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Biomolecular and Health Science Journal
Published by Universitas Airlangga
ISSN : -     EISSN : 26208636     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.
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Articles 16 Documents
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Search results for , issue "Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal" : 16 Documents clear
Front Matter Vol 3 No.2 2020 Front Matter
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.26440

Abstract

A Case Series Of Arthritis In Hansen’s Disease Hendra Gunawan; Deasy Natalia Adriana; Awalia Awalia; Joewono Soeroso
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22287

Abstract

Hansen’s disease or leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. Musculoskeletal complaints might be the initial presentation of patients with Hansen’s disease. Symptoms are common with clinical spectrum ranging from mild to debilitating arthritis.  Regarding its wide clinical spectrum, a history taking especially in an endemic area like Indonesia on the possibility of Hansen’s disease cannot be ruled out in patients with arthritis. We reported 3 cases of arthritis in Hansen’s disease. First case was a 62-year-old Javanese female who had a deformity and chronic poly symmetry arthritis. Second case was a 45-year-old Javanese male with chronic bilateral knee pain as initial presentation of Hansen’s disease and the last case was 61-year-old Javanese male who had acute bilateral knee pain with erythematous maculae associated with Erythema Nodosum Leprosum. All cases responded to corticosteroid 1 mg/BW/day.
Organ Damage due to Elevation of Blood Pressure on NaCl-induced Hotimah Masdan Salim; Ilham Putra Alam; Widya Dio Kharisma
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22089

Abstract

Introduction: High salt diet is known to induce or aggravate hypertension in hypertensive rats and humans. The elevation of blood pressure by NaCl-induced promotes cardiac hypertrophy, the impairment of left ventricular relaxation, endothelial dysfunction, and kidney injury. This study aimed to examine whether NaCl-induced caused increase blood pressure and weight of organs. Methods: Eight weeks old male Mus musculus were divided to two groups, one group was given NaCl 8% by intraperitoneal injection for 8 hours.Results: Blood pressure was measured previously, in this study systolic and diastolic blood pressure increased significantly (p < 0.05). The increasing of blood pressure was followed by significant increase in organ weight, such as heart and kidney (p < 0.05). Conclusion: This result suggested that NaCl-induced caused hypertension and increased organs weight that may cause early process of damages in organs.
The Effectiveness of Extract Basil Leaves on Motility and Morphology of Spermatozoa Mice Exposed with Cigarette Smoke Bagas Setiawan Ihsan Zaini; Izki Masyaqqoni Pujiana; Evi Octavia Djamaludin; Hotimah Masdan Salim
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22169

Abstract

Introduction: The incidence of infertility is still a problem in the world, including Indonesia (21.3%), and throughout Asia. Fertility in men is strongly influenced by several factors, one of them is smoking. Smoking can increase ROS, reduce antioxidants in semen, cause DNA damage, and morphological abnormalities of spermatozoa. Basil contains flavonoids which are rich in antioxidants, boron, and zinc to stimulate androgen hormones.Methods: This research used eight weeks old Mus musculus, exposed with smoke of 20 cigarettes/day and was administered of extract basil leaves (Ocimum sanctum L.) in dose dependency (100 mg/kg, 200mg/kg, and 300mg/kg) for 4 weeks. We examined the motility and morphology of spermatozoa by microscope. This research consisted of 5 groups. In CS-, CSBL-2 and CSBL-3, it showed that the spermatozoa motility was more progressive than CS+ and CSBL-1.Results: The morphology of spermatozoa in CS+ and CS- found different results with a significance value of 0.10 (p < 0.05) but the results of CSBL- 1, CSBL-2, and CSBL-3 were not significantly different from CS- and CS+ (p > 0.05).Conclusion: There was an effect of giving basil leaves to increase motility and improvement of the morphology of spermatozoa that had been exposed to cigarette smoke especially in dose 300 mg/kgBB, but it was not significant.
Back Matter Vol 3 No.2 2020 Back Matter
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.26441

