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Eureka Herba Indonesia
Published by HM Publisher
ISSN : -     EISSN : 27465152     DOI : https://doi.org/10.37275/ehi.v1i1.1
Core Subject : Health,
Medicine & Pharmacology
Eureka Herba Indonesia (EHI) is peer review scientific journal that focused on reserach in exploration potential Herba of Indonesia for enhancing healthy. EHI focused on : 1. Medicinal Plants. 2. Efficacy of Herba Study. 3. Safety of Herba Study. 4. Animals that potential for developing as healthy products. 5. Minerals that potential for developing as healthy products.
Arjuna Subject : Kedokteran - Kedokteran Komplemen dan Alternatif
Articles 100 Documents
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Antibacterial Effectiveness Test of Methanol Extract of Red Galangal Rhizome (Alpinia purpurata (Vieill) K. Schum) Against Streptococcus pyogenes and Klebsiella pneumonia Bacteria Dwi Permatasari Utomo Putri; Listiana Masyita Dewi; Rochmadina Suci Bestari; Nurhayani
Eureka Herba Indonesia Vol. 5 No. 2 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i2.116

Abstract

Red galangal rhizome (Alpinia purpurata (Vieill) K. Schum) is a medicinal plant belonging to the family Zingiberaceae. Red galangal rhizomes have antibacterial benefits because they contain active substances such as flavonoids, saponins, triterpenoids, alkaloids, and tannins. Streptococcus pyogenes causes bacterial infections of the skin and upper respiratory tract, while Klebsiella pneumonia is the bacteria that causes pneumonia. This study aims to determine the antibacterial effectiveness of methanol extract of red galangal rhizomes (Alpinia purpurata (Vieill) K. Schum) against Streptococcus pyogenes and Klebsiella pneumonia bacteria. This research is an experimental laboratory with a post-test-only controlled group design. Red galangal rhizomes were extracted using methanol solvent and tested for antibacterial effectiveness using the well method. There were 6 groups in the study, namely the chloramphenicol positive control group, the distilled water negative control group, and the 20%, 40%, 60%, and 80% concentration groups. The largest inhibition zone diameter was found at a concentration of 80%, with an average of 25.50 mm in Streptococcus pyogenes bacteria and 28.73 mm in Klebsiella pneumonia bacteria. In conclusion, methanol extract of red galangal rhizome (Alpinia purpurata (Vieill) K. Schum) effective against bacteria Streptococcus pyogenes and Klebsiella pneumonia.
Potential of Legetan Leaves (Acmella oleracea) as a Therapeutic Modality for Osteoarthritis: An In Vivo Study Indrayani, Indrayani
Eureka Herba Indonesia Vol. 5 No. 2 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i2.117

Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by inflammation and cartilage damage. Legetan leaves (Acmella oleracea) have anti-inflammatory and antioxidant potential that may help relieve OA symptoms. This study aims to evaluate the potential of legetan leaves as a therapeutic modality for OA in a rat model. Legetan leaf extract was formulated into an oral preparation and given to rats induced by OA with monosodium iodate. The positive control group received standard OA medications. Parameters measured include pain scores, joint inflammation, and cartilage damage. Legetan leaf extract significantly reduced pain scores and joint inflammation in rats with OA. Legetan leaf extract also shows a protective effect against cartilage damage. In conclusion, Legetan leaves have potential as a therapeutic modality for OA.
Analysis of Ethnopharmacological Studies on the Use of the Sambiloto Plant in the Treatment of Malaria in the Asmat Tribal Community in Papua, Indonesia Awotauw, Esther Lea; Ruth Maria Panggabean
Eureka Herba Indonesia Vol. 5 No. 2 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i2.118

