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JCPS (Journal of Current Pharmaceutical Sciences)
Published by Universitas Muhammadiyah Banjarmasin
ISSN : 25982087     EISSN : 25982095     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Current Pharmaceutical Sciences is a scholarly journal and expects to Publish articles related to the science of pharmaceutical science became the main focus of the problem at this time. This journal may publish research results as well as the results of theoretical studies and reviews. JCPS has had an ISSN print version 2598-2087 and has an online version 2598-2095 since Vo. 1 No.1 year 2017.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "Vol 3 No 1 (2019): September 2019" : 6 Documents clear
Farmasi EFEK RAMUAN OBAT TRADISIONAL (BATRA) KALIPUTIH JAWA TENGAH, TERHADAP KOLESTEROL, TRIGLISERIDA DAN HDL TIKUS SPRAGUE DAWLEY YANG DIINDUKSI STREPTOZOTOSIN Urmatul Waznah; Nurkhasanah Nurkhasanah; Kintoko Kintoko; Djati Wulan Kusumo
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 1 (2019): September 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

ABSTRAK Ramuan Batra asli Kaliputih adalah ramuan tradisional yang secara empiris berkhasiat untuk mengobati penyakit diabetes dengan komplikasi gagal ginjal yang terdiri dari tumbuhan obat yaitu, daun keji beling, daun kumis kucing, biji kopi arabika mentah, tunas bambu kuning, cokol tebu ireng, ganyong merah, rimpang temulawak, rimpang kunir putih, rimpang kunyit, buah belimbing wuluh dan srintil hutan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian Ramuan Batra terhadap kadar kolesterol, trigliserid dan HDL. Penelitian ini menggunakan 30 ekor tikus jantan galur Sprague Dawley yang diinduksi dengan Streptozotosin (dosis 40 mg/dl) secara intra peritonial dengan dosis tunggal. Pemberian ramuan dilakukan selama 15 hari sesuai dengan terapi yang dilakukan oleh Batra kepada pasien. Parameter yang diamati meliputi kadar kolesterol, trigiserid dan HDL menggunakan metode enzimatik–kalorimetri secara CHOD–PAP. Hasil Pengukuran kadar kolesterol dan trigliserida menunjukan penurunan dibandingkan kontrol negatif pada dosis 36 mL/kg BB dan dosis 54 mL/kg BB untuk kolesterol dan dosis 18 mL/kg BB, 36 mL/kg BB 54 mL/kg BB untuk trigliserida.Sedangkan pemeriksaan terhadap kadar HDL menunjukkan kenaikan dibandingkan kontrol negatif pada dosis 18 mL/kg BB, 36 mL/kg BB , 54 mL/kg BB. Sehingga ramuan Batra pada ketiga dosis,mampu menurunkan kadar kolesterol, trigliserida dan meningkatkan HDL. Kata kunci : Ramuan Batra Kaliputih, kolesterol, trigliserida, HDL
IDENTIFIKASI SENYAWA KIMIA DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETIL ASETAT BIJI SIRSAK (Annona mucicata Linn.) Anindini Winda Amalia; Atmira Sariwati
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 1 (2019): September 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

Antioxidants are substances that are useful for fighting free radicals. Plants can produce antioxidants to control the oxidative stress.Soursop plants are one of the plants that are known to contain antioxidant flavonoids. The purpose of this study was to determine the content of chemical compounds and antioxidant activity of ethyl acetate extract of soursop seeds. Identification of the content of chemical compounds was carried out qualitatively and quantitatively, while the antioxidant test was carried out using the capture method of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals with ascorbic acid as a comparison. The results showed that the soursop seeds ethyl acetate extract contained flavonoids, alkaloids, and saponins, while the results of the quantitative total phenolic and total flavonoid tests were 28.21 ± 0.03 mg/g and 22.17 ± 0.05 mg/g respectively. DPPH results of soursop seeds ethyl acetate extract were 39.45%. These results show that the soursop ethyl acetate extract has a weak antioxidant activity compared to gallic acid. Keywords: soursop seed extract, chemical identification, antioxidants, ethyl acetate, DPPH
EFEKTIVITAS PEMBERIAN NANOPARTIKEL KITOSAN-IOPAMIDOL MENGGUNAKAN NEBULIZER PADA SALURAN PERNAPASAN AYAM BROILER BERDASARKAN HASIL PENCITRAAN SINAR-X ikhwan wirahadikesuma; Koekoeh Santoso; Hera Maheshwari; Akhiruddin Maddu
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 1 (2019): September 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