Abstract

The Comparison of Giardia lamblia Infection and Nutritional Status of Elementary School Students in Mandangin Island, Sampang and Mojo Village, Surabaya, Indonesia Zaidan Arifiansyah Bachtiar; Amalia Putri Uswatun Hasanah; Muhammad Yasin; Rahmadany Isyaputri; Budiono Budiono; Sukmawati Basuki
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22406

Abstract

Introduction: Giardia lamblia infection can cause impaired absorption of nutrientsand affects to the nutritional status that has not yet fully investigated in Indonesia.This study aimed to investigate the comparison of prevalence of Giardia lambliainfection and nutritional status of elementary students in Mandangin island and Mojovillage where were different condition.Methods: An analytical observational study with cross sectional design wasconducted in Mandangin island in July 2017 and Mojo village in June 2018 byinformed consent. Stools of elementary students were collected for Giardia lambliaidentification under a light microscope using direct smear method. Nutritional statusof students were determined by body mass index (BMI), and categorized as severeunderweight, underweight, healthyweight, overweight, and obese.Results: Forty-five stools samples were collected from elementary students inMandangin island and 55 stools samples in Mojo village. Prevalence of Giardialamblia infection without symptoms was higher in elementary students in Mandanginisland than Mojo village (28,9%, 13/45 and 1,8%, 1/55, respectively). Giardiasisprevalence in Mandangin island was significantly difference with Mojo village(p&lt;0.0001, chi square-test). Nutritional status of students in both study sites showeddominant healthy-weight that were 73.3% (34/55) in Mandangin island and 61.8%(33/45) in Mojo village. Giardiasis was commonly observed in students with healthy-weight and it was higher in Mandangin island (8/33, 24.2%) than Mojo village (1/34,2.9%).Conclusion: Asymptomatic giardiasis was highly found in elementary students inMandangin island and commonly observed in students with healthy-weight from both 3 regions. It suggested that asymptomatic giardiasis might not affect to the nutrition status of students.
Prevalence Proportion of Patient with Coronary Heart Disease in Inpatient Room of RSUD Dr. Soetomo Surabaya in 2017 Faradila Budi Saputri; Dyah Fauziah; Esti Hindariati
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22094

Abstract

Introduction: Coronary heart disease (CHD) is the most common type of heart disease that causes death. It occurs as a result of hardening of the coronary arteries which supply oxigen-rich blood to the entire heart muscle so that the heart can contract properly. However, many patients neglect the symptoms. Moreover, the risk factor and the comorbides disease worsen the condition. This research aims to study the profile of coronary heart disease patients in the inpatient rooms at Dr. Soetomo General Hospital Surabaya in 2017.Methods: This study was a cross-sectional and retrospective study by assessing patients’ medical record and analyzed descriptively.Results: From total 587, 263 patiens met inclusion criteria, aged between 51-60 years (42.6%) with domination of male (82,13%). %). Risk Factors are into one of the Comorbidities of CHD Patient. There are Risk Factor can be aggravate of CHD Patients. Most of subjects had risk factor hipertension (50,79%), and hypertension with DM (38,7%). Hypertension based on systolic pressure and diastolic pressure obtained that systolic pressure <120 mmhg was 39.6% and diastolic pressure <80 was 37.4%.Conclusion: Most of CHD patients in this study were in age group 51 – 60 years old, male, had risk factor hypertension and DM.
Antibiotic Resistance in Escherichia coli and Staphylococcus aureus from Retail Chicken Meat in Surabaya, Indonesia Annisa Aulia Maghfirani Sudarmadi; Subur Prajitno; Agung Dwi Wahyu Widodo
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22170