Abstract

Malaria is still a major health problem in Indonesia, especially in the Papua region. The Asmat tribe has traditional knowledge about the use of medicinal plants to treat malaria, one of which is sambiloto. This research uses a qualitative observational research design with an ethnopharmacological approach. This approach combines aspects of ethnography and pharmacology to study traditional knowledge and the use of medicinal plants in a community. It was discovered that sambiloto has long been used by the Asmat tribe to treat malaria. Sambiloto leaf is processed into a decoction or juice and drunk to relieve malaria symptoms such as fever, chills, and headaches. This ethnopharmacological study shows that sambiloto has potential as an herbal medicine for treating malaria in the Asmat community. Further research is needed to test the effectiveness and safety of sambiloto in the treatment of malaria.
Conservation and Exploration of the Potential of Rare Medicinal Plants in the Tropical Rainforest of Bukit Barisan, Sumatra, Indonesia: An Effort Towards Sustainable Herbal Medicine Maulana, Syaidina
Eureka Herba Indonesia Vol. 5 No. 2 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i2.119

Abstract

The Bukit Barisan tropical rainforest in Sumatra, Indonesia, is one of the most biodiverse areas in the world. It is estimated that there are more than 10,000 plant species in this forest, and many of them have potential as herbal medicines. However, deforestation and overexploitation threaten the preservation of medicinal plants in the Bukit Barisan tropical rainforest. This causes loss of valuable natural resources and hinders research and development of new herbal medicines. This research was conducted in several tropical rainforests in Bukit Barisan, Sumatra. Field surveys were conducted to document rare medicinal plant species. Plant samples were collected and analyzed for their phytochemical content. Bioassay tests were carried out to evaluate antibacterial, antioxidant and anti-inflammatory activities. Strategies for conservation and sustainable exploration of rare medicinal plants are developed based on research results. Field surveys found 27 species of rare medicinal plants. Phytochemical analysis shows that this plant contains various bioactive compounds, such as alkaloids, flavonoids and terpenoids. Bioassay tests show that this plant has significant antibacterial, antioxidant and anti-inflammatory activity. In conclusion, the Bukit Barisan tropical rainforest has great potential for the development of herbal medicine. Sustainable conservation and exploration of rare medicinal plants in the Bukit Barisan tropical rainforest is important to ensure the preservation of these valuable natural resources and to improve community health.
Analysis of Ethnopharmaceutical Studies of Traditional Medicine for the Management of Jaundice Due to Hepatic Disorders by the Mandar Tribe of West Sulawesi, Indonesia Sari, Dewi Weni; Kharisma Jayak Pratama; Annora Rizky Amalia
Eureka Herba Indonesia Vol. 5 No. 2 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i2.120

Abstract

Jaundice, or icterus, is a medical condition characterized by yellowing of the skin and whites of the eyes. This is caused by a buildup of bilirubin in the blood, which is a waste product of the breakdown of red blood cells. Liver disorders, such as hepatitis, are the most common cause of jaundice. The Mandar tribe in West Sulawesi Indonesia has a traditional healing tradition that has been passed down from generation to generation. This traditional medicine is often used to treat various diseases, including jaundice. This study aims to analyze the ethnopharmaceutical traditional treatment for jaundice in the Mandar tribe in West Sulawesi. This research used a descriptive observational method with traditional healthcare respondents. Data was collected through interviews and observations of traditional healers and patients who used traditional medicine. The data was analyzed descriptively to determine the type of plant, part of the plant used, processing methods, and how traditional medicines are used. This research found 14 plant species from 13 families that were used as medicine for jaundice. Two types of plants are typically used by the Mandar tribe, namely lapo-lapo (Melanolepis multiglandulosa) and barorang (Blumea balsamifera). The parts of the plant most commonly used as medicine are leaves (43%), followed by fruit (29%), stems (14%), roots (7%), rhizomes (4%), and herbs (3%). Plant processing by pressing and boiling is the most widely used (50% each). The most common method of use is boiling (70%), followed by pounding (20%) and eating directly (10%). This research found 14 plant species from 13 families that were used by the Mandar tribe as medicine for jaundice. Two types of plants are typically used, namely lapo-lapo and barorang. This research provides important information about the Mandar tribe's ethnopharmacology for jaundice and can be a basis for the development of more effective and safer traditional medicines.
Analysis of Behavioral Factors in the Use of Traditional Medicine: Observational Study in Yogyakarta, Indonesia Adi Nugrahanti, Maria Cyrilla Iglesia; Yosef Wijoyo; Yustina Sri Hartini; Nunung Priyatni
Eureka Herba Indonesia Vol. 5 No. 3 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i3.121

