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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
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Articles 15 Documents
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Search results for , issue "Vol 19 No 2 (2022): Jurnal Farmasi Indonesia" : 15 Documents clear
Analisis Proses Pengelolaan Obat Dengan Pendekatan Lean Hospital Di RSUD X Kabupaten Jombang Muhamad Aulia Putra Tawakal; Jason Merari Peranginangin; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1032

Abstract

The lean approach can make hospitals become more organized so they can improve the quality of services to patients by reducing waste, including the occurrence of errors, movements, transportation and poor service flow that leads to long service waits which certainly is not expected by patient. The purpose of this study was to identify the waste and the root causes of waste that occurred in the Pharmacy Installation at RSUD X Jombang. This research method is a qualitative descriptive study. The stages of the research are the observation of the drug management process flow which is made in the form of value stream mapping, focus group dicussion, and fishbone diagrams to determine the root cause of the problem. The results showed that the waste in the procurement process of 96.07% included in the category of necessary but non-value added, the acceptance process amounted to 62,59% of activities included in the category of necessary but non-value added, in the storage process there was a waste of 53, 39% included in the category of non value added, and in the process of using waste by 36.22% included in the category of non value added. The root cause of the problem of procurement is the length of time it takes to request the approval of PPK and PPTK, at the reception there is no specific place for receipt of goods, in storing all records and reporting is still manual and in use there is only one prescription receipt and delivery of drugs. In the future state mapping it is known to save time by 45.60% on procurement, 58% on revenue, 53.39% on storage, and 69% on usage.
Analisis Perencanaan dan Pengendalian Obat Kategori A dengan Metode ABC-VEN dan EOQ di IFRS RSIS Mojokerto Mustika Wati; Ismi Rahmawati; Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1178

Abstract

The high residualvalue of drug inventory at IFRS RSIS Mojokerto indicates that drug management has not been managed optimally. The priority scale of supervision and control at planning stage needs to be carried out using the ABC-VEN method analyzing and calculating the EOQ value in order to achieve the most economical ordering value to avoid overstock. The purpose of this study was to determine drug classificationusing the ABC-VEN method, planning control using with EQQ and measuringthe efficiency value at IFRS RSIS Mojokerto. The design of this research is descriptive quantitative. Retrieval of retrospective data from the January-October 2020 financial statement at IFRS RSIS Mojokerto. The data were analyzed by ABC-VEN to get categoryA drugs. Drug inventory control was calculated by calculating the value of EOQ,ROP, efficiency value by calculating ITOR. The results of drug classification using the ABC-VEN method obtained categoryA drugs absorbing 68.05% of the total investment value. Control of planning category A drug needs resulted in the value of the remaining inventory dropping from 48.4% to 36% of the total inventory value, ITOR increased from 2.0 to 4.1 times per month. The conclusion of the ABC-VEN, EOQ and ROP analysis can be used to determine the priority scale of procurement and control to avoid over-stocking of drug supplies in the hospital.
Penetapan Kadar Flavonoid Ekstrak dan Fraksi Kulit Buah Citrus reticulata Siska Musiam; Erna Prihandiwati; Eka Kumalasari; Aisyah Aisyah
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1343

Abstract

Citrus reticulata is one of the varieties of citrus endemic to South Kalimantan. So far, the people of South Kalimantan have only used the pulp of the citrus fruit, while the skin is disposed of as waste. Therefore, this study was conducted to see the value of the benefits of the Citrus reticulata rind waste by testing the levels of flavonoids from the extract and its fractions. The rind extraction of Citrus reticulata was carried out by maceration method using methanol as a solvent. The extract obtained was then fractionated using the liquid-liquid method using n-hexane, chloroform, ethyl acetate, and water as solvents. The extract and each fraction were determined for the level of flavonoids using a UV-Visible spectrophotometer at a wavelength of 413 nm and a series of standard concentrations of quercetin 35; 50; 65; 80; and 95 ppm. The results showed that the levels of flavonoids from the highest to the lowest were in the water fraction, methanol extract, n-hexane fraction, ethyl acetate fraction, and chloroform fraction with the respective values ​​of 53.635 ± 0.00697; 30.083 ± 0.00386; 15,524 ± 0.00423; 9.787 ± 0.00198%(w/w).
Pengembangan dan Validasi Metode Spektrofotometri Area Under Curve Untuk Campuran Biner Parasetamol dan Ibuprofen Dalam Bentuk Sediaan Tablet Rida Evalina Tarigan; Lutvia Lutvia; Rina Monica Taruliana Sitorus
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1388

Abstract

The combination of paracetamol (PAR) and ibuprofen (IBU) is the most commonly used over-the-counter medication for fever and pain. This study aimed to develop spechtrophotometry method by area under curve to determine the levels of PAR and IBU in tablet dosage form. This method is based on the area under the curve value of each spectrum in various concentrations is calculated to selected wavelength range analysis, with methanol as solvent. Then, this method was applied to determine levels of PAR and IBU in tablet dosage form. The result of this method is the analysis of selected wavelength ranges of PAR and IBU in the wavelength ranges of 244-254 nm and 220-230 nm, respectively. The mean % recoveries were found to be in 99.35% and 99.49% for PAR and IBU, respectively. The method is successfully applied to determine PAR and IBU in tablet dosage form simultaneously and fulfill the validation requirements.
Interaksi Farmakokinetika Kombinasi Captopril Dengan Rebusan Daun Sirsak (Annona Muricata L.) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar Rina Saputri; Mustaqimah Mustaqimah; Ali Rakhman Hakim
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1451