ABSTRAK. Penyakit pernapasan khususnya pada ayam, diperlukan penghantaran obat yang langsung ke organ target dengan cara diinhalasi menggunakan alat nebulizer. Alat ini menghasilkan aerosol mampu mencapai paru-paru dan langsung berefek, dengan berbasis nanopartikel dapat meningkatkan bioavaibilitas. Penelitian ini bertujuan melihat efektivitas inhalasi nebulizer termodifikasi dikombinasi dengan nanopartikel kitosan-iopamidol terhadap organ target di saluran pernapasan ayam broiler. Sintesis nanopartikel metode gelasi ionik, dipreparasi dengan kitosan 0,1% dan natrium tripolifosfat 0,1% dalam cup nozzle 0,3 mm, rasio volume 5:1, ditambah 150 ml iopamidol 30,6 mg/ml dan diaduk 1300-1500 rpm. Partikel diukur dengan alat: Particle Size Analizer dan Scanning Electron Microscope. Nebulizer ultrasonik dan kompresor dipasang pada chamber 35 cm x 24 cm x 29 cm. Pemeriksaan radiologi tujuh ekor ayam umur 2 minggu, enam ekor masing-masing diinhalasi satu dari dua nebulizer dengan satu dari tiga macam larutan (nanopartikel kitosan, nanopartikel kitosan-iopamidol, dan iopamidol konsentrasi 30,6 mg/ml) sebanyak 3 ml. Kemudian dilakukan pemindaian dengan sinar-x. Hasil pengukuran partikel didapat z-avarage: 409,3 nm, indek polidisperitas 0,53 dan bentuk cenderung bulat. Citra radiograf menunjukkan radiopaque pada saluran pernapasan terutama kantong hawa yang diinhalasi nanopartikel kitosan-iopamidol. Kesimpulan, aerosol yang dihasilkan kedua jenis nebulizer termodifikasi yang dikombinasi dengan media kontras formulasi nanopartikel dapat mencapai saluran pernapasan ayam broiler. Kata kunci: ayam broiler, inhalasi, nebulizer, nanopartikel, sinar-x ABSTRACT. Respiratory diseases, especially in chickens, need proper treatment to deliver drugs directly to the target organs by means of inhalation using a nebulizer. This tool produces aerosols capable of reaching the lungs and having a healer effect immediately, with nanoparticles-based administration which can increase bioavailability. This study aimed to look at the effectiveness of modified inhalation nebulizer in combination with chitosan-iopamidol nanoparticles on target organs in the respiratory tract of broiler chickens. The nanoparticle synthesis of ionic gelation method was prepared with 0.1% chitosan and 0.1% sodium tripolyphosphate in 0.3 mm cup nozzle, with volume ratio 5: 1, plus 150 mL iopamidol 30.6 mg / mL then centrifuged on 1300-1500 rpm. Particles were measured by means of: Particle Size Analizer and Scanning Electron Microscope. Ultrasonic Nebulizer and compressor were installed in chamber with the size of 35 cm x 24 cm x 29 cm. Radiology examination of seven chickens with 2-week-old age was conducted by inhaling one of two nebulizers with one of three solutions (chitosan nanoparticles, chitosan-iopamidol nanoparticles, and iopamidol with the concentrations of 30.6 mg / mL) in the amount of 3 mL to six chickens (1 chicken was the control). Then x-ray scanning was carried out. The results of particle measurement obtained z-avarage in the amount of 409.3 nm, index of polydisperity of 0.53 and form tend to be spherical. Radiographic images revealed the existance of radiopaque in the respiratory tract, especially the bag of air inhaled chitosan-iopamidol nanoparticles. Therefore, the aerosols produced by the two types of modified nebulizers in combination with the nanoparticle formulation contrast media can reach the respiratory tract of broiler chickens. Keywords: broiler chicken, inhalation, nanoparticles, nebulizer, x-rays
Description of Patient Knowledge About Candesartan After Pio Medicine Through Leaflet Media in Outpatient Depo Of RSUD Moch. Ansari Banjarmasin M. Reinaldi Pratama; Sri Rahayu; Ananda Mellyani Hidayat
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 1 (2019): September 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