Abstract

Traditional medicine has long been used by the people of Yogyakarta, Indonesia as an alternative treatment to modern medicine. Various factors influence traditional medicine use, including psychological factors such as attitudes, subjective norms, and perceived behavioral control. This research aims to determine the factors that influence the use of traditional medicine among the people of Yogyakarta Indonesia using the theory of planned behavior (TPB). This research was conducted using an analytical observational research design with a cross-sectional design. Data was collected from 110 respondents living in Yogyakarta who met the inclusion and exclusion criteria. The research instrument is a questionnaire that refers to the TPB construct which has been tested for validity and reliability. Data analysis was carried out using logistic regression statistical tests and Pearson correlation tests. The results of the analysis show that attitudinal factors and perceived behavioral control partially contribute to the intention to use traditional medicine, while the subjective norm construct does not contribute. Attitudes and perceived behavioral control are important factors that influence the intention to use traditional medicine among Indonesian people. This suggests that interventions that focus on increasing positive attitudes and perceived behavioral control can increase the use of traditional medicine.
Potential of Ethanol Extract of Red Gedi Leaves (Abelmoschus manihot L. Medik) Against Endogenous Antioxidant Activity in Rat Model of Diabetes Mellitus Amalia, Annora Rizky; Alfina Nurrahman; Dewi Weni Sari; Muhammad Firdaus
Eureka Herba Indonesia Vol. 5 No. 3 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i3.123

Abstract

Diabetes mellitus (DM) is characterized by chronic hyperglycemia and increased oxidative stress, contributing to disease complications. Red gedi leaves (Abelmoschus manihot L. Medik) are rich in bioactive compounds, including tannins, saponins, alkaloids and flavonoids, with antioxidant potential. This study aims to evaluate the effect of ethanol extract of red gedi leaves on endogenous antioxidant activity in rat model of DM induced by STZ-NA. Male rats were induced with DM with streptozotocin (STZ)-NA. Rats were divided into five groups: normal control (KN), DM control (KDM), glibenclamide positive control (KPG), and group treated with red gedi leaf extract at a dose of 100 mg/kgBW (GEDI 100), 200 mg/kgBW (GEDI 200), and 400 mg/kgBW (GEDI 400). The parameters observed included blood glucose levels, malondialdehyde (MDA) as a marker of oxidative stress, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver tissue. Data analysis used one-way ANOVA and Tukey's post hoc test (p<0.05). The results showed that the yield of ethanol extract from red gedi leaves was 6.984%. Administration of red gedi leaf extract at a dose of 400 mg/kgBW (GEDI 400) significantly reduced blood glucose levels (p<0.05) and MDA (p<0.05), and increased the activity of SOD (p<0.05), CAT (p<0.05), and GPx (p<0.05) in DM rats compared to the DM control group (KDM). The effect of GEDI 400 was comparable to the effect of glibenclamide as a positive control. The ethanol extract of red gedi leaves at a dose of 400 mg/kgBW was effective in increasing endogenous antioxidant activity and reducing oxidative stress in STZ-NA-induced DM rats, showing potential as an antioxidant and antidiabetic agent.
The Effect of Topical Virgin Coconut Oil on Striae Gravidarum Prevention and Severity: A Randomized Controlled Trial Ulya, Rahmatul; Sunesni; Yohana Suganda; Mekar Zenni Radhia
Eureka Herba Indonesia Vol. 5 No. 3 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i3.124