Abstract

Hypertension is a disease that cannot be cured, but can only be controlled, therefore hypertensive patients must get the treatment for the rest of their life. Currently, the treatment pattern of the community has started to return to using natural ingredients as a therapeutic alternative. The community considers the use of herbal medicines is safe, but actually when the herbal medicines is taken together with synthetic medicines, there are interaction potential that should be monitored. The purpose of this study was to analyze the Pharmacokinetic Interaction of Captopril Combination with Soursop Leaf Decoction. This study was an advanced experimental study with a random block design. The group of test animals was divided into three groups, namely the captopril group, the combination group of captopril and soursop leaf decoction at the same time, and the combination group of captopril and soursop leaf decoction with an consumption interval of 2 hours. The results of the descriptive analysis showed that there were differences in the pharmacokinetic profile of each group. Combination with captopril with soursop leaf decoction is able to increase captopril levels in blood plasma and increase the elimination rate of captopril. However, the statistical analysis showed there is no significant difference.
Optimasi HPMC K15M, Karbopol 940, dan Propilen Glikol pada Formula Nanoemulgel Naringenin Metode D-Optimal Mixture Design Rakhmi Hidayati; Opstaria Saptarini; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1460

Abstract

Naringenin is a flavanone from citrus fruit which has antioxidant activity which has low bioavailability in water. The way to increase the bioavailability of naringenin is to create a SNEDDS delivery system. Nanoemulsion preparations are considered to be comfortless to use due to low viscosity, dispersibility and stability. To solve this problem, SNEDDS is combined into a gel base known as nanoemulgel. The nanoemulgel formed is optimized using D-Optimal Mixture Design method. The aim of this study are determining the combination of HPMC K15M, carbopol 940 and propylene glycol in the optimal nanoemulgel naringenin formula. Naringenin is made into SNEDDS formulation, determined by the hydrogel base formula design: HPMC K15M, carbopol 940, and propylene glycol and obtained 16 formulas. The formed naringenin SNEDDS is dispersed in hydrogel and optimization of viscosity, dispersion, adhesion, cumulative percent of naringenin using franz diffusion cells and stability test are carried out. The data is analyzed on the D-Optimal Mixture Design method using Software Design Expert Version 12. The optimum proportions on a hydrogel base are HPMC K15M of 2%, carbopol 940 of 0.50%, and propylene glycol of 2.50% can have an effect on the critical parameters of viscosity of 3996 cp, dispersion of 5.80 cm, adhesion of 63.39 seconds, and the cumulative percent of naringenin penetration test of 26,54%.
Pengaruh Penerapan PROLANIS Pada Pasien Diabetes Mellitus Tipe 2 Di Puskesmas Kota Bekasi Lia Warti; Dian Ratih Laksmitawati; Prih Sarnianto
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1481

Abstract

Prolanis is Chronic Disease Management Program; where this program is an integrated health service program and involves other parties such as BPJS, health facilities and patients. Clinical outcomes ultimately impact the quality of life and, in general, if the quality of life grows well, which is indicated by controlled glucose levels. The result of this research is to know the impact of applying Prolanis to measure the quality of life in type 2 Diabetes Mellitus patients at Pekayon Jaya Health Center and Pengasinan Health Center. The method used in this research is a cohort study with data analysis of SPSS version 24. The study was conducted on 80 patients consisting of 40 prolanis patients at Pekayon Jaya Health Center and 40 non-prolanis patients at Pengasinan Health Center within a period of 3 (three) months. Data on the level of knowledge and compliance were collected using a questionnaire. GDP data was taken from monthly patient control visits, and quality of life data was taken using the European Quality of Life-5 Dimension-5 Level (EQ-5D-5L) instrument and the conversion of health utility to the Indonesian value set. The result is there is a significant effect of applying prolanis program in prolanis and non-prolanis patients on the level of knowledge, compliance, and GDP in describing the quality of life. The utility value of prolanis patients was 0.945±0.101 higher than non-prolanis patients, 0.769±0.197. Based on the level of knowledge of prolanis and non-prolanis patients (34.35±2.13: 28.47±4.09), prolanis and non-prolanis patient compliance (6.38±1.66: 5.11±1.45), and fasting blood sugar values ​​of prolanis and non-prolanis patients (110.05±20.67 : 144.20±29.10). The application of Prolanis is said to have a considerable influence on the level of discipline, knowledge, and GDP to the quality of life of patients, both prolanis and non-prolanis.
Potensi Antihiperpigmentasi Daun Michelia Alba: Studi In Silico Felysia Isman; Paundra Rizky Pratama; Wahida Annisa Ermadayanti; Cici Muarifah; Arif Fadlan
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1531

