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Jurnal Farmamedika (Pharmamedica Journal)

farmamedika
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Published by Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

ISSN : 25026011 EISSN : 26864487 DOI : https://doi.org/10.47219/ath

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

Jurnal Farmamedika dikelola oleh Lembag Penelitian dan Pengabdian Masyarakat, Sekolah Tinggi Teknologi Industri dan Farmasi Bogor. Frekuensi penerbitan jurnal sebanyak 2 kali dalam satu tahun pada bulan Juni dan Desember. Kategori tulisan berupa hasil penelitian dari peneliti maupun akademisi dalam bidang Kimia Bahan Alam, Analisis Farmasi, Farmakologi dan Toksikologi, Kimia Medicinal, Biologi Molekular dan Bioteknologi, Farmakoterapi, Farmasi Klinis, Farmasetika dan Teknologi Farmasi, Biologi Farmasi, Manajemen Farmasi, Farmakoekonomi.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 7 Documents

Search results for , issue "Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)" : 7 Documents clear

EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) TERHADAP PROSES PENYEMBUHAN LUKA GORES PADA KELINCI Ferry Effendi; Padmono Citroreksoko; Deo Subagyo
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Anredera cordifolia (Ten.) Steenis that is known by the name of binahong leaves have medicinal properties traditionally as wound healing. This study aims to determine the effectiveness of leaf binahong extract ointment on graze and to know the effectiveness of the leaf binahong extract ointment as wound healing. This research used experimental research method. Simplicia powder of binahong leaf was extracted using a maceration method. The result of maceration extracted by using a rotary evaporator, the extract obtained are formulated into ointments. Binahong leaf extract ointment made within 5 concentrations that is a concentration of 20%, 25%, 30%, 35% and 40%. The subject of research in the form of a rabbits that amount 3 tails were divided into 7 treatment groups ie negative control (ointment base), positive control (Betadine ointment), ointments leaf extract binahong 20%, ointment leaf extract binahong 25%, ointment leaf extract binahong 30%, ointment binahong 35% leaf extract and leaf extract ointment binahong 40%. Rabbits are scarred on the back with a wound length of 2 cm. Ointment leaf extract with various concentrations carried out the effectiveness test against the healing of scratch on the back of a rabbit that has been injured. On testing ointment was done organoleptic test, homogeneity test and pH test. The data were processed statistically using ANOVA analysis with SPSS method. Results of the research and the results of statistical analysis that extract ointment. Binahong leaf had effectivity on a scratch wound. Binahong leaf extract ointment concentration of 20%, 25% and 30% have given the effect of wound healing, where as the concentration of 35% and 40% give a more effective healing effect. Effects similar to the positive control, namely ointment binahong leaf extract with a concentration of 35%, whereas the leaf extract ointment binahong 40% have the best effect.

Uji Aktivitas Ekstrak Etanol 70% dan Etil Asetat Daun Sukun (Artocarpus altilis (Park.) Fosberg Sebagai Inhibitor Tirosinase. Herson Cahaya Himawan; Antonius Padua Ratu; Maya Miani
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Melanin is a substance that gives brown or blackish brown on the skin. Tyrosinase is the main enzyme in biosynthesis of melanin. Utilization of breadfruit leaves based chemical compounds therein such as flavonoids and tannins which are derivates of phenol.Then tested of tyrosinase inhibitory activity.The purpose of this study was to determine the power of inhibition of tyrosinase at ethanol extracts 70% and ethyl acetate extracts of leaves of breadfruit. Acquisition of extraction by maceration, subsequently evaporated by means of separation (rotary vacuum evaporator). Maserate were obtained for a each standard series of concentration 2000; 1000; 500; 250; 125; 62,5; 31,25; 15,63 ppm and kojic acid as positive control with concentration 500; 250; 125; 62,5; 31,25; 15,63 ppm, then each sample tested the inhibitory activity of tyrosinase.Based on the results of the study for the highest tyrosinase inhibitory activity shown by ethyl acetate extract of leaves of breadfruit, because it value smaller IC50 than ethanol extracts 70% of leaves ofbreadfruit. The value IC50 the ethyl acetate extract was 245,43 ppm, while the value IC50 the is 3143,21 ppm. However the activity of tyrosinase inhibition of ethanol extracts 70% and ethyl acetate extract of leaves of breadfruit was lower than kojic acid as positive control that has a value IC50 is 19,36 ppm, because the smaller the value IC50 The greater power inhibition of tyrosinase.