Abstract

Striae gravidarum (SG), commonly known as stretch marks, is a common concern during pregnancy. Virgin coconut oil (VCO) is traditionally used for skin health and may have potential in SG prevention. This randomized controlled trial (RCT) aimed to assess the efficacy of topical VCO in preventing and reducing the severity of SG among pregnant women in Kerinci Regency, Indonesia. Pregnant women (n=200) in their second trimester were randomized to receive either topical VCO or a placebo (standard emollient) twice daily. SG severity was assessed using a modified striae gravidarum assessment scale (SGAS) at baseline, 32 weeks gestation, and six weeks postpartum. VCO application was associated with a significantly lower incidence of new SG compared to the placebo (25% vs. 45%, p < 0.05). Furthermore, the VCO group showed a significant reduction in SG severity at 32 weeks and postpartum (mean SGAS scores: VCO 1.8 vs. placebo 2.6 at 32 weeks, p < 0.05; VCO 1.4 vs. placebo 2.2 at postpartum, p < 0.01). No adverse effects were reported. In conclusion, topical VCO appears to be safe and effective in preventing new SG and reducing the severity of existing SG during pregnancy. Further research is warranted to explore the underlying mechanisms and long-term effects.
The Hematopoietic Potential of Tamarillo (Cyphomandra betacea) and Pitaya (Hylocereus spp.) Juices in Anemia Management: A Randomized Controlled Trial in Bukittinggi, West Sumatra, Indonesia Nova H, Desri; Yeltra Armi; Mutia Felina; Zaharatul Hikmah; Riri Aprianti
Eureka Herba Indonesia Vol. 5 No. 3 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i3.125

Abstract

Anemia is a global health concern, particularly prevalent in developing countries. Traditional remedies like tamarillo and pitaya have been suggested to boost blood production. This study aimed to evaluate the efficacy and safety of these juices in managing anemia. A randomized, double-blind, placebo-controlled trial was conducted in Bukittinggi, West Sumatra, Indonesia. Participants with mild to moderate anemia (hemoglobin 8-11 g/dL) were randomized to receive daily tamarillo juice, pitaya juice, or a placebo for 12 weeks. Hemoglobin, hematocrit, iron levels, and hematological parameters were assessed at baseline and week 12. A total of 150 participants completed the study (50 per group). Both tamarillo and pitaya juice groups showed significant increases in hemoglobin and hematocrit levels compared to the placebo group (p < 0.05). Pitaya juice also demonstrated a significant increase in iron levels (p < 0.01). No serious adverse events were reported. Tamarillo and pitaya juices show promise as adjunctive therapies for anemia management. Further research is needed to explore their long-term effects and mechanisms of action.
Bay Leaf Extract as a Potential Therapeutic Agent for LDL Reduction in Hypercholesterolemia: A Dose-Response Study Sudarmika, Kadek Adi; Putu Oky Ari Tania
Eureka Herba Indonesia Vol. 5 No. 3 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i3.126

Abstract

Hypercholesterolemia, characterized by elevated low-density lipoprotein (LDL) cholesterol levels, is a major risk factor for cardiovascular disease. The current study investigated the dose-dependent effects of bay leaf extract on LDL cholesterol reduction in a hypercholesterolemic rat model. Male Wistar rats were fed a high-fat diet to induce hypercholesterolemia. They were then randomly assigned to five groups: positive control (simvastatin), negative control (standard diet), and three treatment groups receiving graded doses of bay leaf extract (0.72 g, 1.08 g, and 1.80 g). LDL cholesterol levels were measured after seven days of treatment. Bay leaf extract administration resulted in a dose-dependent reduction in LDL cholesterol levels. The highest dose (1.80 g) exhibited comparable efficacy to simvastatin in lowering LDL cholesterol. In conclusion, bay leaf extract demonstrates potential as a therapeutic agent for managing hypercholesterolemia by effectively reducing LDL cholesterol levels. The optimal dose for LDL reduction appears to be 1.80 g. Further research is warranted to explore the underlying mechanisms and clinical implications of these findings.

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