQoL of the people of Surabaya City in 2019. This study is survey research conducted in a descriptive cross-sectional manner using a survey sheet (questionnaire) SF6D in Indonesian version that has been validated. Quality of life assessment is expressed in utility values and analyzed by correlation test and difference test. The results of a survey conducted on 226 people resulted in an average utility score of 0.8945 with an SD of 0.1109. Significant differences can be seen in the utility values of the age, education, and marital status groups (p<0.05). The results of the study concluded that the HRQoL of productive age in Surabaya was good, while the factors of age, education, and status influenced the level of HRQoL

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