Abstract

Introduction: Antimicrobial resistance is becoming a problem in public health. Zoonotic food-borne bacteria is infectious agent that can be transferred from animal to human through the food-producing animal we consume. Nowadays, antibiotic used for human and animal is not only to cure infection but also to aim animal’s growth promotion. It is known as non therapeutic antimicrobial agent (NTA) leading to antibiotic resistance. The third generation cephalosporins, cefotaxime, and also cefoxitin are included as important antibiotic for human. This study aims to identify the presence of cefotaxime-resistant Escherichia coli and cefoxitin-resistant Staphylococcus aureus isolated from chicken meat of both traditional and modern market in Surabaya.Methods: This is descriptive post test only experimental research. We used 8 samples of chicken meat from 4 different market using purposive sampling technique. We cultured Escherichia coli and Staphylococcus aureus from the chicken meat. Sensitivity test was done using Kirby-bauer disk-diffusion method.Results: All chicken meat sample bought from traditional market in Surabaya are contaminated by cefotaxime-sensitive Escherichia coli (n=4/4) while chicken meat sample bought from modern market are not contaminated by Escherichia coli (n=0/4). All chicken meat sample bought from traditional (n=4/4) are also contaminated by cefoxitin-sensitive Staphylococcus aureus. Half of chicken meat sample bought from modern market (n=2/4) are contaminated by cefoxitin-sensitive Staphylococcus aureus, while the other half (n=2/4) are contaminated by cefoxitin-resistant Staphylococcus aureus.Conclusion: Antibiotic resistance is found and all chicken meat samples have been highly contaminated with bacteria therefore food-processing should be done correctly.
Correlation Between the Severity of Chronic Rhinosinusitis and Sleep Quality in Adult Patients Clarisa Christina Gabriella; Kristanti Wanito Wigati; Budi Sutikno
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22024

Abstract

Introduction: Chronic rhinosinusitis (CRS) usually accompanied by one of the symptoms (nasal obstruction, rhinorrhea) and one of associated symptoms (facial pain and/or hyposmia/anosmia). In addition, most of CRS sufferers have poor sleep quality. Thus, we aim to determine the relationship between the severity of CRS and sleep quality in adult patients.Methods: This study was cross-sectional method study. Consecutive sampling technique with estimate a proportion in finite population formula was used. The variables studied were the CRS severity based on visual analogue scale (VAS), and subjects’ sleep quality based on the Pittsburgh sleep quality index (PSQI). The data collection was carried out using a questionnaire and analyzed using chi-square test and continued with fisher’s exact test.Results: Of the 24 study subjects, 45.8% were male and 54.2% female. 83.3% had a nasal obstruction, 66.7% had rhinorrhea, 54.2% had hyposmia/anosmia, and 66.7% had facial pain. The severity of subject was mild, moderate and severe by 41,67%, 29,17%, and 41,67% respectively. 87.5% had poor sleep quality. There was no significant correlation between the severity of CRS and sleep quality (p=1,00).Conclusion: Although there was no correlation between CRS severity and sleep quality in adult patients, but CRS patients in general had poor sleep.Further study using more subjects, apply objective assessments, and include other more specific will help describe the correlation in population.
The Comparison of Visual Acuity After Congenital Cataract Surgery between Children ≤2 Years and >2-17 Years Adam Surya Romadhon; Joni Susanto; Rozalina Loebis
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22140

Abstract

Introduction: Congenital cataract is turbidity occurs in eye lens that present at birth or immediately after. We aim to find out visual acuity after congenital surgery between children under 2 years old and 2-17 years old after following up 3, 6, 12 months.Methods: This was a cross-sectional study. Data were gathered from medical record of congenital cataract aged ≤2 years and >2-17 years including age of surgery, frequency of eyes, sex, laterality, and visual acuity of patients with best corrected visual acuity (BCVA). All data analyzed using Mann-Whitney test.Results: 41 children (67 affected eyes) in which 45 eyes that were operated at aged ≤2 years and 22 eyes were operated at aged >2-17 years. There was average difference of visual acuity between age group of ≤2 years and >2-17 years while following-up 3 months (1.60 ± 0.34 logMAR, 1.23 ± 0.67 logMAR, p = 0,003). Whereas in follow up 6 months (1.23 ± 0.47 logMAR, 1.15 ± 0.68 logMAR, p = 0,242) and 12 months (0.94 ± 0.47 logMAR, 0.96 ± 0.44 logMAR, p = 0,840), there were no difference significant average of visual acuity.Conclusion: Visual acuity after following-up 3 and 6 months in age group of >2-17 years were better than age group of ≤2 years, whereas after following-up 12 months in age group ≤2 years, it was obtained that visual acuity was better than age group of >2-17 years.

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