AKTIVITAS ANTIBAKTERI EKSTRAK BIJI LABU AIR (Lagenaria siceraria) TERHADAP Staphylococcus epidermidis, Staphylococcus aureus dan Escherichia coli Silvi Nurafni; Siti Mariam; Kasriati
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Lagenaria siceraria, known as water pumpkin seeds containing compounds alkaloids, phenolics, tannins, flavonoids and steroids. The above compounds are potentially as antibacterial. This research aims to know the effectiveness of the inhibition of the growth of the bacteria Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli. Based on the results of the research it is known that phytochemicals may be screening the content of water pumpkin seeds (Lagenaria siceraria) namely alkaloids, tannins, flavonoids, steroids and phenol. From the results of testing the effectiveness of antibacterial water pumpkin seed extract with ethyl acetate solvent, hexane and water is able to inhibit the growth of Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli. However the antibacterial activity of extracts of water pumpkin seeds using solvent hexane has a zone larger than drag the extract water pumpkin seeds using the solvent ethyl acetate and water. Comparison of antimicrobial activity of the solvent on the third with variation concentration of solvent shows a meaningful difference in inhibiting the growth of bacteria Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli. It can be seen from the p-value < 0.05 (p = 0.000).

UJI TOKSISITASEKSTRAK DAUN SIRSAK (Annona muricata L.) YANG BERPOTENSI SEBAGAI ANTIKANKER Triyani Sumiati; Ferry Effendi; Rina arifah puspitasari
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Plant soursop (Annona muricata L.) is one of the Annonaceae familia. This plant has well-known in the society environment and it has been using as a traditional medicine. One of benefits of the soursop is can used as an algernative of cancer treatment. Until now not yet known scientifically whether soursop leaves have anticancer activity.This study aims to determine the potential toxicity of bioactive substances from the ethanol extract, of ethyl acetate and n-hexane of the soursop leaves as an anticancer agent by using Brine Shrimp Lethality Test (BSLT) method. This experimental As many as 100 larvas were use as research objects which divided into 3 groups. Each group consist of 10 larvas and the group repetition were done by randomly, three times per group. The extract concentration used in medium is 500, 100, 10 and as a control 0 ppm. Data obtained from counting the number of dead larvas (letal concentration 50 ppm) after 24 hours treatment. Based on the data obtained from LC50 of extract ethanol, ethyl acetate and n-hexane soursop leaves then determined by using probit analysis. The water content which contained in simplicia (drifed leaves) is 6,49%. The probit analysis results show that the ethanol extract have LC50 values of 86,45 ppm, 92,81 ppm of ethyl acetate extract and n-hexane extracts 37601,05 ppm. The distribution of ethanol and ethyl acetate extracts of soursop leaves in the experiments shown any potential toxicity against Artemia salina Leach, while the n-hexane extract of soursop leaves show no any potential toxicity to against Artemia salina Leach larvas.

ANALISIS SENYAWA SITRULIN EKSTRAK AIR DAN EKSTRAK ETANOL DAGING DAN KULIT BUAH BLEWAH (Cucumis melo L.) Antonius Padua Ratu; Herson Cahaya Himawan; M. Rio Radhi
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Data from the United States Department of Agriculture (USDA) National Nutrient database, that cantaloupe contains amino acids of 0.8 grams / 100 grams. One of the amino acids found in cantaloupe is citrulline which can contribute to oxidative stress as a free radical scavenger. The purpose of this study was to obtain the optimal content of citrulline compound in the flesh and skin of blewah to the method of extraction. The method used is the maceration method with ethanol and water solvent, digestion and dekokta method only with water solvent. Quantitatively, sitrulin is obtained by acid hydrolysis and is reacted with a specific reagent which is 3% diacetyl monoxime in a hot temperature. The reading of the result using the maximum wavelength spectrophotometer is 488 nm. The highest content of citrulline compound was shown by decocta method of aquatic leather water extract (7.72 g / 100g). The citrulline content was significantly different (P <0.05) on the difference in other extraction methods.