Abstract

Michelia alba empirically provides a youthful effect associated with the formation of melanin or skin pigment by tyrosinase enzyme. However, the excessive formation of melanin results in hyperpigmentation and various dermatological disorders such as freckles, melasma, and age spots. Synthetic antihyperpigmentations, which suppress melanin production, have been widely used, but have shown adverse side effects. This study aims to examine the potential of M. alba as a natural antihyperpigmentation agent. The in-silico research was conducted on the compounds contained in M. alba leaves through molecular docking against tyrosinase enzyme (PDB ID: 1BUG) followed by analysis of physicochemical properties and absorption, distribution, metabolism, excretion, and toxicity profiles (ADMET). The molecular docking results of cis-linalool oxide, trans-linalool oxide, linalool, β-elemene, α-humulene, and nerolidol in M. alba leaves against 1BUG indicated that nerolidol, α-humulene, and β-elemene showed lower docking scores than kojic acid and hydroquinone as controls. Nerolidol, α-humulene, and β-elemene interacted with 1BUG via hydrogen bonding, Van der Walls, and alkyl/π-alkyl and π-π stacking interactions. All compounds did not violate Lipinski and Veber rules based on the analysis of physicochemical properties. All compounds also had good absorption, distribution, metabolism, excretion, and toxicity profiles based on the parameters in each of these evaluations in the ADMET analysis.
Pengaruh Variasi Konsentrasi Gelling Agent Terhadap Sifat Fisik Dan Efek Antibakteri Sediaan Gel Handsanitizer Ekstrak Bawang Dayak faizal Mustamin; Irma Novrianti
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1541

Abstract

Currently, there are many alcohol-based hand sanitizers on the market. Alcohol-based products when used in the long term can cause irritation, so it is necessary to develop Handsanitizer preparations that use active substances other than alcohol. Onion Dayak (Eleutherine palmifolia (L.) Merr.) is a typical Kalimantan plant that has antibacterial properties. The purpose of this study was to examine the effect of variations in the concentration of gelling agent in the hand sanitizer gel preparation of Dayak onion extract on the physical properties and antibacterial effects of S. aureus and E. coli bacteria. Gel Handsanitizer preparations were made using the gelling agent carbopol with 3 variations in concentration, namely FI (carbopol 0.3%), FII (carbopol 0.4%), and FIII (carbopol 0.5%). The finished preparation will be tested for physical properties such as organoleptic, pH, viscosity and homogeneity. To see the antibacterial effect of the hand sanitizer, Dayak onion extract was tested on S. aureus and E. Coli bacteria. The hand sanitizer preparation of Dayak onion extract produced has a maroon color, has a distinctive odor, and is homogeneous. The results of the physical properties test showed that the viscosity and pH would increase with increasing gelling agent concentration, while the dispersion decreased with p < 0.05. The results of the test on S. aureus bacteria for FI, FII, FIII, and positive control showed a weak category, while the E. Coli bacteria showed a moderate category for FI, and a strong category for FII, FIII, and positive control with p value > 0, 05. The negative control did not form an inhibition zone. Variations in the concentration of geling agent (carbopol) had an effect on the physical properties of the hand sanitizer gel preparation of Dayak onion extract, but did not affect its effectiveness against S. aureus and E. coli bacteria.
Formulasi dan Uji Antibakteri Masker Peel-Off Ekstrak Daun Gulma Siam (Chromolaena odorata L.) Terhadap Propionibacterium Acnes Sari Wijayanti
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1554

Abstract

Leaves of gulma siam (Choromolaena odorata L.) contain tannins, phenols, flavonoids, saponins, and steroids which are effective for killing acne-causing bacteria. Applied as anti-acne, the extract of gulma siam is formulated as a preparation of a peel-off gel mask. This research produces formulas of peel-off masks made from the extract of gulma siam leaves and perpetrates an antibacterial test on the peel-off masks against propionibacterium acnes. Four formulas of peel-off masks were made using different concentrations of the extract of gulma siam leaves. The concentrations were 3.25% (FI), 7.5% (FII), 15% (FIII), and 20% (FIV). The preparations of the peel-off masks were physically evaluated for organoleptic, spreadability, homogeneity, pH, viscosity, and dry time. A well diffusion method was implemented to test antibacterial potencies against propionibacterium acnes. The potency measurement was based on the resistance around wells in the form of a clear zone. Predicated on the evaluation results of the physical properties of gulma siam leave extracts during storage, organoleptically, the extracts were homogenous, had a pH of 4.5-6.5, and had a dry time of 15-21 minutes. Concerning spreadability, FIII and FIV lived up to the criteria. Meanwhile, for viscosity, all formulas of peel-off masks were unstable during storage. FI and FII presented weak and medium antibacterial activities, respectively. Moreover, FII and FIV showed strong ones. The ANOVA analysis showcased differences in antibacterial activities among the four formulas (p < 0.05). In conclusion, the extract of gulma siam leaves in the form of a peel-off mask preparation was a potential actibacterial ingredient for dealing with propionibacterium acnes.

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