The awareness of the Indonesian population to take antihypertensive medication (OAH) is still low, there needs to be more intensive education about the importance of taking medicine so that hypertension can be controlled. The active role of pharmacy technical staff to assist pharmacists is very much needed in providing drug information (PIO) to patients and families of patients. The purpose of this study was to find out how the description of the knowledge of hypertensive patients about candesartan drugs after the provision of drug information through the media leaflets in the Outpatient Depo of the General Hospital Moch. Ansari Saleh Banjarmasin. The researcher took the data using a questionnaire given to hypertensive patients who used candesartan drugs after PIO through leaflets. The results of this study from 32 respondents obtained respondents who have good knowledge, namely 25 respondents (78.125%) and sufficient knowledge that is 7 respondents (21.875%). There were no respondents with a poor level of knowledge about candesartan drug information.
TINGKAT KEPUASAN KONSUMEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK “X" BANJARMASIN Siti Fadhilah; Herda Ariyani; Faisal Rahman
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 1 (2019): September 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

Pelayanan kefarmasian yang baik tentunya berorientasi langsung kepada konsumen sehingga menjamin keamanan, efektifitas dan kerasionalan penggunaan obat. Penelitian ini untuk mengetahui tingkat kepuasan konsumen terhadap pelayanan kefarmasian di Apotek “X” Banjarmasin. Metode penelitian ini bersifat deskriptif rancangan penelitian deskriptif dengan pengambilan sampel secara accidental sampling. Pengambilan data dilakukan secara langsung melalui wawancara menggunakan kuesioner kepada 100 orang konsumen. Analisis pelanggan dilakukan dengan lima dimensi kualitas layanan. Penelitian menunjukkan bahwa pada semua dimensi kualitas pelayanan baik tangible, reliability, responsiveness, assurance dan emphaty dalam kategori kurang puas. Yakni berturut turut persentase skor rata-rata sebanyak 54,2; 47,9; 44;9 54,8; 49.8.
PROFIL DIFUSI TRANSETHOSOME KURKUMIN DALAM SEDIAAN GEL YANG MENGGUNAKAN KARBOMER 934 SEBAGAI PEMBENTUK GEL Astri Dian Wulandari; Amelia Novianti; Muhammad Andika; Anisa Amalia
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 1 (2019): September 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

Kurkumin merupakan senyawa yang berasal dari tanaman kunyit (Curcuma Longa L.). Kurkumin memiliki banyak khasiat, tetapi kelarutan dan penetrasinya rendah. Oleh karena itu, perlu dibuat dalam sistem transethosome. Penelitian ini bertujuan untuk mengetahui profil difusi transethosome kurkumin secara in vitro menggunakan sel difusi franz. Transethosome kurkumin dibuat dengan metode dingin menggunakan pengaduk magnetik. Selanjutnya, transethosome dibuat sediaan gel dengan menggunakan karbomer 934 sebagai basis gel dengan konsentrasi 0,5%; 0,75%; 1% dan 1,25%. Sediaan gel dibuat dengan mencampurkan transethosome kurkumin kedalam basis gel karbomer. Karbomer dipilih karena menghasilkan gel yang memiliki viskositas yang baik. Evaluasi gel dilakukan dengan beberapa parameter seperti organoleptik, potensial zeta, ukuran partikel, pH, homogenitas, reologi dan profil difusi. Jumlah kumulatif kurkumin yang terdifusi selama 6 jam pada masing-masing formula adalah 1921,76µց, 1662,75µց, 1521,40µց, 1298,28 µg. Berdasarkan hasil difusi formula 1 menunjukan jumlah kumulatif yang besar dengan ukuran partikel 325,4 nm.

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