PENENTUAN KADAR KAFEIN KOPI ROBUSTA TERFERMENTASIOLEH Enterococcus durans, Enterococcus sulfureus, DAN Lactococcus garvieae Sitaresmi Yuningtyas; Syahid Pratama Al-Wali; Winugroho
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Many people like to drink coffee because it has a unique flavor. Coffee also containscaffeine,which is not good for health. One of the most famous type of coffee is civet coffee (kopi luwak).This coffee is unique because lower caffeine and in the process of this coffee should be consumedfirst by civet. The issue is populations of civet who began to decrease and the process that makes itdifficult to be produced on a large scale in a short time. In this research, we tried to apply culture ofEnterococcus durans, Enterococcus sulfureus, and Lactococcusgarviea for processing robustacoffee that resembles the civet coffee. This study aims to determine the caffeine content offermented of robusta coffee and the results will be compared with the civet coffee. Bacteria foundin the digestive system of civet had isolated and added in fermentation process of robusta coffee.Caffeine levels measured by HPLC.From these results it can be concluded that the caffeine contentin fermented of robusta coffee whichfermented using bacterial suspension Enterococcus durans,Enterococcus sulfureus andLactococcusgarvieaehad not been able to equal the caffeine content incivet coffee.Amount of caffeine in fermented of robusta coffee had lower than amount of caffeinein robusta coffee. Percentage of caffeine in fermented of robusta coffee, robusta coffee, and civetcoffeewere 1,20%, 1,90%, and 0,59% respectively.

OPTIMASI WAKTU MASERASI SILDENAFIL SITRAT DALAM JAMU KUAT YANG BEREDAR DI BOGOR BARAT Harry Noviardi; Bina Lohita Sari; Muhamad Wildan Malik
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 2 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Herbal medicine is types traditional medicine that is consumed by people. One type of herbal medicine on the market is Jamu Kuat. According Indonesian Food and Drug Administration, herbal medicine can not contain chemical of drugs. But, Jamu Kuat on the market still found contain chemical of drug, that is sildenafil citrate. In previous research, analysis of sildenafil citrate in the Jamu Kuat has not been accompained by the optimization of extraction time.The aim of research is optimizing the time of maceration sildenafil citrate in Jamu Kuat circulating on the West Bogor. Sampling of Jamu kuat was used purpusive sampling. The sample macerated with constant stirring was used a magnetic stirrer with 560 rpm and analyzis with Thin Layer Chromatography and Spectrophotometry UV-Vis method. Results of the research show that there was 5 from 8 samples Jamu Kuat contained sildenafil citrate. Optimum times of maceration was 60-90 minutes in four samples, 120-150 minutes in one sample and contains sildenafil citrate 8.00-11.00% in four samples and 20.00-21.00% in one sample. The results was concluded there different optimal times for samples

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Harry Noviardi

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+622518323819

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Editorial Address
Jl. Kumbang No.23, Bogor, Jawa Barat, 16151

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Harry Noviardi

Contact Email harry.noviardi@gmail.com

Phone +622518323819

Journal Mail Official lppm@sttif.ac.id

Editorial Address Jl. Kumbang No.23, Bogor, Jawa Barat, 16151

Location Kota bogor, Jawa barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Harry Noviardi

Contact Email
harry.noviardi@gmail.com

Phone
+622518323819

Journal Mail Official
lppm@sttif.ac.id

Editorial Address
Jl. Kumbang No.23, Bogor, Jawa Barat, 16151

Location
Kota bogor,

Jawa barat

INDONESIA